LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein kinase domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HYE8_LEIIN
TriTrypDb:
LINF_190018400
Length:
854

Annotations

Annotations by Jardim et al.

Protein kinase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYE8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYE8

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 5
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016310 phosphorylation 5 5
GO:0019538 protein metabolic process 3 5
GO:0036211 protein modification process 4 5
GO:0043170 macromolecule metabolic process 3 5
GO:0043412 macromolecule modification 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 5
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 5
GO:0003824 catalytic activity 1 5
GO:0004672 protein kinase activity 3 5
GO:0005488 binding 1 5
GO:0005524 ATP binding 5 5
GO:0016301 kinase activity 4 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 5
GO:0017076 purine nucleotide binding 4 5
GO:0030554 adenyl nucleotide binding 5 5
GO:0032553 ribonucleotide binding 3 5
GO:0032555 purine ribonucleotide binding 4 5
GO:0032559 adenyl ribonucleotide binding 5 5
GO:0035639 purine ribonucleoside triphosphate binding 4 5
GO:0036094 small molecule binding 2 5
GO:0043167 ion binding 2 5
GO:0043168 anion binding 3 5
GO:0097159 organic cyclic compound binding 2 5
GO:0097367 carbohydrate derivative binding 2 5
GO:0140096 catalytic activity, acting on a protein 2 5
GO:1901265 nucleoside phosphate binding 3 5
GO:1901363 heterocyclic compound binding 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.675
CLV_C14_Caspase3-7 569 573 PF00656 0.622
CLV_C14_Caspase3-7 602 606 PF00656 0.566
CLV_C14_Caspase3-7 662 666 PF00656 0.595
CLV_NRD_NRD_1 135 137 PF00675 0.664
CLV_NRD_NRD_1 225 227 PF00675 0.651
CLV_NRD_NRD_1 451 453 PF00675 0.629
CLV_NRD_NRD_1 86 88 PF00675 0.487
CLV_PCSK_KEX2_1 135 137 PF00082 0.664
CLV_PCSK_KEX2_1 225 227 PF00082 0.651
CLV_PCSK_KEX2_1 451 453 PF00082 0.629
CLV_PCSK_KEX2_1 86 88 PF00082 0.487
CLV_PCSK_SKI1_1 135 139 PF00082 0.652
CLV_PCSK_SKI1_1 210 214 PF00082 0.609
CLV_PCSK_SKI1_1 225 229 PF00082 0.536
CLV_PCSK_SKI1_1 286 290 PF00082 0.511
CLV_PCSK_SKI1_1 307 311 PF00082 0.525
CLV_PCSK_SKI1_1 370 374 PF00082 0.504
CLV_PCSK_SKI1_1 598 602 PF00082 0.563
CLV_Separin_Metazoa 759 763 PF03568 0.592
DEG_APCC_DBOX_1 597 605 PF00400 0.558
DEG_APCC_DBOX_1 710 718 PF00400 0.580
DEG_SCF_FBW7_1 256 262 PF00400 0.583
DEG_SPOP_SBC_1 116 120 PF00917 0.698
DOC_CDC14_PxL_1 154 162 PF14671 0.517
DOC_CKS1_1 176 181 PF01111 0.658
DOC_CKS1_1 256 261 PF01111 0.583
DOC_CKS1_1 308 313 PF01111 0.513
DOC_CYCLIN_RxL_1 367 377 PF00134 0.523
DOC_CYCLIN_RxL_1 684 695 PF00134 0.614
DOC_CYCLIN_RxL_1 700 709 PF00134 0.456
DOC_CYCLIN_RxL_1 710 718 PF00134 0.492
DOC_CYCLIN_yClb3_PxF_3 179 187 PF00134 0.582
DOC_CYCLIN_yClb5_NLxxxL_5 338 347 PF00134 0.495
DOC_CYCLIN_yCln2_LP_2 127 133 PF00134 0.585
DOC_CYCLIN_yCln2_LP_2 24 27 PF00134 0.634
DOC_CYCLIN_yCln2_LP_2 721 727 PF00134 0.557
DOC_MAPK_gen_1 523 532 PF00069 0.565
DOC_MAPK_gen_1 790 798 PF00069 0.609
DOC_MAPK_MEF2A_6 762 769 PF00069 0.551
DOC_PP1_RVXF_1 588 594 PF00149 0.585
DOC_PP2B_LxvP_1 127 130 PF13499 0.619
DOC_PP2B_LxvP_1 155 158 PF13499 0.599
DOC_PP2B_LxvP_1 23 26 PF13499 0.642
DOC_PP2B_LxvP_1 758 761 PF13499 0.561
DOC_PP4_FxxP_1 28 31 PF00568 0.622
DOC_PP4_FxxP_1 308 311 PF00568 0.517
DOC_USP7_MATH_1 169 173 PF00917 0.645
DOC_USP7_MATH_1 278 282 PF00917 0.597
DOC_USP7_MATH_1 388 392 PF00917 0.618
DOC_USP7_MATH_1 419 423 PF00917 0.517
DOC_USP7_MATH_1 540 544 PF00917 0.760
DOC_USP7_MATH_1 732 736 PF00917 0.585
DOC_USP7_MATH_1 788 792 PF00917 0.624
DOC_USP7_MATH_1 831 835 PF00917 0.562
DOC_WW_Pin1_4 117 122 PF00397 0.693
DOC_WW_Pin1_4 175 180 PF00397 0.681
DOC_WW_Pin1_4 186 191 PF00397 0.566
DOC_WW_Pin1_4 211 216 PF00397 0.664
DOC_WW_Pin1_4 255 260 PF00397 0.590
DOC_WW_Pin1_4 307 312 PF00397 0.527
DOC_WW_Pin1_4 336 341 PF00397 0.524
DOC_WW_Pin1_4 374 379 PF00397 0.490
DOC_WW_Pin1_4 509 514 PF00397 0.654
DOC_WW_Pin1_4 630 635 PF00397 0.566
DOC_WW_Pin1_4 814 819 PF00397 0.564
LIG_14-3-3_CanoR_1 210 215 PF00244 0.606
LIG_14-3-3_CanoR_1 346 352 PF00244 0.538
LIG_14-3-3_CanoR_1 45 51 PF00244 0.620
LIG_14-3-3_CanoR_1 451 455 PF00244 0.700
LIG_14-3-3_CanoR_1 526 531 PF00244 0.504
LIG_14-3-3_CanoR_1 590 600 PF00244 0.572
LIG_14-3-3_CanoR_1 792 797 PF00244 0.605
LIG_Actin_WH2_2 196 212 PF00022 0.642
LIG_Actin_WH2_2 738 754 PF00022 0.456
LIG_AP2alpha_1 798 802 PF02296 0.559
LIG_BIR_III_2 699 703 PF00653 0.519
LIG_BIR_III_4 464 468 PF00653 0.562
LIG_BIR_III_4 572 576 PF00653 0.619
LIG_BRCT_BRCA1_1 141 145 PF00533 0.626
LIG_BRCT_BRCA1_1 180 184 PF00533 0.586
LIG_BRCT_BRCA1_1 528 532 PF00533 0.509
LIG_BRCT_BRCA1_1 663 667 PF00533 0.629
LIG_CaM_IQ_9 738 754 PF13499 0.551
LIG_Clathr_ClatBox_1 714 718 PF01394 0.580
LIG_CtBP_PxDLS_1 560 566 PF00389 0.605
LIG_deltaCOP1_diTrp_1 474 482 PF00928 0.514
LIG_deltaCOP1_diTrp_1 661 667 PF00928 0.625
LIG_FHA_1 406 412 PF00498 0.523
LIG_FHA_1 461 467 PF00498 0.552
LIG_FHA_1 536 542 PF00498 0.559
LIG_FHA_1 621 627 PF00498 0.587
LIG_FHA_1 684 690 PF00498 0.605
LIG_FHA_1 753 759 PF00498 0.572
LIG_FHA_1 764 770 PF00498 0.464
LIG_FHA_2 240 246 PF00498 0.563
LIG_FHA_2 33 39 PF00498 0.607
LIG_FHA_2 434 440 PF00498 0.609
LIG_FHA_2 617 623 PF00498 0.606
LIG_LIR_Gen_1 599 608 PF02991 0.564
LIG_LIR_Gen_1 729 739 PF02991 0.581
LIG_LIR_Nem_3 185 191 PF02991 0.660
LIG_LIR_Nem_3 236 241 PF02991 0.458
LIG_LIR_Nem_3 29 33 PF02991 0.621
LIG_LIR_Nem_3 304 308 PF02991 0.520
LIG_LIR_Nem_3 599 603 PF02991 0.551
LIG_LIR_Nem_3 653 658 PF02991 0.584
LIG_LIR_Nem_3 729 734 PF02991 0.581
LIG_LIR_Nem_3 800 805 PF02991 0.546
LIG_MYND_1 130 134 PF01753 0.602
LIG_NRBOX 716 722 PF00104 0.571
LIG_PCNA_yPIPBox_3 395 405 PF02747 0.567
LIG_Pex14_1 476 480 PF04695 0.500
LIG_Pex14_1 663 667 PF04695 0.629
LIG_Pex14_2 184 188 PF04695 0.577
LIG_Pex14_2 798 802 PF04695 0.559
LIG_PTB_Apo_2 474 481 PF02174 0.509
LIG_SH2_CRK 366 370 PF00017 0.498
LIG_SH2_STAT3 784 787 PF00017 0.607
LIG_SH2_STAT5 191 194 PF00017 0.634
LIG_SH2_STAT5 483 486 PF00017 0.512
LIG_SH2_STAT5 658 661 PF00017 0.717
LIG_SH2_STAT5 851 854 PF00017 0.624
LIG_SH3_1 102 108 PF00018 0.525
LIG_SH3_1 187 193 PF00018 0.647
LIG_SH3_2 130 135 PF14604 0.601
LIG_SH3_3 102 108 PF00018 0.525
LIG_SH3_3 127 133 PF00018 0.611
LIG_SH3_3 173 179 PF00018 0.672
LIG_SH3_3 187 193 PF00018 0.539
LIG_SH3_3 642 648 PF00018 0.599
LIG_SH3_3 66 72 PF00018 0.648
LIG_SH3_3 665 671 PF00018 0.637
LIG_SH3_3 812 818 PF00018 0.598
LIG_SUMO_SIM_anti_2 35 43 PF11976 0.621
LIG_SUMO_SIM_anti_2 599 605 PF11976 0.557
LIG_SUMO_SIM_anti_2 764 769 PF11976 0.577
LIG_SUMO_SIM_par_1 29 35 PF11976 0.616
LIG_SUMO_SIM_par_1 381 386 PF11976 0.530
LIG_SUMO_SIM_par_1 713 718 PF11976 0.581
LIG_TRAF2_1 193 196 PF00917 0.639
LIG_TRAF2_1 242 245 PF00917 0.562
LIG_TRAF2_1 783 786 PF00917 0.626
LIG_TRAF2_2 540 545 PF00917 0.637
LIG_WW_3 132 136 PF00397 0.624
MOD_CDK_SPK_2 211 216 PF00069 0.664
MOD_CDK_SPK_2 509 514 PF00069 0.559
MOD_CDK_SPxK_1 117 123 PF00069 0.694
MOD_CK1_1 171 177 PF00069 0.687
MOD_CK1_1 453 459 PF00069 0.691
MOD_CK1_1 791 797 PF00069 0.633
MOD_CK2_1 239 245 PF00069 0.611
MOD_CK2_1 547 553 PF00069 0.643
MOD_CK2_1 556 562 PF00069 0.671
MOD_CK2_1 616 622 PF00069 0.664
MOD_Cter_Amidation 223 226 PF01082 0.669
MOD_Cter_Amidation 449 452 PF01082 0.616
MOD_GlcNHglycan 171 174 PF01048 0.690
MOD_GlcNHglycan 293 296 PF01048 0.487
MOD_GlcNHglycan 378 381 PF01048 0.705
MOD_GlcNHglycan 390 393 PF01048 0.604
MOD_GlcNHglycan 401 404 PF01048 0.482
MOD_GlcNHglycan 412 415 PF01048 0.449
MOD_GlcNHglycan 444 447 PF01048 0.666
MOD_GlcNHglycan 46 49 PF01048 0.626
MOD_GlcNHglycan 549 552 PF01048 0.577
MOD_GlcNHglycan 558 561 PF01048 0.534
MOD_GlcNHglycan 572 576 PF01048 0.562
MOD_GlcNHglycan 694 697 PF01048 0.625
MOD_GlcNHglycan 736 739 PF01048 0.559
MOD_GlcNHglycan 742 745 PF01048 0.459
MOD_GSK3_1 115 122 PF00069 0.695
MOD_GSK3_1 171 178 PF00069 0.683
MOD_GSK3_1 182 189 PF00069 0.577
MOD_GSK3_1 255 262 PF00069 0.606
MOD_GSK3_1 40 47 PF00069 0.665
MOD_GSK3_1 616 623 PF00069 0.652
MOD_GSK3_1 659 666 PF00069 0.619
MOD_GSK3_1 788 795 PF00069 0.647
MOD_LATS_1 208 214 PF00433 0.563
MOD_N-GLC_1 291 296 PF02516 0.492
MOD_N-GLC_1 336 341 PF02516 0.524
MOD_N-GLC_1 388 393 PF02516 0.586
MOD_NEK2_1 12 17 PF00069 0.593
MOD_NEK2_1 160 165 PF00069 0.552
MOD_NEK2_1 301 306 PF00069 0.521
MOD_NEK2_1 32 37 PF00069 0.463
MOD_NEK2_1 399 404 PF00069 0.549
MOD_NEK2_1 40 45 PF00069 0.587
MOD_NEK2_1 405 410 PF00069 0.509
MOD_NEK2_1 442 447 PF00069 0.571
MOD_NEK2_1 519 524 PF00069 0.688
MOD_NEK2_1 591 596 PF00069 0.575
MOD_NEK2_1 659 664 PF00069 0.615
MOD_NEK2_1 740 745 PF00069 0.541
MOD_NEK2_1 769 774 PF00069 0.562
MOD_NEK2_2 390 395 PF00069 0.510
MOD_NEK2_2 450 455 PF00069 0.697
MOD_PIKK_1 182 188 PF00454 0.673
MOD_PIKK_1 405 411 PF00454 0.549
MOD_PIKK_1 746 752 PF00454 0.547
MOD_PKA_2 12 18 PF00069 0.621
MOD_PKA_2 345 351 PF00069 0.675
MOD_PKA_2 419 425 PF00069 0.530
MOD_PKA_2 44 50 PF00069 0.622
MOD_PKA_2 450 456 PF00069 0.630
MOD_PKA_2 616 622 PF00069 0.686
MOD_PKA_2 791 797 PF00069 0.606
MOD_PKB_1 790 798 PF00069 0.604
MOD_Plk_1 405 411 PF00069 0.549
MOD_Plk_1 763 769 PF00069 0.558
MOD_Plk_1 778 784 PF00069 0.490
MOD_Plk_4 233 239 PF00069 0.497
MOD_Plk_4 663 669 PF00069 0.631
MOD_Plk_4 763 769 PF00069 0.552
MOD_ProDKin_1 117 123 PF00069 0.694
MOD_ProDKin_1 175 181 PF00069 0.681
MOD_ProDKin_1 186 192 PF00069 0.559
MOD_ProDKin_1 211 217 PF00069 0.664
MOD_ProDKin_1 255 261 PF00069 0.585
MOD_ProDKin_1 307 313 PF00069 0.519
MOD_ProDKin_1 336 342 PF00069 0.518
MOD_ProDKin_1 374 380 PF00069 0.492
MOD_ProDKin_1 509 515 PF00069 0.653
MOD_ProDKin_1 630 636 PF00069 0.565
MOD_ProDKin_1 814 820 PF00069 0.563
TRG_DiLeu_BaEn_1 202 207 PF01217 0.635
TRG_DiLeu_BaEn_1 406 411 PF01217 0.527
TRG_DiLeu_BaEn_1 622 627 PF01217 0.583
TRG_DiLeu_BaEn_1 716 721 PF01217 0.567
TRG_DiLeu_BaLyEn_6 368 373 PF01217 0.421
TRG_DiLeu_BaLyEn_6 587 592 PF01217 0.582
TRG_DiLeu_BaLyEn_6 710 715 PF01217 0.579
TRG_DiLeu_BaLyEn_6 816 821 PF01217 0.583
TRG_ENDOCYTIC_2 191 194 PF00928 0.634
TRG_ENDOCYTIC_2 305 308 PF00928 0.515
TRG_ENDOCYTIC_2 366 369 PF00928 0.504
TRG_ENDOCYTIC_2 483 486 PF00928 0.512
TRG_ER_diArg_1 134 136 PF00400 0.661
TRG_ER_diArg_1 225 227 PF00400 0.639
TRG_ER_diArg_1 710 713 PF00400 0.580
TRG_Pf-PMV_PEXEL_1 102 107 PF00026 0.621
TRG_Pf-PMV_PEXEL_1 370 374 PF00026 0.504
TRG_Pf-PMV_PEXEL_1 452 457 PF00026 0.706
TRG_Pf-PMV_PEXEL_1 679 683 PF00026 0.582
TRG_Pf-PMV_PEXEL_1 713 718 PF00026 0.583
TRG_Pf-PMV_PEXEL_1 746 750 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 775 779 PF00026 0.572

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WVK3 Leishmania donovani 99% 100%
E9AS81 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QD85 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS