Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane protein - putative

Species:

Leishmania infantum

UniProt:

A4HYL4_LEIIN

TriTrypDb:

LINF_200007300

Length:

149

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HYL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.575
CLV_NRD_NRD_1	137	139	PF00675	0.625
CLV_NRD_NRD_1	144	146	PF00675	0.595
CLV_NRD_NRD_1	34	36	PF00675	0.401
CLV_PCSK_KEX2_1	115	117	PF00082	0.575
CLV_PCSK_KEX2_1	137	139	PF00082	0.587
CLV_PCSK_KEX2_1	143	145	PF00082	0.547
CLV_PCSK_KEX2_1	36	38	PF00082	0.411
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.587
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.547
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.411
CLV_PCSK_SKI1_1	37	41	PF00082	0.402
DEG_APCC_DBOX_1	115	123	PF00400	0.370
DEG_Nend_UBRbox_1	1	4	PF02207	0.730
DOC_USP7_UBL2_3	139	143	PF12436	0.375
DOC_WW_Pin1_4	1	6	PF00397	0.738
DOC_WW_Pin1_4	100	105	PF00397	0.426
LIG_14-3-3_CanoR_1	37	45	PF00244	0.598
LIG_FHA_2	15	21	PF00498	0.637
LIG_FHA_2	54	60	PF00498	0.741
LIG_LIR_Gen_1	70	80	PF02991	0.481
LIG_LIR_Nem_3	70	76	PF02991	0.464
LIG_PTB_Apo_2	88	95	PF02174	0.486
LIG_PTB_Phospho_1	88	94	PF10480	0.484
LIG_SH2_NCK_1	45	49	PF00017	0.596
LIG_SH2_SRC	9	12	PF00017	0.725
LIG_SH2_STAP1	45	49	PF00017	0.596
LIG_SH2_STAT5	108	111	PF00017	0.473
LIG_SH2_STAT5	82	85	PF00017	0.303
LIG_SH2_STAT5	9	12	PF00017	0.728
LIG_TRAF2_1	51	54	PF00917	0.625
MOD_CDC14_SPxK_1	103	106	PF00782	0.426
MOD_CDK_SPxK_1	100	106	PF00069	0.428
MOD_CK1_1	12	18	PF00069	0.722
MOD_CK1_1	133	139	PF00069	0.410
MOD_CK1_1	4	10	PF00069	0.727
MOD_CK2_1	126	132	PF00069	0.411
MOD_CK2_1	25	31	PF00069	0.635
MOD_GSK3_1	12	19	PF00069	0.649
MOD_GSK3_1	126	133	PF00069	0.442
MOD_GSK3_1	21	28	PF00069	0.610
MOD_N-GLC_1	100	105	PF02516	0.651
MOD_NEK2_2	9	14	PF00069	0.729
MOD_PIKK_1	53	59	PF00454	0.689
MOD_PKA_1	37	43	PF00069	0.588
MOD_PKA_2	25	31	PF00069	0.628
MOD_PKB_1	35	43	PF00069	0.591
MOD_Plk_4	126	132	PF00069	0.397
MOD_Plk_4	4	10	PF00069	0.661
MOD_ProDKin_1	1	7	PF00069	0.736
MOD_ProDKin_1	100	106	PF00069	0.428
MOD_SUMO_for_1	49	52	PF00179	0.601
MOD_SUMO_rev_2	59	64	PF00179	0.710
TRG_ENDOCYTIC_2	72	75	PF00928	0.305
TRG_ER_diArg_1	144	146	PF00400	0.456
TRG_ER_diArg_1	34	37	PF00400	0.601
TRG_NES_CRM1_1	117	132	PF08389	0.410
TRG_NLS_MonoCore_2	34	39	PF00514	0.610
TRG_NLS_MonoExtC_3	35	41	PF00514	0.608
TRG_NLS_MonoExtN_4	35	40	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P526	Leptomonas seymouri	89%	76%
A0A0S4JEM4	Bodo saltans	57%	100%
A0A1X0NWZ6	Trypanosomatidae	77%	79%
A0A3S7WVT3	Leishmania donovani	100%	100%
A0A422NEH4	Trypanosoma rangeli	75%	81%
E9AI77	Leishmania braziliensis	95%	100%
E9AUG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QD21	Leishmania major	99%	100%