Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYT3_LEIIN

TriTrypDb:

LINF_200014000

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.597
CLV_C14_Caspase3-7	260	264	PF00656	0.674
CLV_MEL_PAP_1	30	36	PF00089	0.419
CLV_NRD_NRD_1	173	175	PF00675	0.567
CLV_NRD_NRD_1	207	209	PF00675	0.587
CLV_NRD_NRD_1	213	215	PF00675	0.571
CLV_NRD_NRD_1	277	279	PF00675	0.507
CLV_NRD_NRD_1	75	77	PF00675	0.473
CLV_PCSK_KEX2_1	103	105	PF00082	0.680
CLV_PCSK_KEX2_1	173	175	PF00082	0.567
CLV_PCSK_KEX2_1	213	215	PF00082	0.596
CLV_PCSK_KEX2_1	75	77	PF00082	0.473
CLV_PCSK_KEX2_1	84	86	PF00082	0.395
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.680
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.488
CLV_PCSK_SKI1_1	81	85	PF00082	0.470
DEG_APCC_DBOX_1	84	92	PF00400	0.426
DEG_SPOP_SBC_1	179	183	PF00917	0.684
DEG_SPOP_SBC_1	257	261	PF00917	0.657
DOC_MAPK_MEF2A_6	55	62	PF00069	0.498
DOC_USP7_MATH_1	137	141	PF00917	0.699
DOC_USP7_MATH_1	155	159	PF00917	0.573
DOC_USP7_MATH_1	180	184	PF00917	0.751
DOC_USP7_MATH_1	192	196	PF00917	0.648
DOC_USP7_MATH_1	201	205	PF00917	0.602
DOC_USP7_MATH_1	235	239	PF00917	0.592
DOC_USP7_MATH_1	245	249	PF00917	0.669
DOC_USP7_MATH_1	257	261	PF00917	0.730
DOC_WW_Pin1_4	107	112	PF00397	0.528
DOC_WW_Pin1_4	181	186	PF00397	0.623
DOC_WW_Pin1_4	253	258	PF00397	0.677
LIG_14-3-3_CanoR_1	174	180	PF00244	0.636
LIG_14-3-3_CanoR_1	31	40	PF00244	0.489
LIG_FHA_1	111	117	PF00498	0.529
LIG_FHA_1	268	274	PF00498	0.776
LIG_FHA_2	134	140	PF00498	0.544
LIG_LIR_Gen_1	26	34	PF02991	0.523
LIG_LIR_Nem_3	26	30	PF02991	0.520
LIG_SH2_CRK	80	84	PF00017	0.506
LIG_SH2_STAT3	109	112	PF00017	0.494
LIG_SH2_STAT3	69	72	PF00017	0.440
LIG_SH2_STAT5	24	27	PF00017	0.448
LIG_SH2_STAT5	78	81	PF00017	0.520
LIG_SH3_3	159	165	PF00018	0.602
LIG_SH3_3	182	188	PF00018	0.646
LIG_SUMO_SIM_par_1	58	65	PF11976	0.482
LIG_WRC_WIRS_1	24	29	PF05994	0.462
LIG_WW_3	184	188	PF00397	0.532
MOD_CDC14_SPxK_1	184	187	PF00782	0.619
MOD_CDK_SPxK_1	181	187	PF00069	0.625
MOD_CK1_1	107	113	PF00069	0.529
MOD_CK1_1	141	147	PF00069	0.594
MOD_CK1_1	178	184	PF00069	0.725
MOD_CK1_1	190	196	PF00069	0.687
MOD_CK1_1	204	210	PF00069	0.555
MOD_CK1_1	229	235	PF00069	0.608
MOD_CK1_1	256	262	PF00069	0.693
MOD_CK1_1	61	67	PF00069	0.490
MOD_CK2_1	141	147	PF00069	0.661
MOD_CK2_1	192	198	PF00069	0.684
MOD_CK2_1	268	274	PF00069	0.607
MOD_GlcNHglycan	132	136	PF01048	0.628
MOD_GlcNHglycan	177	180	PF01048	0.677
MOD_GlcNHglycan	194	197	PF01048	0.518
MOD_GlcNHglycan	203	206	PF01048	0.573
MOD_GlcNHglycan	270	273	PF01048	0.710
MOD_GlcNHglycan	3	6	PF01048	0.591
MOD_GlcNHglycan	9	12	PF01048	0.524
MOD_GSK3_1	133	140	PF00069	0.659
MOD_GSK3_1	175	182	PF00069	0.715
MOD_GSK3_1	226	233	PF00069	0.632
MOD_GSK3_1	235	242	PF00069	0.593
MOD_GSK3_1	253	260	PF00069	0.754
MOD_GSK3_1	32	39	PF00069	0.570
MOD_N-GLC_1	116	121	PF02516	0.475
MOD_N-GLC_1	175	180	PF02516	0.718
MOD_N-GLC_1	235	240	PF02516	0.602
MOD_NEK2_1	116	121	PF00069	0.524
MOD_NEK2_1	226	231	PF00069	0.640
MOD_NEK2_1	25	30	PF00069	0.573
MOD_PIKK_1	226	232	PF00454	0.637
MOD_PIKK_1	239	245	PF00454	0.551
MOD_PIKK_1	68	74	PF00454	0.467
MOD_PKA_2	121	127	PF00069	0.575
MOD_PKA_2	32	38	PF00069	0.432
MOD_Plk_1	116	122	PF00069	0.484
MOD_Plk_1	40	46	PF00069	0.443
MOD_Plk_4	116	122	PF00069	0.532
MOD_Plk_4	58	64	PF00069	0.477
MOD_ProDKin_1	107	113	PF00069	0.529
MOD_ProDKin_1	181	187	PF00069	0.625
MOD_ProDKin_1	253	259	PF00069	0.679
MOD_SUMO_for_1	83	86	PF00179	0.477
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.463
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.509
TRG_ENDOCYTIC_2	24	27	PF00928	0.448
TRG_ENDOCYTIC_2	80	83	PF00928	0.503
TRG_ER_diArg_1	172	174	PF00400	0.565
TRG_ER_diArg_1	29	32	PF00400	0.467
TRG_ER_diArg_1	75	77	PF00400	0.473
TRG_ER_diArg_1	94	97	PF00400	0.542
TRG_NLS_MonoExtN_4	100	107	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBK6	Leishmania donovani	100%	100%
E9AIE2	Leishmania braziliensis	68%	95%
E9AUM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	95%
Q4QCV5	Leishmania major	87%	100%