Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYE4_LEIIN

TriTrypDb:

LINF_190018000

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.501
CLV_NRD_NRD_1	36	38	PF00675	0.450
CLV_NRD_NRD_1	51	53	PF00675	0.460
CLV_PCSK_KEX2_1	113	115	PF00082	0.468
CLV_PCSK_KEX2_1	125	127	PF00082	0.575
CLV_PCSK_KEX2_1	17	19	PF00082	0.501
CLV_PCSK_KEX2_1	36	38	PF00082	0.450
CLV_PCSK_KEX2_1	51	53	PF00082	0.460
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.468
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.586
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.475
CLV_PCSK_SKI1_1	139	143	PF00082	0.482
CLV_PCSK_SKI1_1	27	31	PF00082	0.540
DEG_APCC_DBOX_1	138	146	PF00400	0.374
DOC_MAPK_FxFP_2	40	43	PF00069	0.516
DOC_MAPK_gen_1	113	119	PF00069	0.441
DOC_PP4_FxxP_1	29	32	PF00568	0.562
DOC_PP4_FxxP_1	40	43	PF00568	0.450
DOC_USP7_MATH_1	137	141	PF00917	0.378
DOC_USP7_MATH_1	20	24	PF00917	0.495
DOC_USP7_MATH_1	94	98	PF00917	0.760
DOC_WW_Pin1_4	58	63	PF00397	0.522
DOC_WW_Pin1_4	88	93	PF00397	0.751
LIG_14-3-3_CanoR_1	17	24	PF00244	0.593
LIG_14-3-3_CanoR_1	37	41	PF00244	0.553
LIG_14-3-3_CterR_2	169	171	PF00244	0.641
LIG_Actin_WH2_2	4	19	PF00022	0.545
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BRCT_BRCA1_1	82	86	PF00533	0.612
LIG_FHA_1	158	164	PF00498	0.429
LIG_FHA_2	163	169	PF00498	0.536
LIG_LIR_Apic_2	39	43	PF02991	0.602
LIG_LIR_Nem_3	127	132	PF02991	0.398
LIG_RPA_C_Fungi	13	25	PF08784	0.580
LIG_SH2_STAP1	159	163	PF00017	0.421
LIG_SH2_STAT5	159	162	PF00017	0.419
LIG_SUMO_SIM_par_1	140	148	PF11976	0.529
LIG_WRC_WIRS_1	11	16	PF05994	0.505
MOD_CDK_SPK_2	90	95	PF00069	0.681
MOD_CDK_SPxxK_3	88	95	PF00069	0.627
MOD_CK1_1	97	103	PF00069	0.678
MOD_CK2_1	162	168	PF00069	0.537
MOD_Cter_Amidation	123	126	PF01082	0.575
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.758
MOD_GlcNHglycan	139	142	PF01048	0.512
MOD_GlcNHglycan	96	99	PF01048	0.759
MOD_GSK3_1	16	23	PF00069	0.620
MOD_GSK3_1	56	63	PF00069	0.625
MOD_GSK3_1	80	87	PF00069	0.541
MOD_GSK3_1	90	97	PF00069	0.658
MOD_NEK2_1	16	21	PF00069	0.582
MOD_NEK2_1	86	91	PF00069	0.581
MOD_NEK2_2	20	25	PF00069	0.524
MOD_PKA_1	113	119	PF00069	0.554
MOD_PKA_1	125	131	PF00069	0.547
MOD_PKA_1	36	42	PF00069	0.596
MOD_PKA_2	113	119	PF00069	0.449
MOD_PKA_2	125	131	PF00069	0.547
MOD_PKA_2	16	22	PF00069	0.562
MOD_PKA_2	36	42	PF00069	0.547
MOD_PKA_2	80	86	PF00069	0.553
MOD_PKA_2	94	100	PF00069	0.708
MOD_Plk_1	84	90	PF00069	0.546
MOD_Plk_4	10	16	PF00069	0.504
MOD_Plk_4	125	131	PF00069	0.387
MOD_ProDKin_1	58	64	PF00069	0.524
MOD_ProDKin_1	88	94	PF00069	0.756
TRG_ENDOCYTIC_2	71	74	PF00928	0.550
TRG_ER_diArg_1	101	104	PF00400	0.592
TRG_ER_diArg_1	16	18	PF00400	0.483
TRG_ER_diArg_1	51	53	PF00400	0.460
TRG_ER_diArg_1	79	82	PF00400	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JUD0	Bodo saltans	52%	100%
A0A1X0P6W6	Trypanosomatidae	68%	100%
A0A3S7WVI2	Leishmania donovani	100%	100%
A0A422NUM9	Trypanosoma rangeli	68%	100%
A4HA72	Leishmania braziliensis	95%	100%
D0A0S9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AS77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QD89	Leishmania major	98%	100%