LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
Sugar (and other) transporter/Major Facilitator Superfamily - putative
Species:
Leishmania infantum
UniProt:
A4HYN7_LEIIN
TriTrypDb:
LINF_200008700
Length:
732

Annotations

LeishMANIAdb annotations

A transporter protein family expanded in Kinetoplastids. Distantly similar to animal hem transporters (human FLVCR).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0020016 ciliary pocket 2 1

Phosphorylation

Promastigote: 218

Expansion

Sequence features

A4HYN7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYN7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 11
GO:0022857 transmembrane transporter activity 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 321 325 PF00656 0.783
CLV_C14_Caspase3-7 652 656 PF00656 0.696
CLV_NRD_NRD_1 239 241 PF00675 0.569
CLV_NRD_NRD_1 392 394 PF00675 0.299
CLV_NRD_NRD_1 588 590 PF00675 0.340
CLV_NRD_NRD_1 641 643 PF00675 0.491
CLV_NRD_NRD_1 668 670 PF00675 0.608
CLV_NRD_NRD_1 81 83 PF00675 0.274
CLV_PCSK_KEX2_1 239 241 PF00082 0.552
CLV_PCSK_KEX2_1 392 394 PF00082 0.299
CLV_PCSK_KEX2_1 588 590 PF00082 0.365
CLV_PCSK_KEX2_1 641 643 PF00082 0.507
CLV_PCSK_KEX2_1 668 670 PF00082 0.615
CLV_PCSK_KEX2_1 81 83 PF00082 0.274
CLV_PCSK_PC7_1 77 83 PF00082 0.274
CLV_PCSK_SKI1_1 362 366 PF00082 0.390
CLV_PCSK_SKI1_1 43 47 PF00082 0.453
CLV_PCSK_SKI1_1 660 664 PF00082 0.491
CLV_PCSK_SKI1_1 684 688 PF00082 0.434
CLV_PCSK_SKI1_1 82 86 PF00082 0.274
DEG_SPOP_SBC_1 168 172 PF00917 0.291
DEG_SPOP_SBC_1 555 559 PF00917 0.327
DOC_ANK_TNKS_1 289 296 PF00023 0.638
DOC_CDC14_PxL_1 97 105 PF14671 0.278
DOC_CKS1_1 126 131 PF01111 0.342
DOC_MAPK_gen_1 392 398 PF00069 0.462
DOC_MAPK_gen_1 456 466 PF00069 0.502
DOC_MAPK_JIP1_4 105 111 PF00069 0.274
DOC_MAPK_MEF2A_6 105 113 PF00069 0.274
DOC_MAPK_MEF2A_6 459 466 PF00069 0.469
DOC_PP1_SILK_1 94 99 PF00149 0.278
DOC_PP2B_LxvP_1 111 114 PF13499 0.253
DOC_PP2B_LxvP_1 161 164 PF13499 0.282
DOC_PP2B_LxvP_1 200 203 PF13499 0.445
DOC_PP2B_LxvP_1 481 484 PF13499 0.363
DOC_PP4_FxxP_1 162 165 PF00568 0.329
DOC_PP4_FxxP_1 199 202 PF00568 0.344
DOC_PP4_FxxP_1 205 208 PF00568 0.501
DOC_USP7_MATH_1 297 301 PF00917 0.753
DOC_USP7_MATH_1 556 560 PF00917 0.299
DOC_USP7_MATH_1 92 96 PF00917 0.284
DOC_USP7_MATH_2 249 255 PF00917 0.661
DOC_WW_Pin1_4 125 130 PF00397 0.350
DOC_WW_Pin1_4 343 348 PF00397 0.678
DOC_WW_Pin1_4 713 718 PF00397 0.685
LIG_14-3-3_CanoR_1 265 269 PF00244 0.662
LIG_14-3-3_CanoR_1 290 294 PF00244 0.704
LIG_14-3-3_CanoR_1 309 319 PF00244 0.661
LIG_Actin_WH2_2 83 100 PF00022 0.278
LIG_AP2alpha_2 11 13 PF02296 0.542
LIG_BIR_III_4 324 328 PF00653 0.684
LIG_BRCT_BRCA1_1 345 349 PF00533 0.665
LIG_CaM_IQ_9 257 273 PF13499 0.663
LIG_Clathr_ClatBox_1 181 185 PF01394 0.278
LIG_deltaCOP1_diTrp_1 11 15 PF00928 0.537
LIG_eIF4E_1 458 464 PF01652 0.453
LIG_FHA_1 108 114 PF00498 0.279
LIG_FHA_1 126 132 PF00498 0.318
LIG_FHA_1 191 197 PF00498 0.278
LIG_FHA_1 383 389 PF00498 0.524
LIG_FHA_1 48 54 PF00498 0.281
LIG_FHA_1 714 720 PF00498 0.693
LIG_FHA_2 172 178 PF00498 0.285
LIG_FHA_2 349 355 PF00498 0.682
LIG_FHA_2 376 382 PF00498 0.510
LIG_FHA_2 42 48 PF00498 0.229
LIG_FHA_2 650 656 PF00498 0.715
LIG_FHA_2 706 712 PF00498 0.683
LIG_FHA_2 71 77 PF00498 0.278
LIG_Integrin_RGD_1 240 242 PF01839 0.440
LIG_LIR_Apic_2 204 208 PF02991 0.458
LIG_LIR_Apic_2 455 461 PF02991 0.497
LIG_LIR_Apic_2 518 524 PF02991 0.518
LIG_LIR_Gen_1 175 186 PF02991 0.268
LIG_LIR_Gen_1 34 41 PF02991 0.256
LIG_LIR_Gen_1 348 358 PF02991 0.711
LIG_LIR_Gen_1 365 374 PF02991 0.529
LIG_LIR_Gen_1 378 387 PF02991 0.566
LIG_LIR_Gen_1 394 402 PF02991 0.568
LIG_LIR_Gen_1 411 420 PF02991 0.352
LIG_LIR_Gen_1 495 504 PF02991 0.292
LIG_LIR_Gen_1 57 68 PF02991 0.278
LIG_LIR_LC3C_4 110 113 PF02991 0.216
LIG_LIR_Nem_3 11 16 PF02991 0.497
LIG_LIR_Nem_3 175 181 PF02991 0.268
LIG_LIR_Nem_3 185 191 PF02991 0.319
LIG_LIR_Nem_3 34 38 PF02991 0.256
LIG_LIR_Nem_3 348 353 PF02991 0.738
LIG_LIR_Nem_3 365 370 PF02991 0.567
LIG_LIR_Nem_3 378 382 PF02991 0.562
LIG_LIR_Nem_3 385 390 PF02991 0.514
LIG_LIR_Nem_3 394 398 PF02991 0.554
LIG_LIR_Nem_3 411 415 PF02991 0.292
LIG_LIR_Nem_3 42 48 PF02991 0.253
LIG_LIR_Nem_3 495 499 PF02991 0.306
LIG_LIR_Nem_3 57 63 PF02991 0.278
LIG_LYPXL_yS_3 460 463 PF13949 0.433
LIG_NRP_CendR_1 730 732 PF00754 0.504
LIG_Pex14_2 178 182 PF04695 0.299
LIG_Pex14_2 349 353 PF04695 0.681
LIG_Pex14_2 496 500 PF04695 0.292
LIG_Rb_LxCxE_1 177 193 PF01857 0.255
LIG_SH2_CRK 35 39 PF00017 0.253
LIG_SH2_CRK 412 416 PF00017 0.278
LIG_SH2_CRK 458 462 PF00017 0.517
LIG_SH2_CRK 60 64 PF00017 0.278
LIG_SH2_GRB2like 618 621 PF00017 0.595
LIG_SH2_NCK_1 35 39 PF00017 0.253
LIG_SH2_SRC 618 621 PF00017 0.595
LIG_SH2_STAP1 35 39 PF00017 0.253
LIG_SH2_STAP1 412 416 PF00017 0.278
LIG_SH2_STAP1 618 622 PF00017 0.614
LIG_SH2_STAT3 336 339 PF00017 0.701
LIG_SH2_STAT5 108 111 PF00017 0.290
LIG_SH2_STAT5 136 139 PF00017 0.453
LIG_SH2_STAT5 350 353 PF00017 0.721
LIG_SH2_STAT5 387 390 PF00017 0.498
LIG_SH2_STAT5 446 449 PF00017 0.292
LIG_SH2_STAT5 498 501 PF00017 0.494
LIG_SH2_STAT5 69 72 PF00017 0.318
LIG_SH3_3 291 297 PF00018 0.701
LIG_SH3_3 312 318 PF00018 0.654
LIG_SH3_3 625 631 PF00018 0.760
LIG_SUMO_SIM_anti_2 563 569 PF11976 0.269
LIG_SUMO_SIM_par_1 164 172 PF11976 0.253
LIG_SUMO_SIM_par_1 540 545 PF11976 0.292
LIG_SUMO_SIM_par_1 563 569 PF11976 0.298
LIG_TRAF2_1 337 340 PF00917 0.747
LIG_TRAF2_1 708 711 PF00917 0.659
LIG_TYR_ITIM 33 38 PF00017 0.278
LIG_UBA3_1 476 482 PF00899 0.292
LIG_Vh1_VBS_1 555 573 PF01044 0.229
LIG_WRC_WIRS_1 376 381 PF05994 0.517
LIG_WRC_WIRS_1 493 498 PF05994 0.292
LIG_WW_2 630 633 PF00397 0.696
MOD_CK1_1 171 177 PF00069 0.290
MOD_CK1_1 300 306 PF00069 0.756
MOD_CK1_1 37 43 PF00069 0.253
MOD_CK1_1 405 411 PF00069 0.309
MOD_CK1_1 545 551 PF00069 0.292
MOD_CK1_1 603 609 PF00069 0.559
MOD_CK1_1 649 655 PF00069 0.746
MOD_CK2_1 171 177 PF00069 0.285
MOD_CK2_1 263 269 PF00069 0.756
MOD_CK2_1 334 340 PF00069 0.744
MOD_CK2_1 375 381 PF00069 0.522
MOD_CK2_1 632 638 PF00069 0.658
MOD_CK2_1 655 661 PF00069 0.728
MOD_CK2_1 70 76 PF00069 0.278
MOD_CK2_1 705 711 PF00069 0.707
MOD_GlcNHglycan 217 220 PF01048 0.405
MOD_GlcNHglycan 224 227 PF01048 0.425
MOD_GlcNHglycan 24 27 PF01048 0.307
MOD_GlcNHglycan 273 277 PF01048 0.581
MOD_GlcNHglycan 302 305 PF01048 0.482
MOD_GlcNHglycan 336 339 PF01048 0.582
MOD_GlcNHglycan 558 561 PF01048 0.549
MOD_GlcNHglycan 602 605 PF01048 0.408
MOD_GlcNHglycan 634 637 PF01048 0.522
MOD_GlcNHglycan 648 651 PF01048 0.546
MOD_GSK3_1 167 174 PF00069 0.289
MOD_GSK3_1 251 258 PF00069 0.698
MOD_GSK3_1 33 40 PF00069 0.289
MOD_GSK3_1 339 346 PF00069 0.715
MOD_GSK3_1 482 489 PF00069 0.398
MOD_GSK3_1 556 563 PF00069 0.345
MOD_GSK3_1 603 610 PF00069 0.549
MOD_N-GLC_1 310 315 PF02516 0.504
MOD_N-GLC_2 537 539 PF02516 0.292
MOD_NEK2_1 124 129 PF00069 0.281
MOD_NEK2_1 402 407 PF00069 0.344
MOD_NEK2_1 46 51 PF00069 0.295
MOD_NEK2_1 466 471 PF00069 0.296
MOD_NEK2_1 504 509 PF00069 0.296
MOD_NEK2_1 517 522 PF00069 0.553
MOD_NEK2_1 55 60 PF00069 0.352
MOD_NEK2_1 70 75 PF00069 0.342
MOD_NEK2_2 41 46 PF00069 0.242
MOD_PIKK_1 206 212 PF00454 0.568
MOD_PKA_1 668 674 PF00069 0.710
MOD_PKA_2 168 174 PF00069 0.261
MOD_PKA_2 264 270 PF00069 0.687
MOD_PKA_2 289 295 PF00069 0.849
MOD_PKA_2 354 360 PF00069 0.629
MOD_PKA_2 668 674 PF00069 0.711
MOD_PKA_2 705 711 PF00069 0.695
MOD_Plk_1 263 269 PF00069 0.669
MOD_Plk_1 310 316 PF00069 0.642
MOD_Plk_1 339 345 PF00069 0.656
MOD_Plk_1 517 523 PF00069 0.526
MOD_Plk_2-3 264 270 PF00069 0.677
MOD_Plk_2-3 348 354 PF00069 0.702
MOD_Plk_2-3 655 661 PF00069 0.713
MOD_Plk_4 1 7 PF00069 0.624
MOD_Plk_4 107 113 PF00069 0.285
MOD_Plk_4 362 368 PF00069 0.591
MOD_Plk_4 382 388 PF00069 0.421
MOD_Plk_4 405 411 PF00069 0.336
MOD_Plk_4 439 445 PF00069 0.350
MOD_Plk_4 466 472 PF00069 0.348
MOD_Plk_4 492 498 PF00069 0.300
MOD_Plk_4 537 543 PF00069 0.341
MOD_Plk_4 545 551 PF00069 0.364
MOD_Plk_4 55 61 PF00069 0.340
MOD_Plk_4 560 566 PF00069 0.232
MOD_Plk_4 682 688 PF00069 0.646
MOD_Plk_4 92 98 PF00069 0.283
MOD_ProDKin_1 125 131 PF00069 0.350
MOD_ProDKin_1 343 349 PF00069 0.678
MOD_ProDKin_1 713 719 PF00069 0.686
MOD_SUMO_rev_2 671 676 PF00179 0.672
TRG_DiLeu_BaLyEn_6 127 132 PF01217 0.351
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.289
TRG_DiLeu_BaLyEn_6 458 463 PF01217 0.479
TRG_ENDOCYTIC_2 108 111 PF00928 0.253
TRG_ENDOCYTIC_2 35 38 PF00928 0.253
TRG_ENDOCYTIC_2 350 353 PF00928 0.682
TRG_ENDOCYTIC_2 387 390 PF00928 0.498
TRG_ENDOCYTIC_2 412 415 PF00928 0.278
TRG_ENDOCYTIC_2 460 463 PF00928 0.488
TRG_ENDOCYTIC_2 60 63 PF00928 0.294
TRG_ER_diArg_1 587 589 PF00400 0.537
TRG_ER_diArg_1 668 670 PF00400 0.779
TRG_ER_diArg_1 80 82 PF00400 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I416 Leptomonas seymouri 64% 100%
A0A3Q8IBI9 Leishmania donovani 99% 100%
A0A3S5H541 Leishmania donovani 25% 100%
A4H3K8 Leishmania braziliensis 26% 100%
A4HRV1 Leishmania infantum 27% 100%
E9ACI6 Leishmania major 26% 100%
E9AI92 Leishmania braziliensis 69% 99%
E9AJS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AUH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 99%
Q4QD06 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS