Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYL1_LEIIN

TriTrypDb:

LINF_200007000

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.522
CLV_C14_Caspase3-7	443	447	PF00656	0.565
CLV_C14_Caspase3-7	76	80	PF00656	0.514
CLV_NRD_NRD_1	275	277	PF00675	0.779
CLV_NRD_NRD_1	392	394	PF00675	0.486
CLV_NRD_NRD_1	396	398	PF00675	0.466
CLV_NRD_NRD_1	534	536	PF00675	0.573
CLV_NRD_NRD_1	692	694	PF00675	0.612
CLV_NRD_NRD_1	709	711	PF00675	0.391
CLV_NRD_NRD_1	843	845	PF00675	0.534
CLV_PCSK_KEX2_1	206	208	PF00082	0.573
CLV_PCSK_KEX2_1	275	277	PF00082	0.779
CLV_PCSK_KEX2_1	396	398	PF00082	0.517
CLV_PCSK_KEX2_1	692	694	PF00082	0.612
CLV_PCSK_KEX2_1	709	711	PF00082	0.391
CLV_PCSK_KEX2_1	843	845	PF00082	0.534
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.573
CLV_PCSK_SKI1_1	15	19	PF00082	0.464
CLV_PCSK_SKI1_1	207	211	PF00082	0.475
CLV_PCSK_SKI1_1	613	617	PF00082	0.598
CLV_PCSK_SKI1_1	667	671	PF00082	0.504
CLV_PCSK_SKI1_1	851	855	PF00082	0.693
CLV_Separin_Metazoa	240	244	PF03568	0.637
DEG_APCC_DBOX_1	346	354	PF00400	0.537
DEG_SPOP_SBC_1	559	563	PF00917	0.624
DEG_SPOP_SBC_1	743	747	PF00917	0.686
DOC_CKS1_1	579	584	PF01111	0.646
DOC_CYCLIN_RxL_1	664	672	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	608	614	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.674
DOC_MAPK_gen_1	135	143	PF00069	0.605
DOC_MAPK_gen_1	206	212	PF00069	0.576
DOC_MAPK_gen_1	214	223	PF00069	0.479
DOC_MAPK_gen_1	535	544	PF00069	0.446
DOC_MAPK_MEF2A_6	135	143	PF00069	0.605
DOC_PP2B_LxvP_1	586	589	PF13499	0.540
DOC_PP4_FxxP_1	355	358	PF00568	0.524
DOC_USP7_MATH_1	11	15	PF00917	0.580
DOC_USP7_MATH_1	152	156	PF00917	0.489
DOC_USP7_MATH_1	193	197	PF00917	0.413
DOC_USP7_MATH_1	32	36	PF00917	0.716
DOC_USP7_MATH_1	386	390	PF00917	0.655
DOC_USP7_MATH_1	60	64	PF00917	0.481
DOC_USP7_MATH_1	679	683	PF00917	0.503
DOC_USP7_MATH_1	84	88	PF00917	0.562
DOC_USP7_MATH_1	853	857	PF00917	0.727
DOC_USP7_MATH_2	375	381	PF00917	0.610
DOC_WW_Pin1_4	156	161	PF00397	0.404
DOC_WW_Pin1_4	28	33	PF00397	0.680
DOC_WW_Pin1_4	287	292	PF00397	0.728
DOC_WW_Pin1_4	491	496	PF00397	0.550
DOC_WW_Pin1_4	560	565	PF00397	0.658
DOC_WW_Pin1_4	578	583	PF00397	0.335
DOC_WW_Pin1_4	813	818	PF00397	0.510
DOC_WW_Pin1_4	832	837	PF00397	0.515
LIG_14-3-3_CanoR_1	107	113	PF00244	0.490
LIG_14-3-3_CanoR_1	199	205	PF00244	0.358
LIG_14-3-3_CanoR_1	220	224	PF00244	0.499
LIG_14-3-3_CanoR_1	278	286	PF00244	0.696
LIG_14-3-3_CanoR_1	315	321	PF00244	0.549
LIG_14-3-3_CanoR_1	341	350	PF00244	0.526
LIG_14-3-3_CanoR_1	354	358	PF00244	0.521
LIG_14-3-3_CanoR_1	433	441	PF00244	0.601
LIG_14-3-3_CanoR_1	518	525	PF00244	0.479
LIG_14-3-3_CanoR_1	593	602	PF00244	0.474
LIG_14-3-3_CanoR_1	654	664	PF00244	0.491
LIG_14-3-3_CanoR_1	710	718	PF00244	0.512
LIG_14-3-3_CanoR_1	792	800	PF00244	0.587
LIG_14-3-3_CanoR_1	803	808	PF00244	0.394
LIG_Actin_WH2_2	327	343	PF00022	0.550
LIG_Actin_WH2_2	94	109	PF00022	0.492
LIG_BRCT_BRCA1_1	108	112	PF00533	0.489
LIG_BRCT_BRCA1_1	13	17	PF00533	0.592
LIG_BRCT_BRCA1_1	464	468	PF00533	0.426
LIG_CSL_BTD_1	814	817	PF09270	0.515
LIG_deltaCOP1_diTrp_1	259	267	PF00928	0.567
LIG_deltaCOP1_diTrp_1	451	461	PF00928	0.516
LIG_deltaCOP1_diTrp_1	478	483	PF00928	0.476
LIG_DLG_GKlike_1	803	811	PF00625	0.595
LIG_EH1_1	397	405	PF00400	0.497
LIG_EH1_1	821	829	PF00400	0.485
LIG_eIF4E_1	822	828	PF01652	0.479
LIG_FHA_1	295	301	PF00498	0.631
LIG_FHA_1	303	309	PF00498	0.581
LIG_FHA_1	326	332	PF00498	0.601
LIG_FHA_1	360	366	PF00498	0.534
LIG_FHA_1	485	491	PF00498	0.383
LIG_FHA_1	49	55	PF00498	0.493
LIG_FHA_1	550	556	PF00498	0.476
LIG_FHA_1	589	595	PF00498	0.442
LIG_FHA_1	637	643	PF00498	0.543
LIG_FHA_1	706	712	PF00498	0.521
LIG_FHA_1	718	724	PF00498	0.487
LIG_FHA_1	749	755	PF00498	0.468
LIG_FHA_1	833	839	PF00498	0.620
LIG_FHA_2	175	181	PF00498	0.578
LIG_FHA_2	254	260	PF00498	0.755
LIG_FHA_2	317	323	PF00498	0.623
LIG_FHA_2	462	468	PF00498	0.535
LIG_FHA_2	692	698	PF00498	0.406
LIG_FHA_2	754	760	PF00498	0.452
LIG_FHA_2	768	774	PF00498	0.490
LIG_FHA_2	807	813	PF00498	0.533
LIG_LIR_Apic_2	264	270	PF02991	0.717
LIG_LIR_Gen_1	163	174	PF02991	0.509
LIG_LIR_Gen_1	451	461	PF02991	0.492
LIG_LIR_Gen_1	663	670	PF02991	0.460
LIG_LIR_Gen_1	700	711	PF02991	0.595
LIG_LIR_LC3C_4	330	335	PF02991	0.564
LIG_LIR_Nem_3	163	169	PF02991	0.499
LIG_LIR_Nem_3	451	457	PF02991	0.592
LIG_LIR_Nem_3	663	668	PF02991	0.461
LIG_LIR_Nem_3	700	706	PF02991	0.574
LIG_LIR_Nem_3	812	818	PF02991	0.620
LIG_LYPXL_SIV_4	564	572	PF13949	0.560
LIG_NRBOX	312	318	PF00104	0.520
LIG_NRBOX	665	671	PF00104	0.493
LIG_NRBOX	756	762	PF00104	0.458
LIG_Pex14_2	468	472	PF04695	0.459
LIG_SH2_NCK_1	179	183	PF00017	0.480
LIG_SH2_SRC	565	568	PF00017	0.375
LIG_SH2_SRC	822	825	PF00017	0.486
LIG_SH2_STAP1	303	307	PF00017	0.562
LIG_SH2_STAP1	565	569	PF00017	0.532
LIG_SH2_STAT5	303	306	PF00017	0.552
LIG_SH2_STAT5	43	46	PF00017	0.429
LIG_SH2_STAT5	489	492	PF00017	0.476
LIG_SH2_STAT5	557	560	PF00017	0.629
LIG_SH2_STAT5	637	640	PF00017	0.480
LIG_SH2_STAT5	665	668	PF00017	0.562
LIG_SH2_STAT5	822	825	PF00017	0.486
LIG_SH3_3	26	32	PF00018	0.665
LIG_SH3_3	408	414	PF00018	0.579
LIG_SH3_3	608	614	PF00018	0.602
LIG_SH3_3	718	724	PF00018	0.589
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.425
LIG_SUMO_SIM_anti_2	755	762	PF11976	0.450
LIG_SUMO_SIM_par_1	316	322	PF11976	0.655
LIG_SUMO_SIM_par_1	53	58	PF11976	0.505
LIG_TRAF2_1	327	330	PF00917	0.603
LIG_TRAF2_1	476	479	PF00917	0.480
LIG_TRAF2_1	771	774	PF00917	0.596
LIG_TRFH_1	28	32	PF08558	0.600
LIG_WW_3	413	417	PF00397	0.423
LIG_WW_3	88	92	PF00397	0.584
MOD_CDK_SPxxK_3	813	820	PF00069	0.497
MOD_CK1_1	219	225	PF00069	0.470
MOD_CK1_1	279	285	PF00069	0.829
MOD_CK1_1	287	293	PF00069	0.723
MOD_CK1_1	309	315	PF00069	0.606
MOD_CK1_1	321	327	PF00069	0.600
MOD_CK1_1	35	41	PF00069	0.593
MOD_CK1_1	42	48	PF00069	0.493
MOD_CK1_1	449	455	PF00069	0.550
MOD_CK1_1	494	500	PF00069	0.659
MOD_CK1_1	507	513	PF00069	0.605
MOD_CK1_1	806	812	PF00069	0.536
MOD_CK2_1	234	240	PF00069	0.632
MOD_CK2_1	316	322	PF00069	0.655
MOD_CK2_1	473	479	PF00069	0.507
MOD_CK2_1	510	516	PF00069	0.531
MOD_CK2_1	691	697	PF00069	0.405
MOD_CK2_1	767	773	PF00069	0.510
MOD_CK2_1	806	812	PF00069	0.536
MOD_DYRK1A_RPxSP_1	491	495	PF00069	0.536
MOD_GlcNHglycan	108	111	PF01048	0.599
MOD_GlcNHglycan	251	254	PF01048	0.512
MOD_GlcNHglycan	322	326	PF01048	0.592
MOD_GlcNHglycan	408	411	PF01048	0.681
MOD_GlcNHglycan	464	467	PF01048	0.586
MOD_GlcNHglycan	475	478	PF01048	0.448
MOD_GlcNHglycan	496	499	PF01048	0.558
MOD_GlcNHglycan	512	515	PF01048	0.539
MOD_GlcNHglycan	520	523	PF01048	0.498
MOD_GlcNHglycan	595	598	PF01048	0.473
MOD_GlcNHglycan	62	65	PF01048	0.635
MOD_GlcNHglycan	627	630	PF01048	0.572
MOD_GlcNHglycan	677	680	PF01048	0.498
MOD_GlcNHglycan	728	731	PF01048	0.525
MOD_GlcNHglycan	793	796	PF01048	0.546
MOD_GSK3_1	11	18	PF00069	0.516
MOD_GSK3_1	152	159	PF00069	0.409
MOD_GSK3_1	24	31	PF00069	0.728
MOD_GSK3_1	249	256	PF00069	0.712
MOD_GSK3_1	281	288	PF00069	0.751
MOD_GSK3_1	290	297	PF00069	0.699
MOD_GSK3_1	302	309	PF00069	0.626
MOD_GSK3_1	32	39	PF00069	0.688
MOD_GSK3_1	321	328	PF00069	0.596
MOD_GSK3_1	361	368	PF00069	0.651
MOD_GSK3_1	42	49	PF00069	0.377
MOD_GSK3_1	494	501	PF00069	0.698
MOD_GSK3_1	504	511	PF00069	0.559
MOD_GSK3_1	549	556	PF00069	0.599
MOD_GSK3_1	621	628	PF00069	0.654
MOD_GSK3_1	675	682	PF00069	0.504
MOD_GSK3_1	713	720	PF00069	0.516
MOD_GSK3_1	742	749	PF00069	0.572
MOD_GSK3_1	803	810	PF00069	0.509
MOD_NEK2_1	106	111	PF00069	0.487
MOD_NEK2_1	142	147	PF00069	0.487
MOD_NEK2_1	200	205	PF00069	0.458
MOD_NEK2_1	210	215	PF00069	0.498
MOD_NEK2_1	228	233	PF00069	0.381
MOD_NEK2_1	234	239	PF00069	0.569
MOD_NEK2_1	286	291	PF00069	0.786
MOD_NEK2_1	301	306	PF00069	0.495
MOD_NEK2_1	316	321	PF00069	0.544
MOD_NEK2_1	340	345	PF00069	0.580
MOD_NEK2_1	353	358	PF00069	0.466
MOD_NEK2_1	36	41	PF00069	0.632
MOD_NEK2_1	461	466	PF00069	0.514
MOD_NEK2_1	508	513	PF00069	0.621
MOD_NEK2_1	705	710	PF00069	0.487
MOD_NEK2_1	711	716	PF00069	0.536
MOD_NEK2_1	717	722	PF00069	0.485
MOD_NEK2_1	734	739	PF00069	0.471
MOD_NEK2_1	752	757	PF00069	0.413
MOD_NEK2_1	790	795	PF00069	0.620
MOD_PIKK_1	152	158	PF00454	0.528
MOD_PIKK_1	193	199	PF00454	0.628
MOD_PIKK_1	234	240	PF00454	0.589
MOD_PIKK_1	295	301	PF00454	0.631
MOD_PIKK_1	353	359	PF00454	0.619
MOD_PIKK_1	549	555	PF00454	0.491
MOD_PIKK_1	55	61	PF00454	0.577
MOD_PIKK_1	845	851	PF00454	0.774
MOD_PKA_2	1	7	PF00069	0.542
MOD_PKA_2	106	112	PF00069	0.485
MOD_PKA_2	11	17	PF00069	0.535
MOD_PKA_2	216	222	PF00069	0.528
MOD_PKA_2	249	255	PF00069	0.617
MOD_PKA_2	274	280	PF00069	0.655
MOD_PKA_2	340	346	PF00069	0.521
MOD_PKA_2	353	359	PF00069	0.555
MOD_PKA_2	432	438	PF00069	0.572
MOD_PKA_2	534	540	PF00069	0.587
MOD_PKA_2	625	631	PF00069	0.546
MOD_PKA_2	655	661	PF00069	0.498
MOD_PKA_2	691	697	PF00069	0.542
MOD_PKA_2	791	797	PF00069	0.604
MOD_Plk_1	253	259	PF00069	0.747
MOD_Plk_1	282	288	PF00069	0.728
MOD_Plk_1	309	315	PF00069	0.537
MOD_Plk_1	386	392	PF00069	0.571
MOD_Plk_1	78	84	PF00069	0.491
MOD_Plk_1	811	817	PF00069	0.551
MOD_Plk_2-3	254	260	PF00069	0.755
MOD_Plk_2-3	446	452	PF00069	0.556
MOD_Plk_2-3	691	697	PF00069	0.405
MOD_Plk_4	1	7	PF00069	0.617
MOD_Plk_4	180	186	PF00069	0.548
MOD_Plk_4	219	225	PF00069	0.523
MOD_Plk_4	309	315	PF00069	0.640
MOD_Plk_4	386	392	PF00069	0.571
MOD_Plk_4	39	45	PF00069	0.485
MOD_Plk_4	449	455	PF00069	0.619
MOD_Plk_4	600	606	PF00069	0.516
MOD_Plk_4	637	643	PF00069	0.474
MOD_Plk_4	713	719	PF00069	0.566
MOD_Plk_4	748	754	PF00069	0.511
MOD_ProDKin_1	156	162	PF00069	0.395
MOD_ProDKin_1	28	34	PF00069	0.681
MOD_ProDKin_1	287	293	PF00069	0.720
MOD_ProDKin_1	491	497	PF00069	0.552
MOD_ProDKin_1	560	566	PF00069	0.657
MOD_ProDKin_1	578	584	PF00069	0.338
MOD_ProDKin_1	813	819	PF00069	0.502
MOD_ProDKin_1	832	838	PF00069	0.510
TRG_AP2beta_CARGO_1	700	710	PF09066	0.585
TRG_DiLeu_BaEn_1	329	334	PF01217	0.657
TRG_DiLeu_BaEn_1	387	392	PF01217	0.564
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.516
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.336
TRG_DiLeu_BaLyEn_6	590	595	PF01217	0.473
TRG_ENDOCYTIC_2	665	668	PF00928	0.562
TRG_ER_diArg_1	137	140	PF00400	0.510
TRG_ER_diArg_1	274	276	PF00400	0.761
TRG_ER_diArg_1	654	657	PF00400	0.525
TRG_ER_diArg_1	709	711	PF00400	0.524
TRG_ER_diArg_1	842	844	PF00400	0.494
TRG_NLS_MonoExtC_3	392	397	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	687	691	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	709	713	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK8	Leptomonas seymouri	46%	99%
A0A3Q8IBG3	Leishmania donovani	99%	100%
E9AI74	Leishmania braziliensis	74%	100%
E9AUG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QD24	Leishmania major	89%	100%