Cysteine peptidase A (CPA)

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase A (CPA)

Species:

Leishmania infantum

UniProt:

A4HYH2_LEIIN

TriTrypDb:

LINF_190020600

Length:

354

Annotations

Annotations by Jardim et al.

Proteases, Cysteine peptidase A (CPA) CPA

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 37, no: 6
NetGPI	no	yes: 0, no: 43

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 6

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HYH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYH2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	44
GO:0006807	nitrogen compound metabolic process	2	44
GO:0008152	metabolic process	1	44
GO:0019538	protein metabolic process	3	44
GO:0043170	macromolecule metabolic process	3	44
GO:0044238	primary metabolic process	2	44
GO:0071704	organic substance metabolic process	2	44
GO:1901564	organonitrogen compound metabolic process	3	44
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	44
GO:0008233	peptidase activity	3	44
GO:0008234	cysteine-type peptidase activity	4	44
GO:0016787	hydrolase activity	2	44
GO:0140096	catalytic activity, acting on a protein	2	44
GO:0004175	endopeptidase activity	4	27
GO:0004197	cysteine-type endopeptidase activity	5	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.487
CLV_NRD_NRD_1	61	63	PF00675	0.318
CLV_PCSK_KEX2_1	3	5	PF00082	0.472
CLV_PCSK_KEX2_1	47	49	PF00082	0.471
CLV_PCSK_KEX2_1	61	63	PF00082	0.269
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.471
CLV_PCSK_SKI1_1	298	302	PF00082	0.178
DOC_CKS1_1	140	145	PF01111	0.154
DOC_MAPK_gen_1	114	122	PF00069	0.421
DOC_MAPK_gen_1	238	245	PF00069	0.149
DOC_MAPK_MEF2A_6	258	266	PF00069	0.382
DOC_MAPK_MEF2A_6	318	325	PF00069	0.368
DOC_MAPK_NFAT4_5	318	326	PF00069	0.178
DOC_USP7_MATH_1	218	222	PF00917	0.300
DOC_USP7_MATH_1	324	328	PF00917	0.227
DOC_USP7_UBL2_3	47	51	PF12436	0.231
DOC_WW_Pin1_4	139	144	PF00397	0.357
DOC_WW_Pin1_4	26	31	PF00397	0.612
DOC_WW_Pin1_4	92	97	PF00397	0.246
LIG_APCC_ABBAyCdc20_2	117	123	PF00400	0.362
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BRCT_BRCA1_1	87	91	PF00533	0.367
LIG_EH_1	4	8	PF12763	0.316
LIG_FHA_1	157	163	PF00498	0.185
LIG_FHA_1	268	274	PF00498	0.399
LIG_FHA_1	336	342	PF00498	0.382
LIG_FHA_1	344	350	PF00498	0.606
LIG_FHA_2	338	344	PF00498	0.316
LIG_FHA_2	93	99	PF00498	0.204
LIG_LIR_Gen_1	317	325	PF02991	0.355
LIG_LIR_Gen_1	88	99	PF02991	0.209
LIG_LIR_Nem_3	269	274	PF02991	0.294
LIG_LIR_Nem_3	317	323	PF02991	0.300
LIG_LIR_Nem_3	39	45	PF02991	0.310
LIG_LIR_Nem_3	88	94	PF02991	0.400
LIG_LIR_Nem_3	98	102	PF02991	0.437
LIG_PCNA_yPIPBox_3	322	336	PF02747	0.141
LIG_PDZ_Class_1	349	354	PF00595	0.628
LIG_Pex14_1	271	275	PF04695	0.187
LIG_PTB_Apo_2	102	109	PF02174	0.417
LIG_PTB_Apo_2	2	9	PF02174	0.312
LIG_PTB_Phospho_1	102	108	PF10480	0.420
LIG_SH2_CRK	242	246	PF00017	0.171
LIG_SH2_GRB2like	103	106	PF00017	0.426
LIG_SH2_NCK_1	219	223	PF00017	0.328
LIG_SH2_PTP2	320	323	PF00017	0.300
LIG_SH2_SRC	103	106	PF00017	0.459
LIG_SH2_STAT5	103	106	PF00017	0.419
LIG_SH2_STAT5	219	222	PF00017	0.304
LIG_SH2_STAT5	255	258	PF00017	0.284
LIG_SH2_STAT5	274	277	PF00017	0.250
LIG_SH2_STAT5	320	323	PF00017	0.300
LIG_SH2_STAT5	335	338	PF00017	0.300
LIG_SH2_STAT5	74	77	PF00017	0.187
LIG_SH3_3	137	143	PF00018	0.154
LIG_SUMO_SIM_par_1	172	178	PF11976	0.319
LIG_TRAF2_1	95	98	PF00917	0.235
MOD_CDK_SPxK_1	139	145	PF00069	0.357
MOD_CK1_1	125	131	PF00069	0.473
MOD_CK1_1	172	178	PF00069	0.310
MOD_CK1_1	310	316	PF00069	0.274
MOD_CK1_1	344	350	PF00069	0.628
MOD_CK2_1	172	178	PF00069	0.278
MOD_CK2_1	311	317	PF00069	0.294
MOD_CK2_1	92	98	PF00069	0.293
MOD_Cter_Amidation	59	62	PF01082	0.154
MOD_GlcNHglycan	127	130	PF01048	0.574
MOD_GlcNHglycan	22	25	PF01048	0.467
MOD_GlcNHglycan	220	223	PF01048	0.290
MOD_GlcNHglycan	38	41	PF01048	0.343
MOD_GlcNHglycan	86	90	PF01048	0.309
MOD_GSK3_1	125	132	PF00069	0.401
MOD_GSK3_1	213	220	PF00069	0.305
MOD_GSK3_1	307	314	PF00069	0.212
MOD_GSK3_1	337	344	PF00069	0.409
MOD_N-GLC_1	169	174	PF02516	0.171
MOD_N-GLC_1	207	212	PF02516	0.383
MOD_N-GLC_1	231	236	PF02516	0.466
MOD_N-GLC_1	344	349	PF02516	0.436
MOD_N-GLC_2	328	330	PF02516	0.319
MOD_NEK2_1	149	154	PF00069	0.273
MOD_NEK2_1	156	161	PF00069	0.210
MOD_NEK2_1	283	288	PF00069	0.288
MOD_NEK2_1	36	41	PF00069	0.507
MOD_Plk_1	122	128	PF00069	0.663
MOD_Plk_1	169	175	PF00069	0.171
MOD_Plk_1	213	219	PF00069	0.286
MOD_Plk_1	266	272	PF00069	0.300
MOD_Plk_1	344	350	PF00069	0.419
MOD_Plk_4	11	17	PF00069	0.406
MOD_Plk_4	169	175	PF00069	0.344
MOD_ProDKin_1	139	145	PF00069	0.357
MOD_ProDKin_1	26	32	PF00069	0.602
MOD_ProDKin_1	92	98	PF00069	0.246
TRG_ENDOCYTIC_2	242	245	PF00928	0.336
TRG_ENDOCYTIC_2	304	307	PF00928	0.308
TRG_ENDOCYTIC_2	320	323	PF00928	0.300
TRG_ENDOCYTIC_2	42	45	PF00928	0.388
TRG_ER_diArg_1	61	63	PF00400	0.315
TRG_NLS_MonoExtN_4	44	50	PF00514	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	36%	100%
A0A0N0P293	Leptomonas seymouri	30%	95%
A0A0N0P8D1	Leptomonas seymouri	24%	100%
A0A0N1PA65	Leptomonas seymouri	55%	76%
A0A0S4III3	Bodo saltans	47%	100%
A0A0S4IMD3	Bodo saltans	44%	95%
A0A0S4ISD8	Bodo saltans	45%	66%
A0A0S4IWQ5	Bodo saltans	36%	100%
A0A0S4IY45	Bodo saltans	36%	100%
A0A0S4J328	Bodo saltans	49%	100%
A0A0S4J3Q7	Bodo saltans	32%	96%
A0A0S4J918	Bodo saltans	36%	100%
A0A0S4J9K9	Bodo saltans	47%	100%
A0A0S4JIQ4	Bodo saltans	29%	100%
A0A0S4JSZ3	Bodo saltans	31%	96%
A0A0S4JV57	Bodo saltans	29%	96%
A0A0S4JXJ3	Bodo saltans	29%	92%
A0A0S4KGP4	Bodo saltans	46%	100%
A0A0S4KI32	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	47%	76%
A0A1X0NIG8	Trypanosomatidae	30%	82%
A0A1X0NM52	Trypanosomatidae	44%	100%
A0A1X0NTV4	Trypanosomatidae	26%	100%
A0A1X0NXC8	Trypanosomatidae	30%	94%
A0A3R7L7E7	Trypanosoma rangeli	50%	67%
A0A3R7N5T7	Trypanosoma rangeli	27%	100%
A0A3S5H682	Leishmania donovani	50%	90%
A0A3S5H683	Leishmania donovani	49%	80%
A0A3S5H684	Leishmania donovani	48%	80%
A0A3S5H685	Leishmania donovani	49%	80%
A0A3S7WQD0	Leishmania donovani	49%	80%
A0A6L0WJ22	Leishmania infantum	47%	100%
A0E358	Paramecium tetraurelia	35%	100%
A1E295	Sus scrofa	28%	100%
A1KXI0	Blomia tropicalis	27%	100%
A2XQE8	Oryza sativa subsp. indica	38%	100%
A4H5E4	Leishmania braziliensis	46%	100%
A4H5E5	Leishmania braziliensis	47%	100%
A4H5E6	Leishmania braziliensis	47%	100%
A4HA92	Leishmania braziliensis	66%	100%
A4HH90	Leishmania braziliensis	27%	100%
A4HTP0	Leishmania infantum	45%	100%
A4I4D6	Leishmania infantum	29%	100%
A5HII1	Actinidia deliciosa	35%	93%
A8DS38	Tabernaemontana divaricata	36%	97%
B2LSD2	Mucuna pruriens	40%	82%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	78%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	79%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	88%
D3ZZ07	Rattus norvegicus	29%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	66%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
F4JNL3	Arabidopsis thaliana	33%	99%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	34%	100%
O17473	Brugia pahangi	36%	90%
O23791	Ananas comosus	36%	100%
O35186	Rattus norvegicus	37%	100%
O46427	Sus scrofa	33%	100%
O60911	Homo sapiens	36%	100%
O65039	Ricinus communis	40%	98%
O65493	Arabidopsis thaliana	38%	100%
O70370	Mus musculus	37%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	32%	100%
O97397	Phaedon cochleariae	36%	100%
O97578	Canis lupus familiaris	30%	81%
P00784	Carica papaya	34%	100%
P00785	Actinidia chinensis var. chinensis	35%	93%
P00786	Rattus norvegicus	35%	100%
P00787	Rattus norvegicus	27%	100%
P04988	Dictyostelium discoideum	41%	100%
P04989	Dictyostelium discoideum	38%	94%
P05167	Hordeum vulgare	35%	98%
P05994	Carica papaya	34%	100%
P06797	Mus musculus	39%	100%
P07154	Rattus norvegicus	39%	100%
P07688	Bos taurus	25%	100%
P07711	Homo sapiens	37%	100%
P07858	Homo sapiens	28%	100%
P09668	Homo sapiens	33%	100%
P10056	Carica papaya	33%	100%
P10605	Mus musculus	27%	100%
P12412	Vigna mungo	38%	98%
P13277	Homarus americanus	37%	100%
P14080	Carica papaya	37%	100%
P14658	Trypanosoma brucei brucei	47%	79%
P15242	Rattus norvegicus	36%	100%
P16311	Dermatophagoides farinae	27%	100%
P22497	Theileria parva	29%	80%
P22895	Glycine max	36%	93%
P25249	Hordeum vulgare	40%	95%
P25250	Hordeum vulgare	41%	95%
P25251	Brassica napus	39%	100%
P25326	Bos taurus	38%	100%
P25773	Felis catus	35%	100%
P25774	Homo sapiens	36%	100%
P25775	Leishmania mexicana	81%	100%
P25776	Oryza sativa subsp. japonica	39%	77%
P25777	Oryza sativa subsp. japonica	40%	76%
P25778	Oryza sativa subsp. japonica	36%	98%
P25779	Trypanosoma cruzi	50%	76%
P25781	Theileria annulata	31%	80%
P25782	Homarus americanus	35%	100%
P25783	Autographa californica nuclear polyhedrosis virus	34%	100%
P25784	Homarus americanus	40%	100%
P25792	Schistosoma mansoni	25%	100%
P25802	Ostertagia ostertagi	28%	100%
P25803	Phaseolus vulgaris	39%	98%
P25804	Pisum sativum	38%	98%
P25807	Caenorhabditis elegans	28%	100%
P25975	Bos taurus	38%	100%
P35591	Leishmania pifanoi	82%	100%
P36184	Entamoeba histolytica	35%	100%
P36185	Entamoeba histolytica	30%	100%
P36400	Leishmania mexicana	47%	80%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	35%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	34%	100%
P43156	Hemerocallis sp.	38%	98%
P43157	Schistosoma japonicum	27%	100%
P43233	Gallus gallus	27%	100%
P43234	Homo sapiens	37%	100%
P43235	Homo sapiens	37%	100%
P43236	Oryctolagus cuniculus	36%	100%
P43295	Arabidopsis thaliana	38%	98%
P43296	Arabidopsis thaliana	39%	96%
P43297	Arabidopsis thaliana	39%	77%
P43508	Caenorhabditis elegans	26%	100%
P43509	Caenorhabditis elegans	26%	100%
P43510	Caenorhabditis elegans	24%	93%
P46102	Plasmodium vinckei	29%	70%
P49935	Mus musculus	35%	100%
P54639	Dictyostelium discoideum	34%	80%
P54640	Dictyostelium discoideum	37%	100%
P55097	Mus musculus	37%	100%
P56202	Homo sapiens	31%	94%
P56203	Mus musculus	32%	95%
P61276	Macaca fascicularis	37%	100%
P61277	Macaca mulatta	37%	100%
P80067	Rattus norvegicus	31%	77%
P80884	Ananas comosus	36%	100%
P83205	Ovis aries	28%	100%
P92131	Giardia intestinalis	28%	100%
P92132	Giardia intestinalis	29%	100%
P92133	Giardia intestinalis	29%	100%
P97821	Mus musculus	32%	77%
Q01957	Entamoeba histolytica	32%	100%
Q01958	Entamoeba histolytica	34%	100%
Q02765	Rattus norvegicus	35%	100%
Q05094	Leishmania pifanoi	47%	80%
Q06964	Entamoeba histolytica	36%	100%
Q10716	Zea mays	37%	95%
Q10717	Zea mays	34%	98%
Q1EIQ3	Psoroptes ovis	27%	100%
Q23894	Dictyostelium discoideum	37%	100%
Q24940	Fasciola hepatica	36%	100%
Q26534	Schistosoma mansoni	40%	100%
Q26636	Sarcophaga peregrina	41%	100%
Q28944	Sus scrofa	38%	100%
Q3T0I2	Bos taurus	34%	100%
Q3ZKN1	Canis lupus familiaris	36%	100%
Q40143	Solanum lycopersicum	36%	99%
Q4QD68	Leishmania major	88%	100%
Q4QI61	Leishmania major	46%	100%
Q4QI62	Leishmania major	46%	100%
Q4QI64	Leishmania major	46%	100%
Q4QI65	Leishmania major	46%	100%
Q4QI66	Leishmania major	46%	100%
Q4QI67	Leishmania major	46%	100%
Q4QI68	Leishmania major	46%	100%
Q4R5M2	Macaca fascicularis	28%	100%
Q54TR1	Dictyostelium discoideum	36%	67%
Q5E968	Bos taurus	36%	100%
Q5E998	Bos taurus	38%	100%
Q5R6D1	Pongo abelii	28%	100%
Q63088	Rattus norvegicus	32%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	34%	100%
Q6YD92	Petrosia ficiformis	31%	100%
Q7F3A8	Oryza sativa subsp. japonica	38%	95%
Q7GDU7	Oryza sativa subsp. japonica	41%	94%
Q7XR52	Oryza sativa subsp. japonica	41%	72%
Q7XWK5	Oryza sativa subsp. japonica	38%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	32%	100%
Q80UB0	Mus musculus	36%	100%
Q86GF7	Pandalus borealis	37%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	34%	100%
Q8BM88	Mus musculus	34%	100%
Q8H166	Arabidopsis thaliana	36%	99%
Q8HY81	Canis lupus familiaris	37%	100%
Q8HY82	Saimiri boliviensis boliviensis	37%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	36%	100%
Q8RWQ9	Arabidopsis thaliana	37%	99%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	35%	96%
Q8VYS0	Arabidopsis thaliana	39%	96%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	37%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	36%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	35%	100%
Q91ZF2	Mus musculus	30%	100%
Q93VC9	Arabidopsis thaliana	30%	98%
Q94503	Dictyostelium discoideum	39%	82%
Q94504	Dictyostelium discoideum	39%	77%
Q94714	Paramecium tetraurelia	34%	100%
Q94715	Paramecium tetraurelia	29%	100%
Q94B08	Arabidopsis thaliana	40%	94%
Q94K85	Arabidopsis thaliana	25%	99%
Q95029	Drosophila melanogaster	42%	95%
Q9BIE1	Leishmania donovani	99%	100%
Q9EQT5	Rattus norvegicus	25%	76%
Q9FGR9	Arabidopsis thaliana	41%	98%
Q9FJ47	Arabidopsis thaliana	34%	100%
Q9FMH8	Arabidopsis thaliana	40%	76%
Q9GKL8	Chlorocebus aethiops	38%	100%
Q9GL24	Canis lupus familiaris	37%	100%
Q9GLE3	Sus scrofa	35%	100%
Q9GQM5	Leishmania donovani	29%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	36%	100%
Q9JI81	Mus musculus	32%	100%
Q9JIA9	Mus musculus	33%	100%
Q9JL96	Mus musculus	31%	100%
Q9LM66	Arabidopsis thaliana	39%	99%
Q9LT77	Arabidopsis thaliana	39%	98%
Q9LT78	Arabidopsis thaliana	37%	78%
Q9LXW3	Arabidopsis thaliana	36%	94%
Q9PYY5	Xestia c-nigrum granulosis virus	34%	100%
Q9QZE3	Rattus norvegicus	31%	100%
Q9R013	Mus musculus	37%	77%
Q9R014	Mus musculus	34%	100%
Q9STL4	Arabidopsis thaliana	39%	98%
Q9STL5	Arabidopsis thaliana	39%	97%
Q9SUL1	Arabidopsis thaliana	36%	95%
Q9SUS9	Arabidopsis thaliana	36%	95%
Q9SUT0	Arabidopsis thaliana	36%	97%
Q9TST1	Felis catus	32%	95%
Q9UBX1	Homo sapiens	38%	73%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	33%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	33%	99%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	33%	100%
V5B261	Trypanosoma cruzi	30%	90%
V5BNL4	Trypanosoma cruzi	31%	100%
V5LU01	Ambrosia artemisiifolia	38%	92%