DUF1508 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYL0_LEIIN

TriTrypDb:

LINF_200006900

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.563
CLV_NRD_NRD_1	136	138	PF00675	0.547
CLV_NRD_NRD_1	166	168	PF00675	0.547
CLV_NRD_NRD_1	174	176	PF00675	0.450
CLV_NRD_NRD_1	2	4	PF00675	0.631
CLV_NRD_NRD_1	62	64	PF00675	0.630
CLV_PCSK_FUR_1	2	6	PF00082	0.517
CLV_PCSK_KEX2_1	136	138	PF00082	0.582
CLV_PCSK_KEX2_1	166	168	PF00082	0.522
CLV_PCSK_KEX2_1	173	175	PF00082	0.452
CLV_PCSK_KEX2_1	2	4	PF00082	0.625
CLV_PCSK_KEX2_1	61	63	PF00082	0.647
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.448
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.534
DEG_Nend_UBRbox_1	1	4	PF02207	0.564
DEG_SPOP_SBC_1	44	48	PF00917	0.613
DOC_PP2B_LxvP_1	38	41	PF13499	0.404
DOC_SPAK_OSR1_1	80	84	PF12202	0.354
DOC_USP7_MATH_1	17	21	PF00917	0.464
DOC_USP7_MATH_1	45	49	PF00917	0.673
DOC_USP7_MATH_1	57	61	PF00917	0.618
DOC_USP7_MATH_1	66	70	PF00917	0.426
DOC_WW_Pin1_4	52	57	PF00397	0.660
LIG_14-3-3_CanoR_1	128	135	PF00244	0.597
LIG_14-3-3_CanoR_1	3	9	PF00244	0.502
LIG_14-3-3_CanoR_1	39	45	PF00244	0.545
LIG_14-3-3_CanoR_1	61	66	PF00244	0.597
LIG_14-3-3_CterR_2	194	198	PF00244	0.619
LIG_BIR_III_4	76	80	PF00653	0.376
LIG_BRCT_BRCA1_1	149	153	PF00533	0.491
LIG_BRCT_BRCA1_1	45	49	PF00533	0.519
LIG_deltaCOP1_diTrp_1	164	168	PF00928	0.418
LIG_eIF4E_1	31	37	PF01652	0.357
LIG_FHA_1	33	39	PF00498	0.451
LIG_FHA_1	8	14	PF00498	0.453
LIG_FHA_1	86	92	PF00498	0.519
LIG_FHA_2	122	128	PF00498	0.636
LIG_LIR_Gen_1	147	155	PF02991	0.530
LIG_LIR_Nem_3	147	152	PF02991	0.522
LIG_LIR_Nem_3	164	168	PF02991	0.392
LIG_PCNA_PIPBox_1	24	33	PF02747	0.434
LIG_Pex14_2	145	149	PF04695	0.384
LIG_RPA_C_Fungi	162	174	PF08784	0.429
LIG_SH2_STAP1	142	146	PF00017	0.455
LIG_SH2_STAP1	25	29	PF00017	0.351
LIG_SH2_STAT5	8	11	PF00017	0.526
LIG_WRC_WIRS_1	67	72	PF05994	0.474
MOD_CK1_1	147	153	PF00069	0.457
MOD_CK1_1	169	175	PF00069	0.559
MOD_CK1_1	48	54	PF00069	0.592
MOD_CK1_1	7	13	PF00069	0.551
MOD_CK2_1	121	127	PF00069	0.631
MOD_CK2_1	52	58	PF00069	0.704
MOD_GlcNHglycan	129	132	PF01048	0.680
MOD_GlcNHglycan	168	171	PF01048	0.560
MOD_GlcNHglycan	187	190	PF01048	0.333
MOD_GlcNHglycan	51	54	PF01048	0.682
MOD_GlcNHglycan	85	88	PF01048	0.527
MOD_GSK3_1	13	20	PF00069	0.517
MOD_GSK3_1	140	147	PF00069	0.492
MOD_GSK3_1	3	10	PF00069	0.492
MOD_GSK3_1	39	46	PF00069	0.635
MOD_GSK3_1	48	55	PF00069	0.638
MOD_GSK3_1	57	64	PF00069	0.622
MOD_N-GLC_1	13	18	PF02516	0.419
MOD_NEK2_1	144	149	PF00069	0.383
MOD_NEK2_1	49	54	PF00069	0.593
MOD_PKA_1	166	172	PF00069	0.477
MOD_PKA_1	3	9	PF00069	0.544
MOD_PKA_1	61	67	PF00069	0.653
MOD_PKA_2	127	133	PF00069	0.651
MOD_PKA_2	166	172	PF00069	0.477
MOD_PKA_2	4	10	PF00069	0.494
MOD_PKA_2	61	67	PF00069	0.640
MOD_Plk_4	140	146	PF00069	0.417
MOD_Plk_4	32	38	PF00069	0.508
MOD_Plk_4	4	10	PF00069	0.512
MOD_Plk_4	45	51	PF00069	0.691
MOD_ProDKin_1	52	58	PF00069	0.657
MOD_SUMO_rev_2	20	30	PF00179	0.456
TRG_DiLeu_BaEn_1	177	182	PF01217	0.414
TRG_ENDOCYTIC_2	142	145	PF00928	0.402
TRG_ER_diArg_1	1	3	PF00400	0.637
TRG_ER_diArg_1	135	137	PF00400	0.656
TRG_ER_diArg_1	165	167	PF00400	0.516
TRG_ER_diArg_1	61	63	PF00400	0.639
TRG_ER_diArg_1	78	81	PF00400	0.449
TRG_NLS_MonoExtN_4	2	7	PF00514	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWU9	Leptomonas seymouri	33%	100%
A0A1X0NWM2	Trypanosomatidae	25%	100%
A0A3Q8IBI0	Leishmania donovani	96%	99%
A0A422NEH1	Trypanosoma rangeli	28%	100%
E9AUF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QD25	Leishmania major	90%	100%