Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeat/Leucine rich repeat/Leucine Rich Repeat/Leucine Rich repeats (2 copies) - putative

Species:

Leishmania infantum

UniProt:

A4HYR8_LEIIN

TriTrypDb:

LINF_200008300

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HYR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.578
CLV_C14_Caspase3-7	365	369	PF00656	0.665
CLV_C14_Caspase3-7	370	374	PF00656	0.571
CLV_C14_Caspase3-7	85	89	PF00656	0.613
CLV_C14_Caspase3-7	99	103	PF00656	0.671
CLV_NRD_NRD_1	110	112	PF00675	0.699
CLV_NRD_NRD_1	13	15	PF00675	0.543
CLV_NRD_NRD_1	155	157	PF00675	0.514
CLV_NRD_NRD_1	174	176	PF00675	0.202
CLV_NRD_NRD_1	236	238	PF00675	0.420
CLV_NRD_NRD_1	389	391	PF00675	0.601
CLV_NRD_NRD_1	393	395	PF00675	0.581
CLV_NRD_NRD_1	427	429	PF00675	0.550
CLV_NRD_NRD_1	451	453	PF00675	0.695
CLV_PCSK_KEX2_1	109	111	PF00082	0.685
CLV_PCSK_KEX2_1	13	15	PF00082	0.543
CLV_PCSK_KEX2_1	155	157	PF00082	0.618
CLV_PCSK_KEX2_1	236	238	PF00082	0.441
CLV_PCSK_KEX2_1	328	330	PF00082	0.491
CLV_PCSK_KEX2_1	393	395	PF00082	0.646
CLV_PCSK_KEX2_1	427	429	PF00082	0.550
CLV_PCSK_KEX2_1	451	453	PF00082	0.695
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.662
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.491
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.695
CLV_PCSK_PC7_1	106	112	PF00082	0.593
CLV_PCSK_PC7_1	324	330	PF00082	0.466
CLV_PCSK_SKI1_1	156	160	PF00082	0.452
CLV_PCSK_SKI1_1	190	194	PF00082	0.321
CLV_PCSK_SKI1_1	430	434	PF00082	0.565
DEG_APCC_DBOX_1	189	197	PF00400	0.304
DEG_Nend_UBRbox_2	1	3	PF02207	0.475
DEG_SPOP_SBC_1	274	278	PF00917	0.539
DOC_CYCLIN_RxL_1	170	183	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.399
DOC_MAPK_gen_1	155	161	PF00069	0.461
DOC_MAPK_gen_1	170	179	PF00069	0.382
DOC_MAPK_gen_1	236	246	PF00069	0.388
DOC_MAPK_gen_1	292	302	PF00069	0.442
DOC_MAPK_gen_1	427	433	PF00069	0.554
DOC_PP4_FxxP_1	345	348	PF00568	0.548
DOC_USP7_MATH_1	147	151	PF00917	0.466
DOC_USP7_MATH_1	275	279	PF00917	0.522
DOC_USP7_MATH_1	438	442	PF00917	0.657
DOC_USP7_UBL2_3	328	332	PF12436	0.513
DOC_WW_Pin1_4	143	148	PF00397	0.580
DOC_WW_Pin1_4	344	349	PF00397	0.569
DOC_WW_Pin1_4	384	389	PF00397	0.649
DOC_WW_Pin1_4	454	459	PF00397	0.681
LIG_14-3-3_CanoR_1	13	23	PF00244	0.587
LIG_14-3-3_CanoR_1	175	180	PF00244	0.285
LIG_14-3-3_CanoR_1	47	55	PF00244	0.380
LIG_Actin_WH2_2	186	202	PF00022	0.403
LIG_CaM_IQ_9	316	332	PF13499	0.453
LIG_CtBP_PxDLS_1	9	13	PF00389	0.522
LIG_FHA_1	280	286	PF00498	0.478
LIG_FHA_1	40	46	PF00498	0.406
LIG_FHA_1	55	61	PF00498	0.486
LIG_FHA_2	263	269	PF00498	0.525
LIG_IRF3_LxIS_1	219	225	PF10401	0.349
LIG_LIR_Apic_2	343	348	PF02991	0.546
LIG_LIR_Gen_1	166	174	PF02991	0.389
LIG_LIR_Gen_1	32	41	PF02991	0.374
LIG_LIR_Nem_3	166	171	PF02991	0.384
LIG_LIR_Nem_3	32	37	PF02991	0.375
LIG_PCNA_PIPBox_1	290	299	PF02747	0.416
LIG_PCNA_yPIPBox_3	290	301	PF02747	0.418
LIG_PCNA_yPIPBox_3	468	481	PF02747	0.572
LIG_PTB_Apo_2	223	230	PF02174	0.407
LIG_SH2_STAT3	240	243	PF00017	0.394
LIG_SH2_STAT5	240	243	PF00017	0.423
LIG_SH3_3	408	414	PF00018	0.532
LIG_SH3_3	455	461	PF00018	0.596
LIG_SUMO_SIM_par_1	163	169	PF11976	0.385
LIG_SUMO_SIM_par_1	220	225	PF11976	0.367
LIG_SUMO_SIM_par_1	41	46	PF11976	0.406
LIG_UBA3_1	293	301	PF00899	0.433
LIG_WRC_WIRS_1	34	39	PF05994	0.434
MOD_CDC14_SPxK_1	387	390	PF00782	0.626
MOD_CDK_SPxK_1	384	390	PF00069	0.633
MOD_CDK_SPxxK_3	384	391	PF00069	0.631
MOD_CK1_1	16	22	PF00069	0.586
MOD_CK1_1	231	237	PF00069	0.425
MOD_CK1_1	279	285	PF00069	0.584
MOD_CK1_1	362	368	PF00069	0.761
MOD_CK1_1	46	52	PF00069	0.421
MOD_CK2_1	110	116	PF00069	0.556
MOD_CK2_1	163	169	PF00069	0.385
MOD_CK2_1	177	183	PF00069	0.304
MOD_CK2_1	262	268	PF00069	0.511
MOD_CK2_1	344	350	PF00069	0.637
MOD_Cter_Amidation	106	109	PF01082	0.628
MOD_GlcNHglycan	102	105	PF01048	0.728
MOD_GlcNHglycan	112	115	PF01048	0.534
MOD_GlcNHglycan	129	133	PF01048	0.487
MOD_GlcNHglycan	148	152	PF01048	0.363
MOD_GlcNHglycan	179	182	PF01048	0.304
MOD_GlcNHglycan	19	22	PF01048	0.567
MOD_GlcNHglycan	279	282	PF01048	0.664
MOD_GlcNHglycan	324	327	PF01048	0.585
MOD_GlcNHglycan	370	373	PF01048	0.663
MOD_GlcNHglycan	396	399	PF01048	0.692
MOD_GlcNHglycan	440	443	PF01048	0.624
MOD_GlcNHglycan	481	484	PF01048	0.530
MOD_GlcNHglycan	74	77	PF01048	0.609
MOD_GlcNHglycan	94	97	PF01048	0.768
MOD_GSK3_1	128	135	PF00069	0.648
MOD_GSK3_1	143	150	PF00069	0.448
MOD_GSK3_1	273	280	PF00069	0.627
MOD_GSK3_1	362	369	PF00069	0.661
MOD_GSK3_1	39	46	PF00069	0.403
MOD_GSK3_1	413	420	PF00069	0.529
MOD_GSK3_1	475	482	PF00069	0.506
MOD_GSK3_1	8	15	PF00069	0.578
MOD_GSK3_1	88	95	PF00069	0.690
MOD_NEK2_1	12	17	PF00069	0.549
MOD_NEK2_1	177	182	PF00069	0.304
MOD_NEK2_1	222	227	PF00069	0.351
MOD_NEK2_1	228	233	PF00069	0.396
MOD_NEK2_1	475	480	PF00069	0.500
MOD_PKA_1	110	116	PF00069	0.620
MOD_PKA_1	13	19	PF00069	0.552
MOD_PKA_1	175	181	PF00069	0.304
MOD_PKA_2	110	116	PF00069	0.635
MOD_PKA_2	12	18	PF00069	0.597
MOD_PKA_2	169	175	PF00069	0.462
MOD_PKA_2	366	372	PF00069	0.642
MOD_PKA_2	46	52	PF00069	0.435
MOD_PKA_2	72	78	PF00069	0.636
MOD_PKB_1	173	181	PF00069	0.272
MOD_Plk_1	147	153	PF00069	0.430
MOD_Plk_2-3	80	86	PF00069	0.678
MOD_Plk_4	163	169	PF00069	0.398
MOD_Plk_4	39	45	PF00069	0.401
MOD_Plk_4	413	419	PF00069	0.528
MOD_ProDKin_1	143	149	PF00069	0.573
MOD_ProDKin_1	344	350	PF00069	0.571
MOD_ProDKin_1	384	390	PF00069	0.648
MOD_ProDKin_1	454	460	PF00069	0.678
MOD_SUMO_rev_2	403	409	PF00179	0.505
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.470
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.414
TRG_ENDOCYTIC_2	31	34	PF00928	0.423
TRG_ER_diArg_1	12	14	PF00400	0.535
TRG_ER_diArg_1	235	237	PF00400	0.411
TRG_ER_diArg_1	426	428	PF00400	0.547
TRG_NES_CRM1_1	169	183	PF08389	0.304
TRG_NLS_MonoCore_2	107	112	PF00514	0.577
TRG_NLS_MonoExtC_3	389	394	PF00514	0.660
TRG_NLS_MonoExtN_4	106	113	PF00514	0.632
TRG_NLS_MonoExtN_4	388	394	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N9	Leptomonas seymouri	51%	75%
A0A3Q8IBM2	Leishmania donovani	100%	77%
E9AI88	Leishmania braziliensis	70%	100%
E9AUH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QD11	Leishmania major	92%	100%