Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYD2_LEIIN

TriTrypDb:

LINF_190016800

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 0
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.551
CLV_C14_Caspase3-7	43	47	PF00656	0.677
CLV_NRD_NRD_1	159	161	PF00675	0.680
CLV_NRD_NRD_1	187	189	PF00675	0.680
CLV_NRD_NRD_1	190	192	PF00675	0.648
CLV_NRD_NRD_1	227	229	PF00675	0.660
CLV_NRD_NRD_1	328	330	PF00675	0.561
CLV_NRD_NRD_1	387	389	PF00675	0.619
CLV_NRD_NRD_1	434	436	PF00675	0.670
CLV_NRD_NRD_1	517	519	PF00675	0.698
CLV_NRD_NRD_1	740	742	PF00675	0.741
CLV_NRD_NRD_1	798	800	PF00675	0.586
CLV_PCSK_FUR_1	188	192	PF00082	0.600
CLV_PCSK_KEX2_1	158	160	PF00082	0.676
CLV_PCSK_KEX2_1	187	189	PF00082	0.680
CLV_PCSK_KEX2_1	190	192	PF00082	0.648
CLV_PCSK_KEX2_1	227	229	PF00082	0.660
CLV_PCSK_KEX2_1	387	389	PF00082	0.619
CLV_PCSK_KEX2_1	517	519	PF00082	0.698
CLV_PCSK_KEX2_1	740	742	PF00082	0.740
CLV_PCSK_KEX2_1	798	800	PF00082	0.586
CLV_PCSK_SKI1_1	329	333	PF00082	0.531
CLV_PCSK_SKI1_1	374	378	PF00082	0.600
CLV_PCSK_SKI1_1	687	691	PF00082	0.559
DEG_Nend_UBRbox_2	1	3	PF02207	0.680
DEG_SPOP_SBC_1	264	268	PF00917	0.638
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.669
DOC_MAPK_DCC_7	435	443	PF00069	0.598
DOC_MAPK_gen_1	435	443	PF00069	0.598
DOC_MAPK_gen_1	673	681	PF00069	0.612
DOC_MAPK_MEF2A_6	435	443	PF00069	0.598
DOC_PP2B_LxvP_1	688	691	PF13499	0.556
DOC_PP4_FxxP_1	601	604	PF00568	0.824
DOC_PP4_FxxP_1	693	696	PF00568	0.614
DOC_PP4_FxxP_1	9	12	PF00568	0.672
DOC_USP7_MATH_1	110	114	PF00917	0.705
DOC_USP7_MATH_1	117	121	PF00917	0.624
DOC_USP7_MATH_1	135	139	PF00917	0.464
DOC_USP7_MATH_1	264	268	PF00917	0.645
DOC_USP7_MATH_1	295	299	PF00917	0.629
DOC_USP7_MATH_1	398	402	PF00917	0.597
DOC_USP7_MATH_1	501	505	PF00917	0.686
DOC_USP7_MATH_1	559	563	PF00917	0.675
DOC_USP7_MATH_1	595	599	PF00917	0.741
DOC_USP7_MATH_1	722	726	PF00917	0.603
DOC_USP7_MATH_1	727	731	PF00917	0.589
DOC_USP7_MATH_1	743	747	PF00917	0.680
DOC_USP7_MATH_1	81	85	PF00917	0.775
DOC_WW_Pin1_4	113	118	PF00397	0.711
DOC_WW_Pin1_4	119	124	PF00397	0.632
DOC_WW_Pin1_4	247	252	PF00397	0.666
DOC_WW_Pin1_4	334	339	PF00397	0.660
DOC_WW_Pin1_4	468	473	PF00397	0.654
DOC_WW_Pin1_4	553	558	PF00397	0.613
DOC_WW_Pin1_4	82	87	PF00397	0.664
LIG_14-3-3_CanoR_1	159	165	PF00244	0.682
LIG_14-3-3_CanoR_1	228	234	PF00244	0.681
LIG_14-3-3_CanoR_1	329	338	PF00244	0.664
LIG_14-3-3_CanoR_1	507	516	PF00244	0.663
LIG_14-3-3_CanoR_1	537	546	PF00244	0.610
LIG_14-3-3_CanoR_1	712	717	PF00244	0.622
LIG_14-3-3_CanoR_1	718	727	PF00244	0.555
LIG_BRCT_BRCA1_1	597	601	PF00533	0.751
LIG_BRCT_BRCA1_1	693	697	PF00533	0.628
LIG_deltaCOP1_diTrp_1	683	693	PF00928	0.552
LIG_FHA_1	330	336	PF00498	0.555
LIG_FHA_1	67	73	PF00498	0.587
LIG_FHA_2	207	213	PF00498	0.550
LIG_FHA_2	238	244	PF00498	0.800
LIG_FHA_2	348	354	PF00498	0.601
LIG_FHA_2	432	438	PF00498	0.582
LIG_FHA_2	536	542	PF00498	0.679
LIG_FHA_2	600	606	PF00498	0.683
LIG_GBD_Chelix_1	445	453	PF00786	0.525
LIG_Integrin_RGD_1	763	765	PF01839	0.587
LIG_LIR_Apic_2	598	604	PF02991	0.813
LIG_LIR_Apic_2	692	696	PF02991	0.609
LIG_LIR_Gen_1	20	31	PF02991	0.501
LIG_LIR_Gen_1	674	684	PF02991	0.600
LIG_LIR_Nem_3	20	26	PF02991	0.495
LIG_LIR_Nem_3	371	376	PF02991	0.705
LIG_LIR_Nem_3	526	530	PF02991	0.626
LIG_LIR_Nem_3	540	546	PF02991	0.611
LIG_LIR_Nem_3	674	679	PF02991	0.627
LIG_LIR_Nem_3	683	689	PF02991	0.475
LIG_LIR_Nem_3	756	762	PF02991	0.619
LIG_NRBOX	298	304	PF00104	0.620
LIG_NRBOX	448	454	PF00104	0.520
LIG_NRBOX	570	576	PF00104	0.590
LIG_PCNA_yPIPBox_3	782	793	PF02747	0.530
LIG_Pex14_2	693	697	PF04695	0.617
LIG_RPA_C_Fungi	446	458	PF08784	0.530
LIG_RPA_C_Fungi	707	719	PF08784	0.555
LIG_SH2_NCK_1	34	38	PF00017	0.544
LIG_SH2_SRC	649	652	PF00017	0.594
LIG_SH2_STAP1	17	21	PF00017	0.554
LIG_SH2_STAT3	139	142	PF00017	0.686
LIG_SH2_STAT5	139	142	PF00017	0.630
LIG_SH2_STAT5	349	352	PF00017	0.605
LIG_SH2_STAT5	478	481	PF00017	0.677
LIG_SH3_1	8	14	PF00018	0.672
LIG_SH3_3	248	254	PF00018	0.637
LIG_SH3_3	392	398	PF00018	0.647
LIG_SH3_3	412	418	PF00018	0.611
LIG_SH3_3	466	472	PF00018	0.646
LIG_SH3_3	522	528	PF00018	0.666
LIG_SH3_3	8	14	PF00018	0.672
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.598
LIG_TRAF2_1	123	126	PF00917	0.683
LIG_TRAF2_1	350	353	PF00917	0.643
LIG_TRAF2_1	562	565	PF00917	0.667
LIG_TRAF2_1	604	607	PF00917	0.682
LIG_WRC_WIRS_1	690	695	PF05994	0.590
LIG_WW_3	10	14	PF00397	0.639
MOD_CDK_SPK_2	119	124	PF00069	0.617
MOD_CDK_SPxK_1	247	253	PF00069	0.569
MOD_CK1_1	113	119	PF00069	0.815
MOD_CK1_1	138	144	PF00069	0.552
MOD_CK1_1	162	168	PF00069	0.691
MOD_CK1_1	180	186	PF00069	0.733
MOD_CK1_1	241	247	PF00069	0.649
MOD_CK1_1	263	269	PF00069	0.791
MOD_CK1_1	337	343	PF00069	0.650
MOD_CK1_1	380	386	PF00069	0.639
MOD_CK1_1	41	47	PF00069	0.578
MOD_CK1_1	481	487	PF00069	0.572
MOD_CK1_1	508	514	PF00069	0.684
MOD_CK1_1	547	553	PF00069	0.669
MOD_CK1_1	590	596	PF00069	0.660
MOD_CK1_1	677	683	PF00069	0.615
MOD_CK1_1	699	705	PF00069	0.663
MOD_CK1_1	746	752	PF00069	0.727
MOD_CK2_1	180	186	PF00069	0.708
MOD_CK2_1	237	243	PF00069	0.790
MOD_CK2_1	347	353	PF00069	0.608
MOD_CK2_1	365	371	PF00069	0.618
MOD_CK2_1	403	409	PF00069	0.625
MOD_CK2_1	431	437	PF00069	0.595
MOD_CK2_1	559	565	PF00069	0.675
MOD_CK2_1	677	683	PF00069	0.578
MOD_CK2_1	70	76	PF00069	0.672
MOD_CK2_1	800	806	PF00069	0.636
MOD_GlcNHglycan	112	115	PF01048	0.809
MOD_GlcNHglycan	182	185	PF01048	0.708
MOD_GlcNHglycan	196	199	PF01048	0.726
MOD_GlcNHglycan	243	247	PF01048	0.517
MOD_GlcNHglycan	262	265	PF01048	0.666
MOD_GlcNHglycan	283	286	PF01048	0.666
MOD_GlcNHglycan	339	342	PF01048	0.652
MOD_GlcNHglycan	405	408	PF01048	0.701
MOD_GlcNHglycan	503	506	PF01048	0.652
MOD_GlcNHglycan	507	510	PF01048	0.605
MOD_GlcNHglycan	546	549	PF01048	0.695
MOD_GlcNHglycan	56	59	PF01048	0.693
MOD_GlcNHglycan	561	564	PF01048	0.534
MOD_GlcNHglycan	592	596	PF01048	0.719
MOD_GlcNHglycan	630	636	PF01048	0.668
MOD_GlcNHglycan	693	696	PF01048	0.609
MOD_GlcNHglycan	720	723	PF01048	0.630
MOD_GlcNHglycan	736	739	PF01048	0.551
MOD_GlcNHglycan	749	752	PF01048	0.693
MOD_GSK3_1	109	116	PF00069	0.778
MOD_GSK3_1	138	145	PF00069	0.591
MOD_GSK3_1	162	169	PF00069	0.638
MOD_GSK3_1	194	201	PF00069	0.732
MOD_GSK3_1	228	235	PF00069	0.683
MOD_GSK3_1	237	244	PF00069	0.686
MOD_GSK3_1	260	267	PF00069	0.722
MOD_GSK3_1	281	288	PF00069	0.713
MOD_GSK3_1	377	384	PF00069	0.562
MOD_GSK3_1	403	410	PF00069	0.714
MOD_GSK3_1	474	481	PF00069	0.656
MOD_GSK3_1	48	55	PF00069	0.734
MOD_GSK3_1	501	508	PF00069	0.639
MOD_GSK3_1	542	549	PF00069	0.668
MOD_GSK3_1	587	594	PF00069	0.769
MOD_GSK3_1	595	602	PF00069	0.633
MOD_GSK3_1	649	656	PF00069	0.714
MOD_GSK3_1	66	73	PF00069	0.609
MOD_GSK3_1	675	682	PF00069	0.570
MOD_GSK3_1	698	705	PF00069	0.707
MOD_GSK3_1	718	725	PF00069	0.559
MOD_GSK3_1	743	750	PF00069	0.698
MOD_GSK3_1	82	89	PF00069	0.735
MOD_LATS_1	542	548	PF00433	0.694
MOD_N-GLC_1	133	138	PF02516	0.643
MOD_N-GLC_1	241	246	PF02516	0.674
MOD_N-GLC_1	279	284	PF02516	0.650
MOD_N-GLC_1	407	412	PF02516	0.661
MOD_N-GLC_2	422	424	PF02516	0.629
MOD_NEK2_1	237	242	PF00069	0.671
MOD_NEK2_1	281	286	PF00069	0.718
MOD_NEK2_1	377	382	PF00069	0.601
MOD_NEK2_1	459	464	PF00069	0.529
MOD_NEK2_1	48	53	PF00069	0.830
MOD_NEK2_1	546	551	PF00069	0.694
MOD_NEK2_1	575	580	PF00069	0.580
MOD_NEK2_1	591	596	PF00069	0.591
MOD_NEK2_1	659	664	PF00069	0.699
MOD_NEK2_1	66	71	PF00069	0.587
MOD_NEK2_1	697	702	PF00069	0.661
MOD_NEK2_1	94	99	PF00069	0.593
MOD_NEK2_2	665	670	PF00069	0.539
MOD_PIKK_1	138	144	PF00454	0.559
MOD_PIKK_1	2	8	PF00454	0.694
MOD_PIKK_1	407	413	PF00454	0.664
MOD_PIKK_1	94	100	PF00454	0.656
MOD_PK_1	160	166	PF00069	0.686
MOD_PK_1	675	681	PF00069	0.605
MOD_PK_1	712	718	PF00069	0.555
MOD_PKA_1	159	165	PF00069	0.682
MOD_PKA_1	329	335	PF00069	0.542
MOD_PKA_2	127	133	PF00069	0.680
MOD_PKA_2	159	165	PF00069	0.668
MOD_PKA_2	166	172	PF00069	0.654
MOD_PKA_2	381	387	PF00069	0.605
MOD_PKA_2	523	529	PF00069	0.786
MOD_PKA_2	536	542	PF00069	0.581
MOD_PKA_2	711	717	PF00069	0.621
MOD_PKB_1	158	166	PF00069	0.693
MOD_Plk_1	206	212	PF00069	0.593
MOD_Plk_1	242	248	PF00069	0.673
MOD_Plk_1	48	54	PF00069	0.689
MOD_Plk_1	564	570	PF00069	0.584
MOD_Plk_1	606	612	PF00069	0.586
MOD_Plk_1	631	637	PF00069	0.598
MOD_Plk_2-3	206	212	PF00069	0.552
MOD_Plk_2-3	345	351	PF00069	0.585
MOD_Plk_2-3	800	806	PF00069	0.608
MOD_Plk_4	135	141	PF00069	0.625
MOD_Plk_4	17	23	PF00069	0.532
MOD_Plk_4	265	271	PF00069	0.775
MOD_Plk_4	474	480	PF00069	0.576
MOD_Plk_4	570	576	PF00069	0.597
MOD_Plk_4	595	601	PF00069	0.643
MOD_Plk_4	727	733	PF00069	0.611
MOD_ProDKin_1	113	119	PF00069	0.711
MOD_ProDKin_1	247	253	PF00069	0.667
MOD_ProDKin_1	334	340	PF00069	0.662
MOD_ProDKin_1	468	474	PF00069	0.656
MOD_ProDKin_1	553	559	PF00069	0.613
MOD_ProDKin_1	82	88	PF00069	0.664
MOD_SUMO_rev_2	201	210	PF00179	0.560
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.547
TRG_ENDOCYTIC_2	396	399	PF00928	0.644
TRG_ENDOCYTIC_2	759	762	PF00928	0.740
TRG_ER_diArg_1	12	15	PF00400	0.634
TRG_ER_diArg_1	158	160	PF00400	0.676
TRG_ER_diArg_1	187	190	PF00400	0.608
TRG_ER_diArg_1	386	388	PF00400	0.623
TRG_ER_diArg_1	516	518	PF00400	0.583
TRG_ER_diArg_1	739	741	PF00400	0.743
TRG_ER_diArg_1	797	799	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVJ5	Leishmania donovani	99%	100%
E9AS65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	95%
Q4QDA1	Leishmania major	85%	100%