LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF2946) - putative
Species:
Leishmania infantum
UniProt:
A4HYN5_LEIIN
TriTrypDb:
LINF_200008900
Length:
320

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 15, no: 2
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

A4HYN5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYN5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 193 197 PF00656 0.437
CLV_C14_Caspase3-7 277 281 PF00656 0.693
CLV_C14_Caspase3-7 309 313 PF00656 0.677
CLV_PCSK_KEX2_1 2 4 PF00082 0.731
CLV_PCSK_KEX2_1 263 265 PF00082 0.408
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.723
CLV_PCSK_PC1ET2_1 263 265 PF00082 0.394
DEG_Nend_UBRbox_1 1 4 PF02207 0.654
DOC_CYCLIN_yClb1_LxF_4 110 116 PF00134 0.414
DOC_MAPK_gen_1 7 15 PF00069 0.315
DOC_MAPK_MEF2A_6 9 17 PF00069 0.356
DOC_WW_Pin1_4 1 6 PF00397 0.658
DOC_WW_Pin1_4 293 298 PF00397 0.757
LIG_14-3-3_CanoR_1 27 32 PF00244 0.287
LIG_14-3-3_CanoR_1 36 43 PF00244 0.227
LIG_14-3-3_CanoR_1 7 15 PF00244 0.456
LIG_Actin_WH2_2 112 128 PF00022 0.407
LIG_eIF4E_1 209 215 PF01652 0.428
LIG_FHA_1 172 178 PF00498 0.343
LIG_FHA_1 21 27 PF00498 0.352
LIG_FHA_1 8 14 PF00498 0.461
LIG_FHA_2 191 197 PF00498 0.402
LIG_FHA_2 275 281 PF00498 0.706
LIG_LIR_Gen_1 131 142 PF02991 0.444
LIG_LIR_Nem_3 114 120 PF02991 0.310
LIG_LIR_Nem_3 131 137 PF02991 0.439
LIG_LIR_Nem_3 179 183 PF02991 0.332
LIG_LIR_Nem_3 189 194 PF02991 0.410
LIG_NRBOX 13 19 PF00104 0.313
LIG_PCNA_yPIPBox_3 165 173 PF02747 0.415
LIG_Pex14_1 176 180 PF04695 0.275
LIG_SH2_CRK 117 121 PF00017 0.307
LIG_SH2_NCK_1 310 314 PF00017 0.631
LIG_SH2_SRC 183 186 PF00017 0.500
LIG_SH2_STAP1 173 177 PF00017 0.286
LIG_SH2_STAP1 29 33 PF00017 0.312
LIG_SH2_STAT3 172 175 PF00017 0.404
LIG_SH2_STAT3 181 184 PF00017 0.443
LIG_SH2_STAT3 50 53 PF00017 0.278
LIG_SH2_STAT5 173 176 PF00017 0.305
LIG_SH2_STAT5 261 264 PF00017 0.591
LIG_SH2_STAT5 50 53 PF00017 0.305
LIG_SH3_3 136 142 PF00018 0.467
LIG_SH3_3 189 195 PF00018 0.461
LIG_SUMO_SIM_anti_2 244 250 PF11976 0.377
LIG_SUMO_SIM_par_1 238 244 PF11976 0.315
MOD_CDC14_SPxK_1 4 7 PF00782 0.471
MOD_CDK_SPxK_1 1 7 PF00069 0.504
MOD_CK1_1 186 192 PF00069 0.620
MOD_CK1_1 56 62 PF00069 0.394
MOD_CK1_1 89 95 PF00069 0.566
MOD_CK2_1 157 163 PF00069 0.346
MOD_CK2_1 308 314 PF00069 0.710
MOD_GlcNHglycan 37 40 PF01048 0.408
MOD_GlcNHglycan 54 58 PF01048 0.421
MOD_GlcNHglycan 69 72 PF01048 0.421
MOD_GlcNHglycan 91 94 PF01048 0.632
MOD_GSK3_1 186 193 PF00069 0.502
MOD_GSK3_1 3 10 PF00069 0.536
MOD_GSK3_1 63 70 PF00069 0.404
MOD_GSK3_1 89 96 PF00069 0.435
MOD_N-GLC_1 146 151 PF02516 0.611
MOD_N-GLC_1 97 102 PF02516 0.469
MOD_NEK2_1 20 25 PF00069 0.332
MOD_NEK2_2 121 126 PF00069 0.394
MOD_PIKK_1 171 177 PF00454 0.434
MOD_PIKK_1 216 222 PF00454 0.606
MOD_PIKK_1 284 290 PF00454 0.545
MOD_PK_1 27 33 PF00069 0.276
MOD_PKA_2 216 222 PF00069 0.566
MOD_PKA_2 35 41 PF00069 0.249
MOD_PKA_2 89 95 PF00069 0.584
MOD_Plk_1 111 117 PF00069 0.323
MOD_Plk_1 146 152 PF00069 0.599
MOD_Plk_1 186 192 PF00069 0.585
MOD_Plk_1 97 103 PF00069 0.541
MOD_Plk_2-3 308 314 PF00069 0.652
MOD_Plk_4 111 117 PF00069 0.359
MOD_Plk_4 146 152 PF00069 0.570
MOD_Plk_4 168 174 PF00069 0.372
MOD_Plk_4 186 192 PF00069 0.396
MOD_Plk_4 56 62 PF00069 0.301
MOD_ProDKin_1 1 7 PF00069 0.654
MOD_ProDKin_1 293 299 PF00069 0.706
TRG_ENDOCYTIC_2 117 120 PF00928 0.359
TRG_ENDOCYTIC_2 134 137 PF00928 0.420
TRG_Pf-PMV_PEXEL_1 222 226 PF00026 0.558

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P471 Leptomonas seymouri 66% 100%
A0A0N1I022 Leptomonas seymouri 34% 94%
A0A1X0NWG7 Trypanosomatidae 34% 87%
A0A1X0NWG9 Trypanosomatidae 34% 88%
A0A1X0NXT1 Trypanosomatidae 33% 88%
A0A1X0NY10 Trypanosomatidae 30% 100%
A0A3Q8IBH3 Leishmania donovani 98% 100%
A0A3S5H4S6 Leishmania donovani 37% 96%
A4H335 Leishmania braziliensis 36% 100%
A4HRC3 Leishmania infantum 35% 100%
E9ABZ0 Leishmania major 36% 100%
E9AI94 Leishmania braziliensis 74% 100%
E9AJ87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AUH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QD05 Leishmania major 96% 100%
V5DS51 Trypanosoma cruzi 33% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS