Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYD5_LEIIN

TriTrypDb:

LINF_190017100

Length:

990

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.657
CLV_C14_Caspase3-7	463	467	PF00656	0.440
CLV_C14_Caspase3-7	638	642	PF00656	0.669
CLV_C14_Caspase3-7	73	77	PF00656	0.566
CLV_NRD_NRD_1	206	208	PF00675	0.732
CLV_NRD_NRD_1	63	65	PF00675	0.600
CLV_NRD_NRD_1	672	674	PF00675	0.798
CLV_NRD_NRD_1	93	95	PF00675	0.651
CLV_PCSK_KEX2_1	144	146	PF00082	0.605
CLV_PCSK_KEX2_1	206	208	PF00082	0.732
CLV_PCSK_KEX2_1	63	65	PF00082	0.600
CLV_PCSK_KEX2_1	681	683	PF00082	0.693
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.651
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.693
CLV_PCSK_SKI1_1	178	182	PF00082	0.602
CLV_PCSK_SKI1_1	327	331	PF00082	0.693
CLV_PCSK_SKI1_1	465	469	PF00082	0.476
CLV_PCSK_SKI1_1	471	475	PF00082	0.423
CLV_PCSK_SKI1_1	477	481	PF00082	0.433
CLV_PCSK_SKI1_1	530	534	PF00082	0.451
CLV_PCSK_SKI1_1	605	609	PF00082	0.541
CLV_PCSK_SKI1_1	640	644	PF00082	0.657
CLV_PCSK_SKI1_1	919	923	PF00082	0.415
DEG_SPOP_SBC_1	12	16	PF00917	0.524
DEG_SPOP_SBC_1	215	219	PF00917	0.692
DEG_SPOP_SBC_1	224	228	PF00917	0.663
DEG_SPOP_SBC_1	231	235	PF00917	0.574
DEG_SPOP_SBC_1	32	36	PF00917	0.497
DEG_SPOP_SBC_1	328	332	PF00917	0.625
DEG_SPOP_SBC_1	442	446	PF00917	0.626
DEG_SPOP_SBC_1	642	646	PF00917	0.663
DOC_CKS1_1	266	271	PF01111	0.677
DOC_CKS1_1	408	413	PF01111	0.573
DOC_CYCLIN_RxL_1	471	484	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.716
DOC_MAPK_FxFP_2	9	12	PF00069	0.525
DOC_MAPK_gen_1	63	69	PF00069	0.652
DOC_PP1_RVXF_1	142	149	PF00149	0.611
DOC_PP1_RVXF_1	176	182	PF00149	0.605
DOC_PP1_RVXF_1	942	948	PF00149	0.524
DOC_PP4_FxxP_1	9	12	PF00568	0.525
DOC_USP7_MATH_1	12	16	PF00917	0.529
DOC_USP7_MATH_1	163	167	PF00917	0.585
DOC_USP7_MATH_1	187	191	PF00917	0.818
DOC_USP7_MATH_1	215	219	PF00917	0.681
DOC_USP7_MATH_1	222	226	PF00917	0.662
DOC_USP7_MATH_1	231	235	PF00917	0.577
DOC_USP7_MATH_1	277	281	PF00917	0.646
DOC_USP7_MATH_1	316	320	PF00917	0.615
DOC_USP7_MATH_1	32	36	PF00917	0.511
DOC_USP7_MATH_1	346	350	PF00917	0.592
DOC_USP7_MATH_1	371	375	PF00917	0.676
DOC_USP7_MATH_1	378	382	PF00917	0.617
DOC_USP7_MATH_1	433	437	PF00917	0.680
DOC_USP7_MATH_1	441	445	PF00917	0.696
DOC_USP7_MATH_1	51	55	PF00917	0.599
DOC_USP7_MATH_1	546	550	PF00917	0.446
DOC_USP7_MATH_1	586	590	PF00917	0.691
DOC_USP7_MATH_1	630	634	PF00917	0.626
DOC_USP7_MATH_1	635	639	PF00917	0.628
DOC_USP7_MATH_1	642	646	PF00917	0.655
DOC_USP7_MATH_1	657	661	PF00917	0.607
DOC_USP7_MATH_1	701	705	PF00917	0.621
DOC_USP7_MATH_1	756	760	PF00917	0.672
DOC_USP7_MATH_1	761	765	PF00917	0.614
DOC_USP7_MATH_1	767	771	PF00917	0.604
DOC_USP7_MATH_1	785	789	PF00917	0.524
DOC_USP7_MATH_1	82	86	PF00917	0.663
DOC_USP7_MATH_1	835	839	PF00917	0.577
DOC_USP7_MATH_1	871	875	PF00917	0.577
DOC_USP7_MATH_1	969	973	PF00917	0.650
DOC_USP7_MATH_2	812	818	PF00917	0.661
DOC_USP7_UBL2_3	681	685	PF12436	0.686
DOC_WW_Pin1_4	137	142	PF00397	0.632
DOC_WW_Pin1_4	225	230	PF00397	0.732
DOC_WW_Pin1_4	238	243	PF00397	0.562
DOC_WW_Pin1_4	265	270	PF00397	0.666
DOC_WW_Pin1_4	28	33	PF00397	0.550
DOC_WW_Pin1_4	285	290	PF00397	0.493
DOC_WW_Pin1_4	330	335	PF00397	0.648
DOC_WW_Pin1_4	336	341	PF00397	0.614
DOC_WW_Pin1_4	363	368	PF00397	0.604
DOC_WW_Pin1_4	38	43	PF00397	0.628
DOC_WW_Pin1_4	384	389	PF00397	0.670
DOC_WW_Pin1_4	394	399	PF00397	0.672
DOC_WW_Pin1_4	407	412	PF00397	0.559
DOC_WW_Pin1_4	420	425	PF00397	0.736
DOC_WW_Pin1_4	437	442	PF00397	0.766
DOC_WW_Pin1_4	443	448	PF00397	0.620
DOC_WW_Pin1_4	45	50	PF00397	0.643
DOC_WW_Pin1_4	493	498	PF00397	0.709
DOC_WW_Pin1_4	499	504	PF00397	0.678
DOC_WW_Pin1_4	580	585	PF00397	0.720
DOC_WW_Pin1_4	673	678	PF00397	0.686
DOC_WW_Pin1_4	741	746	PF00397	0.638
DOC_WW_Pin1_4	804	809	PF00397	0.651
DOC_WW_Pin1_4	815	820	PF00397	0.653
DOC_WW_Pin1_4	85	90	PF00397	0.671
DOC_WW_Pin1_4	855	860	PF00397	0.626
DOC_WW_Pin1_4	898	903	PF00397	0.602
DOC_WW_Pin1_4	959	964	PF00397	0.643
DOC_WW_Pin1_4	971	976	PF00397	0.727
LIG_14-3-3_CanoR_1	127	136	PF00244	0.578
LIG_14-3-3_CanoR_1	161	169	PF00244	0.653
LIG_14-3-3_CanoR_1	184	192	PF00244	0.648
LIG_14-3-3_CanoR_1	206	212	PF00244	0.740
LIG_14-3-3_CanoR_1	216	224	PF00244	0.686
LIG_14-3-3_CanoR_1	327	334	PF00244	0.617
LIG_14-3-3_CanoR_1	427	435	PF00244	0.674
LIG_14-3-3_CanoR_1	530	539	PF00244	0.467
LIG_14-3-3_CanoR_1	547	554	PF00244	0.445
LIG_14-3-3_CanoR_1	682	691	PF00244	0.718
LIG_14-3-3_CanoR_1	893	898	PF00244	0.625
LIG_14-3-3_CanoR_1	94	99	PF00244	0.543
LIG_14-3-3_CanoR_1	944	948	PF00244	0.517
LIG_Actin_WH2_2	102	119	PF00022	0.460
LIG_Actin_WH2_2	450	467	PF00022	0.520
LIG_APCC_ABBA_1	900	905	PF00400	0.627
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BIR_III_2	273	277	PF00653	0.588
LIG_BIR_III_2	395	399	PF00653	0.594
LIG_BRCT_BRCA1_1	5	9	PF00533	0.508
LIG_BRCT_BRCA1_1	769	773	PF00533	0.524
LIG_CtBP_PxDLS_1	965	969	PF00389	0.594
LIG_eIF4E_1	3	9	PF01652	0.484
LIG_FHA_1	16	22	PF00498	0.623
LIG_FHA_1	233	239	PF00498	0.632
LIG_FHA_1	250	256	PF00498	0.627
LIG_FHA_1	3	9	PF00498	0.528
LIG_FHA_1	310	316	PF00498	0.621
LIG_FHA_1	337	343	PF00498	0.671
LIG_FHA_1	34	40	PF00498	0.537
LIG_FHA_1	457	463	PF00498	0.493
LIG_FHA_1	531	537	PF00498	0.464
LIG_FHA_1	730	736	PF00498	0.550
LIG_FHA_1	868	874	PF00498	0.576
LIG_FHA_1	97	103	PF00498	0.535
LIG_FHA_2	116	122	PF00498	0.458
LIG_FHA_2	169	175	PF00498	0.664
LIG_LIR_Apic_2	6	12	PF02991	0.518
LIG_LIR_Apic_2	858	864	PF02991	0.687
LIG_LIR_Apic_2	896	902	PF02991	0.542
LIG_LIR_Gen_1	770	780	PF02991	0.515
LIG_LIR_LC3C_4	549	554	PF02991	0.522
LIG_LIR_Nem_3	770	776	PF02991	0.629
LIG_MYND_1	724	728	PF01753	0.679
LIG_Pex14_1	610	614	PF04695	0.480
LIG_PTAP_UEV_1	757	762	PF05743	0.639
LIG_SH2_CRK	739	743	PF00017	0.682
LIG_SH2_PTP2	899	902	PF00017	0.535
LIG_SH2_STAP1	614	618	PF00017	0.514
LIG_SH2_STAP1	842	846	PF00017	0.572
LIG_SH2_STAP1	98	102	PF00017	0.531
LIG_SH2_STAT3	915	918	PF00017	0.480
LIG_SH2_STAT3	920	923	PF00017	0.465
LIG_SH2_STAT5	3	6	PF00017	0.496
LIG_SH2_STAT5	762	765	PF00017	0.602
LIG_SH2_STAT5	899	902	PF00017	0.571
LIG_SH2_STAT5	903	906	PF00017	0.534
LIG_SH2_STAT5	920	923	PF00017	0.465
LIG_SH2_STAT5	98	101	PF00017	0.564
LIG_SH3_3	156	162	PF00018	0.595
LIG_SH3_3	26	32	PF00018	0.529
LIG_SH3_3	337	343	PF00018	0.664
LIG_SH3_3	351	357	PF00018	0.536
LIG_SH3_3	40	46	PF00018	0.604
LIG_SH3_3	401	407	PF00018	0.604
LIG_SH3_3	47	53	PF00018	0.636
LIG_SH3_3	511	517	PF00018	0.655
LIG_SH3_3	697	703	PF00018	0.597
LIG_SH3_3	718	724	PF00018	0.614
LIG_SH3_3	747	753	PF00018	0.690
LIG_SH3_3	755	761	PF00018	0.588
LIG_SH3_3	78	84	PF00018	0.644
LIG_SH3_3	805	811	PF00018	0.730
LIG_SH3_3	816	822	PF00018	0.608
LIG_SH3_3	960	966	PF00018	0.693
LIG_SH3_3	972	978	PF00018	0.565
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.655
LIG_SUMO_SIM_par_1	151	157	PF11976	0.655
LIG_SUMO_SIM_par_1	458	466	PF11976	0.498
LIG_SUMO_SIM_par_1	478	484	PF11976	0.377
LIG_TRAF2_1	579	582	PF00917	0.672
LIG_WW_3	158	162	PF00397	0.574
LIG_WW_3	502	506	PF00397	0.695
MOD_CDC14_SPxK_1	496	499	PF00782	0.688
MOD_CDC14_SPxK_1	676	679	PF00782	0.629
MOD_CDK_SPxK_1	493	499	PF00069	0.686
MOD_CDK_SPxK_1	673	679	PF00069	0.629
MOD_CDK_SPxxK_3	137	144	PF00069	0.601
MOD_CDK_SPxxK_3	420	427	PF00069	0.552
MOD_CK1_1	13	19	PF00069	0.511
MOD_CK1_1	140	146	PF00069	0.675
MOD_CK1_1	164	170	PF00069	0.657
MOD_CK1_1	2	8	PF00069	0.545
MOD_CK1_1	218	224	PF00069	0.672
MOD_CK1_1	225	231	PF00069	0.703
MOD_CK1_1	234	240	PF00069	0.557
MOD_CK1_1	279	285	PF00069	0.665
MOD_CK1_1	31	37	PF00069	0.686
MOD_CK1_1	319	325	PF00069	0.655
MOD_CK1_1	38	44	PF00069	0.567
MOD_CK1_1	589	595	PF00069	0.674
MOD_CK1_1	730	736	PF00069	0.651
MOD_CK1_1	741	747	PF00069	0.590
MOD_CK1_1	817	823	PF00069	0.666
MOD_CK1_1	85	91	PF00069	0.696
MOD_CK1_1	866	872	PF00069	0.689
MOD_CK1_1	959	965	PF00069	0.655
MOD_CK1_1	967	973	PF00069	0.602
MOD_CK2_1	115	121	PF00069	0.454
MOD_CMANNOS	610	613	PF00535	0.470
MOD_GlcNHglycan	129	132	PF01048	0.625
MOD_GlcNHglycan	163	166	PF01048	0.714
MOD_GlcNHglycan	185	188	PF01048	0.645
MOD_GlcNHglycan	220	223	PF01048	0.685
MOD_GlcNHglycan	24	27	PF01048	0.567
MOD_GlcNHglycan	349	352	PF01048	0.613
MOD_GlcNHglycan	354	357	PF01048	0.587
MOD_GlcNHglycan	361	364	PF01048	0.534
MOD_GlcNHglycan	389	392	PF01048	0.688
MOD_GlcNHglycan	435	438	PF01048	0.585
MOD_GlcNHglycan	487	490	PF01048	0.623
MOD_GlcNHglycan	592	595	PF01048	0.780
MOD_GlcNHglycan	616	619	PF01048	0.625
MOD_GlcNHglycan	637	640	PF01048	0.661
MOD_GlcNHglycan	658	662	PF01048	0.600
MOD_GlcNHglycan	713	716	PF01048	0.676
MOD_GlcNHglycan	72	75	PF01048	0.628
MOD_GlcNHglycan	729	732	PF01048	0.558
MOD_GlcNHglycan	745	748	PF01048	0.679
MOD_GlcNHglycan	758	761	PF01048	0.556
MOD_GlcNHglycan	763	766	PF01048	0.486
MOD_GlcNHglycan	769	772	PF01048	0.523
MOD_GlcNHglycan	782	785	PF01048	0.619
MOD_GlcNHglycan	787	790	PF01048	0.664
MOD_GlcNHglycan	801	804	PF01048	0.548
MOD_GlcNHglycan	833	836	PF01048	0.742
MOD_GlcNHglycan	84	87	PF01048	0.643
MOD_GlcNHglycan	865	868	PF01048	0.755
MOD_GlcNHglycan	873	876	PF01048	0.661
MOD_GlcNHglycan	957	961	PF01048	0.679
MOD_GlcNHglycan	979	982	PF01048	0.663
MOD_GSK3_1	11	18	PF00069	0.542
MOD_GSK3_1	161	168	PF00069	0.639
MOD_GSK3_1	183	190	PF00069	0.747
MOD_GSK3_1	214	221	PF00069	0.836
MOD_GSK3_1	230	237	PF00069	0.527
MOD_GSK3_1	279	286	PF00069	0.658
MOD_GSK3_1	28	35	PF00069	0.603
MOD_GSK3_1	290	297	PF00069	0.780
MOD_GSK3_1	359	366	PF00069	0.567
MOD_GSK3_1	387	394	PF00069	0.652
MOD_GSK3_1	431	438	PF00069	0.760
MOD_GSK3_1	456	463	PF00069	0.493
MOD_GSK3_1	585	592	PF00069	0.665
MOD_GSK3_1	626	633	PF00069	0.678
MOD_GSK3_1	707	714	PF00069	0.698
MOD_GSK3_1	814	821	PF00069	0.762
MOD_GSK3_1	825	832	PF00069	0.623
MOD_GSK3_1	863	870	PF00069	0.556
MOD_GSK3_1	952	959	PF00069	0.620
MOD_GSK3_1	967	974	PF00069	0.535
MOD_LATS_1	483	489	PF00433	0.522
MOD_N-GLC_1	238	243	PF02516	0.615
MOD_N-GLC_1	316	321	PF02516	0.524
MOD_N-GLC_1	485	490	PF02516	0.602
MOD_N-GLC_1	825	830	PF02516	0.625
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	115	120	PF00069	0.429
MOD_NEK2_1	329	334	PF00069	0.602
MOD_NEK2_1	33	38	PF00069	0.591
MOD_NEK2_1	643	648	PF00069	0.635
MOD_NEK2_1	69	74	PF00069	0.588
MOD_NEK2_1	706	711	PF00069	0.616
MOD_NEK2_1	780	785	PF00069	0.624
MOD_NEK2_1	958	963	PF00069	0.564
MOD_PIKK_1	154	160	PF00454	0.658
MOD_PIKK_1	538	544	PF00454	0.457
MOD_PIKK_1	586	592	PF00454	0.713
MOD_PIKK_1	775	781	PF00454	0.619
MOD_PIKK_1	820	826	PF00454	0.624
MOD_PIKK_1	919	925	PF00454	0.429
MOD_PK_1	220	226	PF00069	0.690
MOD_PK_1	893	899	PF00069	0.533
MOD_PKA_1	707	713	PF00069	0.551
MOD_PKA_1	94	100	PF00069	0.536
MOD_PKA_2	183	189	PF00069	0.639
MOD_PKA_2	215	221	PF00069	0.684
MOD_PKA_2	426	432	PF00069	0.664
MOD_PKA_2	546	552	PF00069	0.640
MOD_PKA_2	943	949	PF00069	0.528
MOD_PKB_1	505	513	PF00069	0.661
MOD_PKB_1	520	528	PF00069	0.431
MOD_Plk_1	319	325	PF00069	0.663
MOD_Plk_2-3	460	466	PF00069	0.495
MOD_Plk_4	149	155	PF00069	0.614
MOD_Plk_4	262	268	PF00069	0.634
MOD_Plk_4	290	296	PF00069	0.611
MOD_Plk_4	298	304	PF00069	0.558
MOD_Plk_4	701	707	PF00069	0.627
MOD_Plk_4	943	949	PF00069	0.529
MOD_ProDKin_1	137	143	PF00069	0.630
MOD_ProDKin_1	225	231	PF00069	0.731
MOD_ProDKin_1	238	244	PF00069	0.562
MOD_ProDKin_1	265	271	PF00069	0.668
MOD_ProDKin_1	28	34	PF00069	0.552
MOD_ProDKin_1	285	291	PF00069	0.493
MOD_ProDKin_1	330	336	PF00069	0.651
MOD_ProDKin_1	363	369	PF00069	0.606
MOD_ProDKin_1	38	44	PF00069	0.629
MOD_ProDKin_1	384	390	PF00069	0.671
MOD_ProDKin_1	394	400	PF00069	0.672
MOD_ProDKin_1	407	413	PF00069	0.558
MOD_ProDKin_1	420	426	PF00069	0.734
MOD_ProDKin_1	437	443	PF00069	0.766
MOD_ProDKin_1	45	51	PF00069	0.645
MOD_ProDKin_1	493	499	PF00069	0.712
MOD_ProDKin_1	580	586	PF00069	0.721
MOD_ProDKin_1	673	679	PF00069	0.688
MOD_ProDKin_1	741	747	PF00069	0.637
MOD_ProDKin_1	804	810	PF00069	0.650
MOD_ProDKin_1	815	821	PF00069	0.654
MOD_ProDKin_1	85	91	PF00069	0.670
MOD_ProDKin_1	855	861	PF00069	0.626
MOD_ProDKin_1	898	904	PF00069	0.599
MOD_ProDKin_1	959	965	PF00069	0.642
MOD_ProDKin_1	971	977	PF00069	0.725
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.448
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.650
TRG_ENDOCYTIC_2	739	742	PF00928	0.683
TRG_ER_diArg_1	176	179	PF00400	0.686
TRG_ER_diArg_1	206	208	PF00400	0.672
TRG_ER_diArg_1	504	507	PF00400	0.751
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	931	935	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I094	Leptomonas seymouri	33%	91%
A0A3S5H766	Leishmania donovani	99%	100%
A4HA64	Leishmania braziliensis	63%	98%
E9AS68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QD98	Leishmania major	84%	98%