Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYE9_LEIIN

TriTrypDb:

LINF_190018500

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.770
CLV_C14_Caspase3-7	234	238	PF00656	0.737
CLV_C14_Caspase3-7	244	248	PF00656	0.669
CLV_C14_Caspase3-7	299	303	PF00656	0.554
CLV_C14_Caspase3-7	439	443	PF00656	0.652
CLV_C14_Caspase3-7	605	609	PF00656	0.620
CLV_C14_Caspase3-7	751	755	PF00656	0.682
CLV_C14_Caspase3-7	883	887	PF00656	0.658
CLV_NRD_NRD_1	154	156	PF00675	0.713
CLV_NRD_NRD_1	160	162	PF00675	0.674
CLV_NRD_NRD_1	287	289	PF00675	0.617
CLV_NRD_NRD_1	363	365	PF00675	0.737
CLV_NRD_NRD_1	417	419	PF00675	0.733
CLV_NRD_NRD_1	579	581	PF00675	0.700
CLV_NRD_NRD_1	64	66	PF00675	0.711
CLV_NRD_NRD_1	862	864	PF00675	0.673
CLV_PCSK_KEX2_1	287	289	PF00082	0.617
CLV_PCSK_KEX2_1	363	365	PF00082	0.737
CLV_PCSK_KEX2_1	417	419	PF00082	0.733
CLV_PCSK_KEX2_1	579	581	PF00082	0.700
CLV_PCSK_KEX2_1	64	66	PF00082	0.711
CLV_PCSK_KEX2_1	743	745	PF00082	0.691
CLV_PCSK_KEX2_1	862	864	PF00082	0.673
CLV_PCSK_PC1ET2_1	743	745	PF00082	0.691
CLV_PCSK_SKI1_1	364	368	PF00082	0.730
CLV_PCSK_SKI1_1	379	383	PF00082	0.558
CLV_PCSK_SKI1_1	579	583	PF00082	0.661
CLV_PCSK_SKI1_1	766	770	PF00082	0.607
CLV_Separin_Metazoa	116	120	PF03568	0.604
DEG_APCC_DBOX_1	662	670	PF00400	0.610
DEG_Nend_UBRbox_2	1	3	PF02207	0.731
DEG_SPOP_SBC_1	246	250	PF00917	0.652
DEG_SPOP_SBC_1	527	531	PF00917	0.597
DOC_ANK_TNKS_1	205	212	PF00023	0.654
DOC_ANK_TNKS_1	63	70	PF00023	0.700
DOC_CKS1_1	613	618	PF01111	0.593
DOC_CKS1_1	931	936	PF01111	0.590
DOC_CYCLIN_RxL_1	576	585	PF00134	0.662
DOC_CYCLIN_RxL_1	763	772	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	912	918	PF00134	0.702
DOC_PP1_RVXF_1	948	955	PF00149	0.647
DOC_PP2B_LxvP_1	730	733	PF13499	0.664
DOC_USP7_MATH_1	150	154	PF00917	0.710
DOC_USP7_MATH_1	184	188	PF00917	0.649
DOC_USP7_MATH_1	196	200	PF00917	0.680
DOC_USP7_MATH_1	216	220	PF00917	0.544
DOC_USP7_MATH_1	245	249	PF00917	0.775
DOC_USP7_MATH_1	369	373	PF00917	0.664
DOC_USP7_MATH_1	42	46	PF00917	0.744
DOC_USP7_MATH_1	48	52	PF00917	0.685
DOC_USP7_MATH_1	528	532	PF00917	0.671
DOC_USP7_MATH_1	551	555	PF00917	0.715
DOC_USP7_MATH_1	705	709	PF00917	0.709
DOC_USP7_MATH_1	725	729	PF00917	0.530
DOC_USP7_MATH_1	781	785	PF00917	0.598
DOC_USP7_MATH_1	844	848	PF00917	0.651
DOC_USP7_MATH_1	929	933	PF00917	0.739
DOC_USP7_MATH_1	946	950	PF00917	0.492
DOC_USP7_MATH_1	961	965	PF00917	0.464
DOC_WW_Pin1_4	106	111	PF00397	0.652
DOC_WW_Pin1_4	160	165	PF00397	0.774
DOC_WW_Pin1_4	235	240	PF00397	0.839
DOC_WW_Pin1_4	258	263	PF00397	0.644
DOC_WW_Pin1_4	268	273	PF00397	0.701
DOC_WW_Pin1_4	327	332	PF00397	0.647
DOC_WW_Pin1_4	348	353	PF00397	0.692
DOC_WW_Pin1_4	355	360	PF00397	0.658
DOC_WW_Pin1_4	380	385	PF00397	0.702
DOC_WW_Pin1_4	389	394	PF00397	0.617
DOC_WW_Pin1_4	441	446	PF00397	0.707
DOC_WW_Pin1_4	448	453	PF00397	0.690
DOC_WW_Pin1_4	53	58	PF00397	0.731
DOC_WW_Pin1_4	555	560	PF00397	0.597
DOC_WW_Pin1_4	612	617	PF00397	0.642
DOC_WW_Pin1_4	76	81	PF00397	0.625
DOC_WW_Pin1_4	900	905	PF00397	0.755
DOC_WW_Pin1_4	930	935	PF00397	0.682
DOC_WW_Pin1_4	940	945	PF00397	0.591
DOC_WW_Pin1_4	965	970	PF00397	0.646
DOC_WW_Pin1_4	97	102	PF00397	0.682
LIG_14-3-3_CanoR_1	119	124	PF00244	0.600
LIG_14-3-3_CanoR_1	155	165	PF00244	0.727
LIG_14-3-3_CanoR_1	204	210	PF00244	0.701
LIG_14-3-3_CanoR_1	475	479	PF00244	0.617
LIG_14-3-3_CanoR_1	643	653	PF00244	0.715
LIG_14-3-3_CanoR_1	70	78	PF00244	0.647
LIG_14-3-3_CanoR_1	729	733	PF00244	0.682
LIG_BIR_III_2	190	194	PF00653	0.603
LIG_BIR_III_2	442	446	PF00653	0.659
LIG_BRCT_BRCA1_1	16	20	PF00533	0.559
LIG_BRCT_BRCA1_1	458	462	PF00533	0.570
LIG_BRCT_BRCA1_1	963	967	PF00533	0.586
LIG_eIF4E_1	270	276	PF01652	0.645
LIG_FHA_1	195	201	PF00498	0.658
LIG_FHA_1	259	265	PF00498	0.560
LIG_FHA_1	408	414	PF00498	0.728
LIG_FHA_1	427	433	PF00498	0.504
LIG_FHA_1	831	837	PF00498	0.666
LIG_FHA_1	90	96	PF00498	0.678
LIG_FHA_2	180	186	PF00498	0.605
LIG_FHA_2	19	25	PF00498	0.580
LIG_FHA_2	269	275	PF00498	0.654
LIG_FHA_2	295	301	PF00498	0.577
LIG_FHA_2	437	443	PF00498	0.651
LIG_FHA_2	475	481	PF00498	0.656
LIG_FHA_2	603	609	PF00498	0.595
LIG_FHA_2	653	659	PF00498	0.657
LIG_FHA_2	663	669	PF00498	0.531
LIG_FHA_2	751	757	PF00498	0.750
LIG_FHA_2	931	937	PF00498	0.651
LIG_FHA_2	955	961	PF00498	0.615
LIG_LIR_Gen_1	24	33	PF02991	0.568
LIG_LIR_Gen_1	436	446	PF02991	0.592
LIG_LIR_Gen_1	960	970	PF02991	0.630
LIG_LIR_LC3C_4	273	277	PF02991	0.628
LIG_LIR_Nem_3	21	25	PF02991	0.610
LIG_LIR_Nem_3	459	465	PF02991	0.693
LIG_LIR_Nem_3	575	581	PF02991	0.662
LIG_LIR_Nem_3	960	965	PF02991	0.614
LIG_PDZ_Class_1	965	970	PF00595	0.646
LIG_SH2_CRK	578	582	PF00017	0.666
LIG_SH2_STAP1	22	26	PF00017	0.626
LIG_SH2_STAP1	787	791	PF00017	0.653
LIG_SH2_STAP1	962	966	PF00017	0.628
LIG_SH2_STAT5	270	273	PF00017	0.652
LIG_SH2_STAT5	350	353	PF00017	0.674
LIG_SH3_1	54	60	PF00018	0.607
LIG_SH3_1	719	725	PF00018	0.584
LIG_SH3_2	59	64	PF14604	0.693
LIG_SH3_3	151	157	PF00018	0.639
LIG_SH3_3	233	239	PF00018	0.728
LIG_SH3_3	483	489	PF00018	0.630
LIG_SH3_3	54	60	PF00018	0.740
LIG_SH3_3	719	725	PF00018	0.620
LIG_SH3_3	77	83	PF00018	0.716
LIG_SH3_3	864	870	PF00018	0.568
LIG_SH3_3	907	913	PF00018	0.781
LIG_SH3_3	916	922	PF00018	0.660
LIG_SH3_3	928	934	PF00018	0.550
LIG_SUMO_SIM_par_1	664	671	PF11976	0.660
LIG_SUMO_SIM_par_1	830	839	PF11976	0.637
LIG_ULM_U2AF65_1	862	867	PF00076	0.566
LIG_WW_2	910	913	PF00397	0.650
MOD_CDC14_SPxK_1	903	906	PF00782	0.657
MOD_CDK_SPK_2	235	240	PF00069	0.682
MOD_CDK_SPK_2	76	81	PF00069	0.610
MOD_CDK_SPxK_1	389	395	PF00069	0.675
MOD_CDK_SPxK_1	900	906	PF00069	0.652
MOD_CDK_SPxxK_3	441	448	PF00069	0.699
MOD_CK1_1	227	233	PF00069	0.624
MOD_CK1_1	294	300	PF00069	0.670
MOD_CK1_1	353	359	PF00069	0.693
MOD_CK1_1	380	386	PF00069	0.652
MOD_CK1_1	405	411	PF00069	0.680
MOD_CK1_1	426	432	PF00069	0.698
MOD_CK1_1	436	442	PF00069	0.593
MOD_CK1_1	456	462	PF00069	0.502
MOD_CK1_1	554	560	PF00069	0.722
MOD_CK1_1	612	618	PF00069	0.614
MOD_CK1_1	639	645	PF00069	0.620
MOD_CK1_1	671	677	PF00069	0.632
MOD_CK1_1	706	712	PF00069	0.714
MOD_CK1_1	720	726	PF00069	0.592
MOD_CK1_1	728	734	PF00069	0.622
MOD_CK1_1	830	836	PF00069	0.709
MOD_CK1_1	85	91	PF00069	0.673
MOD_CK1_1	880	886	PF00069	0.704
MOD_CK1_1	932	938	PF00069	0.642
MOD_CK2_1	18	24	PF00069	0.584
MOD_CK2_1	196	202	PF00069	0.660
MOD_CK2_1	300	306	PF00069	0.696
MOD_CK2_1	327	333	PF00069	0.576
MOD_CK2_1	391	397	PF00069	0.654
MOD_CK2_1	528	534	PF00069	0.622
MOD_CK2_1	544	550	PF00069	0.571
MOD_CK2_1	615	621	PF00069	0.728
MOD_CK2_1	652	658	PF00069	0.666
MOD_CK2_1	662	668	PF00069	0.628
MOD_CK2_1	671	677	PF00069	0.554
MOD_CK2_1	692	698	PF00069	0.738
MOD_CK2_1	750	756	PF00069	0.774
MOD_CK2_1	930	936	PF00069	0.681
MOD_Cter_Amidation	415	418	PF01082	0.738
MOD_Cter_Amidation	741	744	PF01082	0.664
MOD_DYRK1A_RPxSP_1	930	934	PF00069	0.644
MOD_GlcNHglycan	12	15	PF01048	0.679
MOD_GlcNHglycan	145	149	PF01048	0.696
MOD_GlcNHglycan	158	161	PF01048	0.634
MOD_GlcNHglycan	16	19	PF01048	0.628
MOD_GlcNHglycan	177	180	PF01048	0.576
MOD_GlcNHglycan	225	229	PF01048	0.707
MOD_GlcNHglycan	243	246	PF01048	0.673
MOD_GlcNHglycan	249	252	PF01048	0.637
MOD_GlcNHglycan	309	312	PF01048	0.692
MOD_GlcNHglycan	352	355	PF01048	0.721
MOD_GlcNHglycan	404	407	PF01048	0.718
MOD_GlcNHglycan	414	417	PF01048	0.645
MOD_GlcNHglycan	425	428	PF01048	0.596
MOD_GlcNHglycan	455	458	PF01048	0.704
MOD_GlcNHglycan	549	554	PF01048	0.618
MOD_GlcNHglycan	617	620	PF01048	0.691
MOD_GlcNHglycan	72	75	PF01048	0.646
MOD_GlcNHglycan	879	882	PF01048	0.699
MOD_GlcNHglycan	897	900	PF01048	0.651
MOD_GlcNHglycan	944	947	PF01048	0.660
MOD_GSK3_1	10	17	PF00069	0.644
MOD_GSK3_1	117	124	PF00069	0.684
MOD_GSK3_1	156	163	PF00069	0.781
MOD_GSK3_1	175	182	PF00069	0.549
MOD_GSK3_1	223	230	PF00069	0.684
MOD_GSK3_1	241	248	PF00069	0.728
MOD_GSK3_1	25	32	PF00069	0.465
MOD_GSK3_1	307	314	PF00069	0.710
MOD_GSK3_1	327	334	PF00069	0.529
MOD_GSK3_1	353	360	PF00069	0.701
MOD_GSK3_1	369	376	PF00069	0.569
MOD_GSK3_1	380	387	PF00069	0.576
MOD_GSK3_1	398	405	PF00069	0.597
MOD_GSK3_1	407	414	PF00069	0.613
MOD_GSK3_1	426	433	PF00069	0.502
MOD_GSK3_1	453	460	PF00069	0.638
MOD_GSK3_1	551	558	PF00069	0.654
MOD_GSK3_1	639	646	PF00069	0.605
MOD_GSK3_1	667	674	PF00069	0.675
MOD_GSK3_1	711	718	PF00069	0.620
MOD_GSK3_1	728	735	PF00069	0.701
MOD_GSK3_1	824	831	PF00069	0.708
MOD_GSK3_1	85	92	PF00069	0.722
MOD_GSK3_1	895	902	PF00069	0.719
MOD_GSK3_1	938	945	PF00069	0.655
MOD_GSK3_1	961	968	PF00069	0.625
MOD_N-GLC_1	300	305	PF02516	0.586
MOD_N-GLC_1	348	353	PF02516	0.696
MOD_N-GLC_1	651	656	PF02516	0.630
MOD_N-GLC_1	706	711	PF02516	0.683
MOD_N-GLC_1	715	720	PF02516	0.612
MOD_N-GLC_1	76	81	PF02516	0.610
MOD_NEK2_1	118	123	PF00069	0.737
MOD_NEK2_1	255	260	PF00069	0.731
MOD_NEK2_1	526	531	PF00069	0.659
MOD_NEK2_1	715	720	PF00069	0.749
MOD_NEK2_1	786	791	PF00069	0.683
MOD_NEK2_2	150	155	PF00069	0.688
MOD_NEK2_2	196	201	PF00069	0.660
MOD_NEK2_2	457	462	PF00069	0.571
MOD_PIKK_1	396	402	PF00454	0.684
MOD_PIKK_1	497	503	PF00454	0.736
MOD_PKA_1	155	161	PF00069	0.697
MOD_PKA_2	118	124	PF00069	0.601
MOD_PKA_2	194	200	PF00069	0.715
MOD_PKA_2	205	211	PF00069	0.641
MOD_PKA_2	223	229	PF00069	0.551
MOD_PKA_2	474	480	PF00069	0.640
MOD_PKA_2	497	503	PF00069	0.681
MOD_PKA_2	662	668	PF00069	0.583
MOD_PKA_2	69	75	PF00069	0.623
MOD_PKA_2	728	734	PF00069	0.699
MOD_PKA_2	813	819	PF00069	0.625
MOD_PKA_2	875	881	PF00069	0.601
MOD_PKA_2	929	935	PF00069	0.641
MOD_Plk_1	311	317	PF00069	0.623
MOD_Plk_1	482	488	PF00069	0.645
MOD_Plk_1	639	645	PF00069	0.613
MOD_Plk_1	651	657	PF00069	0.609
MOD_Plk_1	938	944	PF00069	0.656
MOD_Plk_2-3	474	480	PF00069	0.653
MOD_Plk_2-3	544	550	PF00069	0.604
MOD_Plk_4	205	211	PF00069	0.679
MOD_Plk_4	25	31	PF00069	0.519
MOD_Plk_4	377	383	PF00069	0.635
MOD_Plk_4	433	439	PF00069	0.690
MOD_Plk_4	457	463	PF00069	0.705
MOD_Plk_4	572	578	PF00069	0.664
MOD_Plk_4	662	668	PF00069	0.655
MOD_Plk_4	781	787	PF00069	0.695
MOD_Plk_4	830	836	PF00069	0.706
MOD_Plk_4	961	967	PF00069	0.624
MOD_ProDKin_1	106	112	PF00069	0.650
MOD_ProDKin_1	160	166	PF00069	0.774
MOD_ProDKin_1	235	241	PF00069	0.840
MOD_ProDKin_1	258	264	PF00069	0.642
MOD_ProDKin_1	268	274	PF00069	0.698
MOD_ProDKin_1	327	333	PF00069	0.648
MOD_ProDKin_1	348	354	PF00069	0.693
MOD_ProDKin_1	355	361	PF00069	0.658
MOD_ProDKin_1	380	386	PF00069	0.703
MOD_ProDKin_1	389	395	PF00069	0.621
MOD_ProDKin_1	441	447	PF00069	0.709
MOD_ProDKin_1	448	454	PF00069	0.692
MOD_ProDKin_1	53	59	PF00069	0.729
MOD_ProDKin_1	555	561	PF00069	0.596
MOD_ProDKin_1	612	618	PF00069	0.642
MOD_ProDKin_1	76	82	PF00069	0.623
MOD_ProDKin_1	900	906	PF00069	0.758
MOD_ProDKin_1	930	936	PF00069	0.681
MOD_ProDKin_1	940	946	PF00069	0.585
MOD_ProDKin_1	97	103	PF00069	0.681
MOD_SUMO_rev_2	372	381	PF00179	0.634
MOD_SUMO_rev_2	464	473	PF00179	0.639
TRG_DiLeu_BaEn_2	799	805	PF01217	0.579
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.612
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.661
TRG_DiLeu_BaLyEn_6	764	769	PF01217	0.670
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.644
TRG_ENDOCYTIC_2	578	581	PF00928	0.666
TRG_ENDOCYTIC_2	962	965	PF00928	0.626
TRG_ER_diArg_1	286	288	PF00400	0.608
TRG_ER_diArg_1	578	580	PF00400	0.671
TRG_ER_diArg_1	64	66	PF00400	0.711
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	790	795	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H768	Leishmania donovani	99%	99%
A4HA78	Leishmania braziliensis	57%	97%
E9AS82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QD84	Leishmania major	85%	100%