Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYS8_LEIIN

TriTrypDb:

LINF_200013500

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.593
CLV_NRD_NRD_1	15	17	PF00675	0.520
CLV_NRD_NRD_1	206	208	PF00675	0.716
CLV_NRD_NRD_1	325	327	PF00675	0.356
CLV_NRD_NRD_1	45	47	PF00675	0.415
CLV_PCSK_FUR_1	43	47	PF00082	0.452
CLV_PCSK_KEX2_1	15	17	PF00082	0.486
CLV_PCSK_KEX2_1	240	242	PF00082	0.561
CLV_PCSK_KEX2_1	302	304	PF00082	0.427
CLV_PCSK_KEX2_1	45	47	PF00082	0.374
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.561
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.486
CLV_PCSK_PC7_1	11	17	PF00082	0.505
CLV_PCSK_SKI1_1	183	187	PF00082	0.536
CLV_PCSK_SKI1_1	240	244	PF00082	0.689
CLV_PCSK_SKI1_1	46	50	PF00082	0.352
CLV_PCSK_SKI1_1	73	77	PF00082	0.431
DEG_APCC_DBOX_1	317	325	PF00400	0.436
DEG_Nend_UBRbox_3	1	3	PF02207	0.483
DEG_SCF_FBW7_1	185	190	PF00400	0.565
DEG_SCF_TRCP1_1	204	210	PF00400	0.578
DEG_SPOP_SBC_1	176	180	PF00917	0.469
DEG_SPOP_SBC_1	195	199	PF00917	0.571
DOC_CDC14_PxL_1	85	93	PF14671	0.333
DOC_CYCLIN_RxL_1	42	53	PF00134	0.447
DOC_CYCLIN_RxL_1	82	94	PF00134	0.336
DOC_MAPK_gen_1	15	22	PF00069	0.397
DOC_MAPK_gen_1	316	324	PF00069	0.507
DOC_MAPK_gen_1	326	332	PF00069	0.371
DOC_MAPK_gen_1	59	69	PF00069	0.473
DOC_PP2B_LxvP_1	150	153	PF13499	0.485
DOC_USP7_MATH_1	177	181	PF00917	0.504
DOC_USP7_MATH_1	194	198	PF00917	0.695
DOC_USP7_UBL2_3	239	243	PF12436	0.532
DOC_WW_Pin1_4	104	109	PF00397	0.392
DOC_WW_Pin1_4	183	188	PF00397	0.593
DOC_WW_Pin1_4	50	55	PF00397	0.525
LIG_14-3-3_CanoR_1	308	315	PF00244	0.520
LIG_eIF4E_1	85	91	PF01652	0.333
LIG_FHA_1	154	160	PF00498	0.445
LIG_FHA_1	180	186	PF00498	0.587
LIG_FHA_1	250	256	PF00498	0.374
LIG_FHA_2	111	117	PF00498	0.439
LIG_FHA_2	143	149	PF00498	0.471
LIG_FHA_2	249	255	PF00498	0.348
LIG_LIR_Gen_1	273	284	PF02991	0.448
LIG_LIR_Gen_1	4	13	PF02991	0.469
LIG_LIR_Gen_1	74	83	PF02991	0.373
LIG_LIR_Gen_1	96	106	PF02991	0.339
LIG_LIR_Nem_3	139	144	PF02991	0.546
LIG_LIR_Nem_3	273	279	PF02991	0.427
LIG_LIR_Nem_3	36	42	PF02991	0.366
LIG_LIR_Nem_3	4	9	PF02991	0.518
LIG_LIR_Nem_3	74	78	PF02991	0.370
LIG_REV1ctd_RIR_1	138	146	PF16727	0.444
LIG_SH2_CRK	6	10	PF00017	0.478
LIG_SH2_CRK	85	89	PF00017	0.364
LIG_SH2_NCK_1	333	337	PF00017	0.422
LIG_SH2_SRC	341	344	PF00017	0.412
LIG_SH2_STAP1	341	345	PF00017	0.427
LIG_SH2_STAP1	6	10	PF00017	0.478
LIG_SH2_STAT3	144	147	PF00017	0.366
LIG_SH2_STAT5	144	147	PF00017	0.464
LIG_SH3_3	105	111	PF00018	0.446
LIG_SH3_3	55	61	PF00018	0.472
LIG_SH3_3	7	13	PF00018	0.571
LIG_TRAF2_1	145	148	PF00917	0.466
LIG_TRFH_1	85	89	PF08558	0.331
LIG_UBA3_1	321	327	PF00899	0.378
LIG_WRC_WIRS_1	72	77	PF05994	0.427
MOD_CK1_1	107	113	PF00069	0.404
MOD_CK1_1	197	203	PF00069	0.677
MOD_CK1_1	5	11	PF00069	0.497
MOD_CK2_1	142	148	PF00069	0.459
MOD_CK2_1	288	294	PF00069	0.447
MOD_CK2_1	334	340	PF00069	0.395
MOD_CK2_1	90	96	PF00069	0.405
MOD_Cter_Amidation	205	208	PF01082	0.638
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.514
MOD_GlcNHglycan	153	156	PF01048	0.513
MOD_GlcNHglycan	204	207	PF01048	0.762
MOD_GlcNHglycan	209	212	PF01048	0.685
MOD_GlcNHglycan	282	285	PF01048	0.487
MOD_GSK3_1	175	182	PF00069	0.570
MOD_GSK3_1	183	190	PF00069	0.635
MOD_GSK3_1	194	201	PF00069	0.735
MOD_NEK2_1	234	239	PF00069	0.577
MOD_PIKK_1	117	123	PF00454	0.462
MOD_PIKK_1	143	149	PF00454	0.374
MOD_PIKK_1	259	265	PF00454	0.417
MOD_PK_1	288	294	PF00069	0.447
MOD_PKA_1	207	213	PF00069	0.619
MOD_PKA_2	125	131	PF00069	0.440
MOD_PKA_2	2	8	PF00069	0.500
MOD_Plk_2-3	334	340	PF00069	0.395
MOD_Plk_4	5	11	PF00069	0.527
MOD_Plk_4	71	77	PF00069	0.440
MOD_ProDKin_1	104	110	PF00069	0.391
MOD_ProDKin_1	183	189	PF00069	0.595
MOD_ProDKin_1	50	56	PF00069	0.524
TRG_DiLeu_BaEn_2	293	299	PF01217	0.422
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.332
TRG_ENDOCYTIC_2	276	279	PF00928	0.396
TRG_ENDOCYTIC_2	333	336	PF00928	0.414
TRG_ENDOCYTIC_2	6	9	PF00928	0.475
TRG_ENDOCYTIC_2	72	75	PF00928	0.382
TRG_ENDOCYTIC_2	85	88	PF00928	0.278
TRG_ER_diArg_1	315	318	PF00400	0.570
TRG_ER_diArg_1	42	45	PF00400	0.396
TRG_NLS_MonoExtC_3	238	243	PF00514	0.525
TRG_NLS_MonoExtN_4	239	244	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD57	Leptomonas seymouri	48%	100%
A0A1X0NWC4	Trypanosomatidae	36%	100%
A0A3S7WVX4	Leishmania donovani	100%	100%
E9AID7	Leishmania braziliensis	80%	100%
E9AUM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCW0	Leishmania major	94%	100%