Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYU1_LEIIN

TriTrypDb:

LINF_200015000

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.642
CLV_C14_Caspase3-7	56	60	PF00656	0.635
CLV_NRD_NRD_1	160	162	PF00675	0.574
CLV_NRD_NRD_1	201	203	PF00675	0.739
CLV_NRD_NRD_1	210	212	PF00675	0.742
CLV_NRD_NRD_1	215	217	PF00675	0.645
CLV_NRD_NRD_1	309	311	PF00675	0.743
CLV_NRD_NRD_1	386	388	PF00675	0.623
CLV_NRD_NRD_1	43	45	PF00675	0.581
CLV_NRD_NRD_1	432	434	PF00675	0.677
CLV_NRD_NRD_1	482	484	PF00675	0.763
CLV_PCSK_FUR_1	382	386	PF00082	0.732
CLV_PCSK_KEX2_1	160	162	PF00082	0.574
CLV_PCSK_KEX2_1	210	212	PF00082	0.778
CLV_PCSK_KEX2_1	215	217	PF00082	0.711
CLV_PCSK_KEX2_1	309	311	PF00082	0.731
CLV_PCSK_KEX2_1	384	386	PF00082	0.737
CLV_PCSK_KEX2_1	43	45	PF00082	0.581
CLV_PCSK_KEX2_1	432	434	PF00082	0.677
CLV_PCSK_KEX2_1	570	572	PF00082	0.699
CLV_PCSK_KEX2_1	75	77	PF00082	0.645
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.612
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.737
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.581
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.683
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.645
CLV_PCSK_PC7_1	211	217	PF00082	0.684
CLV_PCSK_PC7_1	382	388	PF00082	0.624
CLV_PCSK_SKI1_1	12	16	PF00082	0.548
CLV_PCSK_SKI1_1	18	22	PF00082	0.552
CLV_PCSK_SKI1_1	215	219	PF00082	0.673
CLV_PCSK_SKI1_1	284	288	PF00082	0.633
CLV_PCSK_SKI1_1	29	33	PF00082	0.611
CLV_PCSK_SKI1_1	410	414	PF00082	0.645
CLV_PCSK_SKI1_1	44	48	PF00082	0.657
CLV_PCSK_SKI1_1	526	530	PF00082	0.690
DEG_Nend_UBRbox_2	1	3	PF02207	0.582
DEG_SCF_FBW7_1	421	428	PF00400	0.629
DEG_SCF_FBW7_2	359	366	PF00400	0.560
DEG_SPOP_SBC_1	411	415	PF00917	0.572
DEG_SPOP_SBC_1	628	632	PF00917	0.705
DOC_CKS1_1	273	278	PF01111	0.620
DOC_CKS1_1	422	427	PF01111	0.623
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.643
DOC_MAPK_gen_1	309	318	PF00069	0.638
DOC_MAPK_gen_1	429	437	PF00069	0.677
DOC_PP1_RVXF_1	10	16	PF00149	0.552
DOC_PP2B_LxvP_1	458	461	PF13499	0.635
DOC_PP4_FxxP_1	234	237	PF00568	0.632
DOC_USP7_MATH_1	123	127	PF00917	0.720
DOC_USP7_MATH_1	143	147	PF00917	0.690
DOC_USP7_MATH_1	148	152	PF00917	0.646
DOC_USP7_MATH_1	370	374	PF00917	0.804
DOC_USP7_MATH_1	398	402	PF00917	0.672
DOC_USP7_MATH_1	411	415	PF00917	0.597
DOC_USP7_MATH_1	425	429	PF00917	0.584
DOC_USP7_MATH_1	447	451	PF00917	0.704
DOC_USP7_MATH_1	459	463	PF00917	0.579
DOC_USP7_MATH_1	479	483	PF00917	0.561
DOC_USP7_MATH_1	495	499	PF00917	0.553
DOC_USP7_MATH_1	60	64	PF00917	0.633
DOC_USP7_MATH_1	624	628	PF00917	0.704
DOC_USP7_MATH_1	655	659	PF00917	0.674
DOC_USP7_UBL2_3	43	47	PF12436	0.599
DOC_WD40_RPTOR_TOS_1	696	702	PF00400	0.659
DOC_WW_Pin1_4	134	139	PF00397	0.620
DOC_WW_Pin1_4	182	187	PF00397	0.571
DOC_WW_Pin1_4	241	246	PF00397	0.804
DOC_WW_Pin1_4	272	277	PF00397	0.619
DOC_WW_Pin1_4	293	298	PF00397	0.607
DOC_WW_Pin1_4	359	364	PF00397	0.620
DOC_WW_Pin1_4	417	422	PF00397	0.696
DOC_WW_Pin1_4	474	479	PF00397	0.704
DOC_WW_Pin1_4	512	517	PF00397	0.744
DOC_WW_Pin1_4	533	538	PF00397	0.780
DOC_WW_Pin1_4	569	574	PF00397	0.854
DOC_WW_Pin1_4	578	583	PF00397	0.697
DOC_WW_Pin1_4	612	617	PF00397	0.725
DOC_WW_Pin1_4	636	641	PF00397	0.689
DOC_WW_Pin1_4	677	682	PF00397	0.692
LIG_14-3-3_CanoR_1	111	120	PF00244	0.538
LIG_14-3-3_CanoR_1	18	28	PF00244	0.675
LIG_14-3-3_CanoR_1	252	256	PF00244	0.680
LIG_14-3-3_CanoR_1	309	318	PF00244	0.674
LIG_14-3-3_CanoR_1	403	412	PF00244	0.716
LIG_14-3-3_CanoR_1	483	493	PF00244	0.583
LIG_14-3-3_CanoR_1	571	577	PF00244	0.735
LIG_14-3-3_CanoR_1	589	596	PF00244	0.528
LIG_14-3-3_CanoR_1	626	636	PF00244	0.680
LIG_14-3-3_CanoR_1	644	651	PF00244	0.512
LIG_14-3-3_CanoR_1	81	89	PF00244	0.524
LIG_BIR_III_4	331	335	PF00653	0.619
LIG_BRCT_BRCA1_1	489	493	PF00533	0.582
LIG_FHA_1	20	26	PF00498	0.469
LIG_FHA_1	212	218	PF00498	0.705
LIG_FHA_1	285	291	PF00498	0.649
LIG_FHA_1	311	317	PF00498	0.579
LIG_FHA_1	360	366	PF00498	0.559
LIG_FHA_1	417	423	PF00498	0.654
LIG_FHA_1	455	461	PF00498	0.632
LIG_FHA_1	501	507	PF00498	0.763
LIG_FHA_1	542	548	PF00498	0.733
LIG_FHA_1	579	585	PF00498	0.720
LIG_FHA_1	6	12	PF00498	0.545
LIG_FHA_1	628	634	PF00498	0.701
LIG_FHA_2	231	237	PF00498	0.629
LIG_FHA_2	290	296	PF00498	0.559
LIG_FHA_2	390	396	PF00498	0.718
LIG_FHA_2	463	469	PF00498	0.712
LIG_FHA_2	54	60	PF00498	0.634
LIG_FHA_2	595	601	PF00498	0.687
LIG_FHA_2	689	695	PF00498	0.661
LIG_Integrin_RGD_1	57	59	PF01839	0.614
LIG_LIR_Apic_2	231	237	PF02991	0.614
LIG_LIR_Nem_3	646	651	PF02991	0.650
LIG_MYND_1	512	516	PF01753	0.670
LIG_MYND_1	636	640	PF01753	0.641
LIG_NRBOX	27	33	PF00104	0.522
LIG_SH2_GRB2like	586	589	PF00017	0.728
LIG_SH2_STAT5	38	41	PF00017	0.475
LIG_SH2_STAT5	712	715	PF00017	0.673
LIG_SH2_STAT5	94	97	PF00017	0.574
LIG_SH3_3	117	123	PF00018	0.599
LIG_SH3_3	373	379	PF00018	0.696
LIG_SH3_3	394	400	PF00018	0.703
LIG_SH3_3	472	478	PF00018	0.819
LIG_SH3_3	507	513	PF00018	0.805
LIG_SH3_3	590	596	PF00018	0.673
LIG_TRAF2_1	219	222	PF00917	0.632
LIG_TRAF2_1	245	248	PF00917	0.736
LIG_TRAF2_1	292	295	PF00917	0.774
LIG_TRAF2_1	576	579	PF00917	0.661
LIG_WW_3	550	554	PF00397	0.646
MOD_CDK_SPxK_1	421	427	PF00069	0.665
MOD_CDK_SPxxK_3	474	481	PF00069	0.667
MOD_CK1_1	345	351	PF00069	0.618
MOD_CK1_1	462	468	PF00069	0.657
MOD_CK1_1	482	488	PF00069	0.572
MOD_CK1_1	515	521	PF00069	0.661
MOD_CK1_1	572	578	PF00069	0.733
MOD_CK1_1	587	593	PF00069	0.563
MOD_CK1_1	615	621	PF00069	0.720
MOD_CK1_1	627	633	PF00069	0.580
MOD_CK1_1	664	670	PF00069	0.588
MOD_CK1_1	69	75	PF00069	0.623
MOD_CK1_1	707	713	PF00069	0.657
MOD_CK2_1	143	149	PF00069	0.707
MOD_CK2_1	236	242	PF00069	0.728
MOD_CK2_1	289	295	PF00069	0.642
MOD_CK2_1	412	418	PF00069	0.705
MOD_CK2_1	464	470	PF00069	0.710
MOD_CK2_1	688	694	PF00069	0.663
MOD_CK2_1	698	704	PF00069	0.559
MOD_Cter_Amidation	382	385	PF01082	0.733
MOD_Cter_Amidation	532	535	PF01082	0.660
MOD_GlcNHglycan	123	126	PF01048	0.787
MOD_GlcNHglycan	169	172	PF01048	0.650
MOD_GlcNHglycan	186	189	PF01048	0.569
MOD_GlcNHglycan	277	280	PF01048	0.631
MOD_GlcNHglycan	337	340	PF01048	0.703
MOD_GlcNHglycan	441	447	PF01048	0.679
MOD_GlcNHglycan	449	452	PF01048	0.665
MOD_GlcNHglycan	461	464	PF01048	0.548
MOD_GlcNHglycan	470	473	PF01048	0.715
MOD_GlcNHglycan	489	492	PF01048	0.614
MOD_GlcNHglycan	574	577	PF01048	0.700
MOD_GlcNHglycan	610	613	PF01048	0.677
MOD_GlcNHglycan	625	629	PF01048	0.603
MOD_GlcNHglycan	666	669	PF01048	0.610
MOD_GlcNHglycan	67	71	PF01048	0.646
MOD_GlcNHglycan	706	709	PF01048	0.658
MOD_GSK3_1	123	130	PF00069	0.674
MOD_GSK3_1	144	151	PF00069	0.636
MOD_GSK3_1	228	235	PF00069	0.712
MOD_GSK3_1	289	296	PF00069	0.614
MOD_GSK3_1	335	342	PF00069	0.685
MOD_GSK3_1	385	392	PF00069	0.722
MOD_GSK3_1	412	419	PF00069	0.662
MOD_GSK3_1	421	428	PF00069	0.575
MOD_GSK3_1	442	449	PF00069	0.714
MOD_GSK3_1	462	469	PF00069	0.532
MOD_GSK3_1	479	486	PF00069	0.614
MOD_GSK3_1	49	56	PF00069	0.615
MOD_GSK3_1	500	507	PF00069	0.701
MOD_GSK3_1	539	546	PF00069	0.703
MOD_GSK3_1	584	591	PF00069	0.721
MOD_GSK3_1	608	615	PF00069	0.716
MOD_GSK3_1	624	631	PF00069	0.557
MOD_GSK3_1	683	690	PF00069	0.651
MOD_GSK3_1	694	701	PF00069	0.576
MOD_GSK3_1	703	710	PF00069	0.482
MOD_N-GLC_1	587	592	PF02516	0.719
MOD_NEK2_1	127	132	PF00069	0.670
MOD_NEK2_1	141	146	PF00069	0.597
MOD_NEK2_1	229	234	PF00069	0.702
MOD_NEK2_1	412	417	PF00069	0.645
MOD_NEK2_1	453	458	PF00069	0.555
MOD_NEK2_1	48	53	PF00069	0.785
MOD_NEK2_1	661	666	PF00069	0.641
MOD_NEK2_1	683	688	PF00069	0.682
MOD_PIKK_1	127	133	PF00454	0.665
MOD_PIKK_1	243	249	PF00454	0.678
MOD_PIKK_1	370	376	PF00454	0.723
MOD_PIKK_1	404	410	PF00454	0.660
MOD_PIKK_1	615	621	PF00454	0.622
MOD_PIKK_1	643	649	PF00454	0.644
MOD_PIKK_1	683	689	PF00454	0.678
MOD_PK_1	75	81	PF00069	0.586
MOD_PKA_1	211	217	PF00069	0.684
MOD_PKA_1	310	316	PF00069	0.631
MOD_PKA_1	385	391	PF00069	0.625
MOD_PKA_1	483	489	PF00069	0.772
MOD_PKA_1	75	81	PF00069	0.586
MOD_PKA_2	251	257	PF00069	0.680
MOD_PKA_2	342	348	PF00069	0.613
MOD_PKA_2	385	391	PF00069	0.668
MOD_PKA_2	453	459	PF00069	0.571
MOD_PKA_2	482	488	PF00069	0.693
MOD_PKA_2	588	594	PF00069	0.715
MOD_PKA_2	643	649	PF00069	0.584
MOD_PKA_2	75	81	PF00069	0.586
MOD_Plk_1	454	460	PF00069	0.658
MOD_Plk_1	694	700	PF00069	0.661
MOD_Plk_2-3	236	242	PF00069	0.583
MOD_Plk_2-3	694	700	PF00069	0.661
MOD_Plk_4	123	129	PF00069	0.683
MOD_Plk_4	629	635	PF00069	0.695
MOD_Plk_4	661	667	PF00069	0.640
MOD_Plk_4	75	81	PF00069	0.586
MOD_ProDKin_1	134	140	PF00069	0.621
MOD_ProDKin_1	182	188	PF00069	0.571
MOD_ProDKin_1	241	247	PF00069	0.805
MOD_ProDKin_1	272	278	PF00069	0.620
MOD_ProDKin_1	293	299	PF00069	0.600
MOD_ProDKin_1	359	365	PF00069	0.620
MOD_ProDKin_1	417	423	PF00069	0.695
MOD_ProDKin_1	474	480	PF00069	0.704
MOD_ProDKin_1	512	518	PF00069	0.746
MOD_ProDKin_1	533	539	PF00069	0.780
MOD_ProDKin_1	569	575	PF00069	0.855
MOD_ProDKin_1	578	584	PF00069	0.697
MOD_ProDKin_1	612	618	PF00069	0.724
MOD_ProDKin_1	636	642	PF00069	0.687
MOD_ProDKin_1	677	683	PF00069	0.691
MOD_SUMO_for_1	106	109	PF00179	0.493
MOD_SUMO_rev_2	319	328	PF00179	0.623
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.677
TRG_DiLeu_LyEn_5	225	230	PF01217	0.558
TRG_ENDOCYTIC_2	101	104	PF00928	0.481
TRG_ER_diArg_1	215	217	PF00400	0.718
TRG_ER_diArg_1	385	387	PF00400	0.638
TRG_NLS_MonoCore_2	383	388	PF00514	0.623
TRG_NLS_MonoExtC_3	383	389	PF00514	0.685
TRG_NLS_MonoExtN_4	309	314	PF00514	0.612
TRG_NLS_MonoExtN_4	382	388	PF00514	0.733
TRG_NLS_MonoExtN_4	43	48	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW49	Leishmania donovani	99%	100%
E9AIF0	Leishmania braziliensis	61%	98%
E9AUN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QCU6	Leishmania major	84%	100%