Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ESCO acetyltransferase domain-containing protein

Species:

Leishmania infantum

UniProt:

A4HYS2_LEIIN

TriTrypDb:

LINF_200008600

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYS2

Function

Biological processes
Term	Name	Level	Count
GO:0000070	mitotic sister chromatid segregation	4	10
GO:0000819	sister chromatid segregation	4	10
GO:0006996	organelle organization	4	11
GO:0007059	chromosome segregation	2	11
GO:0007062	sister chromatid cohesion	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	11
GO:0022414	reproductive process	1	11
GO:0045132	meiotic chromosome segregation	3	11
GO:0051276	chromosome organization	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0098813	nuclear chromosome segregation	3	11
GO:1903046	meiotic cell cycle process	2	11
GO:1903047	mitotic cell cycle process	3	11
GO:0007064	mitotic sister chromatid cohesion	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016407	acetyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1
GO:0034212	peptide N-acetyltransferase activity	7	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.651
CLV_NRD_NRD_1	295	297	PF00675	0.294
CLV_NRD_NRD_1	72	74	PF00675	0.711
CLV_NRD_NRD_1	96	98	PF00675	0.585
CLV_PCSK_KEX2_1	295	297	PF00082	0.317
CLV_PCSK_KEX2_1	74	76	PF00082	0.660
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.621
CLV_PCSK_PC7_1	70	76	PF00082	0.653
CLV_PCSK_SKI1_1	29	33	PF00082	0.479
CLV_PCSK_SKI1_1	53	57	PF00082	0.569
DOC_MAPK_MEF2A_6	156	165	PF00069	0.480
DOC_PP1_RVXF_1	243	249	PF00149	0.550
DOC_PP4_FxxP_1	274	277	PF00568	0.467
DOC_PP4_FxxP_1	283	286	PF00568	0.452
DOC_USP7_MATH_1	122	126	PF00917	0.479
DOC_USP7_MATH_1	187	191	PF00917	0.649
DOC_USP7_MATH_1	193	197	PF00917	0.679
DOC_USP7_MATH_1	288	292	PF00917	0.552
DOC_WW_Pin1_4	125	130	PF00397	0.619
DOC_WW_Pin1_4	151	156	PF00397	0.657
DOC_WW_Pin1_4	182	187	PF00397	0.574
DOC_WW_Pin1_4	236	241	PF00397	0.482
DOC_WW_Pin1_4	247	252	PF00397	0.467
DOC_WW_Pin1_4	30	35	PF00397	0.570
LIG_14-3-3_CanoR_1	180	186	PF00244	0.580
LIG_14-3-3_CanoR_1	97	103	PF00244	0.530
LIG_Clathr_ClatBox_1	217	221	PF01394	0.497
LIG_FHA_1	58	64	PF00498	0.386
LIG_FHA_2	119	125	PF00498	0.344
LIG_FHA_2	144	150	PF00498	0.422
LIG_FHA_2	195	201	PF00498	0.707
LIG_FHA_2	6	12	PF00498	0.605
LIG_LIR_Nem_3	19	24	PF02991	0.487
LIG_LIR_Nem_3	302	306	PF02991	0.473
LIG_REV1ctd_RIR_1	64	74	PF16727	0.523
LIG_SH2_CRK	272	276	PF00017	0.591
LIG_SH2_NCK_1	260	264	PF00017	0.513
LIG_SH2_STAP1	64	68	PF00017	0.511
LIG_SH2_STAT5	36	39	PF00017	0.501
LIG_SH3_3	272	278	PF00018	0.421
LIG_SH3_3	28	34	PF00018	0.476
LIG_SUMO_SIM_par_1	211	221	PF11976	0.561
LIG_SUMO_SIM_par_1	59	65	PF11976	0.456
LIG_TYR_ITIM	258	263	PF00017	0.544
LIG_TYR_ITIM	270	275	PF00017	0.561
MOD_CDK_SPK_2	151	156	PF00069	0.505
MOD_CDK_SPxxK_3	247	254	PF00069	0.552
MOD_CK1_1	105	111	PF00069	0.486
MOD_CK1_1	125	131	PF00069	0.303
MOD_CK1_1	154	160	PF00069	0.653
MOD_CK1_1	211	217	PF00069	0.649
MOD_CK1_1	234	240	PF00069	0.540
MOD_CK1_1	250	256	PF00069	0.543
MOD_CK1_1	284	290	PF00069	0.493
MOD_CK2_1	118	124	PF00069	0.331
MOD_CK2_1	193	199	PF00069	0.654
MOD_CK2_1	258	264	PF00069	0.492
MOD_GlcNHglycan	107	110	PF01048	0.491
MOD_GlcNHglycan	112	115	PF01048	0.436
MOD_GlcNHglycan	290	293	PF01048	0.365
MOD_GlcNHglycan	50	53	PF01048	0.633
MOD_GlcNHglycan	89	93	PF01048	0.678
MOD_GSK3_1	118	125	PF00069	0.237
MOD_GSK3_1	13	20	PF00069	0.469
MOD_GSK3_1	182	189	PF00069	0.600
MOD_GSK3_1	195	202	PF00069	0.674
MOD_GSK3_1	207	214	PF00069	0.725
MOD_GSK3_1	284	291	PF00069	0.517
MOD_GSK3_1	5	12	PF00069	0.663
MOD_GSK3_1	98	105	PF00069	0.674
MOD_LATS_1	96	102	PF00433	0.490
MOD_N-GLC_1	200	205	PF02516	0.750
MOD_NEK2_2	107	112	PF00069	0.446
MOD_PKA_1	73	79	PF00069	0.567
MOD_PKA_1	98	104	PF00069	0.494
MOD_PKA_2	102	108	PF00069	0.546
MOD_Plk_1	199	205	PF00069	0.679
MOD_Plk_4	258	264	PF00069	0.516
MOD_Plk_4	57	63	PF00069	0.427
MOD_ProDKin_1	125	131	PF00069	0.622
MOD_ProDKin_1	151	157	PF00069	0.655
MOD_ProDKin_1	182	188	PF00069	0.584
MOD_ProDKin_1	236	242	PF00069	0.472
MOD_ProDKin_1	247	253	PF00069	0.467
MOD_ProDKin_1	30	36	PF00069	0.569
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.434
TRG_ENDOCYTIC_2	179	182	PF00928	0.525
TRG_ENDOCYTIC_2	260	263	PF00928	0.544
TRG_ENDOCYTIC_2	272	275	PF00928	0.549
TRG_ENDOCYTIC_2	64	67	PF00928	0.389
TRG_ER_diArg_1	295	297	PF00400	0.517
TRG_NLS_MonoCore_2	96	101	PF00514	0.495
TRG_NLS_MonoExtC_3	72	77	PF00514	0.660
TRG_NLS_MonoExtN_4	70	77	PF00514	0.655
TRG_NLS_MonoExtN_4	97	102	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N8	Leptomonas seymouri	37%	100%
A0A1X0NWH5	Trypanosomatidae	34%	92%
A0A3S7WVV5	Leishmania donovani	100%	100%
A0A422MWP0	Trypanosoma rangeli	35%	99%
C9ZIA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AI91	Leishmania braziliensis	70%	100%
E9AUH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QD07	Leishmania major	87%	100%
V5DS57	Trypanosoma cruzi	32%	100%