LeishMANIAdb
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Transmembrane protein 231

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein 231
Gene product:
Transmembrane protein 231 - putative
Species:
Leishmania infantum
UniProt:
A4HYR5_LEIIN
TriTrypDb:
LINF_200010000
Length:
375

Annotations

LeishMANIAdb annotations

Homologous to mammalian TMEM231 protein. Probably flagellar and required for its maintenance, based on homology.. Localization: Flagellar membrane (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0031090 organelle membrane 3 11
GO:0031253 cell projection membrane 4 11
GO:0060170 ciliary membrane 5 11
GO:0098588 bounding membrane of organelle 4 11
GO:0098590 plasma membrane region 3 11
GO:0110165 cellular anatomical entity 1 11
GO:0035869 ciliary transition zone 2 1

Expansion

Sequence features

A4HYR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYR5

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0032879 regulation of localization 3 1
GO:0032880 regulation of protein localization 5 1
GO:0044782 cilium organization 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0060271 cilium assembly 6 1
GO:0060341 regulation of cellular localization 4 1
GO:0065007 biological regulation 1 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 106 110 PF00656 0.311
CLV_C14_Caspase3-7 151 155 PF00656 0.383
CLV_NRD_NRD_1 187 189 PF00675 0.663
CLV_NRD_NRD_1 289 291 PF00675 0.687
CLV_NRD_NRD_1 372 374 PF00675 0.472
CLV_PCSK_FUR_1 185 189 PF00082 0.649
CLV_PCSK_KEX2_1 187 189 PF00082 0.647
CLV_PCSK_KEX2_1 289 291 PF00082 0.687
CLV_PCSK_KEX2_1 372 374 PF00082 0.472
CLV_PCSK_SKI1_1 353 357 PF00082 0.281
DEG_APCC_DBOX_1 352 360 PF00400 0.556
DEG_Nend_Nbox_1 1 3 PF02207 0.652
DEG_SPOP_SBC_1 200 204 PF00917 0.538
DOC_CDC14_PxL_1 178 186 PF14671 0.390
DOC_CYCLIN_yCln2_LP_2 34 40 PF00134 0.279
DOC_MAPK_MEF2A_6 351 359 PF00069 0.551
DOC_MAPK_RevD_3 174 188 PF00069 0.411
DOC_PP2B_LxvP_1 257 260 PF13499 0.362
DOC_PP2B_LxvP_1 34 37 PF13499 0.295
DOC_USP7_MATH_1 200 204 PF00917 0.521
DOC_USP7_MATH_1 233 237 PF00917 0.432
DOC_WW_Pin1_4 186 191 PF00397 0.466
DOC_WW_Pin1_4 229 234 PF00397 0.360
DOC_WW_Pin1_4 241 246 PF00397 0.296
LIG_14-3-3_CanoR_1 18 24 PF00244 0.544
LIG_14-3-3_CanoR_1 269 274 PF00244 0.308
LIG_14-3-3_CanoR_1 365 375 PF00244 0.671
LIG_14-3-3_CanoR_1 69 74 PF00244 0.329
LIG_Actin_WH2_2 317 334 PF00022 0.311
LIG_Actin_WH2_2 337 355 PF00022 0.361
LIG_APCC_ABBA_1 4 9 PF00400 0.531
LIG_BRCT_BRCA1_1 21 25 PF00533 0.379
LIG_BRCT_BRCA1_1 82 86 PF00533 0.251
LIG_DCNL_PONY_1 1 4 PF03556 0.659
LIG_deltaCOP1_diTrp_1 77 86 PF00928 0.281
LIG_EH1_1 24 32 PF00400 0.443
LIG_eIF4E_1 168 174 PF01652 0.410
LIG_eIF4E_1 224 230 PF01652 0.419
LIG_eIF4E_1 26 32 PF01652 0.350
LIG_eIF4E_1 343 349 PF01652 0.396
LIG_FHA_1 224 230 PF00498 0.325
LIG_FHA_1 307 313 PF00498 0.270
LIG_FHA_1 356 362 PF00498 0.515
LIG_FHA_2 101 107 PF00498 0.347
LIG_FHA_2 215 221 PF00498 0.299
LIG_FHA_2 79 85 PF00498 0.340
LIG_GBD_Chelix_1 20 28 PF00786 0.464
LIG_GBD_Chelix_1 294 302 PF00786 0.663
LIG_GBD_Chelix_1 344 352 PF00786 0.369
LIG_LIR_Gen_1 115 124 PF02991 0.330
LIG_LIR_Gen_1 309 319 PF02991 0.356
LIG_LIR_Gen_1 326 331 PF02991 0.305
LIG_LIR_Nem_3 115 119 PF02991 0.345
LIG_LIR_Nem_3 130 135 PF02991 0.501
LIG_LIR_Nem_3 164 168 PF02991 0.318
LIG_LIR_Nem_3 22 28 PF02991 0.337
LIG_LIR_Nem_3 232 237 PF02991 0.362
LIG_LIR_Nem_3 307 311 PF02991 0.348
LIG_LIR_Nem_3 326 330 PF02991 0.372
LIG_LYPXL_SIV_4 277 285 PF13949 0.391
LIG_Pex14_1 335 339 PF04695 0.321
LIG_Pex14_2 119 123 PF04695 0.333
LIG_Pex14_2 161 165 PF04695 0.282
LIG_Pex14_2 39 43 PF04695 0.449
LIG_PTB_Apo_2 228 235 PF02174 0.394
LIG_PTB_Phospho_1 228 234 PF10480 0.393
LIG_SH2_GRB2like 116 119 PF00017 0.372
LIG_SH2_GRB2like 168 171 PF00017 0.405
LIG_SH2_NCK_1 55 59 PF00017 0.372
LIG_SH2_PTP2 311 314 PF00017 0.356
LIG_SH2_SRC 168 171 PF00017 0.391
LIG_SH2_SRC 278 281 PF00017 0.388
LIG_SH2_SRC 327 330 PF00017 0.316
LIG_SH2_STAP1 116 120 PF00017 0.372
LIG_SH2_STAP1 327 331 PF00017 0.356
LIG_SH2_STAT3 343 346 PF00017 0.356
LIG_SH2_STAT5 100 103 PF00017 0.326
LIG_SH2_STAT5 168 171 PF00017 0.325
LIG_SH2_STAT5 224 227 PF00017 0.374
LIG_SH2_STAT5 234 237 PF00017 0.312
LIG_SH2_STAT5 241 244 PF00017 0.235
LIG_SH2_STAT5 26 29 PF00017 0.321
LIG_SH2_STAT5 278 281 PF00017 0.404
LIG_SH2_STAT5 311 314 PF00017 0.318
LIG_SH2_STAT5 338 341 PF00017 0.312
LIG_SH2_STAT5 343 346 PF00017 0.303
LIG_SH2_STAT5 53 56 PF00017 0.326
LIG_SH2_STAT5 78 81 PF00017 0.301
LIG_SUMO_SIM_anti_2 291 296 PF11976 0.488
LIG_SUMO_SIM_par_1 353 358 PF11976 0.569
LIG_TRAF2_1 245 248 PF00917 0.427
LIG_TYR_ITIM 336 341 PF00017 0.321
LIG_WRC_WIRS_1 305 310 PF05994 0.372
MOD_CDK_SPxxK_3 186 193 PF00069 0.456
MOD_CK1_1 139 145 PF00069 0.544
MOD_CK1_1 204 210 PF00069 0.502
MOD_CK2_1 130 136 PF00069 0.481
MOD_CK2_1 323 329 PF00069 0.270
MOD_CK2_1 99 105 PF00069 0.302
MOD_CMANNOS 347 350 PF00535 0.360
MOD_GlcNHglycan 138 141 PF01048 0.737
MOD_GlcNHglycan 208 211 PF01048 0.676
MOD_GlcNHglycan 262 265 PF01048 0.592
MOD_GlcNHglycan 368 371 PF01048 0.448
MOD_GSK3_1 135 142 PF00069 0.528
MOD_GSK3_1 196 203 PF00069 0.475
MOD_GSK3_1 225 232 PF00069 0.354
MOD_GSK3_1 233 240 PF00069 0.347
MOD_N-GLC_1 176 181 PF02516 0.553
MOD_N-GLC_1 196 201 PF02516 0.728
MOD_N-GLC_1 269 274 PF02516 0.504
MOD_NEK2_1 119 124 PF00069 0.301
MOD_NEK2_1 157 162 PF00069 0.414
MOD_NEK2_1 222 227 PF00069 0.418
MOD_NEK2_1 361 366 PF00069 0.547
MOD_NEK2_1 90 95 PF00069 0.372
MOD_PIKK_1 148 154 PF00454 0.517
MOD_PK_1 269 275 PF00069 0.352
MOD_PK_1 290 296 PF00069 0.484
MOD_PKA_2 260 266 PF00069 0.426
MOD_PKA_2 366 372 PF00069 0.665
MOD_PKA_2 68 74 PF00069 0.287
MOD_Plk_1 157 163 PF00069 0.389
MOD_Plk_1 269 275 PF00069 0.304
MOD_Plk_1 290 296 PF00069 0.400
MOD_Plk_1 58 64 PF00069 0.372
MOD_Plk_2-3 130 136 PF00069 0.521
MOD_Plk_4 157 163 PF00069 0.395
MOD_Plk_4 19 25 PF00069 0.379
MOD_Plk_4 2 8 PF00069 0.536
MOD_Plk_4 225 231 PF00069 0.380
MOD_Plk_4 233 239 PF00069 0.381
MOD_Plk_4 269 275 PF00069 0.340
MOD_Plk_4 290 296 PF00069 0.417
MOD_Plk_4 69 75 PF00069 0.353
MOD_ProDKin_1 186 192 PF00069 0.477
MOD_ProDKin_1 229 235 PF00069 0.361
MOD_ProDKin_1 241 247 PF00069 0.301
MOD_SUMO_rev_2 105 114 PF00179 0.356
TRG_DiLeu_BaLyEn_6 179 184 PF01217 0.340
TRG_ENDOCYTIC_2 116 119 PF00928 0.382
TRG_ENDOCYTIC_2 311 314 PF00928 0.351
TRG_ENDOCYTIC_2 327 330 PF00928 0.270
TRG_ENDOCYTIC_2 338 341 PF00928 0.311
TRG_ER_diArg_1 186 188 PF00400 0.436
TRG_ER_diArg_1 288 290 PF00400 0.457
TRG_ER_diArg_1 365 368 PF00400 0.629
TRG_ER_diArg_1 371 373 PF00400 0.655
TRG_Pf-PMV_PEXEL_1 296 300 PF00026 0.594
TRG_Pf-PMV_PEXEL_1 315 320 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFJ2 Leptomonas seymouri 63% 97%
A0A0S4J387 Bodo saltans 31% 100%
A0A1X0NXU0 Trypanosomatidae 42% 100%
A0A3S7WW02 Leishmania donovani 100% 100%
A0A422NCH0 Trypanosoma rangeli 46% 100%
C9ZI65 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AUJ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QCZ4 Leishmania major 95% 100%
V5DS46 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS