PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYG4_LEIIN

TriTrypDb:

LINF_190020100

Length:

747

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.674
CLV_C14_Caspase3-7	413	417	PF00656	0.494
CLV_NRD_NRD_1	121	123	PF00675	0.495
CLV_NRD_NRD_1	249	251	PF00675	0.590
CLV_NRD_NRD_1	276	278	PF00675	0.601
CLV_NRD_NRD_1	292	294	PF00675	0.630
CLV_NRD_NRD_1	323	325	PF00675	0.679
CLV_NRD_NRD_1	401	403	PF00675	0.475
CLV_NRD_NRD_1	635	637	PF00675	0.640
CLV_NRD_NRD_1	88	90	PF00675	0.422
CLV_PCSK_FUR_1	399	403	PF00082	0.481
CLV_PCSK_KEX2_1	121	123	PF00082	0.495
CLV_PCSK_KEX2_1	249	251	PF00082	0.590
CLV_PCSK_KEX2_1	323	325	PF00082	0.679
CLV_PCSK_KEX2_1	401	403	PF00082	0.488
CLV_PCSK_KEX2_1	408	410	PF00082	0.427
CLV_PCSK_KEX2_1	88	90	PF00082	0.422
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.488
CLV_PCSK_SKI1_1	112	116	PF00082	0.419
CLV_PCSK_SKI1_1	408	412	PF00082	0.496
CLV_PCSK_SKI1_1	476	480	PF00082	0.541
CLV_PCSK_SKI1_1	630	634	PF00082	0.644
CLV_PCSK_SKI1_1	730	734	PF00082	0.568
CLV_Separin_Metazoa	246	250	PF03568	0.561
DEG_APCC_DBOX_1	111	119	PF00400	0.565
DEG_APCC_DBOX_1	467	475	PF00400	0.406
DEG_APCC_DBOX_1	508	516	PF00400	0.599
DEG_APCC_DBOX_1	527	535	PF00400	0.363
DEG_APCC_DBOX_1	578	586	PF00400	0.521
DOC_CKS1_1	462	467	PF01111	0.578
DOC_CYCLIN_RxL_1	473	481	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	735	738	PF00134	0.509
DOC_MAPK_gen_1	509	517	PF00069	0.600
DOC_MAPK_gen_1	725	734	PF00069	0.512
DOC_MAPK_MEF2A_6	25	34	PF00069	0.410
DOC_MAPK_MEF2A_6	528	536	PF00069	0.541
DOC_MAPK_MEF2A_6	579	586	PF00069	0.476
DOC_MAPK_MEF2A_6	67	76	PF00069	0.504
DOC_MAPK_MEF2A_6	728	736	PF00069	0.511
DOC_MAPK_RevD_3	106	122	PF00069	0.430
DOC_MIT_MIM_1	507	515	PF04212	0.548
DOC_PP2B_LxvP_1	286	289	PF13499	0.707
DOC_PP2B_LxvP_1	734	737	PF13499	0.504
DOC_PP2B_PxIxI_1	541	547	PF00149	0.505
DOC_USP7_MATH_1	144	148	PF00917	0.677
DOC_USP7_MATH_1	169	173	PF00917	0.707
DOC_USP7_MATH_1	175	179	PF00917	0.687
DOC_USP7_MATH_1	182	186	PF00917	0.601
DOC_USP7_MATH_1	199	203	PF00917	0.572
DOC_USP7_MATH_1	225	229	PF00917	0.689
DOC_USP7_MATH_1	300	304	PF00917	0.677
DOC_USP7_MATH_1	348	352	PF00917	0.753
DOC_USP7_MATH_1	368	372	PF00917	0.624
DOC_USP7_MATH_1	452	456	PF00917	0.668
DOC_USP7_MATH_1	667	671	PF00917	0.666
DOC_USP7_MATH_1	687	691	PF00917	0.657
DOC_USP7_MATH_1	741	745	PF00917	0.555
DOC_USP7_UBL2_3	404	408	PF12436	0.415
DOC_WW_Pin1_4	147	152	PF00397	0.699
DOC_WW_Pin1_4	165	170	PF00397	0.555
DOC_WW_Pin1_4	180	185	PF00397	0.583
DOC_WW_Pin1_4	230	235	PF00397	0.684
DOC_WW_Pin1_4	333	338	PF00397	0.740
DOC_WW_Pin1_4	378	383	PF00397	0.719
DOC_WW_Pin1_4	384	389	PF00397	0.597
DOC_WW_Pin1_4	461	466	PF00397	0.653
DOC_WW_Pin1_4	624	629	PF00397	0.635
DOC_WW_Pin1_4	691	696	PF00397	0.747
LIG_14-3-3_CanoR_1	193	203	PF00244	0.655
LIG_14-3-3_CanoR_1	335	341	PF00244	0.619
LIG_14-3-3_CanoR_1	374	380	PF00244	0.729
LIG_14-3-3_CanoR_1	476	486	PF00244	0.588
LIG_14-3-3_CanoR_1	522	532	PF00244	0.556
LIG_14-3-3_CanoR_1	547	552	PF00244	0.601
LIG_14-3-3_CanoR_1	559	565	PF00244	0.444
LIG_14-3-3_CanoR_1	649	658	PF00244	0.487
LIG_14-3-3_CanoR_1	668	676	PF00244	0.633
LIG_Actin_WH2_2	417	432	PF00022	0.592
LIG_Actin_WH2_2	533	551	PF00022	0.518
LIG_Actin_WH2_2	714	732	PF00022	0.475
LIG_APCC_ABBA_1	7	12	PF00400	0.694
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_BRCT_MDC1_1	743	747	PF00533	0.602
LIG_Clathr_ClatBox_1	531	535	PF01394	0.523
LIG_CSL_BTD_1	385	388	PF09270	0.618
LIG_FHA_1	258	264	PF00498	0.706
LIG_FHA_1	27	33	PF00498	0.402
LIG_FHA_1	493	499	PF00498	0.514
LIG_FHA_1	731	737	PF00498	0.512
LIG_FHA_2	345	351	PF00498	0.625
LIG_FHA_2	445	451	PF00498	0.712
LIG_FHA_2	499	505	PF00498	0.532
LIG_GBD_Chelix_1	392	400	PF00786	0.570
LIG_GBD_Chelix_1	471	479	PF00786	0.463
LIG_Integrin_RGD_1	468	470	PF01839	0.549
LIG_LIR_Apic_2	385	389	PF02991	0.607
LIG_LIR_Gen_1	309	319	PF02991	0.534
LIG_LIR_Gen_1	57	63	PF02991	0.530
LIG_LIR_Gen_1	670	680	PF02991	0.546
LIG_LIR_Nem_3	309	315	PF02991	0.531
LIG_LIR_Nem_3	406	410	PF02991	0.523
LIG_LIR_Nem_3	484	490	PF02991	0.527
LIG_LIR_Nem_3	550	555	PF02991	0.528
LIG_LIR_Nem_3	57	62	PF02991	0.539
LIG_Pex14_2	605	609	PF04695	0.597
LIG_Pex14_2	696	700	PF04695	0.618
LIG_RPA_C_Fungi	646	658	PF08784	0.615
LIG_SH2_CRK	487	491	PF00017	0.516
LIG_SH2_SRC	518	521	PF00017	0.636
LIG_SH2_STAP1	523	527	PF00017	0.586
LIG_SH2_STAP1	55	59	PF00017	0.545
LIG_SH2_STAT3	593	596	PF00017	0.531
LIG_SH2_STAT5	555	558	PF00017	0.494
LIG_SH2_STAT5	713	716	PF00017	0.525
LIG_SH3_3	17	23	PF00018	0.642
LIG_SH3_3	219	225	PF00018	0.727
LIG_SH3_3	376	382	PF00018	0.675
LIG_SH3_3	459	465	PF00018	0.623
LIG_SH3_3	514	520	PF00018	0.615
LIG_SH3_3	536	542	PF00018	0.544
LIG_SUMO_SIM_anti_2	731	736	PF11976	0.507
LIG_SUMO_SIM_par_1	257	264	PF11976	0.696
LIG_SUMO_SIM_par_1	28	36	PF11976	0.389
LIG_TRAF2_1	501	504	PF00917	0.535
LIG_TYR_ITIM	714	719	PF00017	0.512
LIG_UBA3_1	58	67	PF00899	0.516
LIG_WRC_WIRS_1	606	611	PF05994	0.613
LIG_WRC_WIRS_1	697	702	PF05994	0.603
MOD_CDC14_SPxK_1	627	630	PF00782	0.644
MOD_CDK_SPK_2	147	152	PF00069	0.645
MOD_CDK_SPxK_1	624	630	PF00069	0.637
MOD_CDK_SPxxK_3	461	468	PF00069	0.602
MOD_CK1_1	143	149	PF00069	0.704
MOD_CK1_1	16	22	PF00069	0.607
MOD_CK1_1	165	171	PF00069	0.675
MOD_CK1_1	183	189	PF00069	0.549
MOD_CK1_1	194	200	PF00069	0.659
MOD_CK1_1	232	238	PF00069	0.640
MOD_CK1_1	257	263	PF00069	0.574
MOD_CK1_1	336	342	PF00069	0.789
MOD_CK1_1	356	362	PF00069	0.622
MOD_CK1_1	378	384	PF00069	0.712
MOD_CK1_1	481	487	PF00069	0.458
MOD_CK1_1	575	581	PF00069	0.520
MOD_CK2_1	300	306	PF00069	0.653
MOD_CK2_1	344	350	PF00069	0.627
MOD_CK2_1	444	450	PF00069	0.713
MOD_CK2_1	498	504	PF00069	0.529
MOD_CK2_1	507	513	PF00069	0.475
MOD_GlcNHglycan	118	121	PF01048	0.591
MOD_GlcNHglycan	123	126	PF01048	0.580
MOD_GlcNHglycan	142	145	PF01048	0.565
MOD_GlcNHglycan	185	188	PF01048	0.674
MOD_GlcNHglycan	199	202	PF01048	0.562
MOD_GlcNHglycan	257	260	PF01048	0.681
MOD_GlcNHglycan	344	347	PF01048	0.674
MOD_GlcNHglycan	669	672	PF01048	0.686
MOD_GlcNHglycan	689	692	PF01048	0.624
MOD_GlcNHglycan	701	704	PF01048	0.480
MOD_GlcNHglycan	743	746	PF01048	0.590
MOD_GSK3_1	121	128	PF00069	0.508
MOD_GSK3_1	140	147	PF00069	0.608
MOD_GSK3_1	165	172	PF00069	0.670
MOD_GSK3_1	176	183	PF00069	0.610
MOD_GSK3_1	191	198	PF00069	0.599
MOD_GSK3_1	212	219	PF00069	0.701
MOD_GSK3_1	225	232	PF00069	0.617
MOD_GSK3_1	331	338	PF00069	0.847
MOD_GSK3_1	344	351	PF00069	0.605
MOD_GSK3_1	374	381	PF00069	0.693
MOD_GSK3_1	477	484	PF00069	0.610
MOD_GSK3_1	662	669	PF00069	0.622
MOD_GSK3_1	687	694	PF00069	0.705
MOD_GSK3_1	695	702	PF00069	0.551
MOD_N-GLC_1	140	145	PF02516	0.617
MOD_NEK2_1	191	196	PF00069	0.656
MOD_NEK2_1	229	234	PF00069	0.667
MOD_NEK2_1	254	259	PF00069	0.585
MOD_NEK2_1	478	483	PF00069	0.421
MOD_NEK2_1	605	610	PF00069	0.660
MOD_NEK2_1	62	67	PF00069	0.499
MOD_NEK2_1	676	681	PF00069	0.640
MOD_NEK2_1	686	691	PF00069	0.642
MOD_NEK2_1	696	701	PF00069	0.542
MOD_PIKK_1	162	168	PF00454	0.651
MOD_PIKK_1	205	211	PF00454	0.638
MOD_PIKK_1	369	375	PF00454	0.681
MOD_PIKK_1	48	54	PF00454	0.525
MOD_PKA_1	121	127	PF00069	0.500
MOD_PKA_2	121	127	PF00069	0.566
MOD_PKA_2	176	182	PF00069	0.697
MOD_PKA_2	192	198	PF00069	0.527
MOD_PKA_2	248	254	PF00069	0.594
MOD_PKA_2	450	456	PF00069	0.666
MOD_PKA_2	667	673	PF00069	0.691
MOD_PKB_1	728	736	PF00069	0.487
MOD_Plk_1	125	131	PF00069	0.526
MOD_Plk_1	191	197	PF00069	0.672
MOD_Plk_1	420	426	PF00069	0.584
MOD_Plk_1	630	636	PF00069	0.695
MOD_Plk_1	730	736	PF00069	0.507
MOD_Plk_2-3	45	51	PF00069	0.569
MOD_Plk_4	125	131	PF00069	0.526
MOD_Plk_4	199	205	PF00069	0.704
MOD_Plk_4	257	263	PF00069	0.707
MOD_Plk_4	26	32	PF00069	0.495
MOD_Plk_4	730	736	PF00069	0.538
MOD_ProDKin_1	147	153	PF00069	0.698
MOD_ProDKin_1	165	171	PF00069	0.557
MOD_ProDKin_1	180	186	PF00069	0.582
MOD_ProDKin_1	230	236	PF00069	0.682
MOD_ProDKin_1	333	339	PF00069	0.740
MOD_ProDKin_1	378	384	PF00069	0.712
MOD_ProDKin_1	461	467	PF00069	0.641
MOD_ProDKin_1	624	630	PF00069	0.637
MOD_ProDKin_1	691	697	PF00069	0.748
MOD_SUMO_for_1	130	133	PF00179	0.630
MOD_SUMO_for_1	151	154	PF00179	0.663
TRG_DiLeu_BaEn_4	503	509	PF01217	0.542
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.586
TRG_ENDOCYTIC_2	487	490	PF00928	0.516
TRG_ENDOCYTIC_2	55	58	PF00928	0.547
TRG_ENDOCYTIC_2	716	719	PF00928	0.511
TRG_ER_diArg_1	248	250	PF00400	0.558
TRG_ER_diArg_1	323	325	PF00400	0.684
TRG_ER_diArg_1	399	402	PF00400	0.480
TRG_ER_diArg_1	508	511	PF00400	0.594
TRG_ER_diArg_1	546	549	PF00400	0.492
TRG_NES_CRM1_1	600	613	PF08389	0.587
TRG_NES_CRM1_1	712	726	PF08389	0.540
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBI1	Leishmania donovani	100%	100%
A4HA87	Leishmania braziliensis	67%	100%
E9AS91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QD73	Leishmania major	88%	99%