Putative serine/threonine protein phosphatase 2A regulatory subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase 2A regulatory subunit - putative

Species:

Leishmania infantum

UniProt:

A4HYP6_LEIIN

TriTrypDb:

LINF_200011900

Length:

599

Annotations

Annotations by Jardim et al.

Phosphatase, serine/threonine phosphatase 2A regulatory subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4HYP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYP6

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.694
CLV_C14_Caspase3-7	229	233	PF00656	0.423
CLV_C14_Caspase3-7	9	13	PF00656	0.546
CLV_NRD_NRD_1	131	133	PF00675	0.639
CLV_NRD_NRD_1	148	150	PF00675	0.428
CLV_NRD_NRD_1	196	198	PF00675	0.375
CLV_PCSK_KEX2_1	131	133	PF00082	0.639
CLV_PCSK_KEX2_1	148	150	PF00082	0.428
CLV_PCSK_KEX2_1	196	198	PF00082	0.362
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.583
CLV_PCSK_SKI1_1	273	277	PF00082	0.476
CLV_PCSK_SKI1_1	327	331	PF00082	0.429
CLV_PCSK_SKI1_1	333	337	PF00082	0.373
CLV_PCSK_SKI1_1	390	394	PF00082	0.360
CLV_PCSK_SKI1_1	505	509	PF00082	0.340
CLV_PCSK_SKI1_1	565	569	PF00082	0.475
CLV_Separin_Metazoa	58	62	PF03568	0.396
DEG_APCC_DBOX_1	176	184	PF00400	0.528
DEG_APCC_DBOX_1	504	512	PF00400	0.462
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DEG_ODPH_VHL_1	409	420	PF01847	0.414
DEG_SPOP_SBC_1	116	120	PF00917	0.591
DOC_ANK_TNKS_1	147	154	PF00023	0.547
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.461
DOC_MAPK_DCC_7	539	547	PF00069	0.485
DOC_MAPK_gen_1	40	49	PF00069	0.480
DOC_MAPK_gen_1	425	433	PF00069	0.404
DOC_MAPK_MEF2A_6	40	49	PF00069	0.525
DOC_MAPK_MEF2A_6	539	547	PF00069	0.431
DOC_MAPK_NFAT4_5	42	50	PF00069	0.526
DOC_PP2B_LxvP_1	287	290	PF13499	0.471
DOC_PP2B_LxvP_1	83	86	PF13499	0.491
DOC_USP7_MATH_1	102	106	PF00917	0.367
DOC_USP7_MATH_1	260	264	PF00917	0.438
DOC_USP7_MATH_1	392	396	PF00917	0.376
DOC_USP7_MATH_1	421	425	PF00917	0.535
DOC_USP7_MATH_1	469	473	PF00917	0.371
DOC_USP7_MATH_1	591	595	PF00917	0.660
DOC_USP7_UBL2_3	182	186	PF12436	0.500
DOC_WW_Pin1_4	112	117	PF00397	0.571
DOC_WW_Pin1_4	285	290	PF00397	0.448
DOC_WW_Pin1_4	400	405	PF00397	0.478
LIG_14-3-3_CanoR_1	158	165	PF00244	0.365
LIG_14-3-3_CanoR_1	22	27	PF00244	0.412
LIG_14-3-3_CanoR_1	262	272	PF00244	0.507
LIG_14-3-3_CanoR_1	273	280	PF00244	0.488
LIG_14-3-3_CanoR_1	312	319	PF00244	0.352
LIG_14-3-3_CanoR_1	341	350	PF00244	0.481
LIG_14-3-3_CanoR_1	351	355	PF00244	0.442
LIG_14-3-3_CanoR_1	457	465	PF00244	0.480
LIG_14-3-3_CanoR_1	572	580	PF00244	0.548
LIG_Actin_WH2_2	347	362	PF00022	0.400
LIG_APCC_ABBA_1	535	540	PF00400	0.529
LIG_BIR_III_2	540	544	PF00653	0.496
LIG_BIR_III_4	328	332	PF00653	0.519
LIG_BRCT_BRCA1_1	110	114	PF00533	0.471
LIG_BRCT_BRCA1_1	313	317	PF00533	0.374
LIG_FHA_1	338	344	PF00498	0.507
LIG_FHA_1	370	376	PF00498	0.388
LIG_FHA_1	377	383	PF00498	0.355
LIG_FHA_1	457	463	PF00498	0.497
LIG_FHA_1	48	54	PF00498	0.410
LIG_FHA_1	78	84	PF00498	0.509
LIG_FHA_2	174	180	PF00498	0.514
LIG_FHA_2	39	45	PF00498	0.409
LIG_FHA_2	7	13	PF00498	0.586
LIG_FHA_2	95	101	PF00498	0.399
LIG_LIR_Gen_1	2	11	PF02991	0.494
LIG_LIR_Gen_1	395	404	PF02991	0.427
LIG_LIR_Nem_3	166	172	PF02991	0.323
LIG_LIR_Nem_3	2	7	PF02991	0.484
LIG_LIR_Nem_3	528	534	PF02991	0.459
LIG_LYPXL_S_1	168	172	PF13949	0.315
LIG_LYPXL_yS_3	169	172	PF13949	0.318
LIG_MYND_1	411	415	PF01753	0.397
LIG_Pex14_1	270	274	PF04695	0.407
LIG_SH2_CRK	295	299	PF00017	0.483
LIG_SH2_CRK	512	516	PF00017	0.426
LIG_SH2_STAP1	512	516	PF00017	0.353
LIG_SH2_STAT5	438	441	PF00017	0.487
LIG_SH2_STAT5	48	51	PF00017	0.411
LIG_SH2_STAT5	502	505	PF00017	0.383
LIG_SH2_STAT5	52	55	PF00017	0.418
LIG_SH2_STAT5	79	82	PF00017	0.514
LIG_SH3_3	563	569	PF00018	0.447
LIG_SH3_3	584	590	PF00018	0.521
LIG_SUMO_SIM_par_1	257	263	PF11976	0.504
LIG_SUMO_SIM_par_1	414	419	PF11976	0.413
LIG_TYR_ITSM	165	172	PF00017	0.318
LIG_UBA3_1	180	186	PF00899	0.456
LIG_UBA3_1	553	561	PF00899	0.431
MOD_CDK_SPxxK_3	400	407	PF00069	0.474
MOD_CK1_1	115	121	PF00069	0.613
MOD_CK1_1	123	129	PF00069	0.712
MOD_CK1_1	163	169	PF00069	0.391
MOD_CK1_1	263	269	PF00069	0.431
MOD_CK1_1	353	359	PF00069	0.469
MOD_CK1_1	395	401	PF00069	0.410
MOD_CK1_1	6	12	PF00069	0.498
MOD_CK2_1	304	310	PF00069	0.445
MOD_CK2_1	38	44	PF00069	0.415
MOD_CK2_1	89	95	PF00069	0.411
MOD_Cter_Amidation	330	333	PF01082	0.518
MOD_GlcNHglycan	123	126	PF01048	0.721
MOD_GlcNHglycan	254	257	PF01048	0.450
MOD_GlcNHglycan	313	316	PF01048	0.343
MOD_GlcNHglycan	355	358	PF01048	0.362
MOD_GlcNHglycan	394	397	PF01048	0.379
MOD_GlcNHglycan	445	448	PF01048	0.482
MOD_GlcNHglycan	481	484	PF01048	0.414
MOD_GlcNHglycan	527	530	PF01048	0.523
MOD_GSK3_1	108	115	PF00069	0.443
MOD_GSK3_1	116	123	PF00069	0.635
MOD_GSK3_1	156	163	PF00069	0.461
MOD_GSK3_1	210	217	PF00069	0.464
MOD_GSK3_1	262	269	PF00069	0.463
MOD_GSK3_1	337	344	PF00069	0.483
MOD_GSK3_1	392	399	PF00069	0.388
MOD_GSK3_1	439	446	PF00069	0.447
MOD_NEK2_1	108	113	PF00069	0.469
MOD_NEK2_1	164	169	PF00069	0.406
MOD_NEK2_1	31	36	PF00069	0.427
MOD_NEK2_1	369	374	PF00069	0.380
MOD_NEK2_1	554	559	PF00069	0.468
MOD_NEK2_1	592	597	PF00069	0.622
MOD_PIKK_1	108	114	PF00454	0.467
MOD_PIKK_1	249	255	PF00454	0.461
MOD_PKA_1	132	138	PF00069	0.535
MOD_PKA_2	157	163	PF00069	0.359
MOD_PKA_2	21	27	PF00069	0.435
MOD_PKA_2	311	317	PF00069	0.353
MOD_PKA_2	350	356	PF00069	0.478
MOD_PKA_2	456	462	PF00069	0.478
MOD_PKB_1	271	279	PF00069	0.483
MOD_Plk_1	266	272	PF00069	0.392
MOD_Plk_1	345	351	PF00069	0.470
MOD_Plk_1	94	100	PF00069	0.408
MOD_Plk_2-3	94	100	PF00069	0.408
MOD_Plk_4	160	166	PF00069	0.356
MOD_Plk_4	241	247	PF00069	0.428
MOD_Plk_4	370	376	PF00069	0.400
MOD_Plk_4	409	415	PF00069	0.506
MOD_Plk_4	485	491	PF00069	0.423
MOD_Plk_4	492	498	PF00069	0.457
MOD_Plk_4	6	12	PF00069	0.475
MOD_Plk_4	66	72	PF00069	0.379
MOD_Plk_4	79	85	PF00069	0.386
MOD_ProDKin_1	112	118	PF00069	0.577
MOD_ProDKin_1	285	291	PF00069	0.444
MOD_ProDKin_1	400	406	PF00069	0.471
MOD_SUMO_for_1	227	230	PF00179	0.549
MOD_SUMO_rev_2	399	409	PF00179	0.563
TRG_ENDOCYTIC_2	169	172	PF00928	0.306
TRG_ENDOCYTIC_2	512	515	PF00928	0.358
TRG_ER_diArg_1	147	149	PF00400	0.527
TRG_ER_diArg_1	195	197	PF00400	0.366
TRG_ER_diArg_1	270	273	PF00400	0.388
TRG_ER_diArg_1	426	429	PF00400	0.371
TRG_NES_CRM1_1	88	101	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	23%	82%
A0A0N1IM26	Leptomonas seymouri	84%	100%
A0A0S4IUU5	Bodo saltans	27%	95%
A0A0S4J1S0	Bodo saltans	24%	97%
A0A0S4J2C5	Bodo saltans	54%	100%
A0A1X0NWU2	Trypanosomatidae	60%	100%
A0A1X0P6U3	Trypanosomatidae	24%	100%
A0A3Q8IBL0	Leishmania donovani	100%	100%
A0A3R7MGY7	Trypanosoma rangeli	59%	100%
A4H9H6	Leishmania braziliensis	23%	84%
C9ZI85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZZW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AIC2	Leishmania braziliensis	91%	100%
E9AUK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P30153	Homo sapiens	36%	100%
P30154	Homo sapiens	35%	100%
P31383	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	94%
P36179	Drosophila melanogaster	33%	100%
P54612	Sus scrofa	36%	100%
P54613	Sus scrofa	35%	100%
Q09543	Caenorhabditis elegans	33%	100%
Q32PI5	Bos taurus	36%	100%
Q38845	Arabidopsis thaliana	33%	100%
Q38950	Arabidopsis thaliana	34%	100%
Q38951	Arabidopsis thaliana	33%	100%
Q4QCX5	Leishmania major	97%	100%
Q4QQT4	Rattus norvegicus	35%	100%
Q54QR9	Dictyostelium discoideum	33%	100%
Q76MZ3	Mus musculus	36%	100%
Q7TNP2	Mus musculus	35%	100%
Q9UT08	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
V5C089	Trypanosoma cruzi	57%	100%