Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYP5_LEIIN

TriTrypDb:

LINF_200012000

Length:

248

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HYP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYP5

PDB structure(s): 7aih_Ap , 7am2_Ap , 7ane_Ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.518
CLV_NRD_NRD_1	3	5	PF00675	0.558
CLV_PCSK_KEX2_1	157	159	PF00082	0.523
CLV_PCSK_KEX2_1	3	5	PF00082	0.558
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.548
CLV_PCSK_SKI1_1	111	115	PF00082	0.376
CLV_PCSK_SKI1_1	50	54	PF00082	0.399
CLV_PCSK_SKI1_1	79	83	PF00082	0.360
CLV_Separin_Metazoa	71	75	PF03568	0.348
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DOC_CYCLIN_RxL_1	84	94	PF00134	0.441
DOC_MAPK_gen_1	108	116	PF00069	0.303
DOC_MAPK_gen_1	157	166	PF00069	0.313
DOC_MAPK_gen_1	19	28	PF00069	0.483
DOC_MAPK_MEF2A_6	108	116	PF00069	0.402
DOC_MAPK_MEF2A_6	74	82	PF00069	0.364
DOC_PP1_RVXF_1	77	84	PF00149	0.341
DOC_PP2B_LxvP_1	26	29	PF13499	0.442
DOC_PP4_FxxP_1	53	56	PF00568	0.405
DOC_PP4_FxxP_1	83	86	PF00568	0.378
DOC_USP7_MATH_1	103	107	PF00917	0.365
DOC_USP7_MATH_1	215	219	PF00917	0.627
DOC_USP7_MATH_1	234	238	PF00917	0.399
DOC_USP7_MATH_1	242	246	PF00917	0.486
DOC_USP7_MATH_1	29	33	PF00917	0.469
LIG_14-3-3_CanoR_1	178	184	PF00244	0.494
LIG_14-3-3_CanoR_1	25	29	PF00244	0.396
LIG_14-3-3_CanoR_1	3	7	PF00244	0.511
LIG_BIR_III_2	210	214	PF00653	0.569
LIG_CaM_IQ_9	143	159	PF13499	0.409
LIG_EH1_1	143	151	PF00400	0.517
LIG_eIF4E_1	76	82	PF01652	0.316
LIG_FHA_1	128	134	PF00498	0.409
LIG_FHA_1	141	147	PF00498	0.521
LIG_LIR_Apic_2	51	56	PF02991	0.403
LIG_LIR_Nem_3	131	137	PF02991	0.449
LIG_LRP6_Inhibitor_1	57	63	PF00058	0.430
LIG_MYND_1	16	20	PF01753	0.487
LIG_PCNA_yPIPBox_3	43	53	PF02747	0.409
LIG_Pex14_2	204	208	PF04695	0.459
LIG_SH2_STAT3	137	140	PF00017	0.380
LIG_SH2_STAT5	137	140	PF00017	0.353
LIG_SH2_STAT5	76	79	PF00017	0.344
LIG_SH3_3	9	15	PF00018	0.532
LIG_SH3_4	55	62	PF00018	0.441
LIG_SUMO_SIM_par_1	88	94	PF11976	0.362
LIG_TYR_ITIM	133	138	PF00017	0.372
LIG_UBA3_1	89	97	PF00899	0.439
MOD_CK1_1	237	243	PF00069	0.567
MOD_CK1_1	32	38	PF00069	0.399
MOD_CK2_1	237	243	PF00069	0.575
MOD_GlcNHglycan	105	108	PF01048	0.395
MOD_GlcNHglycan	217	220	PF01048	0.503
MOD_N-GLC_1	127	132	PF02516	0.375
MOD_NEK2_1	190	195	PF00069	0.455
MOD_NEK2_1	2	7	PF00069	0.490
MOD_PKA_2	159	165	PF00069	0.487
MOD_PKA_2	2	8	PF00069	0.516
MOD_PKA_2	24	30	PF00069	0.393
MOD_Plk_1	32	38	PF00069	0.407
MOD_Plk_4	190	196	PF00069	0.465
MOD_Plk_4	32	38	PF00069	0.389
MOD_SUMO_rev_2	161	166	PF00179	0.603
MOD_SUMO_rev_2	205	213	PF00179	0.552
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.423
TRG_ENDOCYTIC_2	135	138	PF00928	0.370
TRG_ER_diArg_1	2	4	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG2	Leptomonas seymouri	31%	100%
A0A0N1PDB1	Leptomonas seymouri	75%	99%
A0A0S4IZI9	Bodo saltans	52%	100%
A0A0S4JXP9	Bodo saltans	28%	81%
A0A1X0NWE3	Trypanosomatidae	67%	100%
A0A1X0P2D2	Trypanosomatidae	27%	100%
A0A3S7WW24	Leishmania donovani	100%	100%
A0A3S7X2W2	Leishmania donovani	29%	100%
A0A422N627	Trypanosoma rangeli	32%	99%
A0A422NJN4	Trypanosoma rangeli	70%	98%
A4HHV1	Leishmania braziliensis	30%	100%
A4I501	Leishmania infantum	31%	100%
C9ZI86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZQF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	82%
E9AIC3	Leishmania braziliensis	87%	100%
E9AUL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B0D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q7V3	Leishmania major	29%	100%
Q4QCX4	Leishmania major	95%	100%
V5BCA8	Trypanosoma cruzi	34%	99%
V5BVG0	Trypanosoma cruzi	70%	100%