Putative RNA editing complex protein MP90

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing endoribonuclease

Species:

Leishmania infantum

UniProt:

A4HYT2_LEIIN

TriTrypDb:

LINF_200013900

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYT2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004525	ribonuclease III activity	6	7
GO:0004540	RNA nuclease activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.689
CLV_C14_Caspase3-7	814	818	PF00656	0.527
CLV_NRD_NRD_1	254	256	PF00675	0.459
CLV_NRD_NRD_1	3	5	PF00675	0.798
CLV_NRD_NRD_1	688	690	PF00675	0.718
CLV_NRD_NRD_1	870	872	PF00675	0.586
CLV_PCSK_FUR_1	250	254	PF00082	0.490
CLV_PCSK_KEX2_1	213	215	PF00082	0.394
CLV_PCSK_KEX2_1	252	254	PF00082	0.480
CLV_PCSK_KEX2_1	3	5	PF00082	0.798
CLV_PCSK_KEX2_1	411	413	PF00082	0.567
CLV_PCSK_KEX2_1	425	427	PF00082	0.547
CLV_PCSK_KEX2_1	688	690	PF00082	0.709
CLV_PCSK_KEX2_1	869	871	PF00082	0.577
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.394
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.567
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.547
CLV_PCSK_PC7_1	250	256	PF00082	0.502
CLV_PCSK_SKI1_1	202	206	PF00082	0.544
CLV_PCSK_SKI1_1	223	227	PF00082	0.529
CLV_PCSK_SKI1_1	255	259	PF00082	0.550
CLV_PCSK_SKI1_1	276	280	PF00082	0.503
CLV_PCSK_SKI1_1	457	461	PF00082	0.687
CLV_PCSK_SKI1_1	586	590	PF00082	0.723
CLV_PCSK_SKI1_1	688	692	PF00082	0.588
CLV_PCSK_SKI1_1	702	706	PF00082	0.546
CLV_PCSK_SKI1_1	793	797	PF00082	0.573
CLV_PCSK_SKI1_1	862	866	PF00082	0.577
DEG_APCC_DBOX_1	687	695	PF00400	0.586
DEG_APCC_DBOX_1	701	709	PF00400	0.561
DEG_Kelch_Keap1_1	755	760	PF01344	0.580
DEG_SCF_FBW7_1	742	749	PF00400	0.774
DEG_SCF_TRCP1_1	528	533	PF00400	0.600
DEG_SPOP_SBC_1	66	70	PF00917	0.730
DOC_ANK_TNKS_1	771	778	PF00023	0.591
DOC_ANK_TNKS_1	833	840	PF00023	0.641
DOC_CDC14_PxL_1	351	359	PF14671	0.633
DOC_CDC14_PxL_1	581	589	PF14671	0.600
DOC_CKS1_1	561	566	PF01111	0.648
DOC_CKS1_1	588	593	PF01111	0.642
DOC_CYCLIN_RxL_1	597	608	PF00134	0.649
DOC_MAPK_FxFP_2	50	53	PF00069	0.640
DOC_MAPK_gen_1	223	233	PF00069	0.463
DOC_MAPK_gen_1	250	258	PF00069	0.570
DOC_MAPK_gen_1	549	557	PF00069	0.663
DOC_MAPK_MEF2A_6	226	235	PF00069	0.492
DOC_MAPK_MEF2A_6	299	308	PF00069	0.395
DOC_PP1_RVXF_1	252	259	PF00149	0.569
DOC_PP1_RVXF_1	30	36	PF00149	0.745
DOC_PP2B_LxvP_1	690	693	PF13499	0.499
DOC_PP4_FxxP_1	193	196	PF00568	0.457
DOC_PP4_FxxP_1	35	38	PF00568	0.685
DOC_PP4_FxxP_1	420	423	PF00568	0.724
DOC_PP4_FxxP_1	50	53	PF00568	0.437
DOC_PP4_FxxP_1	561	564	PF00568	0.689
DOC_PP4_FxxP_1	588	591	PF00568	0.602
DOC_USP7_MATH_1	13	17	PF00917	0.748
DOC_USP7_MATH_1	38	42	PF00917	0.567
DOC_USP7_MATH_1	443	447	PF00917	0.697
DOC_USP7_MATH_1	477	481	PF00917	0.753
DOC_USP7_MATH_1	524	528	PF00917	0.758
DOC_USP7_MATH_1	609	613	PF00917	0.639
DOC_USP7_MATH_1	64	68	PF00917	0.727
DOC_USP7_MATH_1	716	720	PF00917	0.677
DOC_USP7_MATH_1	833	837	PF00917	0.713
DOC_USP7_MATH_1	841	845	PF00917	0.667
DOC_USP7_MATH_1	850	854	PF00917	0.552
DOC_WW_Pin1_4	2	7	PF00397	0.695
DOC_WW_Pin1_4	488	493	PF00397	0.742
DOC_WW_Pin1_4	555	560	PF00397	0.601
DOC_WW_Pin1_4	57	62	PF00397	0.621
DOC_WW_Pin1_4	587	592	PF00397	0.640
DOC_WW_Pin1_4	646	651	PF00397	0.696
DOC_WW_Pin1_4	708	713	PF00397	0.594
DOC_WW_Pin1_4	717	722	PF00397	0.649
DOC_WW_Pin1_4	723	728	PF00397	0.652
DOC_WW_Pin1_4	742	747	PF00397	0.678
DOC_WW_Pin1_4	822	827	PF00397	0.686
DOC_WW_Pin1_4	846	851	PF00397	0.757
LIG_14-3-3_CanoR_1	147	153	PF00244	0.626
LIG_14-3-3_CanoR_1	157	162	PF00244	0.461
LIG_14-3-3_CanoR_1	200	205	PF00244	0.412
LIG_14-3-3_CanoR_1	291	296	PF00244	0.553
LIG_14-3-3_CanoR_1	586	591	PF00244	0.721
LIG_14-3-3_CanoR_1	626	632	PF00244	0.507
LIG_14-3-3_CanoR_1	763	769	PF00244	0.712
LIG_14-3-3_CanoR_1	869	876	PF00244	0.611
LIG_Actin_WH2_2	378	394	PF00022	0.479
LIG_APCC_ABBA_1	278	283	PF00400	0.416
LIG_BRCT_BRCA1_1	128	132	PF00533	0.635
LIG_BRCT_BRCA1_1	557	561	PF00533	0.720
LIG_BRCT_BRCA1_1	620	624	PF00533	0.625
LIG_Clathr_ClatBox_1	691	695	PF01394	0.527
LIG_CtBP_PxDLS_1	564	568	PF00389	0.646
LIG_EH1_1	178	186	PF00400	0.401
LIG_eIF4E_1	631	637	PF01652	0.498
LIG_eIF4E_2	773	779	PF01652	0.598
LIG_EVH1_2	8	12	PF00568	0.774
LIG_FHA_1	101	107	PF00498	0.779
LIG_FHA_1	111	117	PF00498	0.627
LIG_FHA_1	168	174	PF00498	0.403
LIG_FHA_1	239	245	PF00498	0.532
LIG_FHA_1	292	298	PF00498	0.543
LIG_FHA_1	312	318	PF00498	0.234
LIG_FHA_1	397	403	PF00498	0.527
LIG_FHA_1	576	582	PF00498	0.608
LIG_FHA_1	588	594	PF00498	0.610
LIG_FHA_1	814	820	PF00498	0.611
LIG_FHA_2	149	155	PF00498	0.645
LIG_FHA_2	480	486	PF00498	0.621
LIG_FHA_2	617	623	PF00498	0.548
LIG_FHA_2	747	753	PF00498	0.773
LIG_FHA_2	812	818	PF00498	0.663
LIG_GBD_Chelix_1	338	346	PF00786	0.480
LIG_Integrin_isoDGR_2	761	763	PF01839	0.594
LIG_LIR_Apic_2	190	196	PF02991	0.395
LIG_LIR_Apic_2	417	423	PF02991	0.707
LIG_LIR_Apic_2	49	53	PF02991	0.641
LIG_LIR_Apic_2	558	564	PF02991	0.704
LIG_LIR_Apic_2	771	776	PF02991	0.580
LIG_LIR_Gen_1	129	140	PF02991	0.467
LIG_LIR_Gen_1	186	196	PF02991	0.511
LIG_LIR_Gen_1	293	301	PF02991	0.417
LIG_LIR_Gen_1	309	320	PF02991	0.417
LIG_LIR_Gen_1	383	394	PF02991	0.359
LIG_LIR_Gen_1	621	631	PF02991	0.504
LIG_LIR_Nem_3	129	135	PF02991	0.470
LIG_LIR_Nem_3	186	191	PF02991	0.511
LIG_LIR_Nem_3	293	298	PF02991	0.422
LIG_LIR_Nem_3	309	315	PF02991	0.409
LIG_LIR_Nem_3	316	321	PF02991	0.401
LIG_LIR_Nem_3	340	346	PF02991	0.479
LIG_LIR_Nem_3	383	389	PF02991	0.354
LIG_LIR_Nem_3	630	634	PF02991	0.558
LIG_NRBOX	316	322	PF00104	0.523
LIG_OCRL_FandH_1	342	354	PF00620	0.524
LIG_Rb_pABgroove_1	380	388	PF01858	0.353
LIG_Rb_pABgroove_1	482	490	PF01858	0.726
LIG_RPA_C_Fungi	390	402	PF08784	0.476
LIG_SH2_CRK	351	355	PF00017	0.601
LIG_SH2_CRK	386	390	PF00017	0.355
LIG_SH2_NCK_1	88	92	PF00017	0.688
LIG_SH2_PTP2	773	776	PF00017	0.700
LIG_SH2_SRC	20	23	PF00017	0.636
LIG_SH2_SRC	773	776	PF00017	0.653
LIG_SH2_SRC	88	91	PF00017	0.688
LIG_SH2_STAP1	386	390	PF00017	0.355
LIG_SH2_STAT3	281	284	PF00017	0.424
LIG_SH2_STAT5	263	266	PF00017	0.413
LIG_SH2_STAT5	363	366	PF00017	0.672
LIG_SH2_STAT5	615	618	PF00017	0.539
LIG_SH2_STAT5	646	649	PF00017	0.585
LIG_SH2_STAT5	700	703	PF00017	0.568
LIG_SH2_STAT5	773	776	PF00017	0.700
LIG_SH3_1	3	9	PF00018	0.786
LIG_SH3_1	579	585	PF00018	0.597
LIG_SH3_3	156	162	PF00018	0.600
LIG_SH3_3	193	199	PF00018	0.411
LIG_SH3_3	3	9	PF00018	0.757
LIG_SH3_3	553	559	PF00018	0.655
LIG_SH3_3	579	585	PF00018	0.597
LIG_SH3_3	595	601	PF00018	0.566
LIG_SH3_3	644	650	PF00018	0.641
LIG_SH3_3	667	673	PF00018	0.607
LIG_SH3_3	709	715	PF00018	0.721
LIG_SH3_3	823	829	PF00018	0.690
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.406
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.359
LIG_SUMO_SIM_anti_2	521	529	PF11976	0.673
LIG_SUMO_SIM_par_1	373	379	PF11976	0.539
LIG_SUMO_SIM_par_1	562	568	PF11976	0.643
LIG_SxIP_EBH_1	603	616	PF03271	0.639
LIG_SxIP_EBH_1	643	657	PF03271	0.516
LIG_TYR_ITIM	629	634	PF00017	0.451
LIG_UBA3_1	221	226	PF00899	0.388
LIG_UBA3_1	388	392	PF00899	0.479
LIG_WW_3	27	31	PF00397	0.749
MOD_CDK_SPK_2	846	851	PF00069	0.662
MOD_CDK_SPxK_1	742	748	PF00069	0.710
MOD_CK1_1	148	154	PF00069	0.507
MOD_CK1_1	246	252	PF00069	0.511
MOD_CK1_1	293	299	PF00069	0.535
MOD_CK1_1	480	486	PF00069	0.647
MOD_CK1_1	491	497	PF00069	0.757
MOD_CK1_1	67	73	PF00069	0.739
MOD_CK1_1	711	717	PF00069	0.560
MOD_CK1_1	726	732	PF00069	0.597
MOD_CK1_1	764	770	PF00069	0.692
MOD_CK1_1	822	828	PF00069	0.699
MOD_CK1_1	872	878	PF00069	0.612
MOD_CK1_1	880	886	PF00069	0.620
MOD_CK2_1	479	485	PF00069	0.651
MOD_CK2_1	754	760	PF00069	0.604
MOD_CK2_1	832	838	PF00069	0.767
MOD_DYRK1A_RPxSP_1	4	8	PF00069	0.721
MOD_GlcNHglycan	116	119	PF01048	0.667
MOD_GlcNHglycan	330	333	PF01048	0.517
MOD_GlcNHglycan	399	402	PF01048	0.500
MOD_GlcNHglycan	445	448	PF01048	0.647
MOD_GlcNHglycan	449	452	PF01048	0.624
MOD_GlcNHglycan	502	506	PF01048	0.762
MOD_GlcNHglycan	509	512	PF01048	0.644
MOD_GlcNHglycan	528	531	PF01048	0.795
MOD_GlcNHglycan	569	572	PF01048	0.719
MOD_GlcNHglycan	607	610	PF01048	0.568
MOD_GlcNHglycan	683	686	PF01048	0.674
MOD_GlcNHglycan	757	760	PF01048	0.642
MOD_GlcNHglycan	763	766	PF01048	0.684
MOD_GlcNHglycan	78	81	PF01048	0.663
MOD_GlcNHglycan	821	824	PF01048	0.651
MOD_GlcNHglycan	835	838	PF01048	0.693
MOD_GlcNHglycan	843	846	PF01048	0.674
MOD_GlcNHglycan	852	855	PF01048	0.518
MOD_GlcNHglycan	879	882	PF01048	0.649
MOD_GSK3_1	110	117	PF00069	0.690
MOD_GSK3_1	122	129	PF00069	0.737
MOD_GSK3_1	234	241	PF00069	0.482
MOD_GSK3_1	286	293	PF00069	0.541
MOD_GSK3_1	320	327	PF00069	0.499
MOD_GSK3_1	38	45	PF00069	0.577
MOD_GSK3_1	443	450	PF00069	0.702
MOD_GSK3_1	457	464	PF00069	0.716
MOD_GSK3_1	469	476	PF00069	0.599
MOD_GSK3_1	526	533	PF00069	0.819
MOD_GSK3_1	555	562	PF00069	0.613
MOD_GSK3_1	563	570	PF00069	0.762
MOD_GSK3_1	605	612	PF00069	0.639
MOD_GSK3_1	64	71	PF00069	0.762
MOD_GSK3_1	72	79	PF00069	0.628
MOD_GSK3_1	723	730	PF00069	0.748
MOD_GSK3_1	738	745	PF00069	0.793
MOD_GSK3_1	764	771	PF00069	0.666
MOD_GSK3_1	813	820	PF00069	0.694
MOD_GSK3_1	828	835	PF00069	0.549
MOD_GSK3_1	846	853	PF00069	0.732
MOD_GSK3_1	880	887	PF00069	0.648
MOD_LATS_1	326	332	PF00433	0.499
MOD_N-GLC_1	271	276	PF02516	0.511
MOD_N-GLC_1	477	482	PF02516	0.743
MOD_N-GLC_1	57	62	PF02516	0.742
MOD_N-GLC_1	64	69	PF02516	0.722
MOD_N-GLC_1	877	882	PF02516	0.567
MOD_N-GLC_2	790	792	PF02516	0.558
MOD_NEK2_1	320	325	PF00069	0.545
MOD_NEK2_1	397	402	PF00069	0.391
MOD_NEK2_1	565	570	PF00069	0.594
MOD_NEK2_1	575	580	PF00069	0.579
MOD_NEK2_1	658	663	PF00069	0.519
MOD_PIKK_1	869	875	PF00454	0.644
MOD_PKA_1	869	875	PF00069	0.572
MOD_PKA_2	136	142	PF00069	0.535
MOD_PKA_2	207	213	PF00069	0.549
MOD_PKA_2	290	296	PF00069	0.564
MOD_PKA_2	833	839	PF00069	0.783
MOD_PKA_2	869	875	PF00069	0.651
MOD_PKB_1	155	163	PF00069	0.601
MOD_PKB_1	200	208	PF00069	0.540
MOD_PKB_1	431	439	PF00069	0.767
MOD_PKB_1	869	877	PF00069	0.617
MOD_Plk_1	477	483	PF00069	0.739
MOD_Plk_1	884	890	PF00069	0.690
MOD_Plk_4	169	175	PF00069	0.506
MOD_Plk_4	183	189	PF00069	0.306
MOD_Plk_4	217	223	PF00069	0.419
MOD_Plk_4	658	664	PF00069	0.641
MOD_ProDKin_1	2	8	PF00069	0.692
MOD_ProDKin_1	488	494	PF00069	0.745
MOD_ProDKin_1	555	561	PF00069	0.601
MOD_ProDKin_1	57	63	PF00069	0.626
MOD_ProDKin_1	587	593	PF00069	0.642
MOD_ProDKin_1	646	652	PF00069	0.693
MOD_ProDKin_1	708	714	PF00069	0.597
MOD_ProDKin_1	717	723	PF00069	0.647
MOD_ProDKin_1	742	748	PF00069	0.773
MOD_ProDKin_1	822	828	PF00069	0.688
MOD_ProDKin_1	846	852	PF00069	0.752
TRG_DiLeu_BaEn_1	169	174	PF01217	0.523
TRG_DiLeu_BaEn_1	316	321	PF01217	0.519
TRG_DiLeu_BaEn_1	384	389	PF01217	0.353
TRG_DiLeu_BaEn_1	632	637	PF01217	0.618
TRG_DiLeu_BaEn_1	686	691	PF01217	0.639
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.637
TRG_DiLeu_LyEn_5	686	691	PF01217	0.639
TRG_ENDOCYTIC_2	351	354	PF00928	0.593
TRG_ENDOCYTIC_2	386	389	PF00928	0.354
TRG_ENDOCYTIC_2	631	634	PF00928	0.531
TRG_ER_diArg_1	199	202	PF00400	0.536
TRG_ER_diArg_1	251	254	PF00400	0.480
TRG_ER_diArg_1	416	419	PF00400	0.672
TRG_ER_diArg_1	688	690	PF00400	0.718
TRG_ER_diArg_1	868	871	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEA0	Leptomonas seymouri	42%	86%
A0A3S7WW37	Leishmania donovani	100%	100%
E9AIE1	Leishmania braziliensis	76%	100%
E9AUM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCV6	Leishmania major	93%	100%