Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYS4_LEIIN

TriTrypDb:

LINF_200013100

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.620
CLV_NRD_NRD_1	184	186	PF00675	0.685
CLV_PCSK_FUR_1	258	262	PF00082	0.592
CLV_PCSK_KEX2_1	184	186	PF00082	0.649
CLV_PCSK_KEX2_1	257	259	PF00082	0.557
CLV_PCSK_KEX2_1	260	262	PF00082	0.644
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.557
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.644
CLV_PCSK_SKI1_1	197	201	PF00082	0.443
DEG_APCC_KENBOX_2	70	74	PF00400	0.648
DEG_MDM2_SWIB_1	87	95	PF02201	0.532
DOC_CKS1_1	13	18	PF01111	0.670
DOC_CYCLIN_RxL_1	194	202	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.589
DOC_PP1_RVXF_1	140	146	PF00149	0.542
DOC_PP1_RVXF_1	195	201	PF00149	0.504
DOC_PP2B_PxIxI_1	277	283	PF00149	0.519
DOC_USP7_MATH_1	123	127	PF00917	0.551
DOC_USP7_MATH_1	171	175	PF00917	0.652
DOC_USP7_MATH_1	178	182	PF00917	0.753
DOC_USP7_MATH_1	259	263	PF00917	0.589
DOC_USP7_MATH_1	42	46	PF00917	0.667
DOC_USP7_MATH_1	78	82	PF00917	0.690
DOC_USP7_MATH_2	122	128	PF00917	0.462
DOC_WW_Pin1_4	12	17	PF00397	0.729
DOC_WW_Pin1_4	216	221	PF00397	0.635
DOC_WW_Pin1_4	6	11	PF00397	0.728
LIG_14-3-3_CanoR_1	197	207	PF00244	0.464
LIG_eIF4E_1	97	103	PF01652	0.567
LIG_FHA_1	126	132	PF00498	0.469
LIG_FHA_1	217	223	PF00498	0.630
LIG_FHA_1	237	243	PF00498	0.242
LIG_FHA_1	46	52	PF00498	0.604
LIG_FHA_1	97	103	PF00498	0.567
LIG_LIR_Gen_1	287	296	PF02991	0.446
LIG_LIR_Gen_1	300	310	PF02991	0.350
LIG_LIR_Gen_1	49	60	PF02991	0.543
LIG_LIR_Nem_3	287	291	PF02991	0.465
LIG_LIR_Nem_3	300	306	PF02991	0.363
LIG_LIR_Nem_3	49	55	PF02991	0.523
LIG_Pex14_2	110	114	PF04695	0.437
LIG_Pex14_2	145	149	PF04695	0.518
LIG_Pex14_2	87	91	PF04695	0.524
LIG_SH2_SRC	329	332	PF00017	0.676
LIG_SH2_STAT5	156	159	PF00017	0.378
LIG_SH2_STAT5	193	196	PF00017	0.590
LIG_SH3_1	21	27	PF00018	0.755
LIG_SH3_3	21	27	PF00018	0.508
LIG_SH3_3	226	232	PF00018	0.616
LIG_SH3_3	253	259	PF00018	0.429
LIG_SH3_3	7	13	PF00018	0.756
LIG_Sin3_3	52	59	PF02671	0.602
LIG_SUMO_SIM_par_1	124	132	PF11976	0.510
LIG_TRAF2_1	122	125	PF00917	0.579
LIG_TRAF2_1	273	276	PF00917	0.629
MOD_CK1_1	28	34	PF00069	0.611
MOD_CK1_1	297	303	PF00069	0.462
MOD_CK1_1	45	51	PF00069	0.607
MOD_CK1_1	6	12	PF00069	0.736
MOD_CK1_1	76	82	PF00069	0.762
MOD_CK2_1	259	265	PF00069	0.661
MOD_CMANNOS	308	311	PF00535	0.533
MOD_Cter_Amidation	182	185	PF01082	0.530
MOD_GlcNHglycan	138	141	PF01048	0.492
MOD_GlcNHglycan	17	20	PF01048	0.705
MOD_GlcNHglycan	180	183	PF01048	0.714
MOD_GlcNHglycan	261	264	PF01048	0.693
MOD_GlcNHglycan	27	30	PF01048	0.555
MOD_GlcNHglycan	5	8	PF01048	0.688
MOD_GlcNHglycan	75	78	PF01048	0.739
MOD_GSK3_1	125	132	PF00069	0.463
MOD_GSK3_1	144	151	PF00069	0.371
MOD_GSK3_1	198	205	PF00069	0.407
MOD_GSK3_1	2	9	PF00069	0.725
MOD_GSK3_1	236	243	PF00069	0.524
MOD_GSK3_1	72	79	PF00069	0.783
MOD_LATS_1	80	86	PF00433	0.516
MOD_N-GLC_1	214	219	PF02516	0.484
MOD_N-GLC_1	72	77	PF02516	0.663
MOD_NEK2_1	136	141	PF00069	0.469
MOD_NEK2_1	148	153	PF00069	0.330
MOD_NEK2_1	3	8	PF00069	0.724
MOD_OFUCOSY	153	160	PF10250	0.525
MOD_PKA_1	82	88	PF00069	0.707
MOD_Plk_1	124	130	PF00069	0.496
MOD_Plk_4	125	131	PF00069	0.477
MOD_Plk_4	144	150	PF00069	0.245
MOD_Plk_4	202	208	PF00069	0.394
MOD_Plk_4	241	247	PF00069	0.475
MOD_Plk_4	82	88	PF00069	0.645
MOD_ProDKin_1	216	222	PF00069	0.624
MOD_ProDKin_1	6	12	PF00069	0.727
TRG_NES_CRM1_1	109	124	PF08389	0.566
TRG_NLS_MonoCore_2	256	261	PF00514	0.543
TRG_NLS_MonoExtC_3	256	261	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P7	Leptomonas seymouri	55%	100%
A0A1X0NWT5	Trypanosomatidae	33%	100%
A0A3R7NTG5	Trypanosoma rangeli	33%	100%
A0A3S7WW35	Leishmania donovani	100%	100%
E9AID3	Leishmania braziliensis	73%	99%
E9AUM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCW4	Leishmania major	94%	100%
V5BA94	Trypanosoma cruzi	35%	92%