AATF-Che1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AATF protein - putative

Species:

Leishmania infantum

UniProt:

A4HYT4_LEIIN

TriTrypDb:

LINF_200014100

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HYT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.720
CLV_C14_Caspase3-7	162	166	PF00656	0.589
CLV_C14_Caspase3-7	257	261	PF00656	0.779
CLV_C14_Caspase3-7	287	291	PF00656	0.610
CLV_C14_Caspase3-7	384	388	PF00656	0.667
CLV_C14_Caspase3-7	446	450	PF00656	0.337
CLV_NRD_NRD_1	117	119	PF00675	0.635
CLV_NRD_NRD_1	180	182	PF00675	0.714
CLV_NRD_NRD_1	276	278	PF00675	0.690
CLV_NRD_NRD_1	293	295	PF00675	0.538
CLV_NRD_NRD_1	297	299	PF00675	0.500
CLV_NRD_NRD_1	325	327	PF00675	0.582
CLV_NRD_NRD_1	540	542	PF00675	0.335
CLV_NRD_NRD_1	629	631	PF00675	0.371
CLV_NRD_NRD_1	656	658	PF00675	0.396
CLV_NRD_NRD_1	88	90	PF00675	0.547
CLV_PCSK_FUR_1	294	298	PF00082	0.651
CLV_PCSK_KEX2_1	119	121	PF00082	0.547
CLV_PCSK_KEX2_1	180	182	PF00082	0.653
CLV_PCSK_KEX2_1	295	297	PF00082	0.542
CLV_PCSK_KEX2_1	325	327	PF00082	0.555
CLV_PCSK_KEX2_1	629	631	PF00082	0.292
CLV_PCSK_KEX2_1	88	90	PF00082	0.547
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.608
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.523
CLV_PCSK_PC7_1	625	631	PF00082	0.292
CLV_PCSK_PC7_1	84	90	PF00082	0.452
CLV_PCSK_SKI1_1	132	136	PF00082	0.719
CLV_PCSK_SKI1_1	297	301	PF00082	0.616
CLV_PCSK_SKI1_1	409	413	PF00082	0.398
CLV_PCSK_SKI1_1	428	432	PF00082	0.193
CLV_PCSK_SKI1_1	505	509	PF00082	0.357
CLV_PCSK_SKI1_1	647	651	PF00082	0.386
CLV_PCSK_SKI1_1	697	701	PF00082	0.484
CLV_Separin_Metazoa	626	630	PF03568	0.371
DEG_COP1_1	509	518	PF00400	0.346
DEG_Nend_UBRbox_1	1	4	PF02207	0.420
DEG_SPOP_SBC_1	372	376	PF00917	0.545
DOC_CYCLIN_RxL_1	425	435	PF00134	0.391
DOC_CYCLIN_RxL_1	641	654	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	25	28	PF00134	0.413
DOC_MAPK_gen_1	488	497	PF00069	0.480
DOC_MAPK_gen_1	505	515	PF00069	0.357
DOC_MAPK_gen_1	575	585	PF00069	0.467
DOC_MAPK_MEF2A_6	44	53	PF00069	0.352
DOC_PP1_RVXF_1	674	681	PF00149	0.292
DOC_PP2B_LxvP_1	25	28	PF13499	0.413
DOC_PP2B_LxvP_1	513	516	PF13499	0.357
DOC_PP4_FxxP_1	680	683	PF00568	0.312
DOC_USP7_MATH_1	203	207	PF00917	0.731
DOC_USP7_MATH_1	372	376	PF00917	0.659
DOC_USP7_MATH_1	443	447	PF00917	0.436
DOC_USP7_MATH_1	483	487	PF00917	0.491
DOC_USP7_MATH_1	594	598	PF00917	0.526
DOC_USP7_MATH_1	633	637	PF00917	0.357
DOC_USP7_MATH_1	689	693	PF00917	0.361
DOC_USP7_UBL2_3	193	197	PF12436	0.747
DOC_WW_Pin1_4	223	228	PF00397	0.521
DOC_WW_Pin1_4	27	32	PF00397	0.389
LIG_14-3-3_CanoR_1	118	123	PF00244	0.543
LIG_14-3-3_CanoR_1	325	331	PF00244	0.665
LIG_14-3-3_CanoR_1	357	365	PF00244	0.601
LIG_Actin_WH2_2	52	70	PF00022	0.399
LIG_BIR_III_4	247	251	PF00653	0.686
LIG_BIR_III_4	290	294	PF00653	0.690
LIG_BRCT_BRCA1_1	165	169	PF00533	0.642
LIG_eIF4E_1	425	431	PF01652	0.419
LIG_eIF4E_1	538	544	PF01652	0.337
LIG_FHA_1	30	36	PF00498	0.381
LIG_FHA_1	306	312	PF00498	0.555
LIG_FHA_1	389	395	PF00498	0.527
LIG_FHA_1	415	421	PF00498	0.434
LIG_FHA_2	123	129	PF00498	0.547
LIG_FHA_2	301	307	PF00498	0.508
LIG_FHA_2	382	388	PF00498	0.431
LIG_FHA_2	507	513	PF00498	0.307
LIG_FHA_2	532	538	PF00498	0.357
LIG_FHA_2	594	600	PF00498	0.599
LIG_FHA_2	68	74	PF00498	0.454
LIG_GSK3_LRP6_1	27	33	PF00069	0.386
LIG_LIR_Gen_1	158	169	PF02991	0.646
LIG_LIR_Gen_1	462	472	PF02991	0.411
LIG_LIR_Nem_3	158	164	PF02991	0.611
LIG_LIR_Nem_3	235	241	PF02991	0.508
LIG_LIR_Nem_3	462	468	PF02991	0.386
LIG_LIR_Nem_3	517	521	PF02991	0.253
LIG_NRBOX	34	40	PF00104	0.380
LIG_NRBOX	407	413	PF00104	0.400
LIG_PCNA_yPIPBox_3	463	476	PF02747	0.423
LIG_SH2_CRK	402	406	PF00017	0.313
LIG_SH2_NCK_1	480	484	PF00017	0.395
LIG_SH2_NCK_1	618	622	PF00017	0.455
LIG_SH2_SRC	150	153	PF00017	0.688
LIG_SH2_SRC	618	621	PF00017	0.430
LIG_SH2_STAP1	307	311	PF00017	0.529
LIG_SH2_STAP1	426	430	PF00017	0.307
LIG_SH2_STAT5	307	310	PF00017	0.421
LIG_SH3_3	21	27	PF00018	0.433
LIG_SH3_3	679	685	PF00018	0.220
LIG_TRAF2_1	261	264	PF00917	0.606
MOD_CK1_1	111	117	PF00069	0.678
MOD_CK1_1	201	207	PF00069	0.732
MOD_CK1_1	30	36	PF00069	0.428
MOD_CK1_1	37	43	PF00069	0.394
MOD_CK1_1	371	377	PF00069	0.685
MOD_CK1_1	383	389	PF00069	0.587
MOD_CK1_1	499	505	PF00069	0.371
MOD_CK1_1	514	520	PF00069	0.193
MOD_CK1_1	567	573	PF00069	0.632
MOD_CK2_1	118	124	PF00069	0.608
MOD_CK2_1	183	189	PF00069	0.595
MOD_CK2_1	214	220	PF00069	0.572
MOD_CK2_1	300	306	PF00069	0.518
MOD_CK2_1	514	520	PF00069	0.351
MOD_CK2_1	633	639	PF00069	0.413
MOD_CK2_1	67	73	PF00069	0.453
MOD_Cter_Amidation	292	295	PF01082	0.586
MOD_Cter_Amidation	539	542	PF01082	0.220
MOD_GlcNHglycan	106	109	PF01048	0.578
MOD_GlcNHglycan	132	135	PF01048	0.567
MOD_GlcNHglycan	185	188	PF01048	0.707
MOD_GlcNHglycan	201	204	PF01048	0.615
MOD_GlcNHglycan	334	337	PF01048	0.616
MOD_GlcNHglycan	370	373	PF01048	0.690
MOD_GlcNHglycan	375	378	PF01048	0.699
MOD_GlcNHglycan	485	488	PF01048	0.404
MOD_GlcNHglycan	499	502	PF01048	0.480
MOD_GlcNHglycan	547	550	PF01048	0.571
MOD_GlcNHglycan	566	569	PF01048	0.517
MOD_GlcNHglycan	595	599	PF01048	0.505
MOD_GSK3_1	104	111	PF00069	0.626
MOD_GSK3_1	118	125	PF00069	0.587
MOD_GSK3_1	176	183	PF00069	0.736
MOD_GSK3_1	198	205	PF00069	0.697
MOD_GSK3_1	29	36	PF00069	0.383
MOD_GSK3_1	368	375	PF00069	0.654
MOD_GSK3_1	414	421	PF00069	0.402
MOD_GSK3_1	459	466	PF00069	0.405
MOD_GSK3_1	47	54	PF00069	0.339
MOD_GSK3_1	495	502	PF00069	0.446
MOD_GSK3_1	567	574	PF00069	0.544
MOD_GSK3_1	63	70	PF00069	0.425
MOD_GSK3_1	7	14	PF00069	0.423
MOD_GSK3_1	91	98	PF00069	0.619
MOD_LATS_1	591	597	PF00433	0.597
MOD_N-GLC_1	103	108	PF02516	0.685
MOD_N-GLC_1	312	317	PF02516	0.473
MOD_N-GLC_1	578	583	PF02516	0.527
MOD_NEK2_1	103	108	PF00069	0.636
MOD_NEK2_1	122	127	PF00069	0.421
MOD_NEK2_1	130	135	PF00069	0.572
MOD_NEK2_1	214	219	PF00069	0.505
MOD_NEK2_1	324	329	PF00069	0.667
MOD_NEK2_1	34	39	PF00069	0.381
MOD_NEK2_1	356	361	PF00069	0.585
MOD_NEK2_1	5	10	PF00069	0.424
MOD_NEK2_1	67	72	PF00069	0.455
MOD_NEK2_2	426	431	PF00069	0.437
MOD_NEK2_2	63	68	PF00069	0.428
MOD_PIKK_1	356	362	PF00454	0.540
MOD_PIKK_1	381	387	PF00454	0.666
MOD_PIKK_1	633	639	PF00454	0.481
MOD_PKA_1	118	124	PF00069	0.510
MOD_PKA_1	180	186	PF00069	0.691
MOD_PKA_1	88	94	PF00069	0.450
MOD_PKA_2	108	114	PF00069	0.635
MOD_PKA_2	176	182	PF00069	0.792
MOD_PKA_2	324	330	PF00069	0.617
MOD_PKA_2	356	362	PF00069	0.572
MOD_PKA_2	490	496	PF00069	0.288
MOD_PKA_2	661	667	PF00069	0.286
MOD_PKA_2	67	73	PF00069	0.453
MOD_PKA_2	83	89	PF00069	0.446
MOD_Plk_1	214	220	PF00069	0.522
MOD_Plk_1	305	311	PF00069	0.556
MOD_Plk_1	47	53	PF00069	0.346
MOD_Plk_1	511	517	PF00069	0.245
MOD_Plk_1	578	584	PF00069	0.510
MOD_Plk_4	108	114	PF00069	0.697
MOD_Plk_4	14	20	PF00069	0.433
MOD_Plk_4	30	36	PF00069	0.371
MOD_Plk_4	359	365	PF00069	0.613
MOD_Plk_4	475	481	PF00069	0.379
MOD_ProDKin_1	223	229	PF00069	0.515
MOD_ProDKin_1	27	33	PF00069	0.386
MOD_SUMO_for_1	507	510	PF00179	0.432
MOD_SUMO_rev_2	215	224	PF00179	0.656
MOD_SUMO_rev_2	306	316	PF00179	0.561
MOD_SUMO_rev_2	383	391	PF00179	0.627
MOD_SUMO_rev_2	595	602	PF00179	0.477
MOD_SUMO_rev_2	636	642	PF00179	0.357
TRG_DiLeu_BaEn_4	345	351	PF01217	0.525
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.440
TRG_ENDOCYTIC_2	402	405	PF00928	0.326
TRG_ENDOCYTIC_2	465	468	PF00928	0.419
TRG_ENDOCYTIC_2	518	521	PF00928	0.371
TRG_ER_diArg_1	19	22	PF00400	0.448
TRG_ER_diArg_1	208	211	PF00400	0.632
TRG_ER_diArg_1	294	297	PF00400	0.605
TRG_ER_diArg_1	324	326	PF00400	0.589
TRG_ER_diArg_1	406	409	PF00400	0.314
TRG_ER_diArg_1	628	630	PF00400	0.371
TRG_NLS_Bipartite_1	277	299	PF00514	0.493
TRG_NLS_MonoCore_2	293	298	PF00514	0.548
TRG_NLS_MonoExtC_3	293	298	PF00514	0.571
TRG_NLS_MonoExtC_3	504	510	PF00514	0.421
TRG_NLS_MonoExtN_4	116	122	PF00514	0.549
TRG_NLS_MonoExtN_4	294	299	PF00514	0.539
TRG_NLS_MonoExtN_4	503	509	PF00514	0.356
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	428	433	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P4	Leptomonas seymouri	60%	100%
A0A0S4JJ09	Bodo saltans	31%	100%
A0A1X0NXQ8	Trypanosomatidae	38%	100%
A0A3Q8IA20	Leishmania donovani	99%	100%
A0A3R7KQ11	Trypanosoma rangeli	40%	100%
C9ZIB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AIE3	Leishmania braziliensis	79%	99%
E9AUN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCV4	Leishmania major	90%	99%
V5BQR9	Trypanosoma cruzi	37%	100%