CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYR1_LEIIN

TriTrypDb:

LINF_200010400

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYR1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	1
GO:0003824	catalytic activity	1	3
GO:0016462	pyrophosphatase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0070566	adenylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.512
CLV_NRD_NRD_1	30	32	PF00675	0.524
CLV_NRD_NRD_1	385	387	PF00675	0.460
CLV_NRD_NRD_1	422	424	PF00675	0.426
CLV_NRD_NRD_1	429	431	PF00675	0.443
CLV_NRD_NRD_1	502	504	PF00675	0.472
CLV_PCSK_FUR_1	128	132	PF00082	0.605
CLV_PCSK_FUR_1	383	387	PF00082	0.447
CLV_PCSK_KEX2_1	130	132	PF00082	0.514
CLV_PCSK_KEX2_1	30	32	PF00082	0.566
CLV_PCSK_KEX2_1	385	387	PF00082	0.460
CLV_PCSK_KEX2_1	422	424	PF00082	0.437
CLV_PCSK_KEX2_1	429	431	PF00082	0.428
CLV_PCSK_SKI1_1	222	226	PF00082	0.612
CLV_PCSK_SKI1_1	282	286	PF00082	0.504
CLV_PCSK_SKI1_1	30	34	PF00082	0.551
CLV_PCSK_SKI1_1	40	44	PF00082	0.443
DEG_APCC_DBOX_1	281	289	PF00400	0.594
DOC_CKS1_1	395	400	PF01111	0.445
DOC_CYCLIN_RxL_1	34	44	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.434
DOC_MAPK_DCC_7	244	254	PF00069	0.656
DOC_MAPK_gen_1	128	138	PF00069	0.510
DOC_MAPK_gen_1	429	436	PF00069	0.475
DOC_MAPK_MEF2A_6	131	140	PF00069	0.507
DOC_PP1_RVXF_1	81	88	PF00149	0.592
DOC_PP2B_LxvP_1	199	202	PF13499	0.409
DOC_PP2B_LxvP_1	517	520	PF13499	0.450
DOC_USP7_MATH_1	148	152	PF00917	0.636
DOC_USP7_MATH_1	265	269	PF00917	0.581
DOC_USP7_MATH_1	291	295	PF00917	0.686
DOC_USP7_MATH_1	298	302	PF00917	0.626
DOC_USP7_MATH_1	349	353	PF00917	0.741
DOC_USP7_MATH_1	36	40	PF00917	0.504
DOC_USP7_UBL2_3	408	412	PF12436	0.560
DOC_WW_Pin1_4	10	15	PF00397	0.411
DOC_WW_Pin1_4	155	160	PF00397	0.694
DOC_WW_Pin1_4	245	250	PF00397	0.744
DOC_WW_Pin1_4	318	323	PF00397	0.526
DOC_WW_Pin1_4	394	399	PF00397	0.564
LIG_14-3-3_CanoR_1	16	20	PF00244	0.448
LIG_14-3-3_CanoR_1	244	249	PF00244	0.722
LIG_14-3-3_CanoR_1	260	265	PF00244	0.393
LIG_14-3-3_CanoR_1	433	443	PF00244	0.486
LIG_14-3-3_CanoR_1	503	508	PF00244	0.571
LIG_14-3-3_CanoR_1	51	58	PF00244	0.606
LIG_Actin_WH2_2	301	318	PF00022	0.508
LIG_Actin_WH2_2	413	431	PF00022	0.509
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_CaM_IQ_9	372	388	PF13499	0.533
LIG_Clathr_ClatBox_1	455	459	PF01394	0.474
LIG_CtBP_PxDLS_1	249	253	PF00389	0.644
LIG_eIF4E_1	369	375	PF01652	0.572
LIG_FHA_1	109	115	PF00498	0.534
LIG_FHA_1	119	125	PF00498	0.393
LIG_FHA_1	194	200	PF00498	0.390
LIG_FHA_1	370	376	PF00498	0.571
LIG_FHA_1	377	383	PF00498	0.471
LIG_FHA_1	395	401	PF00498	0.334
LIG_FHA_1	438	444	PF00498	0.475
LIG_FHA_1	486	492	PF00498	0.556
LIG_FHA_2	39	45	PF00498	0.481
LIG_FHA_2	470	476	PF00498	0.563
LIG_LIR_Gen_1	223	233	PF02991	0.544
LIG_LIR_LC3C_4	186	189	PF02991	0.427
LIG_LIR_Nem_3	223	228	PF02991	0.518
LIG_LIR_Nem_3	363	367	PF02991	0.439
LIG_SH2_NCK_1	323	327	PF00017	0.418
LIG_SH2_SRC	403	406	PF00017	0.382
LIG_SH2_STAP1	343	347	PF00017	0.698
LIG_SH2_STAP1	403	407	PF00017	0.412
LIG_SH2_STAT5	497	500	PF00017	0.407
LIG_SH3_3	142	148	PF00018	0.517
LIG_SH3_3	461	467	PF00018	0.502
LIG_Sin3_3	225	232	PF02671	0.573
LIG_SUMO_SIM_anti_2	182	189	PF11976	0.502
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.566
LIG_SUMO_SIM_anti_2	251	258	PF11976	0.644
LIG_SUMO_SIM_par_1	397	402	PF11976	0.473
MOD_CDC14_SPxK_1	13	16	PF00782	0.424
MOD_CDK_SPxK_1	10	16	PF00069	0.415
MOD_CK1_1	129	135	PF00069	0.656
MOD_CK1_1	152	158	PF00069	0.754
MOD_CK1_1	209	215	PF00069	0.717
MOD_CK1_1	248	254	PF00069	0.693
MOD_CK1_1	263	269	PF00069	0.516
MOD_CK1_1	318	324	PF00069	0.422
MOD_CK2_1	129	135	PF00069	0.656
MOD_CK2_1	143	149	PF00069	0.496
MOD_CK2_1	174	180	PF00069	0.636
MOD_CK2_1	228	234	PF00069	0.649
MOD_CK2_1	265	271	PF00069	0.600
MOD_CK2_1	38	44	PF00069	0.503
MOD_CK2_1	468	474	PF00069	0.655
MOD_CK2_1	537	543	PF00069	0.509
MOD_Cter_Amidation	501	504	PF01082	0.457
MOD_GlcNHglycan	121	124	PF01048	0.451
MOD_GlcNHglycan	154	157	PF01048	0.703
MOD_GlcNHglycan	230	233	PF01048	0.634
MOD_GlcNHglycan	236	239	PF01048	0.761
MOD_GlcNHglycan	257	260	PF01048	0.602
MOD_GlcNHglycan	267	270	PF01048	0.598
MOD_GlcNHglycan	293	296	PF01048	0.602
MOD_GlcNHglycan	317	320	PF01048	0.608
MOD_GlcNHglycan	323	326	PF01048	0.495
MOD_GlcNHglycan	344	348	PF01048	0.714
MOD_GlcNHglycan	66	69	PF01048	0.524
MOD_GSK3_1	119	126	PF00069	0.506
MOD_GSK3_1	148	155	PF00069	0.683
MOD_GSK3_1	216	223	PF00069	0.583
MOD_GSK3_1	244	251	PF00069	0.725
MOD_GSK3_1	390	397	PF00069	0.650
MOD_GSK3_1	50	57	PF00069	0.433
MOD_N-GLC_1	234	239	PF02516	0.581
MOD_N-GLC_2	549	551	PF02516	0.550
MOD_NEK2_1	315	320	PF00069	0.577
MOD_NEK2_1	79	84	PF00069	0.481
MOD_NEK2_2	298	303	PF00069	0.595
MOD_PIKK_1	51	57	PF00454	0.539
MOD_PK_1	260	266	PF00069	0.528
MOD_PKA_1	30	36	PF00069	0.586
MOD_PKA_1	503	509	PF00069	0.649
MOD_PKA_2	129	135	PF00069	0.546
MOD_PKA_2	15	21	PF00069	0.447
MOD_PKA_2	209	215	PF00069	0.669
MOD_PKA_2	243	249	PF00069	0.714
MOD_PKA_2	30	36	PF00069	0.514
MOD_PKA_2	315	321	PF00069	0.550
MOD_PKA_2	50	56	PF00069	0.289
MOD_Plk_1	390	396	PF00069	0.680
MOD_Plk_1	512	518	PF00069	0.491
MOD_Plk_4	250	256	PF00069	0.691
MOD_Plk_4	437	443	PF00069	0.476
MOD_ProDKin_1	10	16	PF00069	0.411
MOD_ProDKin_1	155	161	PF00069	0.678
MOD_ProDKin_1	245	251	PF00069	0.746
MOD_ProDKin_1	318	324	PF00069	0.519
MOD_ProDKin_1	394	400	PF00069	0.554
TRG_DiLeu_BaEn_1	183	188	PF01217	0.484
TRG_DiLeu_BaEn_1	416	421	PF01217	0.482
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.501
TRG_ENDOCYTIC_2	167	170	PF00928	0.552
TRG_ENDOCYTIC_2	497	500	PF00928	0.409
TRG_ER_diArg_1	128	131	PF00400	0.534
TRG_ER_diArg_1	29	31	PF00400	0.570
TRG_ER_diArg_1	382	385	PF00400	0.552
TRG_ER_diArg_1	421	423	PF00400	0.447
TRG_ER_diArg_1	428	430	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H4	Leptomonas seymouri	54%	100%
A0A0S4ILY4	Bodo saltans	34%	100%
A0A3S7WVU1	Leishmania donovani	99%	100%
E9AIA7	Leishmania braziliensis	79%	100%
E9AUJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCZ0	Leishmania major	92%	100%