Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast ribosomal PPR-repeat containing protein 3 - putative

Species:

Leishmania infantum

UniProt:

A4HYR3_LEIIN

TriTrypDb:

LINF_200010200

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HYR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYR3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.494
CLV_NRD_NRD_1	169	171	PF00675	0.500
CLV_NRD_NRD_1	345	347	PF00675	0.425
CLV_NRD_NRD_1	357	359	PF00675	0.372
CLV_NRD_NRD_1	67	69	PF00675	0.460
CLV_PCSK_KEX2_1	124	126	PF00082	0.526
CLV_PCSK_KEX2_1	169	171	PF00082	0.390
CLV_PCSK_KEX2_1	176	178	PF00082	0.405
CLV_PCSK_KEX2_1	345	347	PF00082	0.423
CLV_PCSK_KEX2_1	356	358	PF00082	0.395
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.431
CLV_PCSK_SKI1_1	131	135	PF00082	0.521
CLV_PCSK_SKI1_1	210	214	PF00082	0.360
CLV_PCSK_SKI1_1	217	221	PF00082	0.408
CLV_PCSK_SKI1_1	345	349	PF00082	0.434
CLV_PCSK_SKI1_1	371	375	PF00082	0.397
CLV_PCSK_SKI1_1	405	409	PF00082	0.576
DEG_SPOP_SBC_1	199	203	PF00917	0.480
DOC_CKS1_1	156	161	PF01111	0.561
DOC_CKS1_1	291	296	PF01111	0.495
DOC_CYCLIN_RxL_1	206	216	PF00134	0.389
DOC_CYCLIN_RxL_1	368	376	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	254	260	PF00134	0.509
DOC_MAPK_DCC_7	177	187	PF00069	0.496
DOC_MAPK_HePTP_8	390	402	PF00069	0.438
DOC_MAPK_MEF2A_6	393	402	PF00069	0.436
DOC_PP2B_LxvP_1	143	146	PF13499	0.704
DOC_PP2B_LxvP_1	254	257	PF13499	0.525
DOC_PP4_FxxP_1	179	182	PF00568	0.509
DOC_USP7_MATH_1	144	148	PF00917	0.650
DOC_WW_Pin1_4	155	160	PF00397	0.612
DOC_WW_Pin1_4	178	183	PF00397	0.378
DOC_WW_Pin1_4	290	295	PF00397	0.491
DOC_WW_Pin1_4	76	81	PF00397	0.424
LIG_14-3-3_CanoR_1	169	179	PF00244	0.408
LIG_14-3-3_CanoR_1	224	233	PF00244	0.331
LIG_14-3-3_CanoR_1	246	254	PF00244	0.468
LIG_14-3-3_CanoR_1	320	325	PF00244	0.431
LIG_14-3-3_CanoR_1	345	354	PF00244	0.419
LIG_14-3-3_CanoR_1	377	382	PF00244	0.425
LIG_FAT_LD_1	187	195	PF03623	0.334
LIG_FHA_1	128	134	PF00498	0.640
LIG_FHA_1	16	22	PF00498	0.611
LIG_FHA_1	191	197	PF00498	0.390
LIG_FHA_1	246	252	PF00498	0.457
LIG_FHA_1	262	268	PF00498	0.211
LIG_FHA_1	291	297	PF00498	0.452
LIG_FHA_1	300	306	PF00498	0.399
LIG_FHA_1	328	334	PF00498	0.344
LIG_FHA_1	346	352	PF00498	0.371
LIG_FHA_1	363	369	PF00498	0.390
LIG_FHA_2	156	162	PF00498	0.602
LIG_LIR_Gen_1	216	222	PF02991	0.395
LIG_LIR_Gen_1	314	324	PF02991	0.436
LIG_LIR_Gen_1	329	337	PF02991	0.281
LIG_LIR_Nem_3	216	221	PF02991	0.397
LIG_LIR_Nem_3	225	230	PF02991	0.373
LIG_LIR_Nem_3	329	334	PF02991	0.365
LIG_LIR_Nem_3	341	347	PF02991	0.373
LIG_NRBOX	262	268	PF00104	0.420
LIG_NRBOX	299	305	PF00104	0.383
LIG_NRBOX	365	371	PF00104	0.344
LIG_NRBOX	72	78	PF00104	0.468
LIG_PCNA_yPIPBox_3	360	374	PF02747	0.367
LIG_Pex3_1	370	381	PF04882	0.472
LIG_PTB_Apo_2	93	100	PF02174	0.435
LIG_PTB_Phospho_1	93	99	PF10480	0.428
LIG_SH2_CRK	331	335	PF00017	0.357
LIG_SH2_NCK_1	117	121	PF00017	0.435
LIG_SH2_SRC	29	32	PF00017	0.403
LIG_SH2_STAP1	227	231	PF00017	0.318
LIG_SH2_STAP1	247	251	PF00017	0.211
LIG_SH2_STAP1	331	335	PF00017	0.332
LIG_SH2_STAP1	99	103	PF00017	0.469
LIG_SH2_STAT3	172	175	PF00017	0.427
LIG_SH2_STAT5	172	175	PF00017	0.374
LIG_SH2_STAT5	227	230	PF00017	0.371
LIG_SH2_STAT5	247	250	PF00017	0.207
LIG_SH2_STAT5	275	278	PF00017	0.420
LIG_SH2_STAT5	29	32	PF00017	0.403
LIG_SH2_STAT5	331	334	PF00017	0.394
LIG_SH3_1	392	398	PF00018	0.524
LIG_SH3_3	150	156	PF00018	0.665
LIG_SH3_3	216	222	PF00018	0.378
LIG_SH3_3	255	261	PF00018	0.508
LIG_SH3_3	288	294	PF00018	0.531
LIG_SH3_3	392	398	PF00018	0.524
LIG_SH3_3	50	56	PF00018	0.523
LIG_SUMO_SIM_anti_2	111	118	PF11976	0.436
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.476
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.291
LIG_SUMO_SIM_anti_2	332	337	PF11976	0.357
LIG_SUMO_SIM_par_1	183	188	PF11976	0.347
LIG_SUMO_SIM_par_1	192	198	PF11976	0.365
LIG_SUMO_SIM_par_1	301	307	PF11976	0.357
LIG_TRFH_1	218	222	PF08558	0.469
LIG_TYR_ITSM	226	233	PF00017	0.474
LIG_UBA3_1	262	268	PF00899	0.420
LIG_UBA3_1	333	340	PF00899	0.465
LIG_WRC_WIRS_1	378	383	PF05994	0.476
MOD_CK1_1	118	124	PF00069	0.457
MOD_CK1_1	195	201	PF00069	0.446
MOD_CK1_1	281	287	PF00069	0.487
MOD_CK1_1	299	305	PF00069	0.347
MOD_CK2_1	29	35	PF00069	0.407
MOD_GlcNHglycan	146	149	PF01048	0.673
MOD_GlcNHglycan	272	275	PF01048	0.390
MOD_GSK3_1	127	134	PF00069	0.485
MOD_GSK3_1	195	202	PF00069	0.413
MOD_GSK3_1	225	232	PF00069	0.492
MOD_GSK3_1	25	32	PF00069	0.516
MOD_GSK3_1	299	306	PF00069	0.459
MOD_N-GLC_1	270	275	PF02516	0.420
MOD_N-GLC_1	296	301	PF02516	0.352
MOD_NEK2_1	115	120	PF00069	0.403
MOD_NEK2_1	190	195	PF00069	0.366
MOD_NEK2_1	25	30	PF00069	0.553
MOD_NEK2_1	270	275	PF00069	0.420
MOD_NEK2_1	319	324	PF00069	0.449
MOD_NEK2_1	385	390	PF00069	0.354
MOD_NEK2_2	311	316	PF00069	0.360
MOD_PIKK_1	338	344	PF00454	0.457
MOD_PK_1	320	326	PF00069	0.449
MOD_PKA_1	345	351	PF00069	0.488
MOD_PKA_2	223	229	PF00069	0.336
MOD_PKA_2	245	251	PF00069	0.455
MOD_PKA_2	319	325	PF00069	0.522
MOD_PKA_2	345	351	PF00069	0.421
MOD_Plk_1	296	302	PF00069	0.350
MOD_Plk_1	362	368	PF00069	0.568
MOD_Plk_4	109	115	PF00069	0.524
MOD_Plk_4	118	124	PF00069	0.448
MOD_Plk_4	192	198	PF00069	0.455
MOD_Plk_4	25	31	PF00069	0.547
MOD_Plk_4	278	284	PF00069	0.331
MOD_Plk_4	299	305	PF00069	0.467
MOD_Plk_4	329	335	PF00069	0.360
MOD_Plk_4	385	391	PF00069	0.379
MOD_ProDKin_1	155	161	PF00069	0.608
MOD_ProDKin_1	178	184	PF00069	0.379
MOD_ProDKin_1	290	296	PF00069	0.484
MOD_ProDKin_1	76	82	PF00069	0.427
TRG_DiLeu_BaEn_1	111	116	PF01217	0.472
TRG_DiLeu_BaEn_1	278	283	PF01217	0.292
TRG_DiLeu_BaEn_1	329	334	PF01217	0.363
TRG_DiLeu_BaEn_2	88	94	PF01217	0.436
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.336
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.495
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.544
TRG_ENDOCYTIC_2	230	233	PF00928	0.428
TRG_ENDOCYTIC_2	316	319	PF00928	0.436
TRG_ENDOCYTIC_2	331	334	PF00928	0.257
TRG_ENDOCYTIC_2	386	389	PF00928	0.362
TRG_ER_diArg_1	123	125	PF00400	0.476
TRG_ER_diArg_1	168	170	PF00400	0.505
TRG_ER_diArg_1	344	346	PF00400	0.429
TRG_ER_diArg_1	356	358	PF00400	0.391
TRG_ER_diArg_1	40	43	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z9	Leptomonas seymouri	76%	74%
A0A1X0NWF6	Trypanosomatidae	54%	76%
A0A3Q8IBN5	Leishmania donovani	100%	74%
A0A3R7K7U1	Trypanosoma rangeli	54%	79%
C9ZI67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	77%
E9AIA5	Leishmania braziliensis	91%	100%
E9AUJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCZ2	Leishmania major	97%	100%
V5BQU6	Trypanosoma cruzi	56%	81%