LeishMANIAdb
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Peptidylprolyl isomerase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peptidylprolyl isomerase
Gene product:
FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase - putative
Species:
Leishmania infantum
UniProt:
A4HYI1_LEIIN
TriTrypDb:
LINF_190021700
Length:
432

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Peptidylprolyl isomerase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYI1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYI1

Function

Biological processes
Term Name Level Count
GO:0000413 protein peptidyl-prolyl isomerization 7 1
GO:0006457 protein folding 2 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018208 peptidyl-proline modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0061077 chaperone-mediated protein folding 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 12
GO:0003824 catalytic activity 1 12
GO:0016853 isomerase activity 2 12
GO:0016859 cis-trans isomerase activity 3 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 292 296 PF00656 0.526
CLV_C14_Caspase3-7 66 70 PF00656 0.396
CLV_NRD_NRD_1 225 227 PF00675 0.346
CLV_NRD_NRD_1 288 290 PF00675 0.344
CLV_NRD_NRD_1 310 312 PF00675 0.318
CLV_NRD_NRD_1 358 360 PF00675 0.371
CLV_PCSK_KEX2_1 227 229 PF00082 0.374
CLV_PCSK_KEX2_1 288 290 PF00082 0.358
CLV_PCSK_KEX2_1 310 312 PF00082 0.303
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.374
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.486
CLV_PCSK_SKI1_1 108 112 PF00082 0.294
CLV_PCSK_SKI1_1 359 363 PF00082 0.331
CLV_PCSK_SKI1_1 370 374 PF00082 0.210
CLV_PCSK_SKI1_1 390 394 PF00082 0.136
CLV_PCSK_SKI1_1 42 46 PF00082 0.344
CLV_PCSK_SKI1_1 424 428 PF00082 0.498
CLV_PCSK_SKI1_1 55 59 PF00082 0.274
DEG_SPOP_SBC_1 5 9 PF00917 0.561
DOC_MAPK_gen_1 153 161 PF00069 0.474
DOC_MAPK_gen_1 307 315 PF00069 0.292
DOC_PP4_FxxP_1 247 250 PF00568 0.412
DOC_USP7_MATH_1 248 252 PF00917 0.388
DOC_USP7_MATH_1 5 9 PF00917 0.548
DOC_USP7_UBL2_3 424 428 PF12436 0.433
DOC_USP7_UBL2_3 94 98 PF12436 0.283
DOC_WW_Pin1_4 111 116 PF00397 0.274
DOC_WW_Pin1_4 121 126 PF00397 0.238
DOC_WW_Pin1_4 194 199 PF00397 0.561
LIG_14-3-3_CanoR_1 271 276 PF00244 0.453
LIG_14-3-3_CanoR_1 359 365 PF00244 0.388
LIG_14-3-3_CanoR_1 4 13 PF00244 0.511
LIG_Actin_WH2_2 375 392 PF00022 0.203
LIG_Actin_WH2_2 96 114 PF00022 0.294
LIG_APCC_ABBA_1 214 219 PF00400 0.315
LIG_BIR_II_1 1 5 PF00653 0.620
LIG_BIR_III_2 242 246 PF00653 0.491
LIG_BRCT_BRCA1_1 353 357 PF00533 0.404
LIG_Clathr_ClatBox_1 135 139 PF01394 0.294
LIG_EH1_1 61 69 PF00400 0.328
LIG_FHA_1 100 106 PF00498 0.292
LIG_FHA_1 142 148 PF00498 0.405
LIG_FHA_1 176 182 PF00498 0.392
LIG_FHA_1 259 265 PF00498 0.317
LIG_FHA_1 367 373 PF00498 0.404
LIG_FHA_1 391 397 PF00498 0.324
LIG_FHA_1 41 47 PF00498 0.363
LIG_FHA_2 199 205 PF00498 0.481
LIG_FHA_2 64 70 PF00498 0.369
LIG_Integrin_RGD_1 79 81 PF01839 0.404
LIG_LIR_Apic_2 167 171 PF02991 0.406
LIG_LIR_Apic_2 246 250 PF02991 0.426
LIG_LIR_Gen_1 274 283 PF02991 0.439
LIG_LIR_Nem_3 194 199 PF02991 0.585
LIG_LIR_Nem_3 204 208 PF02991 0.474
LIG_LIR_Nem_3 274 278 PF02991 0.425
LIG_Pex14_2 427 431 PF04695 0.537
LIG_PTB_Apo_2 167 174 PF02174 0.497
LIG_SH2_CRK 196 200 PF00017 0.581
LIG_SH2_CRK 275 279 PF00017 0.295
LIG_SH2_CRK 41 45 PF00017 0.379
LIG_SH2_GRB2like 168 171 PF00017 0.433
LIG_SH2_NCK_1 168 172 PF00017 0.398
LIG_SH2_SRC 117 120 PF00017 0.404
LIG_SH2_SRC 168 171 PF00017 0.433
LIG_SH2_SRC 351 354 PF00017 0.226
LIG_SH2_STAP1 351 355 PF00017 0.386
LIG_SH2_STAT5 184 187 PF00017 0.394
LIG_SH2_STAT5 196 199 PF00017 0.436
LIG_SH2_STAT5 262 265 PF00017 0.349
LIG_SH2_STAT5 63 66 PF00017 0.274
LIG_SH3_3 123 129 PF00018 0.260
LIG_SH3_3 20 26 PF00018 0.450
LIG_SH3_3 28 34 PF00018 0.385
LIG_SUMO_SIM_par_1 261 268 PF11976 0.376
LIG_SUMO_SIM_par_1 360 367 PF11976 0.331
LIG_SUMO_SIM_par_1 393 399 PF11976 0.320
LIG_SUMO_SIM_par_1 42 47 PF11976 0.438
LIG_UBA3_1 158 163 PF00899 0.479
LIG_UBA3_1 372 377 PF00899 0.404
MOD_CDK_SPxK_1 194 200 PF00069 0.540
MOD_CK1_1 124 130 PF00069 0.353
MOD_CK1_1 175 181 PF00069 0.451
MOD_CK1_1 267 273 PF00069 0.527
MOD_CK1_1 363 369 PF00069 0.282
MOD_CK1_1 8 14 PF00069 0.559
MOD_CK2_1 248 254 PF00069 0.357
MOD_GlcNHglycan 148 152 PF01048 0.405
MOD_GlcNHglycan 229 232 PF01048 0.394
MOD_GlcNHglycan 251 254 PF01048 0.416
MOD_GlcNHglycan 291 294 PF01048 0.508
MOD_GlcNHglycan 353 356 PF01048 0.475
MOD_GlcNHglycan 8 11 PF01048 0.656
MOD_GSK3_1 153 160 PF00069 0.415
MOD_GSK3_1 194 201 PF00069 0.585
MOD_GSK3_1 267 274 PF00069 0.380
MOD_GSK3_1 351 358 PF00069 0.357
MOD_GSK3_1 360 367 PF00069 0.361
MOD_GSK3_1 4 11 PF00069 0.566
MOD_GSK3_1 68 75 PF00069 0.275
MOD_N-GLC_1 130 135 PF02516 0.260
MOD_NEK2_1 157 162 PF00069 0.533
MOD_NEK2_1 173 178 PF00069 0.288
MOD_NEK2_1 322 327 PF00069 0.363
MOD_NEK2_1 364 369 PF00069 0.203
MOD_NEK2_1 40 45 PF00069 0.375
MOD_NEK2_1 68 73 PF00069 0.428
MOD_NEK2_1 83 88 PF00069 0.261
MOD_NEK2_2 57 62 PF00069 0.343
MOD_NEK2_2 99 104 PF00069 0.294
MOD_PIKK_1 14 20 PF00454 0.551
MOD_PIKK_1 48 54 PF00454 0.433
MOD_PKA_1 227 233 PF00069 0.428
MOD_PKA_1 289 295 PF00069 0.412
MOD_PKA_2 227 233 PF00069 0.344
MOD_Plk_1 130 136 PF00069 0.260
MOD_Plk_1 153 159 PF00069 0.333
MOD_Plk_1 173 179 PF00069 0.371
MOD_Plk_1 258 264 PF00069 0.381
MOD_Plk_1 267 273 PF00069 0.326
MOD_Plk_1 322 328 PF00069 0.486
MOD_Plk_1 83 89 PF00069 0.274
MOD_Plk_4 130 136 PF00069 0.274
MOD_Plk_4 153 159 PF00069 0.344
MOD_Plk_4 258 264 PF00069 0.324
MOD_Plk_4 40 46 PF00069 0.344
MOD_Plk_4 422 428 PF00069 0.518
MOD_Plk_4 63 69 PF00069 0.429
MOD_ProDKin_1 111 117 PF00069 0.274
MOD_ProDKin_1 121 127 PF00069 0.238
MOD_ProDKin_1 194 200 PF00069 0.554
MOD_SUMO_for_1 326 329 PF00179 0.505
MOD_SUMO_rev_2 276 284 PF00179 0.374
TRG_ENDOCYTIC_2 196 199 PF00928 0.517
TRG_ENDOCYTIC_2 275 278 PF00928 0.418
TRG_ENDOCYTIC_2 41 44 PF00928 0.372
TRG_ER_diArg_1 225 228 PF00400 0.394
TRG_ER_diArg_1 309 311 PF00400 0.303
TRG_ER_diArg_1 332 335 PF00400 0.459
TRG_ER_diLys_1 428 432 PF00400 0.502
TRG_NES_CRM1_1 387 399 PF08389 0.271

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDU7 Leptomonas seymouri 74% 100%
A0A0S4IT01 Bodo saltans 45% 100%
A0A1X0P656 Trypanosomatidae 52% 100%
A0A3R7L7K6 Trypanosoma rangeli 55% 100%
A0A3S7WVP4 Leishmania donovani 100% 100%
A4HAA2 Leishmania braziliensis 87% 100%
D0A0V5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9ASA6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P27124 Oryctolagus cuniculus 33% 94%
P30416 Mus musculus 33% 94%
Q02790 Homo sapiens 32% 94%
Q13451 Homo sapiens 31% 95%
Q38931 Arabidopsis thaliana 30% 78%
Q43207 Triticum aestivum 30% 77%
Q4QD56 Leishmania major 96% 100%
Q5RF88 Pongo abelii 31% 95%
Q64378 Mus musculus 32% 95%
Q7DMA9 Arabidopsis thaliana 24% 68%
Q95L05 Chlorocebus aethiops 31% 95%
Q9FJL3 Arabidopsis thaliana 29% 75%
Q9QVC8 Rattus norvegicus 32% 94%
Q9TRY0 Bos taurus 33% 94%
Q9VL78 Drosophila melanogaster 31% 98%
Q9XSH5 Saimiri boliviensis boliviensis 30% 95%
Q9XSI2 Saguinus oedipus 31% 95%
Q9XT11 Aotus nancymaae 30% 95%
V5AP12 Trypanosoma cruzi 50% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS