Tubulin delta chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tubulin delta chain

Gene product:

zeta tubulin - putative

Species:

Leishmania infantum

UniProt:

A4HYR4_LEIIN

TriTrypDb:

LINF_200010100

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0005814	centriole	5	8
GO:0005874	microtubule	6	8
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0099080	supramolecular complex	2	8
GO:0099081	supramolecular polymer	3	8
GO:0099512	supramolecular fiber	4	8
GO:0099513	polymeric cytoskeletal fiber	5	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HYR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYR4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0030030	cell projection organization	4	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000278	mitotic cell cycle	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007049	cell cycle	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005198	structural molecule activity	1	8
GO:0005200	structural constituent of cytoskeleton	2	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0017076	purine nucleotide binding	4	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.597
CLV_C14_Caspase3-7	539	543	PF00656	0.488
CLV_NRD_NRD_1	134	136	PF00675	0.392
CLV_NRD_NRD_1	146	148	PF00675	0.338
CLV_NRD_NRD_1	219	221	PF00675	0.340
CLV_NRD_NRD_1	397	399	PF00675	0.760
CLV_NRD_NRD_1	432	434	PF00675	0.781
CLV_NRD_NRD_1	458	460	PF00675	0.723
CLV_NRD_NRD_1	530	532	PF00675	0.497
CLV_NRD_NRD_1	555	557	PF00675	0.454
CLV_NRD_NRD_1	589	591	PF00675	0.471
CLV_PCSK_KEX2_1	107	109	PF00082	0.603
CLV_PCSK_KEX2_1	146	148	PF00082	0.350
CLV_PCSK_KEX2_1	219	221	PF00082	0.340
CLV_PCSK_KEX2_1	397	399	PF00082	0.760
CLV_PCSK_KEX2_1	432	434	PF00082	0.781
CLV_PCSK_KEX2_1	457	459	PF00082	0.724
CLV_PCSK_KEX2_1	530	532	PF00082	0.544
CLV_PCSK_KEX2_1	555	557	PF00082	0.508
CLV_PCSK_KEX2_1	589	591	PF00082	0.466
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.647
CLV_PCSK_SKI1_1	135	139	PF00082	0.287
CLV_PCSK_SKI1_1	286	290	PF00082	0.589
CLV_PCSK_SKI1_1	334	338	PF00082	0.469
CLV_PCSK_SKI1_1	355	359	PF00082	0.456
CLV_PCSK_SKI1_1	383	387	PF00082	0.525
CLV_PCSK_SKI1_1	555	559	PF00082	0.434
CLV_PCSK_SKI1_1	56	60	PF00082	0.317
CLV_PCSK_SKI1_1	65	69	PF00082	0.317
DEG_APCC_DBOX_1	134	142	PF00400	0.356
DEG_APCC_DBOX_1	460	468	PF00400	0.618
DEG_APCC_DBOX_1	499	507	PF00400	0.568
DEG_APCC_DBOX_1	508	516	PF00400	0.441
DEG_APCC_DBOX_1	554	562	PF00400	0.475
DEG_COP1_1	462	470	PF00400	0.619
DOC_MAPK_gen_1	219	229	PF00069	0.518
DOC_MAPK_gen_1	457	467	PF00069	0.611
DOC_MAPK_gen_1	555	561	PF00069	0.484
DOC_MAPK_HePTP_8	175	187	PF00069	0.555
DOC_MAPK_HePTP_8	288	300	PF00069	0.407
DOC_MAPK_MEF2A_6	178	187	PF00069	0.555
DOC_MAPK_MEF2A_6	220	229	PF00069	0.517
DOC_MAPK_MEF2A_6	291	300	PF00069	0.391
DOC_PP1_RVXF_1	182	188	PF00149	0.555
DOC_PP1_RVXF_1	284	291	PF00149	0.591
DOC_PP2B_LxvP_1	300	303	PF13499	0.394
DOC_PP2B_LxvP_1	339	342	PF13499	0.481
DOC_PP2B_LxvP_1	465	468	PF13499	0.779
DOC_PP4_FxxP_1	187	190	PF00568	0.517
DOC_USP7_MATH_1	272	276	PF00917	0.773
DOC_USP7_MATH_1	277	281	PF00917	0.596
DOC_USP7_MATH_1	342	346	PF00917	0.536
DOC_USP7_MATH_1	450	454	PF00917	0.751
DOC_USP7_MATH_1	573	577	PF00917	0.439
DOC_WW_Pin1_4	35	40	PF00397	0.501
DOC_WW_Pin1_4	43	48	PF00397	0.609
DOC_WW_Pin1_4	466	471	PF00397	0.753
DOC_WW_Pin1_4	516	521	PF00397	0.527
LIG_14-3-3_CanoR_1	178	186	PF00244	0.539
LIG_14-3-3_CanoR_1	286	291	PF00244	0.588
LIG_14-3-3_CanoR_1	344	350	PF00244	0.578
LIG_14-3-3_CanoR_1	458	468	PF00244	0.767
LIG_Actin_WH2_2	550	565	PF00022	0.421
LIG_BIR_II_1	1	5	PF00653	0.375
LIG_BIR_III_4	407	411	PF00653	0.595
LIG_BRCT_BRCA1_1	154	158	PF00533	0.555
LIG_BRCT_BRCA1_1	45	49	PF00533	0.523
LIG_FHA_1	178	184	PF00498	0.525
LIG_FHA_1	237	243	PF00498	0.525
LIG_FHA_1	245	251	PF00498	0.517
LIG_FHA_1	283	289	PF00498	0.522
LIG_FHA_1	313	319	PF00498	0.430
LIG_FHA_1	424	430	PF00498	0.742
LIG_FHA_2	287	293	PF00498	0.443
LIG_GBD_Chelix_1	175	183	PF00786	0.355
LIG_LIR_Gen_1	155	164	PF02991	0.520
LIG_LIR_Gen_1	17	25	PF02991	0.555
LIG_LIR_Gen_1	345	353	PF02991	0.508
LIG_LIR_Gen_1	535	546	PF02991	0.429
LIG_LIR_Gen_1	576	583	PF02991	0.440
LIG_LIR_Nem_3	155	161	PF02991	0.520
LIG_LIR_Nem_3	17	23	PF02991	0.517
LIG_LIR_Nem_3	46	51	PF02991	0.510
LIG_LIR_Nem_3	535	541	PF02991	0.496
LIG_LIR_Nem_3	576	581	PF02991	0.444
LIG_LYPXL_SIV_4	591	599	PF13949	0.507
LIG_MAD2	334	342	PF02301	0.492
LIG_MLH1_MIPbox_1	45	49	PF16413	0.517
LIG_NRBOX	296	302	PF00104	0.446
LIG_PCNA_yPIPBox_3	291	301	PF02747	0.456
LIG_PDZ_Class_3	600	605	PF00595	0.445
LIG_Pex14_1	94	98	PF04695	0.517
LIG_REV1ctd_RIR_1	356	366	PF16727	0.531
LIG_SH2_NCK_1	578	582	PF00017	0.495
LIG_SH2_SRC	578	581	PF00017	0.491
LIG_SH2_STAP1	200	204	PF00017	0.555
LIG_SH2_STAT3	307	310	PF00017	0.460
LIG_SH2_STAT5	186	189	PF00017	0.517
LIG_SH2_STAT5	371	374	PF00017	0.638
LIG_SH2_STAT5	511	514	PF00017	0.527
LIG_SH2_STAT5	523	526	PF00017	0.359
LIG_SH3_3	266	272	PF00018	0.625
LIG_SH3_3	370	376	PF00018	0.525
LIG_SH3_3	39	45	PF00018	0.599
LIG_SH3_3	464	470	PF00018	0.753
LIG_SH3_3	554	560	PF00018	0.411
LIG_SUMO_SIM_anti_2	159	166	PF11976	0.517
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.518
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.394
LIG_SUMO_SIM_par_1	159	166	PF11976	0.517
LIG_SUMO_SIM_par_1	462	469	PF11976	0.620
LIG_TRAF2_1	601	604	PF00917	0.497
LIG_TRAF2_2	192	197	PF00917	0.555
LIG_TYR_ITIM	524	529	PF00017	0.542
LIG_TYR_ITIM	96	101	PF00017	0.375
LIG_UBA3_1	318	327	PF00899	0.500
LIG_UBA3_1	357	362	PF00899	0.545
LIG_WW_1	323	326	PF00397	0.517
MOD_CDC14_SPxK_1	38	41	PF00782	0.302
MOD_CDK_SPxK_1	35	41	PF00069	0.302
MOD_CK1_1	106	112	PF00069	0.637
MOD_CK1_1	177	183	PF00069	0.372
MOD_CK1_1	273	279	PF00069	0.686
MOD_CK1_1	282	288	PF00069	0.539
MOD_CK1_1	29	35	PF00069	0.391
MOD_CK1_1	345	351	PF00069	0.531
MOD_CK1_1	453	459	PF00069	0.645
MOD_CK1_1	466	472	PF00069	0.770
MOD_CK2_1	146	152	PF00069	0.419
MOD_CK2_1	286	292	PF00069	0.459
MOD_CK2_1	573	579	PF00069	0.490
MOD_GlcNHglycan	152	157	PF01048	0.363
MOD_GlcNHglycan	172	175	PF01048	0.266
MOD_GlcNHglycan	271	275	PF01048	0.773
MOD_GlcNHglycan	279	282	PF01048	0.584
MOD_GlcNHglycan	29	32	PF01048	0.389
MOD_GlcNHglycan	443	446	PF01048	0.713
MOD_GlcNHglycan	474	477	PF01048	0.678
MOD_GlcNHglycan	489	495	PF01048	0.541
MOD_GlcNHglycan	563	566	PF01048	0.385
MOD_GlcNHglycan	575	578	PF01048	0.409
MOD_GlcNHglycan	87	90	PF01048	0.382
MOD_GSK3_1	142	149	PF00069	0.363
MOD_GSK3_1	170	177	PF00069	0.375
MOD_GSK3_1	25	32	PF00069	0.365
MOD_GSK3_1	272	279	PF00069	0.657
MOD_GSK3_1	282	289	PF00069	0.536
MOD_GSK3_1	322	329	PF00069	0.575
MOD_GSK3_1	397	404	PF00069	0.725
MOD_GSK3_1	446	453	PF00069	0.722
MOD_GSK3_1	459	466	PF00069	0.741
MOD_GSK3_1	490	497	PF00069	0.743
MOD_LATS_1	395	401	PF00433	0.734
MOD_N-GLC_1	225	230	PF02516	0.501
MOD_NEK2_1	25	30	PF00069	0.499
MOD_NEK2_1	381	386	PF00069	0.477
MOD_NEK2_1	561	566	PF00069	0.405
MOD_NEK2_1	567	572	PF00069	0.432
MOD_PIKK_1	18	24	PF00454	0.429
MOD_PIKK_1	214	220	PF00454	0.514
MOD_PIKK_1	236	242	PF00454	0.345
MOD_PKA_1	146	152	PF00069	0.363
MOD_PKA_1	397	403	PF00069	0.785
MOD_PKA_2	142	148	PF00069	0.416
MOD_PKA_2	177	183	PF00069	0.321
MOD_PKA_2	397	403	PF00069	0.765
MOD_PKA_2	460	466	PF00069	0.724
MOD_PKB_1	457	465	PF00069	0.717
MOD_Plk_1	225	231	PF00069	0.493
MOD_Plk_4	157	163	PF00069	0.449
MOD_Plk_4	279	285	PF00069	0.575
MOD_Plk_4	334	340	PF00069	0.427
MOD_Plk_4	460	466	PF00069	0.724
MOD_ProDKin_1	35	41	PF00069	0.353
MOD_ProDKin_1	43	49	PF00069	0.504
MOD_ProDKin_1	466	472	PF00069	0.752
MOD_ProDKin_1	516	522	PF00069	0.522
MOD_SUMO_for_1	101	104	PF00179	0.499
MOD_SUMO_for_1	583	586	PF00179	0.530
MOD_SUMO_rev_2	197	205	PF00179	0.455
MOD_SUMO_rev_2	46	55	PF00179	0.477
MOD_SUMO_rev_2	61	67	PF00179	0.248
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.404
TRG_ENDOCYTIC_2	207	210	PF00928	0.455
TRG_ENDOCYTIC_2	346	349	PF00928	0.512
TRG_ENDOCYTIC_2	526	529	PF00928	0.506
TRG_ENDOCYTIC_2	578	581	PF00928	0.491
TRG_ENDOCYTIC_2	592	595	PF00928	0.473
TRG_ENDOCYTIC_2	98	101	PF00928	0.375
TRG_ER_diArg_1	182	185	PF00400	0.380
TRG_ER_diArg_1	219	222	PF00400	0.410
TRG_ER_diArg_1	396	398	PF00400	0.741
TRG_ER_diArg_1	432	434	PF00400	0.680
TRG_ER_diArg_1	457	459	PF00400	0.725
TRG_ER_diArg_1	529	531	PF00400	0.552
TRG_ER_diArg_1	555	557	PF00400	0.508
TRG_ER_diArg_1	588	590	PF00400	0.473
TRG_ER_KDEL_1	602	605	PF00810	0.503
TRG_NES_CRM1_1	501	513	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1C0	Leptomonas seymouri	59%	89%
A0A1X0NWW5	Trypanosomatidae	45%	100%
A0A3S5H784	Leishmania donovani	100%	100%
E9AIA4	Leishmania braziliensis	85%	100%
E9AUJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCZ3	Leishmania major	93%	100%