Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYR9_LEIIN

TriTrypDb:

LINF_200008400

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.502
CLV_C14_Caspase3-7	48	52	PF00656	0.574
CLV_NRD_NRD_1	284	286	PF00675	0.593
CLV_NRD_NRD_1	30	32	PF00675	0.453
CLV_NRD_NRD_1	314	316	PF00675	0.619
CLV_PCSK_KEX2_1	284	286	PF00082	0.593
CLV_PCSK_KEX2_1	30	32	PF00082	0.453
CLV_PCSK_KEX2_1	314	316	PF00082	0.619
CLV_PCSK_SKI1_1	216	220	PF00082	0.459
CLV_PCSK_SKI1_1	290	294	PF00082	0.573
CLV_PCSK_SKI1_1	30	34	PF00082	0.516
CLV_PCSK_SKI1_1	67	71	PF00082	0.702
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DOC_CYCLIN_RxL_1	26	38	PF00134	0.516
DOC_MAPK_gen_1	213	223	PF00069	0.452
DOC_MAPK_gen_1	27	35	PF00069	0.436
DOC_MAPK_MEF2A_6	213	221	PF00069	0.475
DOC_PP2B_LxvP_1	219	222	PF13499	0.552
DOC_USP7_MATH_1	275	279	PF00917	0.545
DOC_USP7_MATH_1	302	306	PF00917	0.503
DOC_USP7_MATH_1	60	64	PF00917	0.690
DOC_WW_Pin1_4	107	112	PF00397	0.739
DOC_WW_Pin1_4	298	303	PF00397	0.492
DOC_WW_Pin1_4	309	314	PF00397	0.556
DOC_WW_Pin1_4	76	81	PF00397	0.730
LIG_14-3-3_CanoR_1	150	156	PF00244	0.578
LIG_14-3-3_CanoR_1	290	299	PF00244	0.530
LIG_BIR_III_4	51	55	PF00653	0.566
LIG_FHA_1	230	236	PF00498	0.540
LIG_FHA_1	99	105	PF00498	0.565
LIG_FHA_2	104	110	PF00498	0.669
LIG_FHA_2	118	124	PF00498	0.655
LIG_FHA_2	172	178	PF00498	0.564
LIG_FHA_2	195	201	PF00498	0.487
LIG_FHA_2	249	255	PF00498	0.726
LIG_Pex14_2	114	118	PF04695	0.689
LIG_SH2_CRK	262	266	PF00017	0.684
LIG_SH2_STAT5	207	210	PF00017	0.406
LIG_SH2_STAT5	43	46	PF00017	0.610
LIG_SH3_1	132	138	PF00018	0.684
LIG_SH3_1	75	81	PF00018	0.703
LIG_SH3_3	132	138	PF00018	0.614
LIG_SH3_3	190	196	PF00018	0.535
LIG_SH3_3	214	220	PF00018	0.479
LIG_SH3_3	75	81	PF00018	0.714
LIG_SUMO_SIM_par_1	31	38	PF11976	0.450
LIG_TRAF2_1	10	13	PF00917	0.481
LIG_WRC_WIRS_1	104	109	PF05994	0.594
LIG_WW_3	134	138	PF00397	0.629
MOD_CDC14_SPxK_1	312	315	PF00782	0.542
MOD_CDK_SPK_2	309	314	PF00069	0.574
MOD_CDK_SPxK_1	309	315	PF00069	0.526
MOD_CK1_1	301	307	PF00069	0.668
MOD_CK1_1	38	44	PF00069	0.456
MOD_CK2_1	103	109	PF00069	0.771
MOD_CK2_1	171	177	PF00069	0.574
MOD_CK2_1	194	200	PF00069	0.493
MOD_CK2_1	248	254	PF00069	0.574
MOD_CK2_1	34	40	PF00069	0.522
MOD_GlcNHglycan	167	170	PF01048	0.713
MOD_GlcNHglycan	179	182	PF01048	0.522
MOD_GlcNHglycan	58	61	PF01048	0.746
MOD_GlcNHglycan	90	93	PF01048	0.657
MOD_GSK3_1	103	110	PF00069	0.540
MOD_GSK3_1	112	119	PF00069	0.605
MOD_GSK3_1	165	172	PF00069	0.732
MOD_GSK3_1	182	189	PF00069	0.595
MOD_GSK3_1	298	305	PF00069	0.516
MOD_GSK3_1	34	41	PF00069	0.491
MOD_GSK3_1	56	63	PF00069	0.708
MOD_N-GLC_1	169	174	PF02516	0.722
MOD_N-GLC_1	248	253	PF02516	0.566
MOD_NEK2_1	151	156	PF00069	0.738
MOD_NEK2_1	165	170	PF00069	0.611
MOD_NEK2_1	188	193	PF00069	0.595
MOD_NEK2_1	238	243	PF00069	0.549
MOD_PKA_2	116	122	PF00069	0.615
MOD_PKA_2	149	155	PF00069	0.600
MOD_PKA_2	156	162	PF00069	0.655
MOD_Plk_1	302	308	PF00069	0.468
MOD_Plk_1	35	41	PF00069	0.444
MOD_Plk_2-3	194	200	PF00069	0.494
MOD_Plk_4	194	200	PF00069	0.494
MOD_Plk_4	38	44	PF00069	0.488
MOD_ProDKin_1	107	113	PF00069	0.740
MOD_ProDKin_1	298	304	PF00069	0.495
MOD_ProDKin_1	309	315	PF00069	0.562
MOD_ProDKin_1	76	82	PF00069	0.732
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.465
TRG_ENDOCYTIC_2	262	265	PF00928	0.689
TRG_ER_diArg_1	131	134	PF00400	0.601
TRG_ER_diArg_1	230	233	PF00400	0.441
TRG_ER_diArg_1	30	32	PF00400	0.459
TRG_ER_diArg_1	313	315	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P529	Leptomonas seymouri	43%	98%
A0A3S7WVT8	Leishmania donovani	100%	100%
E9AI89	Leishmania braziliensis	67%	100%
E9AUH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4QD10	Leishmania major	90%	100%