LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protein-serine/threonine kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein-serine/threonine kinase
Gene product:
developmentally regulated phosphoprotein-like protein
Species:
Leishmania infantum
UniProt:
A4HYM0_LEIIN
TriTrypDb:
LINF_200007900
Length:
452

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Developmentally regulated phospho-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005759 mitochondrial matrix 5 11
GO:0031974 membrane-enclosed lumen 2 11
GO:0043233 organelle lumen 3 11
GO:0070013 intracellular organelle lumen 4 11
GO:0110165 cellular anatomical entity 1 11
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HYM0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYM0

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0044237 cellular metabolic process 2 11
GO:0006109 regulation of carbohydrate metabolic process 5 1
GO:0006468 protein phosphorylation 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0010675 obsolete regulation of cellular carbohydrate metabolic process 5 1
GO:0010906 regulation of glucose metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0019538 protein metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0062012 regulation of small molecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 146 148 PF00675 0.305
CLV_NRD_NRD_1 180 182 PF00675 0.319
CLV_NRD_NRD_1 2 4 PF00675 0.558
CLV_NRD_NRD_1 247 249 PF00675 0.463
CLV_NRD_NRD_1 62 64 PF00675 0.522
CLV_PCSK_KEX2_1 146 148 PF00082 0.305
CLV_PCSK_KEX2_1 180 182 PF00082 0.336
CLV_PCSK_KEX2_1 2 4 PF00082 0.558
CLV_PCSK_KEX2_1 247 249 PF00082 0.463
CLV_PCSK_KEX2_1 324 326 PF00082 0.454
CLV_PCSK_KEX2_1 66 68 PF00082 0.538
CLV_PCSK_KEX2_1 71 73 PF00082 0.510
CLV_PCSK_PC1ET2_1 324 326 PF00082 0.454
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.545
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.465
CLV_PCSK_PC7_1 67 73 PF00082 0.455
CLV_PCSK_SKI1_1 146 150 PF00082 0.332
CLV_PCSK_SKI1_1 159 163 PF00082 0.200
CLV_PCSK_SKI1_1 180 184 PF00082 0.288
CLV_PCSK_SKI1_1 2 6 PF00082 0.576
CLV_PCSK_SKI1_1 231 235 PF00082 0.287
CLV_PCSK_SKI1_1 312 316 PF00082 0.310
CLV_PCSK_SKI1_1 381 385 PF00082 0.353
CLV_PCSK_SKI1_1 63 67 PF00082 0.563
CLV_PCSK_SKI1_1 71 75 PF00082 0.523
CLV_PCSK_SKI1_1 8 12 PF00082 0.577
DEG_APCC_DBOX_1 145 153 PF00400 0.521
DEG_APCC_DBOX_1 158 166 PF00400 0.418
DEG_APCC_DBOX_1 179 187 PF00400 0.560
DEG_Nend_UBRbox_1 1 4 PF02207 0.567
DOC_CYCLIN_RxL_1 2 14 PF00134 0.486
DOC_MAPK_FxFP_2 294 297 PF00069 0.525
DOC_MAPK_gen_1 180 186 PF00069 0.567
DOC_MAPK_gen_1 247 254 PF00069 0.537
DOC_MAPK_gen_1 63 70 PF00069 0.546
DOC_MAPK_MEF2A_6 247 256 PF00069 0.517
DOC_PP4_FxxP_1 294 297 PF00568 0.525
DOC_USP7_MATH_1 112 116 PF00917 0.465
DOC_USP7_MATH_1 215 219 PF00917 0.560
DOC_USP7_MATH_1 297 301 PF00917 0.381
DOC_USP7_UBL2_3 41 45 PF12436 0.543
DOC_WW_Pin1_4 396 401 PF00397 0.352
LIG_14-3-3_CanoR_1 120 124 PF00244 0.487
LIG_14-3-3_CanoR_1 221 227 PF00244 0.553
LIG_14-3-3_CanoR_1 316 320 PF00244 0.308
LIG_APCC_ABBA_1 74 79 PF00400 0.517
LIG_BIR_III_2 442 446 PF00653 0.581
LIG_BRCT_BRCA1_1 229 233 PF00533 0.560
LIG_BRCT_BRCA1_1 290 294 PF00533 0.509
LIG_EH1_1 304 312 PF00400 0.329
LIG_eIF4E_1 305 311 PF01652 0.310
LIG_FHA_1 25 31 PF00498 0.455
LIG_FHA_2 203 209 PF00498 0.507
LIG_FHA_2 281 287 PF00498 0.544
LIG_FHA_2 330 336 PF00498 0.454
LIG_FHA_2 99 105 PF00498 0.509
LIG_LIR_Apic_2 291 297 PF02991 0.569
LIG_LIR_Apic_2 79 85 PF02991 0.454
LIG_LIR_Gen_1 126 135 PF02991 0.565
LIG_LIR_Gen_1 190 198 PF02991 0.545
LIG_LIR_Gen_1 205 214 PF02991 0.521
LIG_LIR_Gen_1 225 234 PF02991 0.324
LIG_LIR_Gen_1 302 311 PF02991 0.305
LIG_LIR_Gen_1 375 384 PF02991 0.454
LIG_LIR_Nem_3 126 130 PF02991 0.459
LIG_LIR_Nem_3 164 170 PF02991 0.560
LIG_LIR_Nem_3 190 196 PF02991 0.526
LIG_LIR_Nem_3 205 209 PF02991 0.512
LIG_LIR_Nem_3 225 229 PF02991 0.324
LIG_LIR_Nem_3 302 308 PF02991 0.305
LIG_LIR_Nem_3 375 379 PF02991 0.454
LIG_LIR_Nem_3 432 438 PF02991 0.301
LIG_SH2_CRK 226 230 PF00017 0.457
LIG_SH2_CRK 376 380 PF00017 0.353
LIG_SH2_CRK 406 410 PF00017 0.454
LIG_SH2_CRK 82 86 PF00017 0.560
LIG_SH2_NCK_1 206 210 PF00017 0.560
LIG_SH2_NCK_1 376 380 PF00017 0.421
LIG_SH2_PTP2 305 308 PF00017 0.310
LIG_SH2_PTP2 437 440 PF00017 0.353
LIG_SH2_SRC 206 209 PF00017 0.560
LIG_SH2_STAP1 414 418 PF00017 0.310
LIG_SH2_STAT5 175 178 PF00017 0.527
LIG_SH2_STAT5 305 308 PF00017 0.313
LIG_SH2_STAT5 376 379 PF00017 0.353
LIG_SH2_STAT5 437 440 PF00017 0.312
LIG_SH3_3 376 382 PF00018 0.341
LIG_SH3_4 381 388 PF00018 0.454
LIG_SUMO_SIM_par_1 168 174 PF11976 0.477
LIG_SUMO_SIM_par_1 250 255 PF11976 0.499
LIG_TYR_ITIM 204 209 PF00017 0.552
LIG_TYR_ITIM 224 229 PF00017 0.324
LIG_TYR_ITIM 303 308 PF00017 0.310
LIG_UBA3_1 169 173 PF00899 0.487
LIG_UBA3_1 306 312 PF00899 0.421
LIG_UBA3_1 4 9 PF00899 0.516
LIG_WRC_WIRS_1 124 129 PF05994 0.470
MOD_CK1_1 21 27 PF00069 0.611
MOD_CK1_1 375 381 PF00069 0.454
MOD_CK2_1 202 208 PF00069 0.515
MOD_CK2_1 22 28 PF00069 0.576
MOD_CK2_1 280 286 PF00069 0.553
MOD_GlcNHglycan 107 110 PF01048 0.360
MOD_GlcNHglycan 24 27 PF01048 0.621
MOD_GlcNHglycan 388 391 PF01048 0.426
MOD_GSK3_1 119 126 PF00069 0.464
MOD_GSK3_1 18 25 PF00069 0.668
MOD_GSK3_1 192 199 PF00069 0.504
MOD_GSK3_1 392 399 PF00069 0.454
MOD_N-GLC_2 220 222 PF02516 0.360
MOD_NEK2_1 10 15 PF00069 0.639
MOD_NEK2_1 123 128 PF00069 0.495
MOD_NEK2_1 161 166 PF00069 0.560
MOD_NEK2_1 19 24 PF00069 0.530
MOD_NEK2_1 299 304 PF00069 0.329
MOD_NEK2_1 372 377 PF00069 0.361
MOD_NEK2_1 47 52 PF00069 0.484
MOD_NEK2_1 59 64 PF00069 0.325
MOD_PK_1 192 198 PF00069 0.560
MOD_PK_1 72 78 PF00069 0.298
MOD_PKA_1 187 193 PF00069 0.538
MOD_PKA_2 119 125 PF00069 0.487
MOD_PKA_2 315 321 PF00069 0.310
MOD_Plk_1 238 244 PF00069 0.554
MOD_Plk_4 112 118 PF00069 0.461
MOD_Plk_4 119 125 PF00069 0.450
MOD_Plk_4 72 78 PF00069 0.381
MOD_ProDKin_1 396 402 PF00069 0.352
MOD_SUMO_rev_2 267 272 PF00179 0.416
MOD_SUMO_rev_2 284 294 PF00179 0.467
MOD_SUMO_rev_2 48 53 PF00179 0.525
TRG_ENDOCYTIC_2 206 209 PF00928 0.523
TRG_ENDOCYTIC_2 226 229 PF00928 0.324
TRG_ENDOCYTIC_2 305 308 PF00928 0.310
TRG_ENDOCYTIC_2 376 379 PF00928 0.353
TRG_ENDOCYTIC_2 435 438 PF00928 0.294
TRG_ER_diArg_1 1 3 PF00400 0.560
TRG_ER_diArg_1 145 147 PF00400 0.532
TRG_ER_diArg_1 246 248 PF00400 0.565
TRG_NLS_MonoExtC_3 62 67 PF00514 0.561
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.372
TRG_Pf-PMV_PEXEL_1 159 163 PF00026 0.321
TRG_Pf-PMV_PEXEL_1 181 185 PF00026 0.361
TRG_Pf-PMV_PEXEL_1 45 49 PF00026 0.522

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JAB1 Bodo saltans 40% 100%
A0A0S4JGW0 Bodo saltans 22% 98%
A0A1X0NWS5 Trypanosomatidae 49% 100%
A0A3R7K9G7 Trypanosoma rangeli 46% 100%
A0A3S7WVX8 Leishmania donovani 100% 100%
C9ZHT4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AI84 Leishmania braziliensis 92% 100%
E9AUG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O02623 Ascaris suum 30% 100%
O14874 Homo sapiens 26% 100%
O54937 Rattus norvegicus 28% 100%
O55028 Mus musculus 26% 100%
O70571 Mus musculus 28% 100%
O88345 Ictidomys tridecemlineatus 27% 100%
P91622 Drosophila melanogaster 30% 100%
Q00972 Rattus norvegicus 26% 100%
Q02332 Caenorhabditis elegans 28% 100%
Q15118 Homo sapiens 28% 100%
Q15119 Homo sapiens 30% 100%
Q15120 Homo sapiens 29% 100%
Q16654 Homo sapiens 28% 100%
Q1KMR4 Rhinolophus ferrumequinum 28% 100%
Q2KJG8 Bos taurus 26% 100%
Q4QD15 Leishmania major 96% 100%
Q63065 Rattus norvegicus 29% 100%
Q64536 Rattus norvegicus 29% 100%
Q8BFP9 Mus musculus 29% 100%
Q922H2 Mus musculus 29% 100%
Q9JK42 Mus musculus 29% 100%
Q9SBJ1 Arabidopsis thaliana 29% 100%
V5BAE3 Trypanosoma cruzi 50% 100%
V5C0T8 Trypanosoma cruzi 23% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS