LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
SPFH domain / Band 7 family - putative
Species:
Leishmania infantum
UniProt:
A4HYE6_LEIIN
TriTrypDb:
LINF_190018200
Length:
277

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

A4HYE6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYE6

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 125 129 PF00656 0.403
CLV_C14_Caspase3-7 224 228 PF00656 0.477
CLV_NRD_NRD_1 191 193 PF00675 0.460
CLV_NRD_NRD_1 201 203 PF00675 0.391
CLV_NRD_NRD_1 40 42 PF00675 0.363
CLV_PCSK_KEX2_1 179 181 PF00082 0.424
CLV_PCSK_KEX2_1 191 193 PF00082 0.388
CLV_PCSK_KEX2_1 40 42 PF00082 0.363
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.500
CLV_PCSK_PC7_1 187 193 PF00082 0.525
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P7U5 Leptomonas seymouri 88% 100%
A0A0N0P871 Leptomonas seymouri 34% 97%
A0A0S4INL5 Bodo saltans 38% 99%
A0A0S4IW13 Bodo saltans 51% 98%
A0A0S4JWM2 Bodo saltans 28% 89%
A0A1X0NF09 Trypanosomatidae 54% 99%
A0A1X0NZM1 Trypanosomatidae 36% 99%
A0A3Q8IK54 Leishmania donovani 31% 98%
A0A3R7M6V7 Trypanosoma rangeli 23% 72%
A0A3R7NUY2 Trypanosoma rangeli 33% 99%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS