Leucine-rich repeat-containing protein 75A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania infantum

UniProt:

A4HYK8_LEIIN

TriTrypDb:

LINF_200006700

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4HYK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYK8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.439
CLV_NRD_NRD_1	292	294	PF00675	0.496
CLV_NRD_NRD_1	4	6	PF00675	0.573
CLV_PCSK_KEX2_1	149	151	PF00082	0.510
CLV_PCSK_KEX2_1	244	246	PF00082	0.478
CLV_PCSK_KEX2_1	292	294	PF00082	0.496
CLV_PCSK_KEX2_1	4	6	PF00082	0.573
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.570
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.517
CLV_PCSK_SKI1_1	162	166	PF00082	0.382
CLV_PCSK_SKI1_1	244	248	PF00082	0.377
CLV_Separin_Metazoa	188	192	PF03568	0.490
DEG_Nend_Nbox_1	1	3	PF02207	0.341
DEG_SCF_FBW7_1	326	333	PF00400	0.536
DEG_SCF_FBW7_1	6	13	PF00400	0.522
DEG_SPOP_SBC_1	298	302	PF00917	0.385
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.571
DOC_MAPK_gen_1	109	118	PF00069	0.451
DOC_MAPK_HePTP_8	106	118	PF00069	0.385
DOC_MAPK_MEF2A_6	109	118	PF00069	0.388
DOC_USP7_MATH_1	10	14	PF00917	0.480
DOC_USP7_UBL2_3	205	209	PF12436	0.458
DOC_WW_Pin1_4	148	153	PF00397	0.469
DOC_WW_Pin1_4	326	331	PF00397	0.530
DOC_WW_Pin1_4	6	11	PF00397	0.454
LIG_14-3-3_CanoR_1	245	250	PF00244	0.346
LIG_14-3-3_CanoR_1	293	303	PF00244	0.556
LIG_14-3-3_CanoR_1	55	60	PF00244	0.479
LIG_APCC_ABBA_1	199	204	PF00400	0.465
LIG_BRCT_BRCA1_1	57	61	PF00533	0.450
LIG_Clathr_ClatBox_1	227	231	PF01394	0.476
LIG_deltaCOP1_diTrp_1	304	308	PF00928	0.321
LIG_EH1_1	223	231	PF00400	0.462
LIG_FHA_1	194	200	PF00498	0.462
LIG_FHA_1	298	304	PF00498	0.372
LIG_FHA_2	232	238	PF00498	0.434
LIG_FHA_2	27	33	PF00498	0.449
LIG_FHA_2	299	305	PF00498	0.508
LIG_LIR_Gen_1	183	192	PF02991	0.454
LIG_LIR_Gen_1	204	215	PF02991	0.437
LIG_LIR_Gen_1	222	230	PF02991	0.354
LIG_LIR_Gen_1	24	33	PF02991	0.514
LIG_LIR_Gen_1	302	313	PF02991	0.325
LIG_LIR_Nem_3	183	189	PF02991	0.452
LIG_LIR_Nem_3	204	210	PF02991	0.427
LIG_LIR_Nem_3	222	227	PF02991	0.329
LIG_LIR_Nem_3	24	28	PF02991	0.523
LIG_LIR_Nem_3	302	308	PF02991	0.316
LIG_LIR_Nem_3	69	75	PF02991	0.439
LIG_NRBOX	224	230	PF00104	0.451
LIG_SH2_PTP2	115	118	PF00017	0.377
LIG_SH2_STAT3	73	76	PF00017	0.380
LIG_SH2_STAT5	115	118	PF00017	0.471
LIG_SH2_STAT5	160	163	PF00017	0.451
LIG_SH2_STAT5	264	267	PF00017	0.457
LIG_SH2_STAT5	310	313	PF00017	0.375
LIG_SH2_STAT5	37	40	PF00017	0.350
LIG_SH2_STAT5	65	68	PF00017	0.321
LIG_SH2_STAT5	73	76	PF00017	0.317
LIG_SH2_STAT5	94	97	PF00017	0.468
LIG_SH3_1	150	156	PF00018	0.550
LIG_SH3_3	13	19	PF00018	0.423
LIG_SH3_3	150	156	PF00018	0.513
LIG_SH3_3	251	257	PF00018	0.520
LIG_SH3_3	308	314	PF00018	0.476
LIG_SUMO_SIM_par_1	225	231	PF11976	0.425
LIG_TYR_ITIM	113	118	PF00017	0.373
MOD_CK1_1	121	127	PF00069	0.430
MOD_CK1_1	193	199	PF00069	0.506
MOD_CK1_1	280	286	PF00069	0.558
MOD_CK1_1	67	73	PF00069	0.475
MOD_CK2_1	181	187	PF00069	0.495
MOD_CK2_1	231	237	PF00069	0.439
MOD_CK2_1	330	336	PF00069	0.625
MOD_CK2_1	87	93	PF00069	0.357
MOD_GlcNHglycan	12	15	PF01048	0.524
MOD_GlcNHglycan	120	123	PF01048	0.518
MOD_GlcNHglycan	177	180	PF01048	0.408
MOD_GlcNHglycan	183	186	PF01048	0.461
MOD_GlcNHglycan	192	195	PF01048	0.383
MOD_GlcNHglycan	88	92	PF01048	0.477
MOD_GlcNHglycan	97	100	PF01048	0.490
MOD_GSK3_1	118	125	PF00069	0.417
MOD_GSK3_1	138	145	PF00069	0.405
MOD_GSK3_1	177	184	PF00069	0.388
MOD_GSK3_1	231	238	PF00069	0.440
MOD_GSK3_1	27	34	PF00069	0.446
MOD_GSK3_1	294	301	PF00069	0.502
MOD_GSK3_1	326	333	PF00069	0.665
MOD_GSK3_1	6	13	PF00069	0.522
MOD_N-GLC_1	67	72	PF02516	0.339
MOD_NEK2_1	118	123	PF00069	0.436
MOD_NEK2_1	167	172	PF00069	0.430
MOD_NEK2_1	190	195	PF00069	0.491
MOD_NEK2_1	31	36	PF00069	0.393
MOD_NEK2_2	160	165	PF00069	0.488
MOD_PKA_2	118	124	PF00069	0.400
MOD_PKA_2	190	196	PF00069	0.512
MOD_PKA_2	280	286	PF00069	0.572
MOD_Plk_1	235	241	PF00069	0.419
MOD_Plk_1	285	291	PF00069	0.460
MOD_Plk_1	298	304	PF00069	0.287
MOD_Plk_1	67	73	PF00069	0.343
MOD_Plk_2-3	231	237	PF00069	0.530
MOD_Plk_2-3	299	305	PF00069	0.454
MOD_Plk_4	177	183	PF00069	0.453
MOD_Plk_4	55	61	PF00069	0.429
MOD_Plk_4	67	73	PF00069	0.361
MOD_ProDKin_1	148	154	PF00069	0.475
MOD_ProDKin_1	326	332	PF00069	0.531
MOD_ProDKin_1	6	12	PF00069	0.456
MOD_SUMO_rev_2	141	151	PF00179	0.345
TRG_ENDOCYTIC_2	115	118	PF00928	0.377
TRG_ER_diArg_1	292	294	PF00400	0.517
TRG_ER_diArg_1	4	7	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI3	Leptomonas seymouri	61%	85%
A0A0S4JE69	Bodo saltans	35%	90%
A0A1X0NWJ3	Trypanosomatidae	42%	90%
A0A3S5H780	Leishmania donovani	99%	100%
A0A422MW34	Trypanosoma rangeli	40%	90%
A0A422NVZ8	Trypanosoma rangeli	28%	68%
C9ZHV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	89%
E9AI71	Leishmania braziliensis	82%	100%
E9AUF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QD27	Leishmania major	95%	100%
V5BQX0	Trypanosoma cruzi	41%	80%