Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania infantum

UniProt:

A4HYH5_LEIIN

TriTrypDb:

LINF_190021000

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYH5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004497	monooxygenase activity	3	5
GO:0004517	nitric-oxide synthase activity	5	5
GO:0016491	oxidoreductase activity	2	10
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	5
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0010181	FMN binding	4	1
GO:0032553	ribonucleotide binding	3	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.562
CLV_NRD_NRD_1	298	300	PF00675	0.529
CLV_NRD_NRD_1	325	327	PF00675	0.563
CLV_NRD_NRD_1	447	449	PF00675	0.313
CLV_PCSK_KEX2_1	2	4	PF00082	0.507
CLV_PCSK_KEX2_1	298	300	PF00082	0.572
CLV_PCSK_KEX2_1	325	327	PF00082	0.563
CLV_PCSK_KEX2_1	447	449	PF00082	0.313
CLV_PCSK_KEX2_1	512	514	PF00082	0.270
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.270
CLV_PCSK_SKI1_1	125	129	PF00082	0.635
CLV_PCSK_SKI1_1	185	189	PF00082	0.514
CLV_PCSK_SKI1_1	375	379	PF00082	0.686
CLV_PCSK_SKI1_1	505	509	PF00082	0.252
CLV_PCSK_SKI1_1	535	539	PF00082	0.337
CLV_PCSK_SKI1_1	88	92	PF00082	0.621
DEG_Nend_UBRbox_1	1	4	PF02207	0.443
DEG_ODPH_VHL_1	434	446	PF01847	0.420
DEG_SPOP_SBC_1	226	230	PF00917	0.564
DOC_ANK_TNKS_1	4	11	PF00023	0.270
DOC_CYCLIN_RxL_1	151	159	PF00134	0.391
DOC_CYCLIN_RxL_1	532	539	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.352
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.434
DOC_MAPK_gen_1	512	518	PF00069	0.470
DOC_MAPK_RevD_3	283	299	PF00069	0.333
DOC_PP1_RVXF_1	569	575	PF00149	0.577
DOC_PP2B_PxIxI_1	110	116	PF00149	0.402
DOC_USP7_MATH_1	245	249	PF00917	0.404
DOC_USP7_MATH_1	324	328	PF00917	0.379
DOC_USP7_MATH_1	373	377	PF00917	0.404
DOC_USP7_MATH_1	452	456	PF00917	0.517
DOC_WW_Pin1_4	104	109	PF00397	0.411
DOC_WW_Pin1_4	166	171	PF00397	0.333
DOC_WW_Pin1_4	229	234	PF00397	0.523
DOC_WW_Pin1_4	261	266	PF00397	0.403
DOC_WW_Pin1_4	310	315	PF00397	0.427
DOC_WW_Pin1_4	73	78	PF00397	0.448
LIG_14-3-3_CanoR_1	216	223	PF00244	0.352
LIG_14-3-3_CanoR_1	298	303	PF00244	0.323
LIG_14-3-3_CanoR_1	325	331	PF00244	0.398
LIG_14-3-3_CanoR_1	447	457	PF00244	0.500
LIG_Actin_WH2_2	434	449	PF00022	0.462
LIG_APCC_ABBA_1	215	220	PF00400	0.421
LIG_BRCT_BRCA1_1	358	362	PF00533	0.339
LIG_BRCT_BRCA1_1	422	426	PF00533	0.381
LIG_BRCT_BRCA1_1	454	458	PF00533	0.560
LIG_Clathr_ClatBox_1	563	567	PF01394	0.626
LIG_CSL_BTD_1	179	182	PF09270	0.328
LIG_deltaCOP1_diTrp_1	575	583	PF00928	0.574
LIG_eIF4E_1	390	396	PF01652	0.312
LIG_FHA_1	16	22	PF00498	0.313
LIG_FHA_1	482	488	PF00498	0.551
LIG_FHA_1	506	512	PF00498	0.481
LIG_FHA_1	517	523	PF00498	0.568
LIG_FHA_1	577	583	PF00498	0.615
LIG_FHA_2	466	472	PF00498	0.532
LIG_FHA_2	475	481	PF00498	0.541
LIG_LIR_Gen_1	194	204	PF02991	0.323
LIG_LIR_Gen_1	209	218	PF02991	0.326
LIG_LIR_Gen_1	23	32	PF02991	0.307
LIG_LIR_Gen_1	276	285	PF02991	0.334
LIG_LIR_Gen_1	392	401	PF02991	0.411
LIG_LIR_Nem_3	194	199	PF02991	0.309
LIG_LIR_Nem_3	209	214	PF02991	0.336
LIG_LIR_Nem_3	23	29	PF02991	0.307
LIG_LIR_Nem_3	276	281	PF02991	0.329
LIG_LIR_Nem_3	392	396	PF02991	0.400
LIG_LYPXL_yS_3	268	271	PF13949	0.337
LIG_MLH1_MIPbox_1	358	362	PF16413	0.339
LIG_NRBOX	188	194	PF00104	0.392
LIG_Pex14_1	22	26	PF04695	0.284
LIG_Pex14_2	211	215	PF04695	0.342
LIG_PTB_Apo_2	395	402	PF02174	0.412
LIG_SH2_NCK_1	26	30	PF00017	0.215
LIG_SH2_NCK_1	300	304	PF00017	0.408
LIG_SH2_PTP2	196	199	PF00017	0.328
LIG_SH2_PTP2	65	68	PF00017	0.420
LIG_SH2_SRC	196	199	PF00017	0.328
LIG_SH2_SRC	26	29	PF00017	0.215
LIG_SH2_SRC	490	493	PF00017	0.527
LIG_SH2_SRC	65	68	PF00017	0.389
LIG_SH2_STAP1	26	30	PF00017	0.324
LIG_SH2_STAP1	474	478	PF00017	0.553
LIG_SH2_STAP1	490	494	PF00017	0.391
LIG_SH2_STAT5	196	199	PF00017	0.289
LIG_SH2_STAT5	204	207	PF00017	0.309
LIG_SH2_STAT5	390	393	PF00017	0.322
LIG_SH2_STAT5	506	509	PF00017	0.507
LIG_SH2_STAT5	57	60	PF00017	0.367
LIG_SH2_STAT5	65	68	PF00017	0.377
LIG_SH3_3	1	7	PF00018	0.272
LIG_SH3_3	105	111	PF00018	0.431
LIG_SH3_3	167	173	PF00018	0.341
LIG_SH3_3	176	182	PF00018	0.317
LIG_SH3_3	278	284	PF00018	0.350
LIG_SH3_3	288	294	PF00018	0.269
LIG_SH3_3	308	314	PF00018	0.291
LIG_SH3_3	527	533	PF00018	0.531
LIG_SH3_3	66	72	PF00018	0.417
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.416
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.390
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.351
LIG_SUMO_SIM_par_1	270	276	PF11976	0.390
LIG_SUMO_SIM_par_1	286	292	PF11976	0.177
LIG_SUMO_SIM_par_1	562	568	PF11976	0.574
LIG_TRAF2_1	477	480	PF00917	0.481
LIG_TRAF2_1	48	51	PF00917	0.572
LIG_TRAF2_1	495	498	PF00917	0.555
LIG_TRAF2_1	557	560	PF00917	0.617
LIG_TYR_ITIM	24	29	PF00017	0.312
LIG_TYR_ITIM	266	271	PF00017	0.366
LIG_UBA3_1	214	222	PF00899	0.387
LIG_UBA3_1	255	261	PF00899	0.444
LIG_WRC_WIRS_1	277	282	PF05994	0.362
LIG_WRC_WIRS_1	390	395	PF05994	0.381
MOD_CK1_1	100	106	PF00069	0.425
MOD_CK1_1	140	146	PF00069	0.484
MOD_CK1_1	15	21	PF00069	0.338
MOD_CK1_1	200	206	PF00069	0.358
MOD_CK1_1	221	227	PF00069	0.500
MOD_CK1_1	228	234	PF00069	0.510
MOD_CK1_1	248	254	PF00069	0.212
MOD_CK1_1	260	266	PF00069	0.408
MOD_CK1_1	420	426	PF00069	0.409
MOD_CK2_1	206	212	PF00069	0.364
MOD_CK2_1	45	51	PF00069	0.569
MOD_CK2_1	465	471	PF00069	0.503
MOD_CK2_1	474	480	PF00069	0.482
MOD_CK2_1	492	498	PF00069	0.423
MOD_CK2_1	554	560	PF00069	0.562
MOD_CK2_1	73	79	PF00069	0.452
MOD_GlcNHglycan	120	123	PF01048	0.666
MOD_GlcNHglycan	14	17	PF01048	0.483
MOD_GlcNHglycan	193	196	PF01048	0.567
MOD_GlcNHglycan	224	227	PF01048	0.748
MOD_GlcNHglycan	290	294	PF01048	0.552
MOD_GlcNHglycan	326	329	PF01048	0.556
MOD_GlcNHglycan	379	382	PF01048	0.678
MOD_GlcNHglycan	454	457	PF01048	0.368
MOD_GSK3_1	206	213	PF00069	0.352
MOD_GSK3_1	218	225	PF00069	0.373
MOD_GSK3_1	227	234	PF00069	0.483
MOD_GSK3_1	255	262	PF00069	0.426
MOD_GSK3_1	294	301	PF00069	0.373
MOD_GSK3_1	306	313	PF00069	0.385
MOD_GSK3_1	352	359	PF00069	0.372
MOD_GSK3_1	373	380	PF00069	0.358
MOD_GSK3_1	448	455	PF00069	0.541
MOD_GSK3_1	97	104	PF00069	0.346
MOD_NEK2_1	118	123	PF00069	0.417
MOD_NEK2_1	206	211	PF00069	0.326
MOD_NEK2_1	255	260	PF00069	0.392
MOD_NEK2_1	289	294	PF00069	0.328
MOD_NEK2_1	363	368	PF00069	0.349
MOD_NEK2_1	377	382	PF00069	0.392
MOD_NEK2_1	389	394	PF00069	0.258
MOD_NEK2_1	396	401	PF00069	0.238
MOD_NEK2_1	516	521	PF00069	0.404
MOD_NEK2_2	101	106	PF00069	0.381
MOD_NEK2_2	536	541	PF00069	0.572
MOD_PIKK_1	140	146	PF00454	0.491
MOD_PIKK_1	420	426	PF00454	0.444
MOD_PIKK_1	43	49	PF00454	0.552
MOD_PIKK_1	439	445	PF00454	0.371
MOD_PKA_1	298	304	PF00069	0.315
MOD_PKA_1	447	453	PF00069	0.533
MOD_PKA_2	140	146	PF00069	0.330
MOD_PKA_2	298	304	PF00069	0.360
MOD_PKA_2	324	330	PF00069	0.389
MOD_PKA_2	447	453	PF00069	0.477
MOD_Plk_1	474	480	PF00069	0.524
MOD_Plk_1	554	560	PF00069	0.547
MOD_Plk_2-3	554	560	PF00069	0.546
MOD_Plk_4	101	107	PF00069	0.380
MOD_Plk_4	200	206	PF00069	0.316
MOD_Plk_4	210	216	PF00069	0.261
MOD_Plk_4	267	273	PF00069	0.350
MOD_Plk_4	396	402	PF00069	0.390
MOD_Plk_4	57	63	PF00069	0.359
MOD_ProDKin_1	104	110	PF00069	0.410
MOD_ProDKin_1	166	172	PF00069	0.333
MOD_ProDKin_1	229	235	PF00069	0.510
MOD_ProDKin_1	261	267	PF00069	0.395
MOD_ProDKin_1	310	316	PF00069	0.420
MOD_ProDKin_1	73	79	PF00069	0.444
MOD_SUMO_for_1	488	491	PF00179	0.538
MOD_SUMO_rev_2	219	224	PF00179	0.419
MOD_SUMO_rev_2	79	87	PF00179	0.426
TRG_DiLeu_BaEn_1	238	243	PF01217	0.407
TRG_DiLeu_BaEn_1	560	565	PF01217	0.586
TRG_DiLeu_BaEn_2	275	281	PF01217	0.367
TRG_DiLeu_BaEn_2	524	530	PF01217	0.512
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.307
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.404
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.645
TRG_DiLeu_LyEn_5	238	243	PF01217	0.394
TRG_ENDOCYTIC_2	196	199	PF00928	0.328
TRG_ENDOCYTIC_2	26	29	PF00928	0.368
TRG_ENDOCYTIC_2	268	271	PF00928	0.354
TRG_ENDOCYTIC_2	390	393	PF00928	0.385
TRG_ER_diArg_1	1	3	PF00400	0.449
TRG_ER_diArg_1	298	300	PF00400	0.338
TRG_ER_diArg_1	446	448	PF00400	0.515
TRG_ER_diArg_1	513	516	PF00400	0.470
TRG_ER_diArg_1	569	572	PF00400	0.584
TRG_NES_CRM1_1	273	286	PF08389	0.371
TRG_NLS_Bipartite_1	501	516	PF00514	0.415
TRG_Pf-PMV_PEXEL_1	562	567	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB19	Leptomonas seymouri	60%	100%
A0A0S4INF0	Bodo saltans	26%	100%
A0A1X0P608	Trypanosomatidae	38%	94%
A0A3Q8IK79	Leishmania donovani	100%	100%
A4HA95	Leishmania braziliensis	84%	100%
D0A0U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9AS99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QD65	Leishmania major	95%	100%
Q9HDG2	Phanerodontia chrysosporium	23%	79%