LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HYD4_LEIIN
TriTrypDb:
LINF_190017000
Length:
371

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 337
Promastigote/Amastigote: 120, 129, 335

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYD4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYD4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 141 145 PF00656 0.672
CLV_C14_Caspase3-7 191 195 PF00656 0.336
CLV_NRD_NRD_1 108 110 PF00675 0.364
CLV_NRD_NRD_1 131 133 PF00675 0.539
CLV_NRD_NRD_1 247 249 PF00675 0.403
CLV_NRD_NRD_1 305 307 PF00675 0.501
CLV_NRD_NRD_1 79 81 PF00675 0.518
CLV_NRD_NRD_1 85 87 PF00675 0.441
CLV_NRD_NRD_1 92 94 PF00675 0.390
CLV_PCSK_FUR_1 56 60 PF00082 0.472
CLV_PCSK_KEX2_1 107 109 PF00082 0.498
CLV_PCSK_KEX2_1 133 135 PF00082 0.564
CLV_PCSK_KEX2_1 211 213 PF00082 0.433
CLV_PCSK_KEX2_1 299 301 PF00082 0.477
CLV_PCSK_KEX2_1 58 60 PF00082 0.485
CLV_PCSK_KEX2_1 78 80 PF00082 0.343
CLV_PCSK_KEX2_1 84 86 PF00082 0.446
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.609
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.461
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.442
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.441
CLV_PCSK_PC1ET2_1 84 86 PF00082 0.473
CLV_PCSK_PC7_1 80 86 PF00082 0.452
CLV_PCSK_SKI1_1 179 183 PF00082 0.459
DEG_APCC_DBOX_1 247 255 PF00400 0.364
DOC_CKS1_1 274 279 PF01111 0.537
DOC_MAPK_gen_1 53 63 PF00069 0.420
DOC_USP7_MATH_1 126 130 PF00917 0.581
DOC_USP7_MATH_1 313 317 PF00917 0.390
DOC_USP7_MATH_1 363 367 PF00917 0.633
DOC_USP7_UBL2_3 307 311 PF12436 0.339
DOC_WW_Pin1_4 273 278 PF00397 0.501
DOC_WW_Pin1_4 359 364 PF00397 0.653
LIG_14-3-3_CanoR_1 265 274 PF00244 0.528
LIG_BRCT_BRCA1_1 195 199 PF00533 0.553
LIG_FHA_1 176 182 PF00498 0.518
LIG_FHA_1 23 29 PF00498 0.532
LIG_FHA_1 261 267 PF00498 0.583
LIG_FHA_2 161 167 PF00498 0.513
LIG_FHA_2 226 232 PF00498 0.448
LIG_FHA_2 280 286 PF00498 0.452
LIG_LIR_Apic_2 272 277 PF02991 0.484
LIG_SH2_CRK 274 278 PF00017 0.487
LIG_SH2_SRC 192 195 PF00017 0.343
LIG_SH2_STAP1 262 266 PF00017 0.391
LIG_SH2_STAT5 189 192 PF00017 0.330
LIG_SH2_STAT5 262 265 PF00017 0.622
LIG_SH3_3 221 227 PF00018 0.472
LIG_TRAF2_1 120 123 PF00917 0.482
LIG_TRAF2_1 228 231 PF00917 0.462
LIG_TRAF2_1 233 236 PF00917 0.418
LIG_TRAF2_1 331 334 PF00917 0.565
LIG_TRAF2_1 343 346 PF00917 0.557
LIG_TRAF2_1 65 68 PF00917 0.511
LIG_TRAF2_1 71 74 PF00917 0.507
LIG_UBA3_1 47 51 PF00899 0.387
MOD_CK1_1 30 36 PF00069 0.500
MOD_CK1_1 362 368 PF00069 0.601
MOD_CK2_1 117 123 PF00069 0.477
MOD_CK2_1 140 146 PF00069 0.795
MOD_CK2_1 160 166 PF00069 0.503
MOD_CK2_1 207 213 PF00069 0.443
MOD_CK2_1 225 231 PF00069 0.456
MOD_CK2_1 332 338 PF00069 0.631
MOD_GlcNHglycan 119 122 PF01048 0.475
MOD_GlcNHglycan 128 131 PF01048 0.424
MOD_GlcNHglycan 150 156 PF01048 0.595
MOD_GlcNHglycan 168 171 PF01048 0.357
MOD_GlcNHglycan 184 187 PF01048 0.316
MOD_GlcNHglycan 267 270 PF01048 0.445
MOD_GlcNHglycan 287 291 PF01048 0.368
MOD_GlcNHglycan 315 318 PF01048 0.400
MOD_GlcNHglycan 33 36 PF01048 0.599
MOD_GlcNHglycan 365 368 PF01048 0.651
MOD_GSK3_1 136 143 PF00069 0.697
MOD_GSK3_1 193 200 PF00069 0.456
MOD_GSK3_1 27 34 PF00069 0.482
MOD_GSK3_1 357 364 PF00069 0.723
MOD_N-GLC_1 207 212 PF02516 0.402
MOD_N-GLC_2 242 244 PF02516 0.432
MOD_NEK2_1 160 165 PF00069 0.443
MOD_NEK2_1 181 186 PF00069 0.473
MOD_NEK2_1 193 198 PF00069 0.335
MOD_NEK2_1 219 224 PF00069 0.543
MOD_NEK2_1 301 306 PF00069 0.423
MOD_PIKK_1 160 166 PF00454 0.491
MOD_PKA_2 117 123 PF00069 0.547
MOD_Plk_1 230 236 PF00069 0.431
MOD_Plk_1 286 292 PF00069 0.505
MOD_Plk_2-3 140 146 PF00069 0.617
MOD_Plk_2-3 230 236 PF00069 0.449
MOD_Plk_4 153 159 PF00069 0.528
MOD_ProDKin_1 273 279 PF00069 0.497
MOD_ProDKin_1 359 365 PF00069 0.652
MOD_SUMO_for_1 202 205 PF00179 0.421
MOD_SUMO_rev_2 296 301 PF00179 0.558
MOD_SUMO_rev_2 345 355 PF00179 0.547
TRG_ENDOCYTIC_2 10 13 PF00928 0.550
TRG_ENDOCYTIC_2 15 18 PF00928 0.504
TRG_ENDOCYTIC_2 38 41 PF00928 0.528
TRG_ER_diArg_1 107 109 PF00400 0.594
TRG_ER_diArg_1 132 135 PF00400 0.536
TRG_ER_diArg_1 78 80 PF00400 0.525
TRG_NES_CRM1_1 52 67 PF08389 0.565
TRG_Pf-PMV_PEXEL_1 108 113 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 255 259 PF00026 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P630 Trypanosomatidae 29% 100%
A0A3Q8IBB1 Leishmania donovani 99% 100%
A0A3R7KAD6 Trypanosoma rangeli 31% 100%
D0A0R5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AS67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4QD99 Leishmania major 86% 100%
V5AZ24 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS