Putative ATP-dependent RNA helicase

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase - putative

Species:

Leishmania infantum

UniProt:

A4HYS9_LEIIN

TriTrypDb:

LINF_200013600

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 750

Expansion

Sequence features

A4HYS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYS9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.572
CLV_C14_Caspase3-7	174	178	PF00656	0.665
CLV_C14_Caspase3-7	179	183	PF00656	0.631
CLV_C14_Caspase3-7	655	659	PF00656	0.755
CLV_MEL_PAP_1	148	154	PF00089	0.641
CLV_NRD_NRD_1	145	147	PF00675	0.508
CLV_NRD_NRD_1	270	272	PF00675	0.362
CLV_NRD_NRD_1	366	368	PF00675	0.601
CLV_NRD_NRD_1	434	436	PF00675	0.561
CLV_NRD_NRD_1	443	445	PF00675	0.472
CLV_NRD_NRD_1	531	533	PF00675	0.260
CLV_NRD_NRD_1	689	691	PF00675	0.530
CLV_NRD_NRD_1	739	741	PF00675	0.682
CLV_PCSK_KEX2_1	145	147	PF00082	0.508
CLV_PCSK_KEX2_1	270	272	PF00082	0.362
CLV_PCSK_KEX2_1	436	438	PF00082	0.548
CLV_PCSK_KEX2_1	443	445	PF00082	0.493
CLV_PCSK_KEX2_1	530	532	PF00082	0.259
CLV_PCSK_KEX2_1	621	623	PF00082	0.503
CLV_PCSK_KEX2_1	689	691	PF00082	0.530
CLV_PCSK_KEX2_1	741	743	PF00082	0.695
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.557
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.527
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.695
CLV_PCSK_PC7_1	141	147	PF00082	0.564
CLV_PCSK_SKI1_1	146	150	PF00082	0.462
CLV_PCSK_SKI1_1	531	535	PF00082	0.273
CLV_PCSK_SKI1_1	625	629	PF00082	0.434
CLV_PCSK_SKI1_1	637	641	PF00082	0.407
CLV_PCSK_SKI1_1	73	77	PF00082	0.300
CLV_Separin_Metazoa	142	146	PF03568	0.558
DEG_APCC_DBOX_1	624	632	PF00400	0.337
DEG_SPOP_SBC_1	746	750	PF00917	0.557
DOC_CKS1_1	213	218	PF01111	0.459
DOC_CKS1_1	722	727	PF01111	0.680
DOC_CYCLIN_RxL_1	221	233	PF00134	0.520
DOC_CYCLIN_RxL_1	529	538	PF00134	0.490
DOC_CYCLIN_RxL_1	621	630	PF00134	0.434
DOC_CYCLIN_RxL_1	85	95	PF00134	0.491
DOC_MAPK_DCC_7	23	33	PF00069	0.530
DOC_MAPK_gen_1	108	117	PF00069	0.526
DOC_MAPK_gen_1	227	236	PF00069	0.539
DOC_MAPK_gen_1	343	352	PF00069	0.601
DOC_MAPK_gen_1	443	451	PF00069	0.459
DOC_MAPK_gen_1	592	601	PF00069	0.543
DOC_MAPK_MEF2A_6	204	213	PF00069	0.562
DOC_MAPK_MEF2A_6	230	238	PF00069	0.539
DOC_MAPK_MEF2A_6	414	421	PF00069	0.345
DOC_MAPK_MEF2A_6	595	603	PF00069	0.412
DOC_PP2B_LxvP_1	55	58	PF13499	0.459
DOC_PP4_FxxP_1	396	399	PF00568	0.363
DOC_USP7_MATH_1	166	170	PF00917	0.792
DOC_USP7_MATH_1	292	296	PF00917	0.533
DOC_USP7_MATH_1	424	428	PF00917	0.504
DOC_USP7_MATH_1	44	48	PF00917	0.506
DOC_USP7_MATH_1	476	480	PF00917	0.594
DOC_USP7_MATH_1	513	517	PF00917	0.560
DOC_USP7_MATH_1	548	552	PF00917	0.529
DOC_USP7_MATH_1	58	62	PF00917	0.397
DOC_USP7_MATH_1	650	654	PF00917	0.747
DOC_USP7_MATH_1	710	714	PF00917	0.628
DOC_USP7_MATH_1	729	733	PF00917	0.653
DOC_USP7_MATH_1	757	761	PF00917	0.618
DOC_USP7_MATH_2	576	582	PF00917	0.539
DOC_WW_Pin1_4	212	217	PF00397	0.459
DOC_WW_Pin1_4	302	307	PF00397	0.566
DOC_WW_Pin1_4	721	726	PF00397	0.695
DOC_WW_Pin1_4	734	739	PF00397	0.712
LIG_14-3-3_CanoR_1	197	206	PF00244	0.576
LIG_14-3-3_CanoR_1	23	28	PF00244	0.526
LIG_14-3-3_CanoR_1	230	235	PF00244	0.562
LIG_14-3-3_CanoR_1	353	358	PF00244	0.434
LIG_14-3-3_CanoR_1	435	445	PF00244	0.574
LIG_14-3-3_CanoR_1	586	596	PF00244	0.459
LIG_14-3-3_CanoR_1	622	628	PF00244	0.512
LIG_14-3-3_CanoR_1	689	695	PF00244	0.517
LIG_14-3-3_CanoR_1	716	723	PF00244	0.676
LIG_14-3-3_CanoR_1	73	82	PF00244	0.529
LIG_14-3-3_CanoR_1	744	754	PF00244	0.699
LIG_Actin_WH2_2	216	232	PF00022	0.539
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	287	291	PF00533	0.507
LIG_CaM_NSCaTE_8	691	698	PF13499	0.536
LIG_Clathr_ClatBox_1	236	240	PF01394	0.490
LIG_deltaCOP1_diTrp_1	670	679	PF00928	0.517
LIG_DLG_GKlike_1	230	237	PF00625	0.507
LIG_DLG_GKlike_1	353	360	PF00625	0.517
LIG_eIF4E_1	413	419	PF01652	0.363
LIG_FHA_1	224	230	PF00498	0.490
LIG_FHA_1	489	495	PF00498	0.512
LIG_FHA_1	628	634	PF00498	0.481
LIG_FHA_1	93	99	PF00498	0.466
LIG_FHA_2	129	135	PF00498	0.631
LIG_FHA_2	399	405	PF00498	0.456
LIG_FHA_2	4	10	PF00498	0.525
LIG_FHA_2	497	503	PF00498	0.490
LIG_FHA_2	653	659	PF00498	0.756
LIG_LIR_Apic_2	26	30	PF02991	0.595
LIG_LIR_Apic_2	394	399	PF02991	0.406
LIG_LIR_Apic_2	64	70	PF02991	0.459
LIG_LIR_Gen_1	520	528	PF02991	0.475
LIG_LIR_Nem_3	356	360	PF02991	0.511
LIG_LIR_Nem_3	479	485	PF02991	0.579
LIG_LIR_Nem_3	520	524	PF02991	0.475
LIG_LIR_Nem_3	636	642	PF02991	0.449
LIG_LYPXL_yS_3	482	485	PF13949	0.547
LIG_NRP_CendR_1	765	768	PF00754	0.607
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.545
LIG_PTB_Apo_2	351	358	PF02174	0.519
LIG_PTB_Phospho_1	351	357	PF10480	0.521
LIG_REV1ctd_RIR_1	637	645	PF16727	0.574
LIG_RPA_C_Fungi	423	435	PF08784	0.553
LIG_RPA_C_Fungi	439	451	PF08784	0.352
LIG_RPA_C_Fungi	499	511	PF08784	0.424
LIG_SH2_CRK	620	624	PF00017	0.515
LIG_SH2_SRC	67	70	PF00017	0.457
LIG_SH2_STAP1	261	265	PF00017	0.424
LIG_SH2_STAT5	205	208	PF00017	0.424
LIG_SH2_STAT5	358	361	PF00017	0.516
LIG_SH2_STAT5	583	586	PF00017	0.328
LIG_SH2_STAT5	67	70	PF00017	0.304
LIG_SH3_3	144	150	PF00018	0.543
LIG_SH3_3	210	216	PF00018	0.355
LIG_SUMO_SIM_anti_2	207	215	PF11976	0.385
LIG_SUMO_SIM_par_1	235	241	PF11976	0.331
LIG_SUMO_SIM_par_1	89	95	PF11976	0.312
LIG_TRAF2_1	401	404	PF00917	0.484
LIG_TRAF2_1	499	502	PF00917	0.355
LIG_TRAF2_1	662	665	PF00917	0.665
LIG_TRFH_1	396	400	PF08558	0.381
LIG_UBA3_1	74	80	PF00899	0.280
LIG_WRC_WIRS_1	247	252	PF05994	0.385
MOD_CDC14_SPxK_1	737	740	PF00782	0.571
MOD_CDK_SPxK_1	212	218	PF00069	0.312
MOD_CDK_SPxK_1	721	727	PF00069	0.680
MOD_CDK_SPxK_1	734	740	PF00069	0.512
MOD_CDK_SPxxK_3	734	741	PF00069	0.575
MOD_CK1_1	249	255	PF00069	0.332
MOD_CK1_1	294	300	PF00069	0.416
MOD_CK1_1	3	9	PF00069	0.547
MOD_CK1_1	477	483	PF00069	0.495
MOD_CK1_1	61	67	PF00069	0.316
MOD_CK1_1	653	659	PF00069	0.736
MOD_CK1_1	697	703	PF00069	0.562
MOD_CK1_1	745	751	PF00069	0.735
MOD_CK2_1	130	136	PF00069	0.552
MOD_CK2_1	162	168	PF00069	0.752
MOD_CK2_1	290	296	PF00069	0.411
MOD_CK2_1	359	365	PF00069	0.521
MOD_CK2_1	398	404	PF00069	0.459
MOD_CK2_1	496	502	PF00069	0.331
MOD_CK2_1	514	520	PF00069	0.257
MOD_CK2_1	523	529	PF00069	0.268
MOD_CK2_1	543	549	PF00069	0.126
MOD_CK2_1	690	696	PF00069	0.484
MOD_CK2_1	729	735	PF00069	0.771
MOD_Cter_Amidation	738	741	PF01082	0.777
MOD_GlcNHglycan	158	161	PF01048	0.730
MOD_GlcNHglycan	164	167	PF01048	0.734
MOD_GlcNHglycan	318	321	PF01048	0.401
MOD_GlcNHglycan	336	339	PF01048	0.219
MOD_GlcNHglycan	379	382	PF01048	0.586
MOD_GlcNHglycan	438	441	PF01048	0.511
MOD_GlcNHglycan	46	49	PF01048	0.312
MOD_GlcNHglycan	476	479	PF01048	0.583
MOD_GlcNHglycan	545	548	PF01048	0.356
MOD_GlcNHglycan	60	63	PF01048	0.258
MOD_GlcNHglycan	608	611	PF01048	0.488
MOD_GlcNHglycan	646	649	PF01048	0.663
MOD_GlcNHglycan	652	655	PF01048	0.722
MOD_GlcNHglycan	667	670	PF01048	0.451
MOD_GlcNHglycan	696	699	PF01048	0.491
MOD_GlcNHglycan	759	762	PF01048	0.678
MOD_GSK3_1	107	114	PF00069	0.331
MOD_GSK3_1	152	159	PF00069	0.695
MOD_GSK3_1	162	169	PF00069	0.747
MOD_GSK3_1	195	202	PF00069	0.558
MOD_GSK3_1	286	293	PF00069	0.413
MOD_GSK3_1	334	341	PF00069	0.320
MOD_GSK3_1	474	481	PF00069	0.585
MOD_GSK3_1	519	526	PF00069	0.323
MOD_GSK3_1	601	608	PF00069	0.500
MOD_GSK3_1	623	630	PF00069	0.442
MOD_GSK3_1	649	656	PF00069	0.635
MOD_GSK3_1	690	697	PF00069	0.492
MOD_GSK3_1	706	713	PF00069	0.574
MOD_GSK3_1	742	749	PF00069	0.566
MOD_N-GLC_1	199	204	PF02516	0.599
MOD_N-GLC_1	353	358	PF02516	0.491
MOD_NEK2_1	223	228	PF00069	0.419
MOD_NEK2_1	246	251	PF00069	0.243
MOD_NEK2_1	372	377	PF00069	0.740
MOD_NEK2_1	535	540	PF00069	0.312
MOD_NEK2_1	601	606	PF00069	0.489
MOD_NEK2_1	623	628	PF00069	0.505
MOD_NEK2_1	680	685	PF00069	0.428
MOD_PIKK_1	372	378	PF00454	0.777
MOD_PIKK_1	391	397	PF00454	0.618
MOD_PIKK_1	578	584	PF00454	0.376
MOD_PIKK_1	680	686	PF00454	0.431
MOD_PIKK_1	729	735	PF00454	0.777
MOD_PIKK_1	92	98	PF00454	0.369
MOD_PK_1	111	117	PF00069	0.385
MOD_PK_1	690	696	PF00069	0.576
MOD_PK_1	742	748	PF00069	0.772
MOD_PKA_1	436	442	PF00069	0.507
MOD_PKA_1	621	627	PF00069	0.516
MOD_PKA_2	107	113	PF00069	0.317
MOD_PKA_2	128	134	PF00069	0.654
MOD_PKA_2	198	204	PF00069	0.548
MOD_PKA_2	345	351	PF00069	0.440
MOD_PKA_2	436	442	PF00069	0.540
MOD_PKA_2	621	627	PF00069	0.516
MOD_PKA_2	715	721	PF00069	0.676
MOD_PKB_1	197	205	PF00069	0.549
MOD_PKB_1	740	748	PF00069	0.740
MOD_Plk_1	199	205	PF00069	0.556
MOD_Plk_1	295	301	PF00069	0.377
MOD_Plk_1	353	359	PF00069	0.490
MOD_Plk_1	409	415	PF00069	0.530
MOD_Plk_1	471	477	PF00069	0.493
MOD_Plk_1	51	57	PF00069	0.424
MOD_Plk_1	519	525	PF00069	0.331
MOD_Plk_1	548	554	PF00069	0.350
MOD_Plk_1	729	735	PF00069	0.796
MOD_Plk_1	742	748	PF00069	0.570
MOD_Plk_4	353	359	PF00069	0.518
MOD_Plk_4	37	43	PF00069	0.457
MOD_Plk_4	514	520	PF00069	0.424
MOD_Plk_4	690	696	PF00069	0.576
MOD_ProDKin_1	212	218	PF00069	0.312
MOD_ProDKin_1	302	308	PF00069	0.462
MOD_ProDKin_1	721	727	PF00069	0.699
MOD_ProDKin_1	734	740	PF00069	0.711
TRG_DiLeu_BaEn_1	139	144	PF01217	0.448
TRG_DiLeu_BaEn_2	403	409	PF01217	0.385
TRG_DiLeu_BaEn_3	170	176	PF01217	0.692
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.307
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.247
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.378
TRG_ENDOCYTIC_2	103	106	PF00928	0.321
TRG_ENDOCYTIC_2	357	360	PF00928	0.512
TRG_ENDOCYTIC_2	482	485	PF00928	0.547
TRG_ENDOCYTIC_2	620	623	PF00928	0.517
TRG_ER_diArg_1	144	146	PF00400	0.496
TRG_ER_diArg_1	425	428	PF00400	0.529
TRG_ER_diArg_1	443	445	PF00400	0.538
TRG_ER_diArg_1	530	532	PF00400	0.331
TRG_ER_diArg_1	689	691	PF00400	0.556
TRG_ER_diArg_1	762	765	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF6	Leptomonas seymouri	66%	100%
A0A0S4JIC9	Bodo saltans	34%	100%
A0A3R7NJH7	Trypanosoma rangeli	44%	100%
A0A3S7WVZ5	Leishmania donovani	100%	100%
A4QX49	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	93%
C9ZIA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AID8	Leishmania braziliensis	79%	100%
E9AUM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QCV9	Leishmania major	92%	100%
V5DS01	Trypanosoma cruzi	43%	100%