LeishMANIAdb
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rRNA biogenesis protein-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
rRNA biogenesis protein-like protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4HYP7_LEIIN
TriTrypDb:
Length:
733

Annotations

Annotations by Jardim et al.

Nucleic acid binding, rRNA biogenesis -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0030684 preribosome 3 1
GO:0032040 small-subunit processome 4 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYP7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYP7

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006364 rRNA processing 8 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0016072 rRNA metabolic process 7 12
GO:0034470 ncRNA processing 7 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 150 154 PF00656 0.552
CLV_C14_Caspase3-7 434 438 PF00656 0.507
CLV_C14_Caspase3-7 726 730 PF00656 0.586
CLV_NRD_NRD_1 101 103 PF00675 0.384
CLV_NRD_NRD_1 108 110 PF00675 0.283
CLV_NRD_NRD_1 399 401 PF00675 0.530
CLV_NRD_NRD_1 429 431 PF00675 0.514
CLV_NRD_NRD_1 528 530 PF00675 0.405
CLV_NRD_NRD_1 551 553 PF00675 0.376
CLV_NRD_NRD_1 572 574 PF00675 0.423
CLV_NRD_NRD_1 635 637 PF00675 0.475
CLV_NRD_NRD_1 657 659 PF00675 0.442
CLV_PCSK_FUR_1 426 430 PF00082 0.598
CLV_PCSK_KEX2_1 101 103 PF00082 0.453
CLV_PCSK_KEX2_1 399 401 PF00082 0.532
CLV_PCSK_KEX2_1 428 430 PF00082 0.516
CLV_PCSK_KEX2_1 528 530 PF00082 0.346
CLV_PCSK_KEX2_1 54 56 PF00082 0.388
CLV_PCSK_KEX2_1 572 574 PF00082 0.415
CLV_PCSK_KEX2_1 587 589 PF00082 0.283
CLV_PCSK_KEX2_1 592 594 PF00082 0.375
CLV_PCSK_KEX2_1 603 605 PF00082 0.382
CLV_PCSK_KEX2_1 640 642 PF00082 0.471
CLV_PCSK_KEX2_1 709 711 PF00082 0.316
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.392
CLV_PCSK_PC1ET2_1 587 589 PF00082 0.385
CLV_PCSK_PC1ET2_1 592 594 PF00082 0.391
CLV_PCSK_PC1ET2_1 603 605 PF00082 0.398
CLV_PCSK_PC1ET2_1 640 642 PF00082 0.486
CLV_PCSK_PC1ET2_1 709 711 PF00082 0.316
CLV_PCSK_PC7_1 588 594 PF00082 0.380
CLV_PCSK_PC7_1 636 642 PF00082 0.482
CLV_PCSK_SKI1_1 110 114 PF00082 0.339
CLV_PCSK_SKI1_1 382 386 PF00082 0.548
CLV_PCSK_SKI1_1 456 460 PF00082 0.408
CLV_PCSK_SKI1_1 54 58 PF00082 0.335
CLV_PCSK_SKI1_1 562 566 PF00082 0.438
CLV_PCSK_SKI1_1 593 597 PF00082 0.367
CLV_PCSK_SKI1_1 628 632 PF00082 0.338
CLV_PCSK_SKI1_1 669 673 PF00082 0.336
CLV_PCSK_SKI1_1 80 84 PF00082 0.443
CLV_Separin_Metazoa 98 102 PF03568 0.498
DEG_SCF_FBW7_1 237 244 PF00400 0.505
DOC_CYCLIN_RxL_1 51 61 PF00134 0.418
DOC_CYCLIN_RxL_1 688 696 PF00134 0.418
DOC_MAPK_gen_1 106 116 PF00069 0.336
DOC_MAPK_gen_1 552 560 PF00069 0.360
DOC_MAPK_gen_1 572 580 PF00069 0.444
DOC_MAPK_gen_1 603 611 PF00069 0.353
DOC_MAPK_MEF2A_6 109 116 PF00069 0.339
DOC_MAPK_MEF2A_6 573 582 PF00069 0.405
DOC_PP1_RVXF_1 689 696 PF00149 0.420
DOC_PP2B_PxIxI_1 327 333 PF00149 0.261
DOC_USP7_MATH_1 129 133 PF00917 0.507
DOC_USP7_MATH_1 192 196 PF00917 0.499
DOC_USP7_MATH_1 279 283 PF00917 0.565
DOC_USP7_MATH_1 287 291 PF00917 0.513
DOC_USP7_MATH_1 365 369 PF00917 0.672
DOC_USP7_MATH_1 401 405 PF00917 0.645
DOC_USP7_MATH_1 462 466 PF00917 0.396
DOC_USP7_MATH_1 639 643 PF00917 0.355
DOC_USP7_MATH_1 661 665 PF00917 0.428
DOC_USP7_MATH_1 8 12 PF00917 0.630
DOC_USP7_UBL2_3 592 596 PF12436 0.410
DOC_WW_Pin1_4 237 242 PF00397 0.385
DOC_WW_Pin1_4 374 379 PF00397 0.623
DOC_WW_Pin1_4 447 452 PF00397 0.432
DOC_WW_Pin1_4 620 625 PF00397 0.460
DOC_WW_Pin1_4 698 703 PF00397 0.377
LIG_14-3-3_CanoR_1 139 146 PF00244 0.497
LIG_14-3-3_CanoR_1 204 214 PF00244 0.622
LIG_14-3-3_CanoR_1 41 47 PF00244 0.419
LIG_14-3-3_CanoR_1 55 61 PF00244 0.320
LIG_14-3-3_CanoR_1 572 576 PF00244 0.425
LIG_14-3-3_CanoR_1 691 696 PF00244 0.381
LIG_14-3-3_CanoR_1 710 716 PF00244 0.247
LIG_14-3-3_CanoR_1 80 85 PF00244 0.380
LIG_Actin_WH2_2 576 594 PF00022 0.429
LIG_BIR_II_1 1 5 PF00653 0.707
LIG_BIR_III_4 75 79 PF00653 0.500
LIG_BRCT_BRCA1_1 523 527 PF00533 0.386
LIG_Clathr_ClatBox_1 538 542 PF01394 0.230
LIG_Clathr_ClatBox_1 81 85 PF01394 0.440
LIG_DLG_GKlike_1 691 698 PF00625 0.467
LIG_FHA_1 195 201 PF00498 0.722
LIG_FHA_1 24 30 PF00498 0.454
LIG_FHA_1 261 267 PF00498 0.335
LIG_FHA_1 317 323 PF00498 0.437
LIG_FHA_1 374 380 PF00498 0.552
LIG_FHA_1 42 48 PF00498 0.258
LIG_FHA_1 492 498 PF00498 0.373
LIG_FHA_1 606 612 PF00498 0.458
LIG_FHA_1 663 669 PF00498 0.447
LIG_FHA_1 688 694 PF00498 0.412
LIG_FHA_1 722 728 PF00498 0.525
LIG_FHA_1 81 87 PF00498 0.423
LIG_FHA_2 148 154 PF00498 0.380
LIG_FHA_2 238 244 PF00498 0.406
LIG_FHA_2 359 365 PF00498 0.473
LIG_FHA_2 44 50 PF00498 0.469
LIG_FHA_2 447 453 PF00498 0.549
LIG_FHA_2 592 598 PF00498 0.491
LIG_FHA_2 647 653 PF00498 0.460
LIG_FHA_2 699 705 PF00498 0.428
LIG_FHA_2 712 718 PF00498 0.438
LIG_FHA_2 93 99 PF00498 0.511
LIG_GBD_Chelix_1 52 60 PF00786 0.368
LIG_Integrin_isoDGR_2 626 628 PF01839 0.346
LIG_Integrin_RGD_1 175 177 PF01839 0.515
LIG_LIR_Apic_2 95 99 PF02991 0.380
LIG_LIR_Gen_1 452 462 PF02991 0.410
LIG_LIR_Gen_1 574 583 PF02991 0.354
LIG_LIR_Gen_1 690 698 PF02991 0.365
LIG_LIR_Gen_1 88 97 PF02991 0.385
LIG_LIR_Nem_3 36 42 PF02991 0.456
LIG_LIR_Nem_3 452 457 PF02991 0.409
LIG_LIR_Nem_3 465 471 PF02991 0.331
LIG_LIR_Nem_3 574 578 PF02991 0.340
LIG_LIR_Nem_3 642 648 PF02991 0.334
LIG_LIR_Nem_3 690 695 PF02991 0.358
LIG_LIR_Nem_3 88 93 PF02991 0.405
LIG_PCNA_PIPBox_1 686 695 PF02747 0.428
LIG_PCNA_yPIPBox_3 498 507 PF02747 0.460
LIG_PCNA_yPIPBox_3 528 539 PF02747 0.271
LIG_PCNA_yPIPBox_3 683 693 PF02747 0.400
LIG_Pex14_1 390 394 PF04695 0.522
LIG_SH2_CRK 79 83 PF00017 0.349
LIG_SH2_GRB2like 510 513 PF00017 0.292
LIG_SH2_SRC 510 513 PF00017 0.378
LIG_SH2_SRC 715 718 PF00017 0.378
LIG_SH2_STAP1 221 225 PF00017 0.425
LIG_SH2_STAP1 394 398 PF00017 0.585
LIG_SH2_STAT3 648 651 PF00017 0.351
LIG_SH2_STAT5 301 304 PF00017 0.314
LIG_SH2_STAT5 466 469 PF00017 0.325
LIG_SH2_STAT5 510 513 PF00017 0.378
LIG_SH2_STAT5 648 651 PF00017 0.351
LIG_SH2_STAT5 715 718 PF00017 0.378
LIG_SH3_1 308 314 PF00018 0.378
LIG_SH3_3 273 279 PF00018 0.340
LIG_SH3_3 28 34 PF00018 0.352
LIG_SH3_3 308 314 PF00018 0.516
LIG_SH3_3 372 378 PF00018 0.649
LIG_SH3_3 445 451 PF00018 0.456
LIG_SUMO_SIM_anti_2 319 325 PF11976 0.425
LIG_SUMO_SIM_anti_2 329 335 PF11976 0.451
LIG_SUMO_SIM_anti_2 608 613 PF11976 0.400
LIG_SUMO_SIM_par_1 261 271 PF11976 0.334
LIG_SUMO_SIM_par_1 579 584 PF11976 0.380
LIG_SUMO_SIM_par_1 80 85 PF11976 0.420
LIG_TRAF2_1 450 453 PF00917 0.444
LIG_TRAF2_1 649 652 PF00917 0.483
LIG_TYR_ITIM 508 513 PF00017 0.293
LIG_UBA3_1 630 637 PF00899 0.405
LIG_WRC_WIRS_1 158 163 PF05994 0.709
LIG_WRC_WIRS_1 692 697 PF05994 0.374
MOD_CK1_1 132 138 PF00069 0.515
MOD_CK1_1 154 160 PF00069 0.677
MOD_CK1_1 2 8 PF00069 0.697
MOD_CK1_1 368 374 PF00069 0.678
MOD_CK1_1 646 652 PF00069 0.330
MOD_CK2_1 358 364 PF00069 0.622
MOD_CK2_1 446 452 PF00069 0.443
MOD_CK2_1 58 64 PF00069 0.476
MOD_CK2_1 646 652 PF00069 0.483
MOD_CK2_1 711 717 PF00069 0.391
MOD_CK2_1 92 98 PF00069 0.514
MOD_Cter_Amidation 585 588 PF01082 0.483
MOD_GlcNHglycan 10 13 PF01048 0.572
MOD_GlcNHglycan 127 130 PF01048 0.539
MOD_GlcNHglycan 153 157 PF01048 0.670
MOD_GlcNHglycan 161 164 PF01048 0.668
MOD_GlcNHglycan 194 197 PF01048 0.662
MOD_GlcNHglycan 246 249 PF01048 0.413
MOD_GlcNHglycan 291 294 PF01048 0.574
MOD_GlcNHglycan 364 368 PF01048 0.682
MOD_GlcNHglycan 370 373 PF01048 0.663
MOD_GlcNHglycan 414 417 PF01048 0.707
MOD_GlcNHglycan 418 421 PF01048 0.636
MOD_GlcNHglycan 523 526 PF01048 0.388
MOD_GlcNHglycan 6 9 PF01048 0.671
MOD_GlcNHglycan 60 63 PF01048 0.441
MOD_GlcNHglycan 680 683 PF01048 0.449
MOD_GlcNHglycan 90 93 PF01048 0.423
MOD_GSK3_1 125 132 PF00069 0.481
MOD_GSK3_1 147 154 PF00069 0.572
MOD_GSK3_1 194 201 PF00069 0.658
MOD_GSK3_1 237 244 PF00069 0.484
MOD_GSK3_1 260 267 PF00069 0.344
MOD_GSK3_1 289 296 PF00069 0.546
MOD_GSK3_1 3 10 PF00069 0.694
MOD_GSK3_1 359 366 PF00069 0.601
MOD_GSK3_1 412 419 PF00069 0.658
MOD_GSK3_1 442 449 PF00069 0.527
MOD_GSK3_1 462 469 PF00069 0.353
MOD_GSK3_1 567 574 PF00069 0.470
MOD_GSK3_1 639 646 PF00069 0.337
MOD_GSK3_1 687 694 PF00069 0.398
MOD_GSK3_1 711 718 PF00069 0.439
MOD_GSK3_1 88 95 PF00069 0.397
MOD_N-GLC_1 228 233 PF02516 0.351
MOD_N-GLC_1 462 467 PF02516 0.348
MOD_N-GLC_1 678 683 PF02516 0.434
MOD_NEK2_1 1 6 PF00069 0.709
MOD_NEK2_1 116 121 PF00069 0.354
MOD_NEK2_1 358 363 PF00069 0.661
MOD_NEK2_1 56 61 PF00069 0.458
MOD_NEK2_1 591 596 PF00069 0.486
MOD_NEK2_1 672 677 PF00069 0.448
MOD_NEK2_1 678 683 PF00069 0.469
MOD_NEK2_1 711 716 PF00069 0.512
MOD_NEK2_1 723 728 PF00069 0.615
MOD_NEK2_2 250 255 PF00069 0.441
MOD_PIKK_1 466 472 PF00454 0.431
MOD_PKA_2 125 131 PF00069 0.526
MOD_PKA_2 138 144 PF00069 0.440
MOD_PKA_2 2 8 PF00069 0.632
MOD_PKA_2 40 46 PF00069 0.381
MOD_PKA_2 571 577 PF00069 0.412
MOD_Plk_1 359 365 PF00069 0.473
MOD_Plk_1 462 468 PF00069 0.342
MOD_Plk_1 519 525 PF00069 0.476
MOD_Plk_1 605 611 PF00069 0.444
MOD_Plk_2-3 571 577 PF00069 0.402
MOD_Plk_4 129 135 PF00069 0.461
MOD_Plk_4 260 266 PF00069 0.364
MOD_Plk_4 293 299 PF00069 0.424
MOD_Plk_4 462 468 PF00069 0.342
MOD_ProDKin_1 237 243 PF00069 0.389
MOD_ProDKin_1 374 380 PF00069 0.618
MOD_ProDKin_1 447 453 PF00069 0.429
MOD_ProDKin_1 620 626 PF00069 0.454
MOD_ProDKin_1 698 704 PF00069 0.374
MOD_SUMO_rev_2 304 310 PF00179 0.505
TRG_DiLeu_BaEn_1 453 458 PF01217 0.393
TRG_DiLeu_BaEn_1 499 504 PF01217 0.442
TRG_DiLeu_BaLyEn_6 103 108 PF01217 0.445
TRG_DiLeu_BaLyEn_6 52 57 PF01217 0.397
TRG_DiLeu_BaLyEn_6 77 82 PF01217 0.389
TRG_DiLeu_LyEn_5 453 458 PF01217 0.409
TRG_ENDOCYTIC_2 510 513 PF00928 0.292
TRG_ENDOCYTIC_2 79 82 PF00928 0.339
TRG_ER_diArg_1 100 102 PF00400 0.451
TRG_ER_diArg_1 426 429 PF00400 0.510
TRG_ER_diArg_1 527 529 PF00400 0.413
TRG_ER_diArg_1 71 74 PF00400 0.449
TRG_NES_CRM1_1 502 514 PF08389 0.300
TRG_Pf-PMV_PEXEL_1 101 105 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 217 222 PF00026 0.323
TRG_Pf-PMV_PEXEL_1 430 434 PF00026 0.520
TRG_Pf-PMV_PEXEL_1 533 537 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 593 597 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 628 632 PF00026 0.345
TRG_Pf-PMV_PEXEL_1 669 673 PF00026 0.341
TRG_Pf-PMV_PEXEL_1 691 696 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 80 85 PF00026 0.342

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9P1 Leptomonas seymouri 71% 100%
A0A0S4J3E1 Bodo saltans 42% 100%
A0A1X0NXS8 Trypanosomatidae 43% 100%
A0A3Q8IBQ3 Leishmania donovani 99% 99%
A0A3R7KD39 Trypanosoma rangeli 49% 100%
C9ZI84 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AIC1 Leishmania braziliensis 83% 100%
E9AUK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QCX6 Leishmania major 94% 100%
V5BQT5 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS