TPR_REGION domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4HYH0_LEIIN

TriTrypDb:

LINF_190020400

Length:

228

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005737	cytoplasm	2	1
GO:0005874	microtubule	6	1
GO:0005876	spindle microtubule	7	1
GO:0097431	mitotic spindle pole	3	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HYH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYH0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.503
CLV_NRD_NRD_1	197	199	PF00675	0.405
CLV_PCSK_KEX2_1	215	217	PF00082	0.442
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.442
DEG_SPOP_SBC_1	156	160	PF00917	0.390
DOC_MAPK_gen_1	146	153	PF00069	0.513
DOC_MAPK_gen_1	215	222	PF00069	0.395
DOC_USP7_MATH_1	189	193	PF00917	0.390
DOC_USP7_MATH_1	52	56	PF00917	0.479
DOC_USP7_MATH_1	8	12	PF00917	0.472
DOC_USP7_UBL2_3	17	21	PF12436	0.472
DOC_USP7_UBL2_3	199	203	PF12436	0.363
DOC_USP7_UBL2_3	97	101	PF12436	0.509
LIG_14-3-3_CanoR_1	43	49	PF00244	0.355
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_FHA_2	158	164	PF00498	0.388
LIG_LIR_Gen_1	2	8	PF02991	0.465
LIG_LIR_Nem_3	2	7	PF02991	0.422
LIG_LIR_Nem_3	85	91	PF02991	0.367
LIG_NRBOX	164	170	PF00104	0.367
LIG_PTB_Apo_2	130	137	PF02174	0.424
LIG_SH2_NCK_1	49	53	PF00017	0.386
LIG_SH2_STAP1	161	165	PF00017	0.465
LIG_SH2_STAT3	188	191	PF00017	0.361
LIG_SH2_STAT5	108	111	PF00017	0.333
LIG_SH2_STAT5	167	170	PF00017	0.351
LIG_SH2_STAT5	210	213	PF00017	0.398
LIG_SH2_STAT5	64	67	PF00017	0.426
LIG_SH3_3	57	63	PF00018	0.509
LIG_SH3_4	17	24	PF00018	0.467
LIG_TRAF2_1	160	163	PF00917	0.397
MOD_CK2_1	156	162	PF00069	0.387
MOD_CK2_1	44	50	PF00069	0.404
MOD_GlcNHglycan	170	173	PF01048	0.449
MOD_GSK3_1	174	181	PF00069	0.450
MOD_N-GLC_1	179	184	PF02516	0.446
MOD_N-GLC_1	52	57	PF02516	0.511
MOD_N-GLC_2	133	135	PF02516	0.418
MOD_NEK2_1	44	49	PF00069	0.437
MOD_NEK2_2	174	179	PF00069	0.455
MOD_NEK2_2	189	194	PF00069	0.241
MOD_Plk_1	123	129	PF00069	0.408
MOD_Plk_1	179	185	PF00069	0.422
MOD_Plk_4	179	185	PF00069	0.437
MOD_SUMO_rev_2	94	98	PF00179	0.474
TRG_ENDOCYTIC_2	210	213	PF00928	0.398
TRG_ENDOCYTIC_2	48	51	PF00928	0.453
TRG_ER_diLys_1	224	228	PF00400	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK9	Leptomonas seymouri	81%	99%
A0A0S4IT21	Bodo saltans	49%	100%
A0A0S4KN82	Bodo saltans	38%	99%
A0A1X0P7G2	Trypanosomatidae	52%	99%
A0A3R7M541	Trypanosoma rangeli	52%	99%
A0A3S5H772	Leishmania donovani	100%	100%
A4HA90	Leishmania braziliensis	91%	100%
D0A0U0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	99%
E9AS94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P34560	Caenorhabditis elegans	29%	100%
Q32KL4	Bos taurus	37%	72%
Q4G069	Rattus norvegicus	37%	74%
Q4QD70	Leishmania major	96%	100%
Q5R8E4	Pongo abelii	35%	73%
Q96DB5	Homo sapiens	36%	73%
Q9DCV4	Mus musculus	37%	75%