Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYQ4_LEIIN

TriTrypDb:

LINF_200011100

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HYQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.409
CLV_C14_Caspase3-7	332	336	PF00656	0.408
CLV_C14_Caspase3-7	557	561	PF00656	0.565
CLV_NRD_NRD_1	428	430	PF00675	0.633
CLV_NRD_NRD_1	554	556	PF00675	0.727
CLV_NRD_NRD_1	691	693	PF00675	0.720
CLV_NRD_NRD_1	699	701	PF00675	0.677
CLV_NRD_NRD_1	780	782	PF00675	0.703
CLV_NRD_NRD_1	790	792	PF00675	0.680
CLV_NRD_NRD_1	86	88	PF00675	0.694
CLV_PCSK_FUR_1	84	88	PF00082	0.700
CLV_PCSK_KEX2_1	553	555	PF00082	0.731
CLV_PCSK_KEX2_1	691	693	PF00082	0.720
CLV_PCSK_KEX2_1	790	792	PF00082	0.723
CLV_PCSK_KEX2_1	84	86	PF00082	0.696
CLV_PCSK_SKI1_1	235	239	PF00082	0.665
CLV_PCSK_SKI1_1	247	251	PF00082	0.585
CLV_PCSK_SKI1_1	302	306	PF00082	0.632
CLV_PCSK_SKI1_1	353	357	PF00082	0.316
CLV_PCSK_SKI1_1	672	676	PF00082	0.694
DEG_APCC_DBOX_1	352	360	PF00400	0.316
DEG_Nend_UBRbox_2	1	3	PF02207	0.551
DEG_ODPH_VHL_1	342	354	PF01847	0.316
DEG_SCF_FBW7_1	147	154	PF00400	0.488
DEG_SCF_TRCP1_1	560	566	PF00400	0.523
DOC_CDC14_PxL_1	227	235	PF14671	0.473
DOC_CYCLIN_RxL_1	371	384	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	807	810	PF00134	0.494
DOC_MAPK_gen_1	400	410	PF00069	0.596
DOC_MAPK_MEF2A_6	400	408	PF00069	0.633
DOC_PP2B_LxvP_1	304	307	PF13499	0.518
DOC_PP2B_LxvP_1	615	618	PF13499	0.491
DOC_PP2B_LxvP_1	807	810	PF13499	0.494
DOC_PP4_FxxP_1	491	494	PF00568	0.546
DOC_USP7_MATH_1	145	149	PF00917	0.613
DOC_USP7_MATH_1	151	155	PF00917	0.552
DOC_USP7_MATH_1	157	161	PF00917	0.486
DOC_USP7_MATH_1	179	183	PF00917	0.516
DOC_USP7_MATH_1	254	258	PF00917	0.418
DOC_USP7_MATH_1	313	317	PF00917	0.440
DOC_USP7_MATH_1	328	332	PF00917	0.405
DOC_USP7_MATH_1	336	340	PF00917	0.438
DOC_USP7_MATH_1	388	392	PF00917	0.673
DOC_USP7_MATH_1	474	478	PF00917	0.499
DOC_USP7_MATH_1	520	524	PF00917	0.511
DOC_USP7_MATH_1	544	548	PF00917	0.512
DOC_USP7_MATH_1	556	560	PF00917	0.475
DOC_USP7_MATH_1	576	580	PF00917	0.451
DOC_USP7_MATH_1	594	598	PF00917	0.453
DOC_USP7_MATH_1	599	603	PF00917	0.468
DOC_USP7_MATH_1	718	722	PF00917	0.496
DOC_USP7_MATH_1	769	773	PF00917	0.497
DOC_USP7_MATH_1	834	838	PF00917	0.479
DOC_WW_Pin1_4	147	152	PF00397	0.519
DOC_WW_Pin1_4	153	158	PF00397	0.471
DOC_WW_Pin1_4	172	177	PF00397	0.430
DOC_WW_Pin1_4	463	468	PF00397	0.470
DOC_WW_Pin1_4	497	502	PF00397	0.500
DOC_WW_Pin1_4	548	553	PF00397	0.483
DOC_WW_Pin1_4	645	650	PF00397	0.496
DOC_WW_Pin1_4	672	677	PF00397	0.500
DOC_WW_Pin1_4	686	691	PF00397	0.470
DOC_WW_Pin1_4	744	749	PF00397	0.453
DOC_WW_Pin1_4	790	795	PF00397	0.518
DOC_WW_Pin1_4	796	801	PF00397	0.477
LIG_14-3-3_CanoR_1	220	227	PF00244	0.459
LIG_14-3-3_CanoR_1	235	244	PF00244	0.428
LIG_14-3-3_CanoR_1	276	282	PF00244	0.398
LIG_14-3-3_CanoR_1	302	307	PF00244	0.444
LIG_14-3-3_CanoR_1	429	438	PF00244	0.471
LIG_14-3-3_CanoR_1	465	473	PF00244	0.456
LIG_Actin_WH2_2	352	370	PF00022	0.342
LIG_BRCT_BRCA1_1	238	242	PF00533	0.469
LIG_BRCT_BRCA1_1	411	415	PF00533	0.375
LIG_BRCT_BRCA1_1	746	750	PF00533	0.449
LIG_Clathr_ClatBox_1	377	381	PF01394	0.629
LIG_deltaCOP1_diTrp_1	260	265	PF00928	0.456
LIG_Dynein_DLC8_1	428	434	PF01221	0.390
LIG_EH1_1	349	357	PF00400	0.316
LIG_eIF4E_1	350	356	PF01652	0.316
LIG_eIF4E_1	361	367	PF01652	0.520
LIG_FHA_1	159	165	PF00498	0.580
LIG_FHA_1	236	242	PF00498	0.537
LIG_FHA_1	396	402	PF00498	0.623
LIG_FHA_1	411	417	PF00498	0.250
LIG_FHA_1	430	436	PF00498	0.455
LIG_FHA_1	610	616	PF00498	0.491
LIG_FHA_1	7	13	PF00498	0.511
LIG_FHA_1	734	740	PF00498	0.467
LIG_FHA_2	102	108	PF00498	0.518
LIG_FHA_2	325	331	PF00498	0.410
LIG_FHA_2	444	450	PF00498	0.427
LIG_FHA_2	718	724	PF00498	0.498
LIG_FHA_2	824	830	PF00498	0.494
LIG_FXI_DFP_1	250	254	PF00024	0.629
LIG_IRF3_LxIS_1	615	622	PF10401	0.492
LIG_LIR_Apic_2	206	210	PF02991	0.463
LIG_LIR_Apic_2	489	494	PF02991	0.544
LIG_LIR_Gen_1	260	269	PF02991	0.448
LIG_LIR_Gen_1	412	423	PF02991	0.375
LIG_LIR_Gen_1	52	62	PF02991	0.375
LIG_LIR_Gen_1	531	541	PF02991	0.470
LIG_LIR_Gen_1	72	83	PF02991	0.435
LIG_LIR_Gen_1	844	852	PF02991	0.470
LIG_LIR_Nem_3	260	265	PF02991	0.467
LIG_LIR_Nem_3	412	418	PF02991	0.418
LIG_LIR_Nem_3	52	57	PF02991	0.436
LIG_LIR_Nem_3	529	535	PF02991	0.496
LIG_LIR_Nem_3	72	78	PF02991	0.399
LIG_LIR_Nem_3	844	850	PF02991	0.469
LIG_NRBOX	362	368	PF00104	0.520
LIG_PTB_Apo_2	226	233	PF02174	0.389
LIG_PTB_Phospho_1	226	232	PF10480	0.389
LIG_SH2_NCK_1	62	66	PF00017	0.472
LIG_SH2_PTP2	421	424	PF00017	0.287
LIG_SH2_PTP2	534	537	PF00017	0.494
LIG_SH2_SRC	534	537	PF00017	0.546
LIG_SH2_SRC	60	63	PF00017	0.476
LIG_SH2_STAP1	350	354	PF00017	0.316
LIG_SH2_STAP1	431	435	PF00017	0.431
LIG_SH2_STAP1	62	66	PF00017	0.472
LIG_SH2_STAT3	274	277	PF00017	0.458
LIG_SH2_STAT3	361	364	PF00017	0.432
LIG_SH2_STAT5	19	22	PF00017	0.527
LIG_SH2_STAT5	232	235	PF00017	0.476
LIG_SH2_STAT5	421	424	PF00017	0.331
LIG_SH2_STAT5	431	434	PF00017	0.399
LIG_SH2_STAT5	534	537	PF00017	0.535
LIG_SH2_STAT5	60	63	PF00017	0.476
LIG_SH2_STAT5	847	850	PF00017	0.472
LIG_SH3_3	117	123	PF00018	0.449
LIG_SH3_3	338	344	PF00018	0.324
LIG_SH3_3	546	552	PF00018	0.500
LIG_SH3_3	806	812	PF00018	0.517
LIG_SUMO_SIM_par_1	616	623	PF11976	0.492
LIG_SUMO_SIM_par_1	66	72	PF11976	0.442
LIG_SUMO_SIM_par_1	99	104	PF11976	0.510
LIG_TRAF2_1	122	125	PF00917	0.543
LIG_TRAF2_1	507	510	PF00917	0.489
LIG_TRAF2_1	512	515	PF00917	0.463
LIG_TYR_ITIM	419	424	PF00017	0.287
LIG_UBA3_1	392	400	PF00899	0.631
LIG_ULM_U2AF65_1	84	89	PF00076	0.482
LIG_Vh1_VBS_1	345	363	PF01044	0.316
LIG_WW_3	808	812	PF00397	0.497
MOD_CDC14_SPxK_1	551	554	PF00782	0.484
MOD_CDK_SPK_2	548	553	PF00069	0.483
MOD_CDK_SPK_2	686	691	PF00069	0.513
MOD_CDK_SPxK_1	548	554	PF00069	0.484
MOD_CDK_SPxK_1	686	692	PF00069	0.515
MOD_CDK_SPxxK_3	548	555	PF00069	0.484
MOD_CDK_SPxxK_3	796	803	PF00069	0.497
MOD_CK1_1	146	152	PF00069	0.586
MOD_CK1_1	155	161	PF00069	0.513
MOD_CK1_1	284	290	PF00069	0.473
MOD_CK1_1	295	301	PF00069	0.391
MOD_CK1_1	323	329	PF00069	0.495
MOD_CK1_1	437	443	PF00069	0.388
MOD_CK1_1	481	487	PF00069	0.528
MOD_CK1_1	539	545	PF00069	0.502
MOD_CK1_1	547	553	PF00069	0.540
MOD_CK1_1	558	564	PF00069	0.470
MOD_CK1_1	607	613	PF00069	0.495
MOD_CK1_1	635	641	PF00069	0.525
MOD_CK1_1	658	664	PF00069	0.506
MOD_CK1_1	684	690	PF00069	0.512
MOD_CK1_1	717	723	PF00069	0.497
MOD_CK1_1	77	83	PF00069	0.492
MOD_CK1_1	843	849	PF00069	0.452
MOD_CK2_1	254	260	PF00069	0.460
MOD_CK2_1	443	449	PF00069	0.426
MOD_CK2_1	504	510	PF00069	0.487
MOD_CK2_1	520	526	PF00069	0.451
MOD_CK2_1	568	574	PF00069	0.518
MOD_CK2_1	823	829	PF00069	0.498
MOD_CMANNOS	285	288	PF00535	0.679
MOD_DYRK1A_RPxSP_1	645	649	PF00069	0.475
MOD_GlcNHglycan	215	218	PF01048	0.772
MOD_GlcNHglycan	288	291	PF01048	0.657
MOD_GlcNHglycan	294	297	PF01048	0.668
MOD_GlcNHglycan	315	318	PF01048	0.762
MOD_GlcNHglycan	33	36	PF01048	0.730
MOD_GlcNHglycan	338	341	PF01048	0.632
MOD_GlcNHglycan	43	46	PF01048	0.693
MOD_GlcNHglycan	468	471	PF01048	0.699
MOD_GlcNHglycan	480	483	PF01048	0.716
MOD_GlcNHglycan	485	488	PF01048	0.709
MOD_GlcNHglycan	502	505	PF01048	0.657
MOD_GlcNHglycan	522	525	PF01048	0.685
MOD_GlcNHglycan	560	563	PF01048	0.751
MOD_GlcNHglycan	571	574	PF01048	0.688
MOD_GlcNHglycan	627	630	PF01048	0.689
MOD_GlcNHglycan	637	640	PF01048	0.670
MOD_GlcNHglycan	651	654	PF01048	0.645
MOD_GlcNHglycan	684	687	PF01048	0.711
MOD_GlcNHglycan	716	719	PF01048	0.699
MOD_GlcNHglycan	726	729	PF01048	0.663
MOD_GlcNHglycan	771	774	PF01048	0.697
MOD_GlcNHglycan	79	82	PF01048	0.699
MOD_GlcNHglycan	821	824	PF01048	0.691
MOD_GSK3_1	143	150	PF00069	0.543
MOD_GSK3_1	151	158	PF00069	0.538
MOD_GSK3_1	159	166	PF00069	0.469
MOD_GSK3_1	179	186	PF00069	0.422
MOD_GSK3_1	277	284	PF00069	0.433
MOD_GSK3_1	298	305	PF00069	0.447
MOD_GSK3_1	31	38	PF00069	0.524
MOD_GSK3_1	320	327	PF00069	0.410
MOD_GSK3_1	388	395	PF00069	0.668
MOD_GSK3_1	474	481	PF00069	0.506
MOD_GSK3_1	483	490	PF00069	0.482
MOD_GSK3_1	496	503	PF00069	0.536
MOD_GSK3_1	509	516	PF00069	0.525
MOD_GSK3_1	544	551	PF00069	0.534
MOD_GSK3_1	556	563	PF00069	0.515
MOD_GSK3_1	595	602	PF00069	0.530
MOD_GSK3_1	607	614	PF00069	0.474
MOD_GSK3_1	631	638	PF00069	0.508
MOD_GSK3_1	645	652	PF00069	0.440
MOD_GSK3_1	654	661	PF00069	0.467
MOD_GSK3_1	677	684	PF00069	0.510
MOD_GSK3_1	714	721	PF00069	0.480
MOD_GSK3_1	817	824	PF00069	0.519
MOD_GSK3_1	836	843	PF00069	0.402
MOD_GSK3_1	99	106	PF00069	0.495
MOD_N-GLC_1	166	171	PF02516	0.703
MOD_N-GLC_1	220	225	PF02516	0.711
MOD_N-GLC_1	260	265	PF02516	0.614
MOD_N-GLC_1	313	318	PF02516	0.680
MOD_N-GLC_1	635	640	PF02516	0.704
MOD_N-GLC_1	658	663	PF02516	0.704
MOD_NEK2_1	108	113	PF00069	0.527
MOD_NEK2_1	292	297	PF00069	0.422
MOD_NEK2_1	33	38	PF00069	0.536
MOD_NEK2_1	380	385	PF00069	0.637
MOD_NEK2_1	409	414	PF00069	0.375
MOD_NEK2_1	47	52	PF00069	0.459
MOD_NEK2_1	478	483	PF00069	0.491
MOD_NEK2_1	495	500	PF00069	0.428
MOD_NEK2_1	513	518	PF00069	0.426
MOD_NEK2_1	611	616	PF00069	0.466
MOD_NEK2_1	625	630	PF00069	0.448
MOD_NEK2_1	632	637	PF00069	0.487
MOD_NEK2_1	655	660	PF00069	0.505
MOD_NEK2_1	702	707	PF00069	0.484
MOD_NEK2_1	743	748	PF00069	0.445
MOD_NEK2_2	269	274	PF00069	0.439
MOD_NEK2_2	474	479	PF00069	0.478
MOD_NEK2_2	576	581	PF00069	0.494
MOD_NEK2_2	823	828	PF00069	0.499
MOD_PIKK_1	166	172	PF00454	0.503
MOD_PIKK_1	429	435	PF00454	0.392
MOD_PIKK_1	566	572	PF00454	0.522
MOD_PKA_1	429	435	PF00069	0.434
MOD_PKA_1	700	706	PF00069	0.482
MOD_PKA_2	179	185	PF00069	0.504
MOD_PKA_2	219	225	PF00069	0.446
MOD_PKA_2	443	449	PF00069	0.411
MOD_PKA_2	769	775	PF00069	0.499
MOD_PKA_2	810	816	PF00069	0.501
MOD_PKB_1	427	435	PF00069	0.432
MOD_PKB_1	553	561	PF00069	0.526
MOD_PKB_1	698	706	PF00069	0.505
MOD_Plk_1	260	266	PF00069	0.454
MOD_Plk_1	509	515	PF00069	0.483
MOD_Plk_1	528	534	PF00069	0.458
MOD_Plk_1	563	569	PF00069	0.561
MOD_Plk_1	665	671	PF00069	0.516
MOD_Plk_1	843	849	PF00069	0.466
MOD_Plk_4	159	165	PF00069	0.504
MOD_Plk_4	269	275	PF00069	0.441
MOD_Plk_4	281	287	PF00069	0.396
MOD_Plk_4	388	394	PF00069	0.652
MOD_Plk_4	528	534	PF00069	0.538
MOD_Plk_4	563	569	PF00069	0.523
MOD_Plk_4	836	842	PF00069	0.459
MOD_Plk_4	843	849	PF00069	0.443
MOD_ProDKin_1	147	153	PF00069	0.518
MOD_ProDKin_1	172	178	PF00069	0.509
MOD_ProDKin_1	463	469	PF00069	0.471
MOD_ProDKin_1	497	503	PF00069	0.501
MOD_ProDKin_1	548	554	PF00069	0.484
MOD_ProDKin_1	645	651	PF00069	0.497
MOD_ProDKin_1	672	678	PF00069	0.500
MOD_ProDKin_1	686	692	PF00069	0.471
MOD_ProDKin_1	744	750	PF00069	0.453
MOD_ProDKin_1	790	796	PF00069	0.515
MOD_SUMO_for_1	537	540	PF00179	0.468
MOD_SUMO_rev_2	531	539	PF00179	0.471
TRG_DiLeu_BaEn_1	245	250	PF01217	0.559
TRG_DiLeu_BaEn_1	844	849	PF01217	0.469
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.592
TRG_ENDOCYTIC_2	421	424	PF00928	0.287
TRG_ENDOCYTIC_2	534	537	PF00928	0.494
TRG_ENDOCYTIC_2	847	850	PF00928	0.472
TRG_ER_diArg_1	459	462	PF00400	0.488
TRG_ER_diArg_1	552	555	PF00400	0.527
TRG_ER_diArg_1	580	583	PF00400	0.516
TRG_ER_diArg_1	690	692	PF00400	0.522
TRG_ER_diArg_1	697	700	PF00400	0.481
TRG_ER_diArg_1	84	87	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVX7	Leishmania donovani	97%	100%
E9AIB4	Leishmania braziliensis	56%	99%
E9AUK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%