LeishMANIAdb
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Putative calpain-like cysteine peptidase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative calpain-like cysteine peptidase
Gene product:
cysteine peptidase - Clan CA - family C2 - putative
Species:
Leishmania infantum
UniProt:
A4HYN0_LEIIN
TriTrypDb:
LINF_200016900
Length:
821

Annotations

Annotations by Jardim et al.

Proteases, calpain-like cysteine peptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 3
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 16
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 102
NetGPI no yes: 0, no: 104
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 5
GO:0005815 microtubule organizing center 2 1
GO:0005856 cytoskeleton 5 1
GO:0020016 ciliary pocket 2 1
GO:0020038 subpellicular network 2 1
GO:0030863 cortical cytoskeleton 6 1
GO:0036064 ciliary basal body 3 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0005930 axoneme 2 1
GO:0016020 membrane 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYN0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYN0

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 105
GO:0006807 nitrogen compound metabolic process 2 105
GO:0008152 metabolic process 1 105
GO:0019538 protein metabolic process 3 105
GO:0043170 macromolecule metabolic process 3 105
GO:0044238 primary metabolic process 2 105
GO:0071704 organic substance metabolic process 2 105
GO:1901564 organonitrogen compound metabolic process 3 105
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 105
GO:0004175 endopeptidase activity 4 105
GO:0004197 cysteine-type endopeptidase activity 5 105
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6 105
GO:0008233 peptidase activity 3 105
GO:0008234 cysteine-type peptidase activity 4 105
GO:0016787 hydrolase activity 2 105
GO:0140096 catalytic activity, acting on a protein 2 105

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 141 145 PF00656 0.375
CLV_C14_Caspase3-7 303 307 PF00656 0.491
CLV_C14_Caspase3-7 378 382 PF00656 0.422
CLV_C14_Caspase3-7 617 621 PF00656 0.528
CLV_NRD_NRD_1 284 286 PF00675 0.426
CLV_NRD_NRD_1 621 623 PF00675 0.372
CLV_PCSK_KEX2_1 284 286 PF00082 0.383
CLV_PCSK_KEX2_1 674 676 PF00082 0.379
CLV_PCSK_KEX2_1 774 776 PF00082 0.462
CLV_PCSK_KEX2_1 804 806 PF00082 0.456
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.389
CLV_PCSK_PC1ET2_1 774 776 PF00082 0.491
CLV_PCSK_PC1ET2_1 804 806 PF00082 0.512
CLV_PCSK_SKI1_1 127 131 PF00082 0.579
CLV_PCSK_SKI1_1 285 289 PF00082 0.529
CLV_PCSK_SKI1_1 340 344 PF00082 0.358
CLV_PCSK_SKI1_1 431 435 PF00082 0.302
CLV_PCSK_SKI1_1 447 451 PF00082 0.161
CLV_PCSK_SKI1_1 569 573 PF00082 0.243
CLV_PCSK_SKI1_1 716 720 PF00082 0.438
DEG_SCF_FBW7_2 156 161 PF00400 0.496
DEG_SIAH_1 117 125 PF03145 0.347
DOC_PP1_RVXF_1 419 425 PF00149 0.457
DOC_PP1_RVXF_1 577 584 PF00149 0.515
DOC_PP4_FxxP_1 189 192 PF00568 0.275
DOC_PP4_FxxP_1 322 325 PF00568 0.508
DOC_PP4_FxxP_1 402 405 PF00568 0.461
DOC_USP7_MATH_1 389 393 PF00917 0.476
DOC_USP7_MATH_1 47 51 PF00917 0.621
DOC_USP7_MATH_2 355 361 PF00917 0.512
DOC_USP7_UBL2_3 465 469 PF12436 0.456
DOC_USP7_UBL2_3 619 623 PF12436 0.482
DOC_WW_Pin1_4 113 118 PF00397 0.626
DOC_WW_Pin1_4 154 159 PF00397 0.415
DOC_WW_Pin1_4 49 54 PF00397 0.722
DOC_WW_Pin1_4 525 530 PF00397 0.463
DOC_WW_Pin1_4 658 663 PF00397 0.403
LIG_14-3-3_CanoR_1 127 133 PF00244 0.553
LIG_14-3-3_CanoR_1 284 292 PF00244 0.507
LIG_14-3-3_CanoR_1 421 425 PF00244 0.443
LIG_14-3-3_CanoR_1 711 720 PF00244 0.495
LIG_Actin_WH2_2 257 274 PF00022 0.309
LIG_Actin_WH2_2 432 449 PF00022 0.540
LIG_BIR_II_1 1 5 PF00653 0.477
LIG_BIR_III_2 595 599 PF00653 0.362
LIG_BRCT_BRCA1_1 769 773 PF00533 0.452
LIG_Clathr_ClatBox_1 793 797 PF01394 0.541
LIG_CtBP_PxDLS_1 355 359 PF00389 0.364
LIG_deltaCOP1_diTrp_1 582 587 PF00928 0.453
LIG_deltaCOP1_diTrp_1 715 719 PF00928 0.408
LIG_eIF4E_1 544 550 PF01652 0.471
LIG_FHA_1 124 130 PF00498 0.589
LIG_FHA_1 266 272 PF00498 0.313
LIG_FHA_1 286 292 PF00498 0.448
LIG_FHA_1 645 651 PF00498 0.415
LIG_FHA_1 664 670 PF00498 0.430
LIG_FHA_2 252 258 PF00498 0.392
LIG_FHA_2 301 307 PF00498 0.491
LIG_FHA_2 4 10 PF00498 0.491
LIG_FHA_2 554 560 PF00498 0.467
LIG_FHA_2 590 596 PF00498 0.553
LIG_LIR_Apic_2 187 192 PF02991 0.263
LIG_LIR_Gen_1 464 475 PF02991 0.462
LIG_LIR_Gen_1 490 497 PF02991 0.474
LIG_LIR_Gen_1 508 519 PF02991 0.462
LIG_LIR_Gen_1 542 550 PF02991 0.471
LIG_LIR_Gen_1 663 669 PF02991 0.339
LIG_LIR_Gen_1 714 725 PF02991 0.402
LIG_LIR_Nem_3 205 209 PF02991 0.285
LIG_LIR_Nem_3 436 441 PF02991 0.484
LIG_LIR_Nem_3 457 462 PF02991 0.445
LIG_LIR_Nem_3 464 470 PF02991 0.451
LIG_LIR_Nem_3 473 477 PF02991 0.440
LIG_LIR_Nem_3 508 514 PF02991 0.429
LIG_LIR_Nem_3 542 547 PF02991 0.414
LIG_LIR_Nem_3 663 668 PF02991 0.361
LIG_LIR_Nem_3 681 686 PF02991 0.412
LIG_LIR_Nem_3 697 702 PF02991 0.306
LIG_LIR_Nem_3 714 720 PF02991 0.424
LIG_LIR_Nem_3 770 776 PF02991 0.367
LIG_LIR_Nem_3 784 789 PF02991 0.438
LIG_LIR_Nem_3 9 13 PF02991 0.500
LIG_PDZ_Class_3 816 821 PF00595 0.476
LIG_Pex14_2 614 618 PF04695 0.454
LIG_SH2_CRK 467 471 PF00017 0.451
LIG_SH2_CRK 474 478 PF00017 0.451
LIG_SH2_CRK 522 526 PF00017 0.473
LIG_SH2_CRK 544 548 PF00017 0.446
LIG_SH2_CRK 683 687 PF00017 0.381
LIG_SH2_CRK 699 703 PF00017 0.460
LIG_SH2_CRK 86 90 PF00017 0.489
LIG_SH2_GRB2like 280 283 PF00017 0.497
LIG_SH2_GRB2like 624 627 PF00017 0.441
LIG_SH2_NCK_1 544 548 PF00017 0.478
LIG_SH2_NCK_1 86 90 PF00017 0.489
LIG_SH2_NCK_1 93 97 PF00017 0.473
LIG_SH2_PTP2 736 739 PF00017 0.371
LIG_SH2_SRC 438 441 PF00017 0.470
LIG_SH2_STAP1 215 219 PF00017 0.296
LIG_SH2_STAP1 448 452 PF00017 0.487
LIG_SH2_STAP1 638 642 PF00017 0.319
LIG_SH2_STAP1 70 74 PF00017 0.736
LIG_SH2_STAP1 93 97 PF00017 0.779
LIG_SH2_STAT5 245 248 PF00017 0.329
LIG_SH2_STAT5 438 441 PF00017 0.461
LIG_SH2_STAT5 522 525 PF00017 0.465
LIG_SH2_STAT5 555 558 PF00017 0.439
LIG_SH2_STAT5 56 59 PF00017 0.750
LIG_SH2_STAT5 624 627 PF00017 0.456
LIG_SH2_STAT5 736 739 PF00017 0.326
LIG_SH2_STAT5 754 757 PF00017 0.334
LIG_SH3_3 247 253 PF00018 0.297
LIG_SH3_3 322 328 PF00018 0.505
LIG_SH3_3 338 344 PF00018 0.539
LIG_SH3_3 656 662 PF00018 0.359
LIG_SH3_3 745 751 PF00018 0.575
LIG_SH3_3 793 799 PF00018 0.437
LIG_SH3_3 92 98 PF00018 0.677
LIG_SH3_5 636 640 PF00018 0.392
LIG_SUMO_SIM_anti_2 724 729 PF11976 0.354
LIG_SUMO_SIM_par_1 652 658 PF11976 0.375
LIG_SUMO_SIM_par_1 684 689 PF11976 0.360
LIG_TRAF2_1 69 72 PF00917 0.788
LIG_TRAF2_1 74 77 PF00917 0.786
LIG_TYR_ITIM 194 199 PF00017 0.321
LIG_UBA3_1 194 202 PF00899 0.327
LIG_UBA3_1 613 619 PF00899 0.362
LIG_UBA3_1 727 735 PF00899 0.430
LIG_WRPW_2 342 345 PF00400 0.362
MOD_CDK_SPxK_1 525 531 PF00069 0.468
MOD_CK1_1 387 393 PF00069 0.475
MOD_CK2_1 143 149 PF00069 0.427
MOD_CK2_1 251 257 PF00069 0.480
MOD_CK2_1 3 9 PF00069 0.728
MOD_CK2_1 387 393 PF00069 0.443
MOD_CK2_1 553 559 PF00069 0.537
MOD_CK2_1 686 692 PF00069 0.354
MOD_CMANNOS 615 618 PF00535 0.255
MOD_GlcNHglycan 118 121 PF01048 0.515
MOD_GlcNHglycan 317 320 PF01048 0.530
MOD_GlcNHglycan 441 444 PF01048 0.287
MOD_GlcNHglycan 450 453 PF01048 0.291
MOD_GlcNHglycan 478 481 PF01048 0.246
MOD_GlcNHglycan 582 586 PF01048 0.310
MOD_GlcNHglycan 651 654 PF01048 0.468
MOD_GlcNHglycan 705 708 PF01048 0.413
MOD_GSK3_1 150 157 PF00069 0.442
MOD_GSK3_1 487 494 PF00069 0.454
MOD_GSK3_1 520 527 PF00069 0.476
MOD_GSK3_1 663 670 PF00069 0.421
MOD_N-GLC_1 209 214 PF02516 0.299
MOD_N-GLC_1 233 238 PF02516 0.322
MOD_N-GLC_1 3 8 PF02516 0.704
MOD_N-GLC_1 678 683 PF02516 0.585
MOD_N-GLC_1 703 708 PF02516 0.375
MOD_NEK2_1 150 155 PF00069 0.488
MOD_NEK2_1 232 237 PF00069 0.262
MOD_NEK2_1 260 265 PF00069 0.371
MOD_NEK2_1 379 384 PF00069 0.467
MOD_NEK2_1 434 439 PF00069 0.494
MOD_NEK2_1 470 475 PF00069 0.464
MOD_NEK2_1 497 502 PF00069 0.514
MOD_NEK2_1 614 619 PF00069 0.455
MOD_NEK2_1 703 708 PF00069 0.416
MOD_NEK2_2 491 496 PF00069 0.541
MOD_NEK2_2 767 772 PF00069 0.521
MOD_OFUCOSY 181 188 PF10250 0.171
MOD_PIKK_1 357 363 PF00454 0.522
MOD_PIKK_1 667 673 PF00454 0.338
MOD_PIKK_1 811 817 PF00454 0.549
MOD_PKA_2 420 426 PF00069 0.436
MOD_PKA_2 710 716 PF00069 0.551
MOD_Plk_1 169 175 PF00069 0.563
MOD_Plk_1 209 215 PF00069 0.308
MOD_Plk_1 232 238 PF00069 0.276
MOD_Plk_1 497 503 PF00069 0.497
MOD_Plk_1 723 729 PF00069 0.355
MOD_Plk_1 767 773 PF00069 0.440
MOD_Plk_2-3 499 505 PF00069 0.496
MOD_Plk_4 169 175 PF00069 0.574
MOD_Plk_4 379 385 PF00069 0.460
MOD_Plk_4 434 440 PF00069 0.488
MOD_Plk_4 520 526 PF00069 0.493
MOD_Plk_4 553 559 PF00069 0.473
MOD_Plk_4 723 729 PF00069 0.407
MOD_ProDKin_1 113 119 PF00069 0.621
MOD_ProDKin_1 154 160 PF00069 0.417
MOD_ProDKin_1 49 55 PF00069 0.722
MOD_ProDKin_1 525 531 PF00069 0.463
MOD_ProDKin_1 658 664 PF00069 0.406
MOD_SUMO_for_1 787 790 PF00179 0.405
MOD_SUMO_rev_2 498 507 PF00179 0.464
MOD_SUMO_rev_2 559 568 PF00179 0.503
MOD_SUMO_rev_2 681 686 PF00179 0.448
TRG_DiLeu_BaEn_2 254 260 PF01217 0.235
TRG_DiLeu_BaEn_4 15 21 PF01217 0.493
TRG_ENDOCYTIC_2 196 199 PF00928 0.296
TRG_ENDOCYTIC_2 438 441 PF00928 0.480
TRG_ENDOCYTIC_2 467 470 PF00928 0.457
TRG_ENDOCYTIC_2 474 477 PF00928 0.455
TRG_ENDOCYTIC_2 522 525 PF00928 0.454
TRG_ENDOCYTIC_2 544 547 PF00928 0.453
TRG_ENDOCYTIC_2 555 558 PF00928 0.487
TRG_ENDOCYTIC_2 683 686 PF00928 0.360
TRG_ENDOCYTIC_2 699 702 PF00928 0.394
TRG_ENDOCYTIC_2 736 739 PF00928 0.301
TRG_ENDOCYTIC_2 93 96 PF00928 0.493
TRG_ER_diArg_1 124 127 PF00400 0.589
TRG_Pf-PMV_PEXEL_1 11 15 PF00026 0.494
TRG_Pf-PMV_PEXEL_1 285 289 PF00026 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8T6 Leptomonas seymouri 33% 100%
A0A0N1I8N2 Leptomonas seymouri 29% 83%
A0A0N1IGQ2 Leptomonas seymouri 32% 100%
A0A0N1ILF1 Leptomonas seymouri 40% 100%
A0A0N1IMH1 Leptomonas seymouri 34% 100%
A0A0N1P9P1 Leptomonas seymouri 40% 96%
A0A0N1PCA9 Leptomonas seymouri 35% 100%
A0A0N1PE91 Leptomonas seymouri 28% 92%
A0A0N1PFI4 Leptomonas seymouri 36% 100%
A0A0S4JLK6 Bodo saltans 30% 100%
A0A0S4KGT2 Bodo saltans 40% 100%
A0A0S4KKP7 Bodo saltans 24% 100%
A0A1X0NJ19 Trypanosomatidae 28% 67%
A0A1X0NJK2 Trypanosomatidae 31% 100%
A0A1X0NJX8 Trypanosomatidae 36% 100%
A0A1X0NKT7 Trypanosomatidae 32% 100%
A0A1X0NKX8 Trypanosomatidae 32% 100%
A0A1X0NMT3 Trypanosomatidae 41% 96%
A0A1X0NW84 Trypanosomatidae 39% 100%
A0A1X0NW85 Trypanosomatidae 38% 100%
A0A1X0NW89 Trypanosomatidae 55% 95%
A0A1X0NWA6 Trypanosomatidae 30% 94%
A0A1X0NWW1 Trypanosomatidae 40% 100%
A0A3Q8IBS3 Leishmania donovani 99% 90%
A0A3Q8IDD4 Leishmania donovani 34% 100%
A0A3Q8IJT4 Leishmania donovani 25% 100%
A0A3S5H5A5 Leishmania donovani 41% 96%
A0A3S5ISG2 Trypanosoma rangeli 32% 100%
A0A3S7WW13 Leishmania donovani 27% 74%
A0A3S7WW18 Leishmania donovani 100% 100%
A0A3S7WW41 Leishmania donovani 35% 100%
A0A3S7WW71 Leishmania donovani 40% 100%
A0A3S7X430 Leishmania donovani 34% 100%
A0A3S7X438 Leishmania donovani 30% 87%
A0A3S7X460 Leishmania donovani 35% 100%
A0A3S7X463 Leishmania donovani 26% 88%
A0A3S7X470 Leishmania donovani 35% 100%
A0A422MYU1 Trypanosoma rangeli 52% 89%
A0A422MYX0 Trypanosoma rangeli 38% 100%
A4H3W4 Leishmania braziliensis 40% 100%
A4HE81 Leishmania braziliensis 34% 100%
A4HJ14 Leishmania braziliensis 34% 100%
A4HJ22 Leishmania braziliensis 32% 100%
A4HJ24 Leishmania braziliensis 34% 100%
A4HS39 Leishmania infantum 41% 100%
A4HYW1 Leishmania infantum 99% 81%
A4HYW2 Leishmania infantum 40% 100%
A4HYW3 Leishmania infantum 36% 100%
A4HYW4 Leishmania infantum 28% 82%
A4I1J4 Leishmania infantum 34% 100%
A4I6E4 Leishmania infantum 35% 100%
A4I6E6 Leishmania infantum 35% 100%
A4I6F0 Leishmania infantum 30% 87%
A4I6K4 Leishmania infantum 34% 100%
A4I6K5 Leishmania infantum 26% 88%
A4I6K6 Leishmania infantum 25% 100%
C9ZIE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 76%
C9ZIE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZIE9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZN52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZN53 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 96%
C9ZWY4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZY36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 96%
E8NHG6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E8NHG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E8NHG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E8NHM2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E8NHM4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E8NHM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AIH1 Leishmania braziliensis 84% 99%
E9AIH3 Leishmania braziliensis 40% 100%
E9AIH4 Leishmania braziliensis 36% 100%
E9AIH6 Leishmania braziliensis 28% 100%
E9AK26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AUQ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AUQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AUR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AUR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AXM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B1J0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B1J1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1J2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B1J6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
Q4Q6L7 Leishmania major 35% 100%
Q4Q6L9 Leishmania major 35% 100%
Q4Q6M0 Leishmania major 31% 100%
Q4Q6M2 Leishmania major 26% 100%
Q4Q6M3 Leishmania major 27% 100%
Q4Q6M4 Leishmania major 33% 100%
Q4Q9U3 Leishmania major 34% 100%
Q4QCS6 Leishmania major 36% 100%
Q4QCS7 Leishmania major 40% 100%
Q4QCS8 Leishmania major 95% 100%
Q4QCS9 Leishmania major 95% 100%
Q9U0T9 Leishmania major 41% 100%
V5AYJ1 Trypanosoma cruzi 31% 100%
V5B5I4 Trypanosoma cruzi 54% 98%
V5BA05 Trypanosoma cruzi 41% 100%
V5BEL3 Trypanosoma cruzi 37% 100%
V5BII7 Trypanosoma cruzi 29% 67%
V5BN20 Trypanosoma cruzi 33% 100%
V5D9Y2 Trypanosoma cruzi 41% 97%
V5DES7 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS