LeishMANIAdb
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Vesicle-fusing ATPase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Vesicle-fusing ATPase
Gene product:
vesicular-fusion protein nsf - putative
Species:
Leishmania infantum
UniProt:
A4HYS3_LEIIN
TriTrypDb:
LINF_200013000
Length:
738

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, vesicle-fusing ATPase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 11
GO:0110165 cellular anatomical entity 1 12
GO:0005795 Golgi stack 4 1
GO:0031984 organelle subcompartment 2 1
GO:0098791 Golgi apparatus subcompartment 3 1
GO:0016020 membrane 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYS3

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0016043 cellular component organization 3 12
GO:0022411 cellular component disassembly 4 12
GO:0032984 protein-containing complex disassembly 5 12
GO:0033036 macromolecule localization 2 12
GO:0035494 SNARE complex disassembly 6 12
GO:0043933 protein-containing complex organization 4 12
GO:0045184 establishment of protein localization 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0006891 intra-Golgi vesicle-mediated transport 6 1
GO:0006892 post-Golgi vesicle-mediated transport 6 1
GO:0006893 Golgi to plasma membrane transport 5 1
GO:0016192 vesicle-mediated transport 4 1
GO:0043001 Golgi to plasma membrane protein transport 5 1
GO:0048193 Golgi vesicle transport 5 1
GO:0051668 localization within membrane 3 1
GO:0061951 establishment of protein localization to plasma membrane 5 1
GO:0072657 protein localization to membrane 4 1
GO:0072659 protein localization to plasma membrane 5 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:0098876 vesicle-mediated transport to the plasma membrane 4 1
GO:1990778 protein localization to cell periphery 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 355 359 PF00656 0.257
CLV_C14_Caspase3-7 505 509 PF00656 0.414
CLV_C14_Caspase3-7 647 651 PF00656 0.316
CLV_NRD_NRD_1 231 233 PF00675 0.356
CLV_NRD_NRD_1 269 271 PF00675 0.266
CLV_NRD_NRD_1 301 303 PF00675 0.241
CLV_NRD_NRD_1 499 501 PF00675 0.525
CLV_NRD_NRD_1 582 584 PF00675 0.241
CLV_NRD_NRD_1 72 74 PF00675 0.337
CLV_PCSK_FUR_1 516 520 PF00082 0.414
CLV_PCSK_KEX2_1 231 233 PF00082 0.369
CLV_PCSK_KEX2_1 499 501 PF00082 0.456
CLV_PCSK_KEX2_1 518 520 PF00082 0.272
CLV_PCSK_KEX2_1 529 531 PF00082 0.358
CLV_PCSK_KEX2_1 628 630 PF00082 0.281
CLV_PCSK_KEX2_1 72 74 PF00082 0.352
CLV_PCSK_PC1ET2_1 518 520 PF00082 0.456
CLV_PCSK_PC1ET2_1 529 531 PF00082 0.379
CLV_PCSK_PC1ET2_1 628 630 PF00082 0.241
CLV_PCSK_SKI1_1 176 180 PF00082 0.466
CLV_PCSK_SKI1_1 231 235 PF00082 0.335
CLV_PCSK_SKI1_1 237 241 PF00082 0.356
CLV_PCSK_SKI1_1 246 250 PF00082 0.377
CLV_PCSK_SKI1_1 253 257 PF00082 0.180
CLV_PCSK_SKI1_1 302 306 PF00082 0.241
CLV_PCSK_SKI1_1 445 449 PF00082 0.335
CLV_PCSK_SKI1_1 583 587 PF00082 0.241
CLV_PCSK_SKI1_1 635 639 PF00082 0.257
CLV_PCSK_SKI1_1 72 76 PF00082 0.373
DOC_ANK_TNKS_1 628 635 PF00023 0.276
DOC_CYCLIN_RxL_1 69 79 PF00134 0.368
DOC_CYCLIN_RxL_1 698 710 PF00134 0.347
DOC_MAPK_DCC_7 661 669 PF00069 0.349
DOC_MAPK_gen_1 173 183 PF00069 0.473
DOC_MAPK_gen_1 384 394 PF00069 0.241
DOC_MAPK_gen_1 529 536 PF00069 0.362
DOC_MAPK_MEF2A_6 134 143 PF00069 0.317
DOC_MAPK_MEF2A_6 387 396 PF00069 0.241
DOC_MAPK_MEF2A_6 529 538 PF00069 0.335
DOC_MAPK_MEF2A_6 661 669 PF00069 0.484
DOC_MAPK_MEF2A_6 674 683 PF00069 0.406
DOC_MAPK_MEF2A_6 703 711 PF00069 0.336
DOC_MAPK_RevD_3 255 271 PF00069 0.241
DOC_PP1_RVXF_1 602 609 PF00149 0.257
DOC_PP2B_LxvP_1 662 665 PF13499 0.343
DOC_SPAK_OSR1_1 387 391 PF12202 0.241
DOC_USP7_MATH_1 233 237 PF00917 0.316
DOC_USP7_MATH_1 66 70 PF00917 0.380
DOC_USP7_MATH_1 682 686 PF00917 0.399
DOC_USP7_MATH_1 731 735 PF00917 0.386
DOC_USP7_UBL2_3 246 250 PF12436 0.370
DOC_USP7_UBL2_3 514 518 PF12436 0.433
DOC_WW_Pin1_4 482 487 PF00397 0.513
DOC_WW_Pin1_4 589 594 PF00397 0.257
LIG_14-3-3_CanoR_1 134 142 PF00244 0.425
LIG_14-3-3_CanoR_1 148 154 PF00244 0.263
LIG_14-3-3_CanoR_1 176 183 PF00244 0.470
LIG_14-3-3_CanoR_1 3 8 PF00244 0.479
LIG_14-3-3_CanoR_1 614 620 PF00244 0.335
LIG_14-3-3_CanoR_1 720 726 PF00244 0.476
LIG_14-3-3_CanoR_1 82 86 PF00244 0.481
LIG_Actin_WH2_2 368 386 PF00022 0.246
LIG_APCC_ABBA_1 323 328 PF00400 0.241
LIG_APCC_ABBA_1 388 393 PF00400 0.241
LIG_APCC_ABBAyCdc20_2 387 393 PF00400 0.241
LIG_BIR_II_1 1 5 PF00653 0.471
LIG_BRCT_BRCA1_1 448 452 PF00533 0.241
LIG_Clathr_ClatBox_1 323 327 PF01394 0.241
LIG_DLG_GKlike_1 530 537 PF00625 0.475
LIG_FHA_1 134 140 PF00498 0.414
LIG_FHA_1 153 159 PF00498 0.232
LIG_FHA_1 16 22 PF00498 0.343
LIG_FHA_1 177 183 PF00498 0.378
LIG_FHA_1 370 376 PF00498 0.268
LIG_FHA_1 519 525 PF00498 0.465
LIG_FHA_1 82 88 PF00498 0.395
LIG_FHA_2 10 16 PF00498 0.409
LIG_FHA_2 182 188 PF00498 0.486
LIG_FHA_2 471 477 PF00498 0.350
LIG_GBD_Chelix_1 268 276 PF00786 0.241
LIG_LIR_Apic_2 587 593 PF02991 0.276
LIG_LIR_Gen_1 25 36 PF02991 0.506
LIG_LIR_Gen_1 288 294 PF02991 0.304
LIG_LIR_Gen_1 42 51 PF02991 0.411
LIG_LIR_Gen_1 558 567 PF02991 0.276
LIG_LIR_Gen_1 607 615 PF02991 0.266
LIG_LIR_Gen_1 643 654 PF02991 0.297
LIG_LIR_Gen_1 724 731 PF02991 0.463
LIG_LIR_Nem_3 129 135 PF02991 0.397
LIG_LIR_Nem_3 2 7 PF02991 0.484
LIG_LIR_Nem_3 225 229 PF02991 0.322
LIG_LIR_Nem_3 25 31 PF02991 0.480
LIG_LIR_Nem_3 288 293 PF02991 0.269
LIG_LIR_Nem_3 327 332 PF02991 0.241
LIG_LIR_Nem_3 42 46 PF02991 0.412
LIG_LIR_Nem_3 508 513 PF02991 0.370
LIG_LIR_Nem_3 558 564 PF02991 0.277
LIG_LIR_Nem_3 607 611 PF02991 0.266
LIG_MAD2 98 106 PF02301 0.325
LIG_NRBOX 619 625 PF00104 0.241
LIG_NRBOX 704 710 PF00104 0.471
LIG_PCNA_yPIPBox_3 614 624 PF02747 0.241
LIG_Pex14_2 226 230 PF04695 0.321
LIG_Rb_LxCxE_1 274 288 PF01857 0.385
LIG_SH2_CRK 258 262 PF00017 0.234
LIG_SH2_CRK 590 594 PF00017 0.276
LIG_SH2_GRB2like 615 618 PF00017 0.241
LIG_SH2_PTP2 561 564 PF00017 0.257
LIG_SH2_STAP1 520 524 PF00017 0.476
LIG_SH2_STAP1 615 619 PF00017 0.241
LIG_SH2_STAT3 128 131 PF00017 0.440
LIG_SH2_STAT3 520 523 PF00017 0.389
LIG_SH2_STAT5 132 135 PF00017 0.370
LIG_SH2_STAT5 520 523 PF00017 0.353
LIG_SH2_STAT5 552 555 PF00017 0.263
LIG_SH2_STAT5 561 564 PF00017 0.215
LIG_SH3_2 397 402 PF14604 0.420
LIG_SH3_3 28 34 PF00018 0.432
LIG_SH3_3 281 287 PF00018 0.241
LIG_SH3_3 394 400 PF00018 0.425
LIG_SH3_3 662 668 PF00018 0.343
LIG_SH3_3 83 89 PF00018 0.479
LIG_SUMO_SIM_anti_2 532 539 PF11976 0.364
LIG_SUMO_SIM_anti_2 690 697 PF11976 0.419
LIG_SUMO_SIM_par_1 622 627 PF11976 0.309
LIG_SUMO_SIM_par_1 636 643 PF11976 0.233
LIG_SUMO_SIM_par_1 705 710 PF11976 0.332
LIG_SUMO_SIM_par_1 83 88 PF11976 0.396
LIG_SxIP_EBH_1 665 674 PF03271 0.434
LIG_TRAF2_1 424 427 PF00917 0.385
LIG_TRAF2_1 480 483 PF00917 0.358
LIG_TRAF2_1 491 494 PF00917 0.419
LIG_UBA3_1 619 628 PF00899 0.241
LIG_UBA3_1 707 716 PF00899 0.417
MOD_CK1_1 165 171 PF00069 0.574
MOD_CK1_1 186 192 PF00069 0.356
MOD_CK1_1 421 427 PF00069 0.377
MOD_CK1_1 544 550 PF00069 0.279
MOD_CK1_1 592 598 PF00069 0.241
MOD_CK1_1 6 12 PF00069 0.362
MOD_CK1_1 691 697 PF00069 0.484
MOD_CK2_1 181 187 PF00069 0.468
MOD_CK2_1 421 427 PF00069 0.310
MOD_CK2_1 433 439 PF00069 0.192
MOD_Cter_Amidation 527 530 PF01082 0.447
MOD_Cter_Amidation 633 636 PF01082 0.276
MOD_GlcNHglycan 107 110 PF01048 0.502
MOD_GlcNHglycan 128 131 PF01048 0.350
MOD_GlcNHglycan 144 147 PF01048 0.373
MOD_GlcNHglycan 163 167 PF01048 0.536
MOD_GlcNHglycan 187 191 PF01048 0.512
MOD_GlcNHglycan 435 438 PF01048 0.241
MOD_GlcNHglycan 543 546 PF01048 0.225
MOD_GlcNHglycan 549 552 PF01048 0.236
MOD_GlcNHglycan 565 568 PF01048 0.358
MOD_GlcNHglycan 669 672 PF01048 0.420
MOD_GlcNHglycan 717 720 PF01048 0.563
MOD_GSK3_1 149 156 PF00069 0.491
MOD_GSK3_1 158 165 PF00069 0.598
MOD_GSK3_1 172 179 PF00069 0.324
MOD_GSK3_1 417 424 PF00069 0.478
MOD_GSK3_1 429 436 PF00069 0.202
MOD_GSK3_1 50 57 PF00069 0.471
MOD_GSK3_1 663 670 PF00069 0.359
MOD_GSK3_1 76 83 PF00069 0.370
MOD_GSK3_1 9 16 PF00069 0.391
MOD_N-GLC_1 13 18 PF02516 0.502
MOD_N-GLC_1 194 199 PF02516 0.523
MOD_N-GLC_1 433 438 PF02516 0.246
MOD_NEK2_1 133 138 PF00069 0.370
MOD_NEK2_1 149 154 PF00069 0.310
MOD_NEK2_1 624 629 PF00069 0.330
MOD_NEK2_1 75 80 PF00069 0.380
MOD_NEK2_2 656 661 PF00069 0.442
MOD_PIKK_1 133 139 PF00454 0.390
MOD_PIKK_1 176 182 PF00454 0.476
MOD_PIKK_1 606 612 PF00454 0.385
MOD_PIKK_1 682 688 PF00454 0.401
MOD_PK_1 3 9 PF00069 0.465
MOD_PKA_1 518 524 PF00069 0.420
MOD_PKA_2 133 139 PF00069 0.354
MOD_PKA_2 149 155 PF00069 0.293
MOD_PKA_2 172 178 PF00069 0.456
MOD_PKA_2 339 345 PF00069 0.257
MOD_PKA_2 518 524 PF00069 0.451
MOD_PKA_2 613 619 PF00069 0.241
MOD_PKA_2 81 87 PF00069 0.486
MOD_Plk_1 316 322 PF00069 0.308
MOD_Plk_1 421 427 PF00069 0.317
MOD_Plk_1 606 612 PF00069 0.252
MOD_Plk_4 149 155 PF00069 0.432
MOD_Plk_4 239 245 PF00069 0.352
MOD_Plk_4 263 269 PF00069 0.241
MOD_Plk_4 615 621 PF00069 0.307
MOD_Plk_4 691 697 PF00069 0.484
MOD_Plk_4 81 87 PF00069 0.405
MOD_ProDKin_1 482 488 PF00069 0.512
MOD_ProDKin_1 589 595 PF00069 0.257
MOD_SUMO_for_1 491 494 PF00179 0.419
MOD_SUMO_rev_2 157 164 PF00179 0.567
MOD_SUMO_rev_2 274 284 PF00179 0.385
MOD_SUMO_rev_2 710 718 PF00179 0.470
MOD_SUMO_rev_2 9 18 PF00179 0.487
TRG_DiLeu_BaEn_1 633 638 PF01217 0.242
TRG_DiLeu_BaEn_4 493 499 PF01217 0.397
TRG_DiLeu_BaLyEn_6 601 606 PF01217 0.335
TRG_DiLeu_BaLyEn_6 70 75 PF01217 0.350
TRG_DiLeu_BaLyEn_6 718 723 PF01217 0.480
TRG_ENDOCYTIC_2 132 135 PF00928 0.470
TRG_ENDOCYTIC_2 4 7 PF00928 0.471
TRG_ENDOCYTIC_2 561 564 PF00928 0.241
TRG_ENDOCYTIC_2 573 576 PF00928 0.241
TRG_ENDOCYTIC_2 646 649 PF00928 0.276
TRG_ENDOCYTIC_2 725 728 PF00928 0.508
TRG_ER_diArg_1 230 232 PF00400 0.355
TRG_ER_diArg_1 498 500 PF00400 0.524
TRG_ER_diArg_1 72 74 PF00400 0.352
TRG_Pf-PMV_PEXEL_1 270 274 PF00026 0.241
TRG_Pf-PMV_PEXEL_1 302 307 PF00026 0.241
TRG_Pf-PMV_PEXEL_1 98 103 PF00026 0.388

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P640 Leptomonas seymouri 83% 100%
A0A0N0P6X6 Leptomonas seymouri 33% 72%
A0A0S4JAU3 Bodo saltans 26% 100%
A0A0S4JTC3 Bodo saltans 57% 100%
A0A1X0NXR8 Trypanosomatidae 63% 100%
A0A1X0P437 Trypanosomatidae 28% 79%
A0A3Q8IKK0 Leishmania donovani 100% 100%
A0A3S7X0L3 Leishmania donovani 26% 100%
A0A422MWC2 Trypanosoma rangeli 28% 83%
A0A422NPR7 Trypanosoma rangeli 63% 100%
A4HFM9 Leishmania braziliensis 26% 100%
A4HFN1 Leishmania braziliensis 34% 74%
A4I2Q7 Leishmania infantum 26% 100%
C9ZI97 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
D0A5W2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 83%
E9AD83 Leishmania major 26% 100%
E9AID2 Leishmania braziliensis 94% 100%
E9AUL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9AZ07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
O14325 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 95%
O28972 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 32% 100%
P18708 Cricetulus griseus 40% 99%
P18759 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 97%
P34732 Candida albicans 42% 93%
P46459 Homo sapiens 41% 99%
P46460 Mus musculus 40% 99%
P46461 Drosophila melanogaster 41% 99%
P54351 Drosophila melanogaster 42% 98%
Q07844 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 88%
Q0DGP6 Oryza sativa subsp. japonica 44% 99%
Q4QCW5 Leishmania major 98% 100%
Q54SY2 Dictyostelium discoideum 25% 85%
Q58556 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 29% 82%
Q5R410 Pongo abelii 41% 99%
Q75JI3 Dictyostelium discoideum 44% 100%
Q94392 Caenorhabditis elegans 44% 90%
Q9DBY8 Mus musculus 26% 86%
Q9M0Y8 Arabidopsis thaliana 44% 99%
Q9NAG4 Caenorhabditis elegans 26% 91%
Q9P7Q4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 93%
Q9QUL6 Rattus norvegicus 42% 99%
V5DS04 Trypanosoma cruzi 64% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS