MORN repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase related

Species:

Leishmania infantum

UniProt:

A4HYK3_LEIIN

TriTrypDb:

LINF_200006300

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 13
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYK3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.400
CLV_C14_Caspase3-7	190	194	PF00656	0.393
CLV_NRD_NRD_1	197	199	PF00675	0.418
CLV_NRD_NRD_1	3	5	PF00675	0.560
CLV_NRD_NRD_1	388	390	PF00675	0.692
CLV_PCSK_KEX2_1	197	199	PF00082	0.399
CLV_PCSK_KEX2_1	3	5	PF00082	0.560
CLV_PCSK_KEX2_1	388	390	PF00082	0.692
CLV_PCSK_SKI1_1	154	158	PF00082	0.326
CLV_PCSK_SKI1_1	35	39	PF00082	0.485
CLV_PCSK_SKI1_1	353	357	PF00082	0.572
CLV_PCSK_SKI1_1	407	411	PF00082	0.472
CLV_PCSK_SKI1_1	438	442	PF00082	0.582
DEG_Nend_Nbox_1	1	3	PF02207	0.529
DEG_SCF_FBW7_1	201	207	PF00400	0.423
DOC_ANK_TNKS_1	216	223	PF00023	0.306
DOC_CKS1_1	201	206	PF01111	0.427
DOC_PP1_RVXF_1	152	158	PF00149	0.306
DOC_PP1_RVXF_1	230	236	PF00149	0.381
DOC_PP1_RVXF_1	382	388	PF00149	0.672
DOC_PP4_FxxP_1	412	415	PF00568	0.618
DOC_PP4_FxxP_1	56	59	PF00568	0.539
DOC_USP7_UBL2_3	410	414	PF12436	0.624
DOC_WW_Pin1_4	200	205	PF00397	0.419
DOC_WW_Pin1_4	413	418	PF00397	0.756
DOC_WW_Pin1_4	438	443	PF00397	0.589
LIG_14-3-3_CanoR_1	232	236	PF00244	0.477
LIG_14-3-3_CanoR_1	4	10	PF00244	0.625
LIG_14-3-3_CanoR_1	407	413	PF00244	0.483
LIG_FHA_1	102	108	PF00498	0.421
LIG_FHA_1	112	118	PF00498	0.355
LIG_FHA_1	157	163	PF00498	0.504
LIG_FHA_1	223	229	PF00498	0.507
LIG_FHA_2	120	126	PF00498	0.424
LIG_FHA_2	132	138	PF00498	0.326
LIG_FHA_2	319	325	PF00498	0.595
LIG_LIR_Apic_2	411	415	PF02991	0.609
LIG_LIR_Apic_2	53	59	PF02991	0.551
LIG_LIR_Gen_1	182	192	PF02991	0.385
LIG_LIR_Gen_1	362	370	PF02991	0.527
LIG_LIR_Gen_1	402	412	PF02991	0.470
LIG_LIR_Nem_3	182	188	PF02991	0.435
LIG_LIR_Nem_3	234	238	PF02991	0.492
LIG_LIR_Nem_3	362	366	PF02991	0.595
LIG_LIR_Nem_3	402	408	PF02991	0.460
LIG_LIR_Nem_3	92	97	PF02991	0.488
LIG_Pex14_2	235	239	PF04695	0.336
LIG_Pex14_2	408	412	PF04695	0.474
LIG_Pex14_2	74	78	PF04695	0.413
LIG_REV1ctd_RIR_1	165	174	PF16727	0.409
LIG_SH2_CRK	94	98	PF00017	0.487
LIG_SH2_STAP1	305	309	PF00017	0.500
LIG_SH2_STAT5	187	190	PF00017	0.388
LIG_SH2_STAT5	202	205	PF00017	0.480
LIG_SH2_STAT5	206	209	PF00017	0.442
LIG_SH2_STAT5	226	229	PF00017	0.441
LIG_SH2_STAT5	286	289	PF00017	0.601
LIG_SH3_3	105	111	PF00018	0.374
LIG_SH3_3	24	30	PF00018	0.455
LIG_SH3_3	416	422	PF00018	0.574
LIG_TRAF2_1	161	164	PF00917	0.360
LIG_TYR_ITSM	90	97	PF00017	0.502
LIG_WRC_WIRS_1	409	414	PF05994	0.505
MOD_CDK_SPxK_1	438	444	PF00069	0.598
MOD_CK1_1	285	291	PF00069	0.621
MOD_CK2_1	142	148	PF00069	0.435
MOD_CK2_1	301	307	PF00069	0.596
MOD_CK2_1	58	64	PF00069	0.433
MOD_GlcNHglycan	254	257	PF01048	0.430
MOD_GlcNHglycan	287	290	PF01048	0.531
MOD_GlcNHglycan	367	370	PF01048	0.769
MOD_GlcNHglycan	394	399	PF01048	0.563
MOD_GlcNHglycan	46	49	PF01048	0.443
MOD_GSK3_1	200	207	PF00069	0.451
MOD_GSK3_1	233	240	PF00069	0.510
MOD_GSK3_1	271	278	PF00069	0.658
MOD_GSK3_1	46	53	PF00069	0.568
MOD_GSK3_1	5	12	PF00069	0.525
MOD_N-GLC_1	111	116	PF02516	0.443
MOD_N-GLC_1	16	21	PF02516	0.503
MOD_NEK2_1	119	124	PF00069	0.457
MOD_NEK2_1	233	238	PF00069	0.389
MOD_NEK2_1	301	306	PF00069	0.498
MOD_NEK2_1	408	413	PF00069	0.598
MOD_NEK2_1	5	10	PF00069	0.575
MOD_PIKK_1	131	137	PF00454	0.388
MOD_PIKK_1	58	64	PF00454	0.537
MOD_PKA_1	197	203	PF00069	0.522
MOD_PKA_2	197	203	PF00069	0.536
MOD_PKA_2	231	237	PF00069	0.470
MOD_Plk_4	16	22	PF00069	0.415
MOD_Plk_4	163	169	PF00069	0.400
MOD_Plk_4	197	203	PF00069	0.504
MOD_Plk_4	222	228	PF00069	0.324
MOD_Plk_4	28	34	PF00069	0.506
MOD_Plk_4	5	11	PF00069	0.639
MOD_ProDKin_1	200	206	PF00069	0.421
MOD_ProDKin_1	413	419	PF00069	0.761
MOD_ProDKin_1	438	444	PF00069	0.598
MOD_SUMO_for_1	123	126	PF00179	0.330
TRG_DiLeu_BaEn_4	64	70	PF01217	0.547
TRG_ENDOCYTIC_2	94	97	PF00928	0.493
TRG_ER_diArg_1	196	198	PF00400	0.418
TRG_ER_diArg_1	2	4	PF00400	0.564
TRG_ER_diArg_1	387	389	PF00400	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S2	Leptomonas seymouri	78%	100%
A0A0S4JFV2	Bodo saltans	51%	100%
A0A1X0NX05	Trypanosomatidae	60%	100%
A0A3S7WVR3	Leishmania donovani	100%	100%
A0A3S7X3U7	Leishmania donovani	31%	100%
A0A422N7V9	Trypanosoma rangeli	58%	100%
A4HBI1	Leishmania braziliensis	89%	100%
A4HIR9	Leishmania braziliensis	31%	100%
A4I615	Leishmania infantum	31%	100%
C9ZHV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AUF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6V8	Leishmania major	31%	100%
Q4QD31	Leishmania major	96%	100%
V5C0D1	Trypanosoma cruzi	59%	100%