Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SPFH domain / Band 7 family - putative

Species:

Leishmania infantum

UniProt:

A4HYE7_LEIIN

TriTrypDb:

LINF_190018300

Length:

283

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.290
CLV_PCSK_KEX2_1	168	170	PF00082	0.311
CLV_PCSK_KEX2_1	194	196	PF00082	0.409
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.409
CLV_PCSK_SKI1_1	210	214	PF00082	0.514
CLV_PCSK_SKI1_1	254	258	PF00082	0.555
DOC_MAPK_gen_1	194	201	PF00069	0.377
DOC_MAPK_gen_1	227	236	PF00069	0.504
DOC_MAPK_gen_1	59	68	PF00069	0.347
DOC_MAPK_MEF2A_6	227	236	PF00069	0.383
DOC_MAPK_MEF2A_6	42	51	PF00069	0.298
DOC_MAPK_NFAT4_5	229	237	PF00069	0.415
DOC_PP4_FxxP_1	88	91	PF00568	0.290
DOC_USP7_MATH_1	151	155	PF00917	0.350
DOC_USP7_MATH_1	222	226	PF00917	0.550
LIG_14-3-3_CanoR_1	42	48	PF00244	0.273
LIG_Actin_WH2_2	34	50	PF00022	0.350
LIG_eIF4E_1	110	116	PF01652	0.350
LIG_FHA_1	129	135	PF00498	0.434
LIG_FHA_1	51	57	PF00498	0.348
LIG_FHA_1	9	15	PF00498	0.271
LIG_FHA_2	109	115	PF00498	0.276
LIG_FHA_2	145	151	PF00498	0.257
LIG_FHA_2	168	174	PF00498	0.290
LIG_LIR_Nem_3	82	88	PF02991	0.281
LIG_PTB_Apo_2	235	242	PF02174	0.415
LIG_SH2_CRK	74	78	PF00017	0.257
LIG_SH2_STAP1	80	84	PF00017	0.397
LIG_SH2_STAT5	110	113	PF00017	0.309
LIG_SH2_STAT5	240	243	PF00017	0.367
LIG_TYR_ITIM	72	77	PF00017	0.257
LIG_UBA3_1	115	123	PF00899	0.309
LIG_UBA3_1	208	213	PF00899	0.512
LIG_WRC_WIRS_1	216	221	PF05994	0.411
LIG_WRC_WIRS_1	95	100	PF05994	0.271
MOD_CK1_1	140	146	PF00069	0.449
MOD_CK1_1	154	160	PF00069	0.403
MOD_CK1_1	215	221	PF00069	0.392
MOD_CK1_1	249	255	PF00069	0.570
MOD_CK1_1	89	95	PF00069	0.346
MOD_CK2_1	108	114	PF00069	0.284
MOD_CK2_1	144	150	PF00069	0.290
MOD_CK2_1	167	173	PF00069	0.290
MOD_CK2_1	211	217	PF00069	0.392
MOD_CK2_1	7	13	PF00069	0.406
MOD_GlcNHglycan	126	129	PF01048	0.331
MOD_GlcNHglycan	150	154	PF01048	0.375
MOD_GlcNHglycan	196	199	PF01048	0.494
MOD_GlcNHglycan	248	251	PF01048	0.608
MOD_GSK3_1	124	131	PF00069	0.412
MOD_GSK3_1	137	144	PF00069	0.460
MOD_GSK3_1	211	218	PF00069	0.416
MOD_GSK3_1	94	101	PF00069	0.382
MOD_N-GLC_2	260	262	PF02516	0.506
MOD_NEK2_1	141	146	PF00069	0.289
MOD_NEK2_1	98	103	PF00069	0.385
MOD_NEK2_2	151	156	PF00069	0.344
MOD_NEK2_2	37	42	PF00069	0.265
MOD_NEK2_2	43	48	PF00069	0.247
MOD_NEK2_2	50	55	PF00069	0.238
MOD_PIKK_1	157	163	PF00454	0.309
MOD_PKA_1	194	200	PF00069	0.491
MOD_PKA_2	167	173	PF00069	0.290
MOD_PKA_2	194	200	PF00069	0.491
MOD_PKA_2	86	92	PF00069	0.319
MOD_Plk_1	141	147	PF00069	0.290
MOD_Plk_4	141	147	PF00069	0.271
MOD_Plk_4	215	221	PF00069	0.404
MOD_Plk_4	98	104	PF00069	0.403
MOD_SUMO_rev_2	119	125	PF00179	0.403
MOD_SUMO_rev_2	188	196	PF00179	0.392
MOD_SUMO_rev_2	52	60	PF00179	0.348
TRG_ENDOCYTIC_2	74	77	PF00928	0.257
TRG_ER_diArg_1	167	169	PF00400	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U5	Leptomonas seymouri	32%	100%
A0A0N0P871	Leptomonas seymouri	81%	99%
A0A0S4INL5	Bodo saltans	47%	100%
A0A0S4IW13	Bodo saltans	42%	100%
A0A0S4JWM2	Bodo saltans	33%	91%
A0A1X0NF09	Trypanosomatidae	35%	100%
A0A1X0NYS7	Trypanosomatidae	24%	100%
A0A1X0NZM1	Trypanosomatidae	58%	100%
A0A3Q8IK54	Leishmania donovani	99%	100%
A0A3R7M6V7	Trypanosoma rangeli	23%	74%
A0A3R7NUY2	Trypanosoma rangeli	60%	100%
A0A3S7WVJ3	Leishmania donovani	32%	100%
A4HA74	Leishmania braziliensis	31%	100%
A4HYE6	Leishmania infantum	32%	99%
E9AS79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E9AS80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O26788	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	89%
P0AA53	Escherichia coli (strain K12)	22%	93%
P0AA54	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	93%
P0AA55	Escherichia coli O157:H7	22%	93%
P0AA56	Shigella flexneri	22%	93%
P0DKS0	Wigglesworthia glossinidia brevipalpis	25%	90%
P63694	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	74%
P72655	Synechocystis sp. (strain PCC 6803 / Kazusa)	21%	88%
P9WPR8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	74%
P9WPR9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	74%
Q32LL2	Bos taurus	23%	79%
Q4FZT0	Rattus norvegicus	23%	80%
Q4QD86	Leishmania major	99%	100%
Q4QD87	Leishmania major	32%	99%
Q5GI04	Capsicum annuum	40%	99%
Q6K550	Oryza sativa subsp. japonica	39%	99%
Q6L4S3	Oryza sativa subsp. japonica	41%	98%
Q6ZIV7	Oryza sativa subsp. japonica	41%	100%
Q99JB2	Mus musculus	23%	80%
Q9CAR7	Arabidopsis thaliana	39%	99%
Q9FHM7	Arabidopsis thaliana	39%	97%
Q9FM19	Arabidopsis thaliana	41%	99%
Q9SRH6	Arabidopsis thaliana	38%	99%
Q9UJZ1	Homo sapiens	24%	79%
V5BBU5	Trypanosoma cruzi	23%	70%
V5BQ22	Trypanosoma cruzi	61%	100%
V5D2B9	Trypanosoma cruzi	36%	100%