LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
membrane-bound O-acyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4HYG3_LEIIN
TriTrypDb:
LINF_190019700
Length:
734

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005737 cytoplasm 2 1
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HYG3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYG3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016740 transferase activity 2 2
GO:0016746 acyltransferase activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.709
CLV_C14_Caspase3-7 281 285 PF00656 0.438
CLV_C14_Caspase3-7 43 47 PF00656 0.698
CLV_C14_Caspase3-7 713 717 PF00656 0.324
CLV_NRD_NRD_1 141 143 PF00675 0.391
CLV_NRD_NRD_1 144 146 PF00675 0.366
CLV_NRD_NRD_1 199 201 PF00675 0.449
CLV_NRD_NRD_1 321 323 PF00675 0.539
CLV_PCSK_FUR_1 142 146 PF00082 0.323
CLV_PCSK_FUR_1 645 649 PF00082 0.310
CLV_PCSK_KEX2_1 141 143 PF00082 0.327
CLV_PCSK_KEX2_1 144 146 PF00082 0.319
CLV_PCSK_KEX2_1 245 247 PF00082 0.461
CLV_PCSK_KEX2_1 321 323 PF00082 0.539
CLV_PCSK_KEX2_1 647 649 PF00082 0.310
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.371
CLV_PCSK_PC1ET2_1 647 649 PF00082 0.310
CLV_PCSK_SKI1_1 150 154 PF00082 0.372
CLV_PCSK_SKI1_1 614 618 PF00082 0.510
DEG_APCC_DBOX_1 57 65 PF00400 0.560
DEG_APCC_KENBOX_2 93 97 PF00400 0.380
DEG_MDM2_SWIB_1 604 611 PF02201 0.299
DEG_ODPH_VHL_1 240 253 PF01847 0.421
DEG_ODPH_VHL_1 701 714 PF01847 0.264
DEG_SCF_FBW7_1 439 446 PF00400 0.379
DEG_SPOP_SBC_1 4 8 PF00917 0.703
DEG_SPOP_SBC_1 475 479 PF00917 0.489
DEG_SPOP_SBC_1 491 495 PF00917 0.415
DOC_CKS1_1 440 445 PF01111 0.424
DOC_CYCLIN_yCln2_LP_2 97 103 PF00134 0.335
DOC_MAPK_DCC_7 594 603 PF00069 0.303
DOC_MAPK_gen_1 200 208 PF00069 0.559
DOC_MAPK_MEF2A_6 190 199 PF00069 0.643
DOC_MAPK_RevD_3 128 142 PF00069 0.362
DOC_PP1_RVXF_1 301 308 PF00149 0.271
DOC_PP1_RVXF_1 612 619 PF00149 0.310
DOC_PP2B_LxvP_1 239 242 PF13499 0.404
DOC_PP2B_LxvP_1 97 100 PF13499 0.376
DOC_PP2B_PxIxI_1 627 633 PF00149 0.333
DOC_PP4_FxxP_1 381 384 PF00568 0.299
DOC_PP4_FxxP_1 549 552 PF00568 0.456
DOC_USP7_MATH_1 16 20 PF00917 0.660
DOC_USP7_MATH_1 346 350 PF00917 0.421
DOC_USP7_MATH_1 390 394 PF00917 0.299
DOC_USP7_MATH_1 396 400 PF00917 0.477
DOC_USP7_MATH_1 4 8 PF00917 0.755
DOC_USP7_MATH_1 443 447 PF00917 0.421
DOC_USP7_MATH_1 468 472 PF00917 0.357
DOC_USP7_MATH_1 47 51 PF00917 0.697
DOC_USP7_MATH_2 351 357 PF00917 0.347
DOC_USP7_UBL2_3 324 328 PF12436 0.334
DOC_USP7_UBL2_3 94 98 PF12436 0.389
DOC_WW_Pin1_4 191 196 PF00397 0.616
DOC_WW_Pin1_4 285 290 PF00397 0.439
DOC_WW_Pin1_4 439 444 PF00397 0.410
DOC_WW_Pin1_4 478 483 PF00397 0.459
DOC_WW_Pin1_4 496 501 PF00397 0.419
DOC_WW_Pin1_4 646 651 PF00397 0.574
LIG_14-3-3_CanoR_1 246 250 PF00244 0.572
LIG_14-3-3_CanoR_1 303 308 PF00244 0.379
LIG_14-3-3_CanoR_1 321 327 PF00244 0.335
LIG_14-3-3_CanoR_1 344 352 PF00244 0.366
LIG_14-3-3_CanoR_1 41 45 PF00244 0.639
LIG_14-3-3_CanoR_1 58 62 PF00244 0.536
LIG_14-3-3_CanoR_1 592 597 PF00244 0.440
LIG_Actin_RPEL_3 408 427 PF02755 0.506
LIG_Actin_WH2_2 598 616 PF00022 0.362
LIG_BIR_II_1 1 5 PF00653 0.654
LIG_BIR_III_3 1 5 PF00653 0.654
LIG_BRCT_BRCA1_1 694 698 PF00533 0.264
LIG_CSL_BTD_1 286 289 PF09270 0.374
LIG_deltaCOP1_diTrp_1 284 293 PF00928 0.362
LIG_deltaCOP1_diTrp_1 534 543 PF00928 0.362
LIG_deltaCOP1_diTrp_1 571 579 PF00928 0.478
LIG_EH1_1 227 235 PF00400 0.465
LIG_eIF4E_1 132 138 PF01652 0.362
LIG_FHA_1 194 200 PF00498 0.622
LIG_FHA_1 31 37 PF00498 0.729
LIG_FHA_1 499 505 PF00498 0.458
LIG_FHA_1 560 566 PF00498 0.428
LIG_FHA_1 591 597 PF00498 0.510
LIG_FHA_1 622 628 PF00498 0.258
LIG_FHA_1 695 701 PF00498 0.432
LIG_FHA_2 41 47 PF00498 0.668
LIG_FHA_2 57 63 PF00498 0.482
LIG_LIR_Apic_2 547 552 PF02991 0.465
LIG_LIR_Gen_1 205 216 PF02991 0.440
LIG_LIR_Gen_1 309 319 PF02991 0.335
LIG_LIR_Nem_3 205 211 PF02991 0.440
LIG_LIR_Nem_3 284 290 PF02991 0.431
LIG_LIR_Nem_3 309 315 PF02991 0.359
LIG_LIR_Nem_3 374 379 PF02991 0.308
LIG_LIR_Nem_3 392 397 PF02991 0.366
LIG_LIR_Nem_3 399 403 PF02991 0.496
LIG_LIR_Nem_3 534 540 PF02991 0.342
LIG_LIR_Nem_3 597 602 PF02991 0.342
LIG_LIR_Nem_3 695 701 PF02991 0.302
LIG_Pex14_1 293 297 PF04695 0.286
LIG_Pex14_1 414 418 PF04695 0.505
LIG_Pex14_1 572 576 PF04695 0.465
LIG_Pex14_1 579 583 PF04695 0.465
LIG_Pex14_2 278 282 PF04695 0.301
LIG_Pex14_2 533 537 PF04695 0.290
LIG_Pex14_2 539 543 PF04695 0.474
LIG_Pex14_2 568 572 PF04695 0.465
LIG_Pex14_2 599 603 PF04695 0.290
LIG_Pex14_2 604 608 PF04695 0.287
LIG_REV1ctd_RIR_1 537 545 PF16727 0.465
LIG_SH2_CRK 583 587 PF00017 0.465
LIG_SH2_CRK 76 80 PF00017 0.362
LIG_SH2_NCK_1 76 80 PF00017 0.333
LIG_SH2_PTP2 433 436 PF00017 0.299
LIG_SH2_SRC 238 241 PF00017 0.362
LIG_SH2_SRC 433 436 PF00017 0.299
LIG_SH2_STAP1 76 80 PF00017 0.362
LIG_SH2_STAT3 722 725 PF00017 0.580
LIG_SH2_STAT3 731 734 PF00017 0.509
LIG_SH2_STAT5 121 124 PF00017 0.362
LIG_SH2_STAT5 238 241 PF00017 0.362
LIG_SH2_STAT5 376 379 PF00017 0.299
LIG_SH2_STAT5 382 385 PF00017 0.299
LIG_SH2_STAT5 397 400 PF00017 0.449
LIG_SH2_STAT5 433 436 PF00017 0.299
LIG_SH2_STAT5 55 58 PF00017 0.567
LIG_SH2_STAT5 585 588 PF00017 0.465
LIG_SH2_STAT5 63 66 PF00017 0.272
LIG_SH2_STAT5 655 658 PF00017 0.465
LIG_SH2_STAT5 706 709 PF00017 0.303
LIG_SH3_3 121 127 PF00018 0.362
LIG_SUMO_SIM_anti_2 506 511 PF11976 0.375
LIG_SUMO_SIM_anti_2 661 667 PF11976 0.362
LIG_SUMO_SIM_par_1 503 508 PF11976 0.418
LIG_SUMO_SIM_par_1 710 718 PF11976 0.322
LIG_TYR_ITIM 380 385 PF00017 0.305
LIG_TYR_ITIM 581 586 PF00017 0.465
LIG_TYR_ITIM 74 79 PF00017 0.362
LIG_UBA3_1 239 245 PF00899 0.412
LIG_UBA3_1 690 699 PF00899 0.290
LIG_WRC_WIRS_1 304 309 PF05994 0.317
LIG_WRC_WIRS_1 391 396 PF05994 0.299
LIG_WRC_WIRS_1 565 570 PF05994 0.460
MOD_CK1_1 14 20 PF00069 0.663
MOD_CK1_1 172 178 PF00069 0.756
MOD_CK1_1 306 312 PF00069 0.338
MOD_CK1_1 404 410 PF00069 0.545
MOD_CK1_1 492 498 PF00069 0.558
MOD_CK1_1 57 63 PF00069 0.592
MOD_CK1_1 677 683 PF00069 0.484
MOD_CK1_1 7 13 PF00069 0.708
MOD_CK2_1 313 319 PF00069 0.399
MOD_CK2_1 56 62 PF00069 0.571
MOD_CMANNOS 569 572 PF00535 0.265
MOD_GlcNHglycan 168 172 PF01048 0.534
MOD_GlcNHglycan 373 376 PF01048 0.526
MOD_GlcNHglycan 403 406 PF01048 0.333
MOD_GlcNHglycan 445 448 PF01048 0.729
MOD_GlcNHglycan 470 473 PF01048 0.567
MOD_GSK3_1 146 153 PF00069 0.614
MOD_GSK3_1 189 196 PF00069 0.705
MOD_GSK3_1 245 252 PF00069 0.540
MOD_GSK3_1 3 10 PF00069 0.713
MOD_GSK3_1 439 446 PF00069 0.325
MOD_GSK3_1 474 481 PF00069 0.508
MOD_GSK3_1 490 497 PF00069 0.455
MOD_GSK3_1 513 520 PF00069 0.408
MOD_GSK3_1 588 595 PF00069 0.503
MOD_GSK3_1 617 624 PF00069 0.279
MOD_GSK3_1 630 637 PF00069 0.325
MOD_GSK3_1 674 681 PF00069 0.592
MOD_GSK3_1 710 717 PF00069 0.300
MOD_N-GLC_1 297 302 PF02516 0.466
MOD_NEK2_1 137 142 PF00069 0.357
MOD_NEK2_1 249 254 PF00069 0.486
MOD_NEK2_1 278 283 PF00069 0.385
MOD_NEK2_1 311 316 PF00069 0.351
MOD_NEK2_1 371 376 PF00069 0.345
MOD_NEK2_1 426 431 PF00069 0.305
MOD_NEK2_1 467 472 PF00069 0.449
MOD_NEK2_1 474 479 PF00069 0.480
MOD_NEK2_1 490 495 PF00069 0.414
MOD_NEK2_1 559 564 PF00069 0.440
MOD_NEK2_1 56 61 PF00069 0.629
MOD_NEK2_1 588 593 PF00069 0.565
MOD_NEK2_1 617 622 PF00069 0.331
MOD_NEK2_1 666 671 PF00069 0.264
MOD_NEK2_1 694 699 PF00069 0.376
MOD_PIKK_1 292 298 PF00454 0.334
MOD_PIKK_1 658 664 PF00454 0.369
MOD_PK_1 594 600 PF00069 0.362
MOD_PKA_1 245 251 PF00069 0.572
MOD_PKA_2 189 195 PF00069 0.661
MOD_PKA_2 245 251 PF00069 0.572
MOD_PKA_2 40 46 PF00069 0.752
MOD_PKA_2 468 474 PF00069 0.432
MOD_PKA_2 57 63 PF00069 0.472
MOD_Plk_1 156 162 PF00069 0.547
MOD_Plk_1 184 190 PF00069 0.679
MOD_Plk_1 201 207 PF00069 0.447
MOD_Plk_1 297 303 PF00069 0.265
MOD_Plk_1 369 375 PF00069 0.340
MOD_Plk_1 47 53 PF00069 0.587
MOD_Plk_1 666 672 PF00069 0.362
MOD_Plk_1 692 698 PF00069 0.260
MOD_Plk_4 193 199 PF00069 0.681
MOD_Plk_4 251 257 PF00069 0.326
MOD_Plk_4 278 284 PF00069 0.404
MOD_Plk_4 297 303 PF00069 0.342
MOD_Plk_4 32 38 PF00069 0.712
MOD_Plk_4 426 432 PF00069 0.413
MOD_Plk_4 505 511 PF00069 0.387
MOD_Plk_4 517 523 PF00069 0.234
MOD_Plk_4 564 570 PF00069 0.510
MOD_Plk_4 594 600 PF00069 0.362
MOD_Plk_4 617 623 PF00069 0.297
MOD_Plk_4 630 636 PF00069 0.307
MOD_ProDKin_1 191 197 PF00069 0.615
MOD_ProDKin_1 285 291 PF00069 0.435
MOD_ProDKin_1 439 445 PF00069 0.416
MOD_ProDKin_1 478 484 PF00069 0.457
MOD_ProDKin_1 496 502 PF00069 0.417
MOD_ProDKin_1 646 652 PF00069 0.574
MOD_SUMO_rev_2 404 413 PF00179 0.559
MOD_SUMO_rev_2 713 721 PF00179 0.341
TRG_DiLeu_BaLyEn_6 286 291 PF01217 0.367
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.547
TRG_DiLeu_BaLyEn_6 611 616 PF01217 0.310
TRG_ENDOCYTIC_2 104 107 PF00928 0.372
TRG_ENDOCYTIC_2 120 123 PF00928 0.216
TRG_ENDOCYTIC_2 382 385 PF00928 0.414
TRG_ENDOCYTIC_2 433 436 PF00928 0.299
TRG_ENDOCYTIC_2 583 586 PF00928 0.465
TRG_ENDOCYTIC_2 655 658 PF00928 0.469
TRG_ENDOCYTIC_2 76 79 PF00928 0.362
TRG_ER_diArg_1 141 144 PF00400 0.514
TRG_NES_CRM1_1 553 566 PF08389 0.430
TRG_Pf-PMV_PEXEL_1 657 662 PF00026 0.362

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5IRW9 Trypanosoma rangeli 34% 100%
A0A3S7WVM5 Leishmania donovani 100% 100%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QD77 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS