Miff domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HYC6_LEIIN

TriTrypDb:

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HYC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.733
CLV_NRD_NRD_1	180	182	PF00675	0.420
CLV_PCSK_KEX2_1	180	182	PF00082	0.420
CLV_PCSK_KEX2_1	23	25	PF00082	0.551
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.426
CLV_PCSK_SKI1_1	190	194	PF00082	0.443
DEG_MDM2_SWIB_1	210	217	PF02201	0.607
DEG_Nend_UBRbox_3	1	3	PF02207	0.590
DOC_CYCLIN_yClb5_NLxxxL_5	213	221	PF00134	0.462
DOC_MAPK_gen_1	57	65	PF00069	0.584
DOC_MAPK_MEF2A_6	109	118	PF00069	0.596
DOC_MAPK_MEF2A_6	59	67	PF00069	0.578
DOC_PP1_RVXF_1	107	114	PF00149	0.632
DOC_PP4_FxxP_1	124	127	PF00568	0.594
DOC_USP7_MATH_1	148	152	PF00917	0.659
LIG_14-3-3_CanoR_1	164	174	PF00244	0.617
LIG_14-3-3_CanoR_1	74	82	PF00244	0.548
LIG_14-3-3_CanoR_1	93	98	PF00244	0.567
LIG_deltaCOP1_diTrp_1	112	118	PF00928	0.621
LIG_EVH1_2	114	118	PF00568	0.622
LIG_FHA_1	234	240	PF00498	0.507
LIG_FHA_1	62	68	PF00498	0.531
LIG_GBD_Chelix_1	225	233	PF00786	0.345
LIG_LIR_Apic_2	122	127	PF02991	0.599
LIG_LIR_Gen_1	158	166	PF02991	0.632
LIG_LIR_Gen_1	199	210	PF02991	0.615
LIG_LIR_Gen_1	212	222	PF02991	0.463
LIG_LIR_Nem_3	112	116	PF02991	0.607
LIG_LIR_Nem_3	158	163	PF02991	0.641
LIG_LIR_Nem_3	199	205	PF02991	0.651
LIG_LIR_Nem_3	212	217	PF02991	0.436
LIG_NRBOX	170	176	PF00104	0.625
LIG_Pex14_2	210	214	PF04695	0.613
LIG_Pex14_2	230	234	PF04695	0.345
LIG_PTB_Apo_2	204	211	PF02174	0.662
LIG_SH2_STAP1	61	65	PF00017	0.680
LIG_SH2_STAT3	136	139	PF00017	0.608
LIG_SH2_STAT5	10	13	PF00017	0.660
LIG_SH2_STAT5	202	205	PF00017	0.746
LIG_SH2_STAT5	231	234	PF00017	0.345
LIG_SH3_3	95	101	PF00018	0.628
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.527
LIG_WW_3	97	101	PF00397	0.596
MOD_CK1_1	120	126	PF00069	0.718
MOD_Cter_Amidation	21	24	PF01082	0.424
MOD_GlcNHglycan	194	197	PF01048	0.511
MOD_GlcNHglycan	75	78	PF01048	0.330
MOD_GSK3_1	175	182	PF00069	0.610
MOD_GSK3_1	192	199	PF00069	0.614
MOD_NEK2_1	119	124	PF00069	0.623
MOD_NEK2_1	175	180	PF00069	0.675
MOD_PKA_1	180	186	PF00069	0.628
MOD_PKA_2	179	185	PF00069	0.619
MOD_PKA_2	73	79	PF00069	0.537
MOD_Plk_1	61	67	PF00069	0.577
MOD_Plk_4	127	133	PF00069	0.528
MOD_Plk_4	170	176	PF00069	0.625
MOD_Plk_4	43	49	PF00069	0.706
MOD_SUMO_rev_2	26	31	PF00179	0.609
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.590
TRG_ENDOCYTIC_2	160	163	PF00928	0.638
TRG_ENDOCYTIC_2	202	205	PF00928	0.609
TRG_ER_diArg_1	142	145	PF00400	0.668
TRG_ER_diArg_1	57	60	PF00400	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AS60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4QDA6	Leishmania major	78%	100%