WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat - putative

Species:

Leishmania infantum

UniProt:

A4HYQ9_LEIIN

TriTrypDb:

LINF_200010600

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.662
CLV_C14_Caspase3-7	671	675	PF00656	0.450
CLV_C14_Caspase3-7	732	736	PF00656	0.623
CLV_NRD_NRD_1	19	21	PF00675	0.580
CLV_NRD_NRD_1	399	401	PF00675	0.554
CLV_NRD_NRD_1	440	442	PF00675	0.592
CLV_NRD_NRD_1	584	586	PF00675	0.806
CLV_NRD_NRD_1	70	72	PF00675	0.657
CLV_NRD_NRD_1	801	803	PF00675	0.734
CLV_PCSK_KEX2_1	19	21	PF00082	0.640
CLV_PCSK_KEX2_1	398	400	PF00082	0.557
CLV_PCSK_KEX2_1	440	442	PF00082	0.601
CLV_PCSK_KEX2_1	584	586	PF00082	0.806
CLV_PCSK_KEX2_1	647	649	PF00082	0.571
CLV_PCSK_KEX2_1	672	674	PF00082	0.450
CLV_PCSK_KEX2_1	801	803	PF00082	0.736
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.571
CLV_PCSK_PC1ET2_1	672	674	PF00082	0.450
CLV_PCSK_SKI1_1	399	403	PF00082	0.595
CLV_PCSK_SKI1_1	767	771	PF00082	0.612
CLV_PCSK_SKI1_1	903	907	PF00082	0.401
DEG_APCC_DBOX_1	423	431	PF00400	0.631
DEG_APCC_KENBOX_2	304	308	PF00400	0.740
DEG_SCF_FBW7_1	310	317	PF00400	0.799
DEG_SPOP_SBC_1	573	577	PF00917	0.757
DEG_SPOP_SBC_1	630	634	PF00917	0.753
DEG_SPOP_SBC_1	751	755	PF00917	0.779
DEG_SPOP_SBC_1	824	828	PF00917	0.774
DOC_CKS1_1	311	316	PF01111	0.721
DOC_CKS1_1	517	522	PF01111	0.749
DOC_CKS1_1	638	643	PF01111	0.699
DOC_CYCLIN_RxL_1	898	907	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	638	644	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	695	701	PF00134	0.717
DOC_MAPK_gen_1	132	139	PF00069	0.810
DOC_MAPK_gen_1	398	404	PF00069	0.563
DOC_MAPK_gen_1	71	79	PF00069	0.675
DOC_MAPK_gen_1	778	787	PF00069	0.714
DOC_MAPK_MEF2A_6	132	139	PF00069	0.810
DOC_MAPK_MEF2A_6	495	503	PF00069	0.656
DOC_PP1_RVXF_1	839	845	PF00149	0.565
DOC_PP2B_LxvP_1	341	344	PF13499	0.632
DOC_PP2B_LxvP_1	518	521	PF13499	0.806
DOC_PP2B_LxvP_1	679	682	PF13499	0.411
DOC_PP2B_LxvP_1	721	724	PF13499	0.736
DOC_PP2B_LxvP_1	796	799	PF13499	0.671
DOC_USP7_MATH_1	154	158	PF00917	0.717
DOC_USP7_MATH_1	178	182	PF00917	0.731
DOC_USP7_MATH_1	213	217	PF00917	0.714
DOC_USP7_MATH_1	331	335	PF00917	0.726
DOC_USP7_MATH_1	394	398	PF00917	0.592
DOC_USP7_MATH_1	44	48	PF00917	0.612
DOC_USP7_MATH_1	470	474	PF00917	0.657
DOC_USP7_MATH_1	507	511	PF00917	0.726
DOC_USP7_MATH_1	606	610	PF00917	0.684
DOC_USP7_MATH_1	630	634	PF00917	0.735
DOC_USP7_MATH_1	717	721	PF00917	0.740
DOC_USP7_MATH_1	738	742	PF00917	0.837
DOC_USP7_MATH_1	810	814	PF00917	0.756
DOC_USP7_MATH_1	825	829	PF00917	0.790
DOC_WW_Pin1_4	143	148	PF00397	0.705
DOC_WW_Pin1_4	161	166	PF00397	0.745
DOC_WW_Pin1_4	241	246	PF00397	0.719
DOC_WW_Pin1_4	267	272	PF00397	0.735
DOC_WW_Pin1_4	310	315	PF00397	0.808
DOC_WW_Pin1_4	37	42	PF00397	0.658
DOC_WW_Pin1_4	516	521	PF00397	0.784
DOC_WW_Pin1_4	529	534	PF00397	0.672
DOC_WW_Pin1_4	539	544	PF00397	0.670
DOC_WW_Pin1_4	637	642	PF00397	0.699
DOC_WW_Pin1_4	805	810	PF00397	0.769
DOC_WW_Pin1_4	817	822	PF00397	0.653
LIG_14-3-3_CanoR_1	210	218	PF00244	0.718
LIG_14-3-3_CanoR_1	52	56	PF00244	0.571
LIG_14-3-3_CanoR_1	567	573	PF00244	0.725
LIG_14-3-3_CanoR_1	605	611	PF00244	0.690
LIG_14-3-3_CanoR_1	629	638	PF00244	0.812
LIG_14-3-3_CanoR_1	71	75	PF00244	0.549
LIG_APCC_ABBAyCdc20_2	120	126	PF00400	0.760
LIG_BIR_III_4	130	134	PF00653	0.699
LIG_BRCT_BRCA1_1	606	610	PF00533	0.746
LIG_deltaCOP1_diTrp_1	942	948	PF00928	0.466
LIG_FHA_1	11	17	PF00498	0.562
LIG_FHA_1	138	144	PF00498	0.768
LIG_FHA_1	268	274	PF00498	0.757
LIG_FHA_1	637	643	PF00498	0.737
LIG_FHA_1	681	687	PF00498	0.593
LIG_FHA_1	751	757	PF00498	0.716
LIG_FHA_1	84	90	PF00498	0.672
LIG_FHA_1	950	956	PF00498	0.511
LIG_FHA_2	225	231	PF00498	0.702
LIG_FHA_2	333	339	PF00498	0.761
LIG_FHA_2	431	437	PF00498	0.609
LIG_FHA_2	517	523	PF00498	0.706
LIG_FHA_2	665	671	PF00498	0.512
LIG_FHA_2	945	951	PF00498	0.491
LIG_Integrin_RGD_1	691	693	PF01839	0.511
LIG_LIR_Apic_2	24	28	PF02991	0.505
LIG_LIR_Apic_2	73	78	PF02991	0.565
LIG_LIR_Nem_3	13	18	PF02991	0.537
LIG_LIR_Nem_3	497	503	PF02991	0.592
LIG_PDZ_Class_1	957	962	PF00595	0.625
LIG_Pex14_1	944	948	PF04695	0.461
LIG_Pex14_2	664	668	PF04695	0.411
LIG_RPA_C_Fungi	414	426	PF08784	0.663
LIG_SH2_CRK	591	595	PF00017	0.695
LIG_SH2_CRK	958	962	PF00017	0.574
LIG_SH2_PTP2	15	18	PF00017	0.558
LIG_SH2_PTP2	500	503	PF00017	0.599
LIG_SH2_SRC	500	503	PF00017	0.599
LIG_SH2_STAP1	279	283	PF00017	0.751
LIG_SH2_STAP1	481	485	PF00017	0.553
LIG_SH2_STAP1	958	962	PF00017	0.574
LIG_SH2_STAP1	99	103	PF00017	0.764
LIG_SH2_STAT3	783	786	PF00017	0.611
LIG_SH2_STAT5	15	18	PF00017	0.519
LIG_SH2_STAT5	26	29	PF00017	0.516
LIG_SH2_STAT5	281	284	PF00017	0.760
LIG_SH2_STAT5	460	463	PF00017	0.552
LIG_SH2_STAT5	500	503	PF00017	0.599
LIG_SH2_STAT5	783	786	PF00017	0.589
LIG_SH2_STAT5	792	795	PF00017	0.479
LIG_SH2_STAT5	850	853	PF00017	0.510
LIG_SH2_STAT5	874	877	PF00017	0.411
LIG_SH2_STAT5	919	922	PF00017	0.442
LIG_SH2_STAT5	958	961	PF00017	0.556
LIG_SH3_2	2	7	PF14604	0.707
LIG_SH3_3	162	168	PF00018	0.775
LIG_SH3_3	239	245	PF00018	0.705
LIG_SH3_3	272	278	PF00018	0.809
LIG_SH3_3	308	314	PF00018	0.723
LIG_SH3_3	360	366	PF00018	0.781
LIG_SH3_3	38	44	PF00018	0.662
LIG_SH3_3	496	502	PF00018	0.727
LIG_SH3_3	776	782	PF00018	0.622
LIG_SUMO_SIM_par_1	677	684	PF11976	0.512
LIG_TRAF2_1	367	370	PF00917	0.648
LIG_TRAF2_1	773	776	PF00917	0.640
LIG_WW_3	626	630	PF00397	0.819
MOD_CDK_SPK_2	143	148	PF00069	0.606
MOD_CDK_SPK_2	37	42	PF00069	0.680
MOD_CK1_1	116	122	PF00069	0.756
MOD_CK1_1	142	148	PF00069	0.792
MOD_CK1_1	157	163	PF00069	0.601
MOD_CK1_1	181	187	PF00069	0.698
MOD_CK1_1	558	564	PF00069	0.629
MOD_CK1_1	576	582	PF00069	0.522
MOD_CK1_1	608	614	PF00069	0.688
MOD_CK1_1	680	686	PF00069	0.690
MOD_CK1_1	741	747	PF00069	0.794
MOD_CK1_1	826	832	PF00069	0.781
MOD_CK2_1	241	247	PF00069	0.752
MOD_CK2_1	293	299	PF00069	0.733
MOD_CK2_1	332	338	PF00069	0.764
MOD_CK2_1	430	436	PF00069	0.625
MOD_CK2_1	507	513	PF00069	0.759
MOD_CK2_1	664	670	PF00069	0.512
MOD_GlcNHglycan	150	153	PF01048	0.777
MOD_GlcNHglycan	183	186	PF01048	0.758
MOD_GlcNHglycan	198	201	PF01048	0.669
MOD_GlcNHglycan	211	214	PF01048	0.780
MOD_GlcNHglycan	215	218	PF01048	0.683
MOD_GlcNHglycan	296	299	PF01048	0.800
MOD_GlcNHglycan	327	330	PF01048	0.649
MOD_GlcNHglycan	445	449	PF01048	0.545
MOD_GlcNHglycan	472	475	PF01048	0.657
MOD_GlcNHglycan	509	512	PF01048	0.791
MOD_GlcNHglycan	513	517	PF01048	0.802
MOD_GlcNHglycan	557	560	PF01048	0.772
MOD_GlcNHglycan	633	636	PF01048	0.698
MOD_GlcNHglycan	713	716	PF01048	0.811
MOD_GlcNHglycan	812	815	PF01048	0.751
MOD_GlcNHglycan	828	831	PF01048	0.723
MOD_GSK3_1	137	144	PF00069	0.722
MOD_GSK3_1	157	164	PF00069	0.559
MOD_GSK3_1	209	216	PF00069	0.796
MOD_GSK3_1	261	268	PF00069	0.852
MOD_GSK3_1	279	286	PF00069	0.693
MOD_GSK3_1	310	317	PF00069	0.751
MOD_GSK3_1	318	325	PF00069	0.776
MOD_GSK3_1	512	519	PF00069	0.734
MOD_GSK3_1	555	562	PF00069	0.772
MOD_GSK3_1	568	575	PF00069	0.644
MOD_GSK3_1	600	607	PF00069	0.747
MOD_GSK3_1	677	684	PF00069	0.411
MOD_GSK3_1	726	733	PF00069	0.814
MOD_GSK3_1	739	746	PF00069	0.833
MOD_GSK3_1	750	757	PF00069	0.755
MOD_GSK3_1	826	833	PF00069	0.821
MOD_N-GLC_1	181	186	PF02516	0.614
MOD_N-GLC_1	361	366	PF02516	0.570
MOD_NEK2_1	322	327	PF00069	0.758
MOD_NEK2_1	444	449	PF00069	0.661
MOD_NEK2_1	631	636	PF00069	0.711
MOD_NEK2_1	664	669	PF00069	0.512
MOD_NEK2_2	944	949	PF00069	0.479
MOD_PIKK_1	314	320	PF00454	0.732
MOD_PIKK_1	322	328	PF00454	0.828
MOD_PIKK_1	650	656	PF00454	0.535
MOD_PKA_1	555	561	PF00069	0.756
MOD_PKA_2	116	122	PF00069	0.658
MOD_PKA_2	209	215	PF00069	0.712
MOD_PKA_2	224	230	PF00069	0.769
MOD_PKA_2	431	437	PF00069	0.631
MOD_PKA_2	51	57	PF00069	0.574
MOD_PKA_2	566	572	PF00069	0.685
MOD_PKA_2	604	610	PF00069	0.744
MOD_PKA_2	70	76	PF00069	0.545
MOD_PKA_2	703	709	PF00069	0.788
MOD_Plk_1	111	117	PF00069	0.595
MOD_Plk_1	125	131	PF00069	0.660
MOD_Plk_1	512	518	PF00069	0.662
MOD_Plk_1	846	852	PF00069	0.556
MOD_Plk_1	949	955	PF00069	0.483
MOD_Plk_4	11	17	PF00069	0.562
MOD_Plk_4	269	275	PF00069	0.761
MOD_Plk_4	318	324	PF00069	0.621
MOD_Plk_4	59	65	PF00069	0.559
MOD_Plk_4	70	76	PF00069	0.545
MOD_Plk_4	846	852	PF00069	0.517
MOD_ProDKin_1	143	149	PF00069	0.707
MOD_ProDKin_1	161	167	PF00069	0.746
MOD_ProDKin_1	241	247	PF00069	0.721
MOD_ProDKin_1	267	273	PF00069	0.734
MOD_ProDKin_1	310	316	PF00069	0.807
MOD_ProDKin_1	37	43	PF00069	0.649
MOD_ProDKin_1	516	522	PF00069	0.784
MOD_ProDKin_1	529	535	PF00069	0.673
MOD_ProDKin_1	539	545	PF00069	0.672
MOD_ProDKin_1	637	643	PF00069	0.700
MOD_ProDKin_1	805	811	PF00069	0.768
MOD_ProDKin_1	817	823	PF00069	0.655
MOD_SUMO_for_1	554	557	PF00179	0.759
MOD_SUMO_rev_2	763	769	PF00179	0.622
TRG_DiLeu_BaEn_1	513	518	PF01217	0.663
TRG_DiLeu_BaEn_4	410	416	PF01217	0.663
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.596
TRG_ENDOCYTIC_2	15	18	PF00928	0.519
TRG_ENDOCYTIC_2	500	503	PF00928	0.599
TRG_ENDOCYTIC_2	864	867	PF00928	0.495
TRG_ENDOCYTIC_2	958	961	PF00928	0.556
TRG_ENDOCYTIC_2	99	102	PF00928	0.761
TRG_ER_diArg_1	18	20	PF00400	0.614
TRG_ER_diArg_1	201	204	PF00400	0.576
TRG_ER_diArg_1	235	238	PF00400	0.688
TRG_ER_diArg_1	398	400	PF00400	0.556
TRG_ER_diArg_1	412	415	PF00400	0.563
TRG_ER_diArg_1	424	427	PF00400	0.562
TRG_ER_diArg_1	841	844	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	400	405	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V3	Leptomonas seymouri	42%	95%
A0A3Q8IBI8	Leishmania donovani	100%	100%
E9AIA9	Leishmania braziliensis	68%	98%
E9AUJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QCY8	Leishmania major	89%	100%