LeishMANIAdb
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Leucine-rich repeat-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat-containing protein
Gene product:
leucine-rich repeat-containing protein
Species:
Leishmania infantum
UniProt:
A4HYM2_LEIIN
TriTrypDb:
LINF_200008100
Length:
311

Annotations

Annotations by Jardim et al.

Structural Proteins, leucine-rich repeat-containing Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005929 cilium 4 10
GO:0042995 cell projection 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0110165 cellular anatomical entity 1 10
GO:0120025 plasma membrane bounded cell projection 3 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HYM2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYM2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 214 218 PF00656 0.451
CLV_NRD_NRD_1 199 201 PF00675 0.488
CLV_NRD_NRD_1 282 284 PF00675 0.423
CLV_PCSK_FUR_1 42 46 PF00082 0.410
CLV_PCSK_KEX2_1 199 201 PF00082 0.546
CLV_PCSK_KEX2_1 282 284 PF00082 0.449
CLV_PCSK_KEX2_1 44 46 PF00082 0.586
CLV_PCSK_PC1ET2_1 44 46 PF00082 0.439
CLV_PCSK_SKI1_1 104 108 PF00082 0.330
CLV_PCSK_SKI1_1 177 181 PF00082 0.495
CLV_PCSK_SKI1_1 231 235 PF00082 0.364
CLV_PCSK_SKI1_1 270 274 PF00082 0.499
CLV_PCSK_SKI1_1 283 287 PF00082 0.281
CLV_PCSK_SKI1_1 44 48 PF00082 0.439
DEG_APCC_DBOX_1 52 60 PF00400 0.406
DEG_Nend_UBRbox_2 1 3 PF02207 0.615
DOC_MAPK_gen_1 101 111 PF00069 0.373
DOC_MAPK_gen_1 199 206 PF00069 0.555
DOC_MAPK_MEF2A_6 199 206 PF00069 0.427
DOC_MAPK_MEF2A_6 304 311 PF00069 0.492
DOC_PP1_RVXF_1 99 106 PF00149 0.383
DOC_USP7_MATH_1 126 130 PF00917 0.429
DOC_USP7_MATH_1 170 174 PF00917 0.417
DOC_USP7_UBL2_3 44 48 PF12436 0.439
DOC_WW_Pin1_4 182 187 PF00397 0.364
DOC_WW_Pin1_4 19 24 PF00397 0.615
DOC_WW_Pin1_4 254 259 PF00397 0.421
DOC_WW_Pin1_4 298 303 PF00397 0.531
LIG_14-3-3_CanoR_1 104 110 PF00244 0.267
LIG_14-3-3_CanoR_1 62 71 PF00244 0.530
LIG_14-3-3_CanoR_1 93 99 PF00244 0.414
LIG_Actin_WH2_2 91 106 PF00022 0.473
LIG_APCC_ABBA_1 234 239 PF00400 0.406
LIG_Clathr_ClatBox_1 163 167 PF01394 0.390
LIG_eIF4E_1 89 95 PF01652 0.368
LIG_FHA_1 240 246 PF00498 0.556
LIG_FHA_1 71 77 PF00498 0.547
LIG_FHA_2 63 69 PF00498 0.529
LIG_LIR_Apic_2 79 85 PF02991 0.431
LIG_LIR_Gen_1 263 272 PF02991 0.519
LIG_LIR_Gen_1 49 59 PF02991 0.454
LIG_LIR_Nem_3 263 268 PF02991 0.457
LIG_LIR_Nem_3 49 54 PF02991 0.461
LIG_LYPXL_yS_3 277 280 PF13949 0.451
LIG_NRBOX 229 235 PF00104 0.433
LIG_PCNA_PIPBox_1 153 162 PF02747 0.382
LIG_PDZ_Class_2 306 311 PF00595 0.482
LIG_Pex14_2 160 164 PF04695 0.437
LIG_Pex14_2 261 265 PF04695 0.447
LIG_PTAP_UEV_1 84 89 PF05743 0.409
LIG_PTB_Apo_2 271 278 PF02174 0.357
LIG_PTB_Phospho_1 271 277 PF10480 0.364
LIG_SH2_CRK 51 55 PF00017 0.512
LIG_SH2_GRB2like 145 148 PF00017 0.348
LIG_SH2_SRC 238 241 PF00017 0.497
LIG_SH2_STAT5 115 118 PF00017 0.497
LIG_SH2_STAT5 145 148 PF00017 0.348
LIG_SH2_STAT5 162 165 PF00017 0.175
LIG_SH2_STAT5 194 197 PF00017 0.530
LIG_SH2_STAT5 260 263 PF00017 0.368
LIG_SH2_STAT5 264 267 PF00017 0.351
LIG_SH2_STAT5 89 92 PF00017 0.363
LIG_SH3_1 199 205 PF00018 0.511
LIG_SH3_1 82 88 PF00018 0.414
LIG_SH3_2 278 283 PF14604 0.462
LIG_SH3_3 199 205 PF00018 0.427
LIG_SH3_3 275 281 PF00018 0.483
LIG_SH3_3 82 88 PF00018 0.414
LIG_SUMO_SIM_anti_2 242 247 PF11976 0.438
LIG_SUMO_SIM_par_1 211 217 PF11976 0.349
LIG_SUMO_SIM_par_1 241 247 PF11976 0.352
LIG_SUMO_SIM_par_1 72 77 PF11976 0.503
LIG_UBA3_1 94 101 PF00899 0.400
MOD_CDC14_SPxK_1 301 304 PF00782 0.490
MOD_CDK_SPK_2 254 259 PF00069 0.421
MOD_CDK_SPxK_1 298 304 PF00069 0.457
MOD_CDK_SPxxK_3 182 189 PF00069 0.371
MOD_CDK_SPxxK_3 19 26 PF00069 0.685
MOD_CK1_1 172 178 PF00069 0.566
MOD_CK1_1 185 191 PF00069 0.559
MOD_CK1_1 7 13 PF00069 0.577
MOD_CK2_1 19 25 PF00069 0.625
MOD_CK2_1 62 68 PF00069 0.524
MOD_CK2_1 69 75 PF00069 0.434
MOD_CMANNOS 34 37 PF00535 0.348
MOD_GlcNHglycan 128 131 PF01048 0.487
MOD_GlcNHglycan 13 16 PF01048 0.674
MOD_GSK3_1 120 127 PF00069 0.438
MOD_GSK3_1 298 305 PF00069 0.430
MOD_GSK3_1 4 11 PF00069 0.566
MOD_GSK3_1 58 65 PF00069 0.557
MOD_LATS_1 60 66 PF00433 0.523
MOD_N-GLC_2 274 276 PF02516 0.362
MOD_NEK2_1 124 129 PF00069 0.483
MOD_NEK2_1 246 251 PF00069 0.399
MOD_NEK2_1 4 9 PF00069 0.613
MOD_NEK2_1 76 81 PF00069 0.406
MOD_NEK2_1 94 99 PF00069 0.343
MOD_NEK2_2 105 110 PF00069 0.390
MOD_PIKK_1 172 178 PF00454 0.517
MOD_PIKK_1 62 68 PF00454 0.524
MOD_PKA_1 44 50 PF00069 0.446
MOD_PKA_2 188 194 PF00069 0.518
MOD_PKA_2 44 50 PF00069 0.432
MOD_PKA_2 61 67 PF00069 0.427
MOD_Plk_1 133 139 PF00069 0.454
MOD_Plk_1 4 10 PF00069 0.670
MOD_Plk_4 120 126 PF00069 0.399
MOD_Plk_4 133 139 PF00069 0.425
MOD_Plk_4 241 247 PF00069 0.383
MOD_ProDKin_1 182 188 PF00069 0.368
MOD_ProDKin_1 19 25 PF00069 0.614
MOD_ProDKin_1 254 260 PF00069 0.417
MOD_ProDKin_1 298 304 PF00069 0.537
TRG_DiLeu_BaLyEn_6 136 141 PF01217 0.336
TRG_ENDOCYTIC_2 277 280 PF00928 0.409
TRG_ENDOCYTIC_2 51 54 PF00928 0.452
TRG_ER_diArg_1 281 283 PF00400 0.431
TRG_NES_CRM1_1 102 112 PF08389 0.330
TRG_NES_CRM1_1 224 239 PF08389 0.431

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4U2 Leptomonas seymouri 70% 75%
A0A3Q8IKD6 Leishmania donovani 100% 100%
A0A422NEI1 Trypanosoma rangeli 55% 74%
C9ZHT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 66%
E9AI86 Leishmania braziliensis 81% 100%
E9AUH1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QD13 Leishmania major 94% 100%
V5BAD8 Trypanosoma cruzi 52% 76%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS