Chaperone protein DNAJ-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAJ-like protein

Species:

Leishmania infantum

UniProt:

A4HYQ6_LEIIN

TriTrypDb:

LINF_200010900

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HYQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	18
GO:0009987	cellular process	1	18
GO:0006458	'de novo' protein folding	3	2
GO:0006950	response to stress	2	7
GO:0009266	response to temperature stimulus	3	7
GO:0009408	response to heat	3	7
GO:0009628	response to abiotic stimulus	2	7
GO:0042026	protein refolding	3	2
GO:0050896	response to stimulus	1	7
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0031072	heat shock protein binding	3	18
GO:0051082	unfolded protein binding	3	18
GO:0000166	nucleotide binding	3	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.502
CLV_NRD_NRD_1	14	16	PF00675	0.643
CLV_NRD_NRD_1	284	286	PF00675	0.252
CLV_NRD_NRD_1	307	309	PF00675	0.326
CLV_NRD_NRD_1	44	46	PF00675	0.571
CLV_NRD_NRD_1	77	79	PF00675	0.419
CLV_NRD_NRD_1	89	91	PF00675	0.340
CLV_PCSK_KEX2_1	105	107	PF00082	0.396
CLV_PCSK_KEX2_1	14	16	PF00082	0.707
CLV_PCSK_KEX2_1	307	309	PF00082	0.326
CLV_PCSK_KEX2_1	44	46	PF00082	0.571
CLV_PCSK_KEX2_1	77	79	PF00082	0.441
CLV_PCSK_KEX2_1	89	91	PF00082	0.497
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.541
CLV_PCSK_SKI1_1	209	213	PF00082	0.556
CLV_PCSK_SKI1_1	269	273	PF00082	0.306
CLV_PCSK_SKI1_1	476	480	PF00082	0.402
CLV_PCSK_SKI1_1	84	88	PF00082	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.518
DOC_CKS1_1	281	286	PF01111	0.444
DOC_CYCLIN_yClb1_LxF_4	62	67	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.364
DOC_MAPK_DCC_7	428	437	PF00069	0.252
DOC_MAPK_gen_1	474	481	PF00069	0.394
DOC_MAPK_MEF2A_6	428	437	PF00069	0.252
DOC_PP1_RVXF_1	3	10	PF00149	0.518
DOC_PP1_RVXF_1	62	68	PF00149	0.509
DOC_PP2B_LxvP_1	397	400	PF13499	0.331
DOC_USP7_MATH_1	183	187	PF00917	0.728
DOC_USP7_MATH_1	193	197	PF00917	0.546
DOC_USP7_MATH_1	221	225	PF00917	0.623
DOC_USP7_MATH_1	387	391	PF00917	0.290
DOC_USP7_MATH_1	484	488	PF00917	0.567
DOC_USP7_MATH_1	507	511	PF00917	0.714
DOC_USP7_MATH_1	515	519	PF00917	0.752
DOC_USP7_MATH_1	533	537	PF00917	0.602
DOC_USP7_MATH_1	57	61	PF00917	0.573
DOC_WW_Pin1_4	280	285	PF00397	0.444
DOC_WW_Pin1_4	383	388	PF00397	0.409
LIG_14-3-3_CanoR_1	106	114	PF00244	0.580
LIG_14-3-3_CanoR_1	14	22	PF00244	0.742
LIG_14-3-3_CanoR_1	248	252	PF00244	0.248
LIG_14-3-3_CanoR_1	446	454	PF00244	0.619
LIG_14-3-3_CanoR_1	501	506	PF00244	0.527
LIG_14-3-3_CanoR_1	77	87	PF00244	0.464
LIG_BIR_III_4	233	237	PF00653	0.467
LIG_BRCT_BRCA1_1	501	505	PF00533	0.463
LIG_CSL_BTD_1	33	36	PF09270	0.515
LIG_FHA_1	242	248	PF00498	0.360
LIG_FHA_1	300	306	PF00498	0.453
LIG_FHA_1	372	378	PF00498	0.307
LIG_FHA_1	418	424	PF00498	0.410
LIG_FHA_1	78	84	PF00498	0.400
LIG_FHA_2	157	163	PF00498	0.579
LIG_FHA_2	490	496	PF00498	0.679
LIG_HCF-1_HBM_1	379	382	PF13415	0.252
LIG_LIR_Apic_2	436	441	PF02991	0.243
LIG_LIR_Gen_1	112	122	PF02991	0.400
LIG_LIR_Gen_1	456	466	PF02991	0.409
LIG_LIR_Gen_1	59	68	PF02991	0.406
LIG_LIR_Nem_3	112	117	PF02991	0.358
LIG_LIR_Nem_3	456	462	PF02991	0.393
LIG_LIR_Nem_3	59	65	PF02991	0.406
LIG_OCRL_FandH_1	352	364	PF00620	0.387
LIG_PTB_Apo_2	347	354	PF02174	0.405
LIG_SH2_CRK	114	118	PF00017	0.341
LIG_SH2_CRK	459	463	PF00017	0.341
LIG_SH2_CRK	62	66	PF00017	0.455
LIG_SH2_SRC	160	163	PF00017	0.693
LIG_SH2_STAP1	126	130	PF00017	0.443
LIG_SH2_STAP1	538	542	PF00017	0.344
LIG_SH2_STAT5	114	117	PF00017	0.446
LIG_SH2_STAT5	160	163	PF00017	0.693
LIG_SH2_STAT5	311	314	PF00017	0.440
LIG_SH2_STAT5	382	385	PF00017	0.392
LIG_SH2_STAT5	538	541	PF00017	0.333
LIG_SH3_2	319	324	PF14604	0.526
LIG_SH3_3	30	36	PF00018	0.521
LIG_SH3_3	315	321	PF00018	0.497
LIG_SH3_3	334	340	PF00018	0.356
LIG_SH3_3	407	413	PF00018	0.296
LIG_SH3_3	418	424	PF00018	0.267
LIG_SH3_3	460	466	PF00018	0.374
LIG_SUMO_SIM_anti_2	402	407	PF11976	0.356
LIG_SUMO_SIM_par_1	373	379	PF11976	0.297
LIG_TYR_ITIM	457	462	PF00017	0.339
MOD_CDC14_SPxK_1	386	389	PF00782	0.252
MOD_CDK_SPK_2	280	285	PF00069	0.290
MOD_CDK_SPxK_1	280	286	PF00069	0.290
MOD_CDK_SPxK_1	383	389	PF00069	0.252
MOD_CK1_1	16	22	PF00069	0.691
MOD_CK1_1	169	175	PF00069	0.580
MOD_CK1_1	186	192	PF00069	0.687
MOD_CK1_1	219	225	PF00069	0.603
MOD_CK1_1	487	493	PF00069	0.614
MOD_CK1_1	518	524	PF00069	0.504
MOD_CK1_1	536	542	PF00069	0.530
MOD_CK2_1	489	495	PF00069	0.630
MOD_CK2_1	76	82	PF00069	0.394
MOD_CMANNOS	34	37	PF00535	0.656
MOD_GlcNHglycan	16	19	PF01048	0.638
MOD_GlcNHglycan	171	174	PF01048	0.610
MOD_GlcNHglycan	185	188	PF01048	0.719
MOD_GlcNHglycan	189	192	PF01048	0.675
MOD_GlcNHglycan	216	219	PF01048	0.615
MOD_GlcNHglycan	275	278	PF01048	0.322
MOD_GlcNHglycan	294	297	PF01048	0.300
MOD_GlcNHglycan	299	302	PF01048	0.275
MOD_GlcNHglycan	428	431	PF01048	0.362
MOD_GlcNHglycan	447	450	PF01048	0.472
MOD_GlcNHglycan	471	474	PF01048	0.519
MOD_GlcNHglycan	489	492	PF01048	0.591
MOD_GlcNHglycan	517	520	PF01048	0.729
MOD_GSK3_1	121	128	PF00069	0.528
MOD_GSK3_1	14	21	PF00069	0.648
MOD_GSK3_1	183	190	PF00069	0.660
MOD_GSK3_1	193	200	PF00069	0.671
MOD_GSK3_1	216	223	PF00069	0.564
MOD_GSK3_1	247	254	PF00069	0.281
MOD_GSK3_1	269	276	PF00069	0.346
MOD_GSK3_1	344	351	PF00069	0.300
MOD_GSK3_1	371	378	PF00069	0.409
MOD_GSK3_1	383	390	PF00069	0.408
MOD_GSK3_1	441	448	PF00069	0.569
MOD_GSK3_1	514	521	PF00069	0.728
MOD_N-GLC_1	209	214	PF02516	0.570
MOD_N-GLC_1	224	229	PF02516	0.519
MOD_N-GLC_1	238	243	PF02516	0.436
MOD_NEK2_1	251	256	PF00069	0.285
MOD_NEK2_1	348	353	PF00069	0.360
MOD_NEK2_1	371	376	PF00069	0.260
MOD_NEK2_1	527	532	PF00069	0.393
MOD_NEK2_1	534	539	PF00069	0.374
MOD_NEK2_2	417	422	PF00069	0.252
MOD_NEK2_2	57	62	PF00069	0.558
MOD_PIKK_1	507	513	PF00454	0.699
MOD_PKA_1	105	111	PF00069	0.382
MOD_PKA_1	14	20	PF00069	0.531
MOD_PKA_1	77	83	PF00069	0.407
MOD_PKA_2	105	111	PF00069	0.382
MOD_PKA_2	13	19	PF00069	0.698
MOD_PKA_2	166	172	PF00069	0.672
MOD_PKA_2	247	253	PF00069	0.250
MOD_PKA_2	273	279	PF00069	0.331
MOD_PKA_2	28	34	PF00069	0.605
MOD_PKA_2	292	298	PF00069	0.298
MOD_PKA_2	445	451	PF00069	0.680
MOD_PKA_2	76	82	PF00069	0.447
MOD_Plk_1	224	230	PF00069	0.666
MOD_Plk_1	241	247	PF00069	0.306
MOD_Plk_1	251	257	PF00069	0.260
MOD_Plk_4	348	354	PF00069	0.407
MOD_Plk_4	36	42	PF00069	0.615
MOD_Plk_4	371	377	PF00069	0.278
MOD_Plk_4	453	459	PF00069	0.334
MOD_Plk_4	57	63	PF00069	0.476
MOD_ProDKin_1	280	286	PF00069	0.290
MOD_ProDKin_1	383	389	PF00069	0.409
MOD_SUMO_rev_2	100	107	PF00179	0.475
MOD_SUMO_rev_2	108	113	PF00179	0.422
MOD_SUMO_rev_2	92	97	PF00179	0.525
TRG_ENDOCYTIC_2	114	117	PF00928	0.421
TRG_ENDOCYTIC_2	459	462	PF00928	0.405
TRG_ENDOCYTIC_2	62	65	PF00928	0.451
TRG_ER_diArg_1	353	356	PF00400	0.314
TRG_ER_diArg_1	76	78	PF00400	0.446
TRG_ER_diArg_1	88	90	PF00400	0.446
TRG_NES_CRM1_1	242	252	PF08389	0.387
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS2	Leptomonas seymouri	62%	100%
A0A0S4J3B2	Bodo saltans	33%	100%
A0A1X0NLD4	Trypanosomatidae	26%	100%
A0A1X0NWP1	Trypanosomatidae	45%	100%
A0A3Q8IET3	Leishmania donovani	100%	100%
A0A3R7KX88	Trypanosoma rangeli	43%	100%
A0A3S7WNT6	Leishmania donovani	26%	100%
A0A422N924	Trypanosoma rangeli	27%	100%
A4HS91	Leishmania infantum	26%	100%
C9ZI72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZY84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AIB2	Leishmania braziliensis	85%	100%
E9AK75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	98%
E9AUJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O97016	Leishmania major	26%	100%
Q493S6	Blochmannia pennsylvanicus (strain BPEN)	23%	100%
Q4QCY5	Leishmania major	95%	100%