Phosphatidic acid phosphatase protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase protein-like protein

Species:

Leishmania infantum

UniProt:

A4HYG7_LEIIN

TriTrypDb:

LINF_190019800

Length:

400

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Annotations by Jardim et al.

Phospholipid biosynthesis, Phosphatidic acid phosphatase -like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A4HYG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYG7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	24
GO:0006644	phospholipid metabolic process	4	24
GO:0006793	phosphorus metabolic process	3	24
GO:0006796	phosphate-containing compound metabolic process	4	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0019637	organophosphate metabolic process	3	24
GO:0044237	cellular metabolic process	2	24
GO:0044238	primary metabolic process	2	24
GO:0044255	cellular lipid metabolic process	3	24
GO:0071704	organic substance metabolic process	2	24

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008195	phosphatidate phosphatase activity	6	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.413
CLV_C14_Caspase3-7	46	50	PF00656	0.339
CLV_NRD_NRD_1	380	382	PF00675	0.762
CLV_NRD_NRD_1	388	390	PF00675	0.684
CLV_PCSK_KEX2_1	352	354	PF00082	0.754
CLV_PCSK_KEX2_1	380	382	PF00082	0.762
CLV_PCSK_KEX2_1	388	390	PF00082	0.684
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.627
CLV_PCSK_SKI1_1	309	313	PF00082	0.544
DEG_APCC_DBOX_1	143	151	PF00400	0.508
DOC_MAPK_DCC_7	248	258	PF00069	0.283
DOC_PP1_RVXF_1	209	215	PF00149	0.429
DOC_USP7_MATH_1	106	110	PF00917	0.660
DOC_USP7_MATH_1	340	344	PF00917	0.458
DOC_USP7_MATH_1	53	57	PF00917	0.357
DOC_WW_Pin1_4	360	365	PF00397	0.534
LIG_14-3-3_CanoR_1	211	215	PF00244	0.419
LIG_14-3-3_CanoR_1	242	247	PF00244	0.238
LIG_14-3-3_CanoR_1	309	316	PF00244	0.385
LIG_14-3-3_CanoR_1	358	365	PF00244	0.537
LIG_14-3-3_CanoR_1	43	48	PF00244	0.241
LIG_BIR_III_2	202	206	PF00653	0.411
LIG_BRCT_BRCA1_1	219	223	PF00533	0.292
LIG_BRCT_BRCA1_1	72	76	PF00533	0.325
LIG_DLG_GKlike_1	242	249	PF00625	0.286
LIG_FHA_1	155	161	PF00498	0.508
LIG_FHA_1	23	29	PF00498	0.223
LIG_FHA_1	245	251	PF00498	0.373
LIG_FHA_2	106	112	PF00498	0.669
LIG_FHA_2	190	196	PF00498	0.499
LIG_FHA_2	308	314	PF00498	0.431
LIG_FHA_2	372	378	PF00498	0.413
LIG_FHA_2	58	64	PF00498	0.382
LIG_IRF3_LxIS_1	24	31	PF10401	0.397
LIG_IRF3_LxIS_1	250	257	PF10401	0.276
LIG_LIR_Gen_1	195	205	PF02991	0.455
LIG_LIR_Gen_1	20	29	PF02991	0.342
LIG_LIR_Gen_1	245	254	PF02991	0.354
LIG_LIR_Gen_1	287	296	PF02991	0.406
LIG_LIR_Gen_1	313	321	PF02991	0.455
LIG_LIR_Nem_3	195	200	PF02991	0.445
LIG_LIR_Nem_3	20	24	PF02991	0.342
LIG_LIR_Nem_3	245	249	PF02991	0.301
LIG_LIR_Nem_3	287	292	PF02991	0.362
LIG_LIR_Nem_3	295	299	PF02991	0.464
LIG_LIR_Nem_3	313	319	PF02991	0.386
LIG_LIR_Nem_3	59	64	PF02991	0.299
LIG_LIR_Nem_3	73	79	PF02991	0.249
LIG_LIR_Nem_3	97	101	PF02991	0.577
LIG_LYPXL_S_1	139	143	PF13949	0.369
LIG_LYPXL_yS_3	140	143	PF13949	0.569
LIG_NRBOX	23	29	PF00104	0.409
LIG_PDZ_Wminus1_1	398	400	PF00595	0.530
LIG_Pex14_2	292	296	PF04695	0.317
LIG_Pex14_2	72	76	PF04695	0.365
LIG_Pex14_2	9	13	PF04695	0.577
LIG_PTB_Apo_2	190	197	PF02174	0.557
LIG_PTB_Phospho_1	190	196	PF10480	0.557
LIG_SH2_CRK	197	201	PF00017	0.469
LIG_SH2_STAP1	180	184	PF00017	0.531
LIG_SH2_STAP1	64	68	PF00017	0.378
LIG_SH2_STAT5	171	174	PF00017	0.471
LIG_SH2_STAT5	180	183	PF00017	0.469
LIG_SH2_STAT5	197	200	PF00017	0.403
LIG_SH2_STAT5	306	309	PF00017	0.403
LIG_SH2_STAT5	77	80	PF00017	0.286
LIG_SH2_STAT5	83	86	PF00017	0.379
LIG_SH3_3	332	338	PF00018	0.543
LIG_SH3_3	376	382	PF00018	0.423
LIG_SH3_3	89	95	PF00018	0.576
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.360
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.434
LIG_SUMO_SIM_anti_2	65	70	PF11976	0.307
LIG_SUMO_SIM_par_1	25	31	PF11976	0.310
LIG_SUMO_SIM_par_1	254	259	PF11976	0.371
LIG_SUMO_SIM_par_1	32	37	PF11976	0.310
LIG_TRAF2_1	87	90	PF00917	0.446
LIG_TYR_ITIM	138	143	PF00017	0.597
LIG_TYR_ITIM	314	319	PF00017	0.453
LIG_UBA3_1	32	39	PF00899	0.169
LIG_WRC_WIRS_1	289	294	PF05994	0.360
LIG_WRC_WIRS_1	372	377	PF05994	0.409
MOD_CDK_SPxxK_3	360	367	PF00069	0.533
MOD_CK1_1	154	160	PF00069	0.411
MOD_CK1_1	182	188	PF00069	0.512
MOD_CK1_1	213	219	PF00069	0.419
MOD_CK2_1	105	111	PF00069	0.692
MOD_CK2_1	2	8	PF00069	0.493
MOD_CK2_1	309	315	PF00069	0.345
MOD_DYRK1A_RPxSP_1	360	364	PF00069	0.379
MOD_GlcNHglycan	108	111	PF01048	0.513
MOD_GlcNHglycan	215	218	PF01048	0.219
MOD_GlcNHglycan	286	289	PF01048	0.325
MOD_GlcNHglycan	323	326	PF01048	0.573
MOD_GlcNHglycan	329	333	PF01048	0.670
MOD_GlcNHglycan	343	346	PF01048	0.718
MOD_GlcNHglycan	360	363	PF01048	0.725
MOD_GSK3_1	117	124	PF00069	0.697
MOD_GSK3_1	178	185	PF00069	0.486
MOD_GSK3_1	213	220	PF00069	0.437
MOD_GSK3_1	28	35	PF00069	0.344
MOD_GSK3_1	284	291	PF00069	0.344
MOD_GSK3_1	305	312	PF00069	0.365
MOD_GSK3_1	336	343	PF00069	0.522
MOD_GSK3_1	371	378	PF00069	0.416
MOD_GSK3_1	53	60	PF00069	0.307
MOD_LATS_1	41	47	PF00433	0.292
MOD_N-GLC_1	375	380	PF02516	0.615
MOD_NEK2_1	28	33	PF00069	0.267
MOD_NEK2_1	292	297	PF00069	0.326
MOD_NEK2_1	307	312	PF00069	0.302
MOD_NEK2_1	375	380	PF00069	0.562
MOD_NEK2_1	70	75	PF00069	0.333
MOD_NEK2_2	288	293	PF00069	0.358
MOD_PKA_1	380	386	PF00069	0.416
MOD_PKA_2	210	216	PF00069	0.419
MOD_PKA_2	380	386	PF00069	0.558
MOD_Plk_1	375	381	PF00069	0.416
MOD_Plk_1	48	54	PF00069	0.283
MOD_Plk_1	62	68	PF00069	0.229
MOD_Plk_4	117	123	PF00069	0.671
MOD_Plk_4	22	28	PF00069	0.319
MOD_Plk_4	224	230	PF00069	0.257
MOD_Plk_4	256	262	PF00069	0.332
MOD_Plk_4	278	284	PF00069	0.279
MOD_Plk_4	288	294	PF00069	0.294
MOD_ProDKin_1	360	366	PF00069	0.532
MOD_SUMO_rev_2	315	325	PF00179	0.386
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.315
TRG_ENDOCYTIC_2	115	118	PF00928	0.675
TRG_ENDOCYTIC_2	140	143	PF00928	0.506
TRG_ENDOCYTIC_2	16	19	PF00928	0.304
TRG_ENDOCYTIC_2	197	200	PF00928	0.469
TRG_ENDOCYTIC_2	293	296	PF00928	0.310
TRG_ENDOCYTIC_2	316	319	PF00928	0.460
TRG_ENDOCYTIC_2	77	80	PF00928	0.252
TRG_ER_diArg_1	127	130	PF00400	0.647
TRG_ER_diArg_1	166	169	PF00400	0.424
TRG_ER_diArg_1	379	381	PF00400	0.559
TRG_ER_diArg_1	388	390	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.723
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P344	Leptomonas seymouri	59%	100%
A0A0N1I1J3	Leptomonas seymouri	30%	100%
A0A0S4JH63	Bodo saltans	32%	100%
A0A1X0P677	Trypanosomatidae	39%	100%
A0A1X0P6S8	Trypanosomatidae	32%	100%
A0A1X0P729	Trypanosomatidae	32%	100%
A0A3Q8ID01	Leishmania donovani	28%	100%
A0A3Q8IK66	Leishmania donovani	100%	100%
A0A3S5IRX0	Trypanosoma rangeli	39%	100%
A0A422MQK2	Trypanosoma rangeli	33%	100%
A4H9I2	Leishmania braziliensis	29%	100%
A4HA84	Leishmania braziliensis	71%	100%
A4HXR8	Leishmania infantum	28%	100%
C9ZUG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZZW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A051	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AS87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AS88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O08564	Rattus norvegicus	26%	100%
O88956	Cavia porcellus	27%	100%
P60588	Sus scrofa	26%	100%
Q4QD76	Leishmania major	92%	100%
Q61469	Mus musculus	28%	100%
Q8K593	Rattus norvegicus	24%	100%
Q8LFD1	Arabidopsis thaliana	25%	100%
Q9UUA6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
V5B5J9	Trypanosoma cruzi	39%	100%
V5BM01	Trypanosoma cruzi	32%	100%
V5BWA7	Trypanosoma cruzi	33%	100%