Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein - unknown function

Species:

Leishmania infantum

UniProt:

A4HYT7_LEIIN

TriTrypDb:

LINF_200014400

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.745
CLV_C14_Caspase3-7	548	552	PF00656	0.699
CLV_C14_Caspase3-7	625	629	PF00656	0.682
CLV_NRD_NRD_1	228	230	PF00675	0.563
CLV_NRD_NRD_1	333	335	PF00675	0.713
CLV_NRD_NRD_1	360	362	PF00675	0.679
CLV_NRD_NRD_1	363	365	PF00675	0.727
CLV_NRD_NRD_1	471	473	PF00675	0.662
CLV_NRD_NRD_1	553	555	PF00675	0.774
CLV_NRD_NRD_1	573	575	PF00675	0.748
CLV_NRD_NRD_1	631	633	PF00675	0.732
CLV_NRD_NRD_1	638	640	PF00675	0.676
CLV_NRD_NRD_1	680	682	PF00675	0.677
CLV_NRD_NRD_1	687	689	PF00675	0.650
CLV_PCSK_FUR_1	361	365	PF00082	0.590
CLV_PCSK_FUR_1	636	640	PF00082	0.824
CLV_PCSK_FUR_1	685	689	PF00082	0.740
CLV_PCSK_KEX2_1	228	230	PF00082	0.563
CLV_PCSK_KEX2_1	333	335	PF00082	0.713
CLV_PCSK_KEX2_1	360	362	PF00082	0.679
CLV_PCSK_KEX2_1	363	365	PF00082	0.727
CLV_PCSK_KEX2_1	471	473	PF00082	0.662
CLV_PCSK_KEX2_1	509	511	PF00082	0.769
CLV_PCSK_KEX2_1	553	555	PF00082	0.810
CLV_PCSK_KEX2_1	573	575	PF00082	0.751
CLV_PCSK_KEX2_1	631	633	PF00082	0.735
CLV_PCSK_KEX2_1	638	640	PF00082	0.739
CLV_PCSK_KEX2_1	687	689	PF00082	0.682
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.598
CLV_PCSK_PC7_1	569	575	PF00082	0.752
CLV_PCSK_SKI1_1	193	197	PF00082	0.552
CLV_PCSK_SKI1_1	322	326	PF00082	0.708
CLV_PCSK_SKI1_1	348	352	PF00082	0.587
DEG_APCC_DBOX_1	192	200	PF00400	0.616
DEG_APCC_DBOX_1	371	379	PF00400	0.708
DEG_COP1_1	51	60	PF00400	0.429
DEG_SPOP_SBC_1	601	605	PF00917	0.771
DOC_CKS1_1	297	302	PF01111	0.581
DOC_CKS1_1	485	490	PF01111	0.807
DOC_CKS1_1	677	682	PF01111	0.736
DOC_CYCLIN_RxL_1	319	328	PF00134	0.777
DOC_MAPK_DCC_7	238	246	PF00069	0.653
DOC_MAPK_gen_1	38	47	PF00069	0.619
DOC_MAPK_gen_1	636	644	PF00069	0.769
DOC_MAPK_gen_1	652	660	PF00069	0.579
DOC_MAPK_MEF2A_6	238	246	PF00069	0.714
DOC_MAPK_MEF2A_6	38	47	PF00069	0.634
DOC_MAPK_MEF2A_6	652	660	PF00069	0.688
DOC_PP1_RVXF_1	172	179	PF00149	0.549
DOC_PP2B_LxvP_1	456	459	PF13499	0.643
DOC_PP2B_LxvP_1	642	645	PF13499	0.709
DOC_PP4_FxxP_1	195	198	PF00568	0.456
DOC_PP4_FxxP_1	674	677	PF00568	0.746
DOC_USP7_MATH_1	116	120	PF00917	0.728
DOC_USP7_MATH_1	122	126	PF00917	0.786
DOC_USP7_MATH_1	191	195	PF00917	0.640
DOC_USP7_MATH_1	309	313	PF00917	0.723
DOC_USP7_MATH_1	31	35	PF00917	0.683
DOC_USP7_MATH_1	335	339	PF00917	0.716
DOC_USP7_MATH_1	342	346	PF00917	0.534
DOC_USP7_MATH_1	391	395	PF00917	0.698
DOC_USP7_MATH_1	601	605	PF00917	0.771
DOC_USP7_MATH_1	663	667	PF00917	0.784
DOC_WW_Pin1_4	205	210	PF00397	0.610
DOC_WW_Pin1_4	296	301	PF00397	0.604
DOC_WW_Pin1_4	325	330	PF00397	0.728
DOC_WW_Pin1_4	373	378	PF00397	0.764
DOC_WW_Pin1_4	472	477	PF00397	0.779
DOC_WW_Pin1_4	484	489	PF00397	0.614
DOC_WW_Pin1_4	676	681	PF00397	0.782
LIG_14-3-3_CanoR_1	307	316	PF00244	0.657
LIG_14-3-3_CanoR_1	455	459	PF00244	0.706
LIG_14-3-3_CanoR_1	554	564	PF00244	0.743
LIG_14-3-3_CanoR_1	639	645	PF00244	0.755
LIG_14-3-3_CanoR_1	80	88	PF00244	0.480
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BRCT_BRCA1_1	247	251	PF00533	0.595
LIG_CSL_BTD_1	177	180	PF09270	0.605
LIG_FHA_1	171	177	PF00498	0.507
LIG_FHA_1	182	188	PF00498	0.593
LIG_FHA_1	344	350	PF00498	0.546
LIG_FHA_1	35	41	PF00498	0.760
LIG_FHA_1	374	380	PF00498	0.751
LIG_FHA_1	522	528	PF00498	0.660
LIG_FHA_1	613	619	PF00498	0.749
LIG_FHA_1	72	78	PF00498	0.440
LIG_FHA_2	145	151	PF00498	0.568
LIG_FHA_2	393	399	PF00498	0.765
LIG_FHA_2	447	453	PF00498	0.683
LIG_FHA_2	524	530	PF00498	0.759
LIG_LIR_Apic_2	194	198	PF02991	0.454
LIG_LIR_Gen_1	401	410	PF02991	0.634
LIG_LIR_Nem_3	220	224	PF02991	0.555
LIG_LIR_Nem_3	401	407	PF02991	0.594
LIG_Pex14_1	404	408	PF04695	0.622
LIG_SH2_PTP2	420	423	PF00017	0.713
LIG_SH2_SRC	420	423	PF00017	0.736
LIG_SH2_STAT5	355	358	PF00017	0.671
LIG_SH2_STAT5	420	423	PF00017	0.643
LIG_SH2_STAT5	428	431	PF00017	0.649
LIG_SH3_2	677	682	PF14604	0.697
LIG_SH3_3	130	136	PF00018	0.759
LIG_SH3_3	44	50	PF00018	0.522
LIG_SH3_3	467	473	PF00018	0.698
LIG_SH3_3	514	520	PF00018	0.811
LIG_SH3_3	674	680	PF00018	0.693
LIG_SUMO_SIM_par_1	242	249	PF11976	0.668
LIG_TRAF2_1	208	211	PF00917	0.591
MOD_CDK_SPK_2	472	477	PF00069	0.725
MOD_CDK_SPK_2	676	681	PF00069	0.674
MOD_CDK_SPxK_1	676	682	PF00069	0.676
MOD_CDK_SPxxK_3	472	479	PF00069	0.789
MOD_CK1_1	166	172	PF00069	0.542
MOD_CK1_1	186	192	PF00069	0.369
MOD_CK1_1	271	277	PF00069	0.727
MOD_CK1_1	311	317	PF00069	0.767
MOD_CK1_1	328	334	PF00069	0.738
MOD_CK1_1	34	40	PF00069	0.766
MOD_CK1_1	446	452	PF00069	0.699
MOD_CK1_1	500	506	PF00069	0.792
MOD_CK1_1	563	569	PF00069	0.662
MOD_CK1_1	572	578	PF00069	0.779
MOD_CK1_1	626	632	PF00069	0.714
MOD_CK1_1	9	15	PF00069	0.567
MOD_CK2_1	205	211	PF00069	0.553
MOD_CK2_1	365	371	PF00069	0.766
MOD_CK2_1	392	398	PF00069	0.589
MOD_CK2_1	435	441	PF00069	0.638
MOD_CK2_1	523	529	PF00069	0.707
MOD_CK2_1	594	600	PF00069	0.663
MOD_CK2_1	66	72	PF00069	0.500
MOD_DYRK1A_RPxSP_1	472	476	PF00069	0.779
MOD_GlcNHglycan	110	113	PF01048	0.681
MOD_GlcNHglycan	115	119	PF01048	0.733
MOD_GlcNHglycan	120	123	PF01048	0.727
MOD_GlcNHglycan	188	191	PF01048	0.706
MOD_GlcNHglycan	205	208	PF01048	0.555
MOD_GlcNHglycan	262	265	PF01048	0.654
MOD_GlcNHglycan	294	297	PF01048	0.722
MOD_GlcNHglycan	311	314	PF01048	0.715
MOD_GlcNHglycan	337	340	PF01048	0.667
MOD_GlcNHglycan	413	416	PF01048	0.625
MOD_GlcNHglycan	437	440	PF01048	0.731
MOD_GlcNHglycan	501	505	PF01048	0.760
MOD_GlcNHglycan	542	548	PF01048	0.755
MOD_GlcNHglycan	574	577	PF01048	0.757
MOD_GlcNHglycan	586	589	PF01048	0.638
MOD_GlcNHglycan	625	628	PF01048	0.663
MOD_GlcNHglycan	666	669	PF01048	0.726
MOD_GlcNHglycan	694	697	PF01048	0.717
MOD_GSK3_1	114	121	PF00069	0.748
MOD_GSK3_1	140	147	PF00069	0.602
MOD_GSK3_1	166	173	PF00069	0.498
MOD_GSK3_1	179	186	PF00069	0.565
MOD_GSK3_1	292	299	PF00069	0.541
MOD_GSK3_1	366	373	PF00069	0.715
MOD_GSK3_1	378	385	PF00069	0.646
MOD_GSK3_1	398	405	PF00069	0.675
MOD_GSK3_1	446	453	PF00069	0.785
MOD_GSK3_1	496	503	PF00069	0.685
MOD_GSK3_1	545	552	PF00069	0.614
MOD_GSK3_1	580	587	PF00069	0.676
MOD_GSK3_1	612	619	PF00069	0.749
MOD_GSK3_1	622	629	PF00069	0.580
MOD_N-GLC_1	496	501	PF02516	0.601
MOD_NEK2_1	144	149	PF00069	0.505
MOD_NEK2_1	251	256	PF00069	0.639
MOD_NEK2_1	382	387	PF00069	0.546
MOD_NEK2_1	454	459	PF00069	0.711
MOD_NEK2_1	521	526	PF00069	0.662
MOD_NEK2_1	584	589	PF00069	0.599
MOD_NEK2_1	622	627	PF00069	0.779
MOD_NEK2_1	640	645	PF00069	0.551
MOD_NEK2_2	343	348	PF00069	0.688
MOD_PIKK_1	398	404	PF00454	0.548
MOD_PKA_2	271	277	PF00069	0.697
MOD_PKA_2	292	298	PF00069	0.739
MOD_PKA_2	411	417	PF00069	0.682
MOD_PKA_2	454	460	PF00069	0.775
MOD_PKA_2	555	561	PF00069	0.720
MOD_PKA_2	572	578	PF00069	0.548
MOD_PKA_2	630	636	PF00069	0.706
MOD_PKA_2	640	646	PF00069	0.663
MOD_PKA_2	79	85	PF00069	0.482
MOD_Plk_1	370	376	PF00069	0.720
MOD_Plk_1	440	446	PF00069	0.795
MOD_Plk_1	500	506	PF00069	0.740
MOD_Plk_1	71	77	PF00069	0.459
MOD_Plk_2-3	594	600	PF00069	0.700
MOD_Plk_4	461	467	PF00069	0.747
MOD_Plk_4	580	586	PF00069	0.671
MOD_Plk_4	72	78	PF00069	0.433
MOD_ProDKin_1	205	211	PF00069	0.607
MOD_ProDKin_1	296	302	PF00069	0.607
MOD_ProDKin_1	325	331	PF00069	0.729
MOD_ProDKin_1	373	379	PF00069	0.761
MOD_ProDKin_1	472	478	PF00069	0.779
MOD_ProDKin_1	484	490	PF00069	0.614
MOD_ProDKin_1	676	682	PF00069	0.785
TRG_DiLeu_BaEn_1	72	77	PF01217	0.500
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.627
TRG_ENDOCYTIC_2	355	358	PF00928	0.546
TRG_ER_diArg_1	227	229	PF00400	0.557
TRG_ER_diArg_1	359	361	PF00400	0.536
TRG_ER_diArg_1	372	375	PF00400	0.510
TRG_ER_diArg_1	470	472	PF00400	0.666
TRG_ER_diArg_1	476	479	PF00400	0.671
TRG_ER_diArg_1	553	556	PF00400	0.732
TRG_ER_diArg_1	636	639	PF00400	0.764
TRG_ER_diArg_1	685	688	PF00400	0.692
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ6	Leptomonas seymouri	35%	86%
A0A3Q8IEV0	Leishmania donovani	100%	100%
A0A3R7M1N2	Trypanosoma rangeli	30%	100%
E9AIE6	Leishmania braziliensis	69%	100%
E9AUN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCV1	Leishmania major	90%	100%