LeishMANIAdb
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DAGKc domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DAGKc domain-containing protein
Gene product:
Diacylglycerol kinase catalytic domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HYC4_LEIIN
TriTrypDb:
LINF_190016000
Length:
964

Annotations

LeishMANIAdb annotations

Could be a sphingosine kinase. Membrane-associated without any TM segments.

Annotations by Jardim et al.

Protein kinase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 1
GO:0042721 TIM22 mitochondrial import inner membrane insertion complex 4 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYC4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006839 mitochondrial transport 4 1
GO:0006886 intracellular protein transport 4 1
GO:0006996 organelle organization 4 1
GO:0007005 mitochondrion organization 5 1
GO:0007006 mitochondrial membrane organization 5 1
GO:0007007 inner mitochondrial membrane organization 6 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 2
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0045039 protein insertion into mitochondrial inner membrane 6 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051204 protein insertion into mitochondrial membrane 5 1
GO:0051205 protein insertion into membrane 5 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0061024 membrane organization 4 1
GO:0070585 protein localization to mitochondrion 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072655 establishment of protein localization to mitochondrion 5 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:0090151 establishment of protein localization to mitochondrial membrane 4 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0016310 phosphorylation 5 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016301 kinase activity 4 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0017050 D-erythro-sphingosine kinase activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 491 495 PF00656 0.461
CLV_C14_Caspase3-7 849 853 PF00656 0.451
CLV_NRD_NRD_1 7 9 PF00675 0.378
CLV_NRD_NRD_1 706 708 PF00675 0.684
CLV_NRD_NRD_1 935 937 PF00675 0.409
CLV_NRD_NRD_1 949 951 PF00675 0.360
CLV_NRD_NRD_1 962 964 PF00675 0.341
CLV_PCSK_KEX2_1 229 231 PF00082 0.398
CLV_PCSK_KEX2_1 708 710 PF00082 0.692
CLV_PCSK_KEX2_1 935 937 PF00082 0.409
CLV_PCSK_KEX2_1 949 951 PF00082 0.380
CLV_PCSK_KEX2_1 962 964 PF00082 0.325
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.398
CLV_PCSK_PC1ET2_1 708 710 PF00082 0.624
CLV_PCSK_PC7_1 958 964 PF00082 0.357
CLV_PCSK_SKI1_1 35 39 PF00082 0.244
CLV_PCSK_SKI1_1 409 413 PF00082 0.236
CLV_PCSK_SKI1_1 682 686 PF00082 0.761
CLV_PCSK_SKI1_1 841 845 PF00082 0.215
CLV_PCSK_SKI1_1 882 886 PF00082 0.273
DEG_APCC_DBOX_1 940 948 PF00400 0.562
DEG_SPOP_SBC_1 533 537 PF00917 0.386
DEG_SPOP_SBC_1 664 668 PF00917 0.480
DEG_SPOP_SBC_1 691 695 PF00917 0.486
DEG_SPOP_SBC_1 92 96 PF00917 0.656
DOC_ANK_TNKS_1 573 580 PF00023 0.496
DOC_CKS1_1 139 144 PF01111 0.583
DOC_CKS1_1 630 635 PF01111 0.333
DOC_CYCLIN_yCln2_LP_2 308 314 PF00134 0.455
DOC_CYCLIN_yCln2_LP_2 596 602 PF00134 0.434
DOC_MAPK_gen_1 165 174 PF00069 0.459
DOC_MAPK_MEF2A_6 35 42 PF00069 0.503
DOC_MAPK_MEF2A_6 466 473 PF00069 0.353
DOC_PP1_RVXF_1 398 404 PF00149 0.432
DOC_PP1_RVXF_1 880 886 PF00149 0.433
DOC_PP2B_LxvP_1 313 316 PF13499 0.402
DOC_PP2B_LxvP_1 596 599 PF13499 0.424
DOC_PP2B_LxvP_1 779 782 PF13499 0.255
DOC_PP2B_LxvP_1 930 933 PF13499 0.630
DOC_PP4_FxxP_1 885 888 PF00568 0.426
DOC_SPAK_OSR1_1 828 832 PF12202 0.411
DOC_USP7_MATH_1 108 112 PF00917 0.709
DOC_USP7_MATH_1 122 126 PF00917 0.598
DOC_USP7_MATH_1 146 150 PF00917 0.733
DOC_USP7_MATH_1 208 212 PF00917 0.715
DOC_USP7_MATH_1 238 242 PF00917 0.667
DOC_USP7_MATH_1 291 295 PF00917 0.509
DOC_USP7_MATH_1 350 354 PF00917 0.708
DOC_USP7_MATH_1 4 8 PF00917 0.622
DOC_USP7_MATH_1 418 422 PF00917 0.521
DOC_USP7_MATH_1 447 451 PF00917 0.328
DOC_USP7_MATH_1 533 537 PF00917 0.465
DOC_USP7_MATH_1 664 668 PF00917 0.451
DOC_USP7_MATH_1 691 695 PF00917 0.459
DOC_USP7_MATH_1 76 80 PF00917 0.491
DOC_USP7_MATH_1 92 96 PF00917 0.609
DOC_WW_Pin1_4 138 143 PF00397 0.608
DOC_WW_Pin1_4 201 206 PF00397 0.743
DOC_WW_Pin1_4 220 225 PF00397 0.614
DOC_WW_Pin1_4 329 334 PF00397 0.419
DOC_WW_Pin1_4 372 377 PF00397 0.658
DOC_WW_Pin1_4 525 530 PF00397 0.469
DOC_WW_Pin1_4 534 539 PF00397 0.387
DOC_WW_Pin1_4 613 618 PF00397 0.471
DOC_WW_Pin1_4 629 634 PF00397 0.280
DOC_WW_Pin1_4 641 646 PF00397 0.419
DOC_WW_Pin1_4 832 837 PF00397 0.385
LIG_14-3-3_CanoR_1 230 236 PF00244 0.709
LIG_14-3-3_CanoR_1 379 385 PF00244 0.647
LIG_14-3-3_CanoR_1 387 394 PF00244 0.480
LIG_14-3-3_CanoR_1 435 440 PF00244 0.455
LIG_14-3-3_CanoR_1 564 573 PF00244 0.451
LIG_14-3-3_CanoR_1 627 631 PF00244 0.381
LIG_14-3-3_CanoR_1 817 824 PF00244 0.417
LIG_14-3-3_CanoR_1 920 928 PF00244 0.700
LIG_14-3-3_CterR_2 962 964 PF00244 0.579
LIG_BIR_II_1 1 5 PF00653 0.668
LIG_BIR_III_2 734 738 PF00653 0.428
LIG_BIR_III_2 742 746 PF00653 0.445
LIG_BIR_III_3 1 5 PF00653 0.629
LIG_BIR_III_4 576 580 PF00653 0.475
LIG_BRCT_BRCA1_1 667 671 PF00533 0.459
LIG_CaM_IQ_9 422 437 PF13499 0.499
LIG_DLG_GKlike_1 435 443 PF00625 0.455
LIG_EH1_1 634 642 PF00400 0.339
LIG_eIF4E_1 774 780 PF01652 0.255
LIG_FHA_1 159 165 PF00498 0.495
LIG_FHA_1 246 252 PF00498 0.508
LIG_FHA_1 263 269 PF00498 0.459
LIG_FHA_1 525 531 PF00498 0.522
LIG_FHA_1 785 791 PF00498 0.270
LIG_FHA_1 792 798 PF00498 0.221
LIG_FHA_1 842 848 PF00498 0.455
LIG_FHA_1 888 894 PF00498 0.518
LIG_FHA_2 139 145 PF00498 0.585
LIG_FHA_2 258 264 PF00498 0.436
LIG_FHA_2 317 323 PF00498 0.429
LIG_FHA_2 330 336 PF00498 0.427
LIG_FHA_2 489 495 PF00498 0.476
LIG_FHA_2 755 761 PF00498 0.247
LIG_FHA_2 900 906 PF00498 0.577
LIG_Integrin_isoDGR_2 770 772 PF01839 0.411
LIG_IRF3_LxIS_1 637 644 PF10401 0.320
LIG_LIR_Gen_1 321 328 PF02991 0.414
LIG_LIR_Gen_1 36 46 PF02991 0.495
LIG_LIR_Gen_1 449 459 PF02991 0.307
LIG_LIR_Gen_1 755 766 PF02991 0.267
LIG_LIR_Nem_3 321 326 PF02991 0.414
LIG_LIR_Nem_3 36 42 PF02991 0.493
LIG_LIR_Nem_3 449 454 PF02991 0.307
LIG_LIR_Nem_3 755 761 PF02991 0.269
LIG_LIR_Nem_3 806 811 PF02991 0.209
LIG_NRBOX 943 949 PF00104 0.568
LIG_Pex14_2 64 68 PF04695 0.513
LIG_SH2_PTP2 39 42 PF00017 0.442
LIG_SH2_SRC 314 317 PF00017 0.385
LIG_SH2_SRC 732 735 PF00017 0.460
LIG_SH2_STAP1 123 127 PF00017 0.566
LIG_SH2_STAP1 394 398 PF00017 0.483
LIG_SH2_STAP1 610 614 PF00017 0.384
LIG_SH2_STAT3 592 595 PF00017 0.394
LIG_SH2_STAT5 314 317 PF00017 0.386
LIG_SH2_STAT5 39 42 PF00017 0.442
LIG_SH2_STAT5 463 466 PF00017 0.248
LIG_SH2_STAT5 592 595 PF00017 0.418
LIG_SH2_STAT5 610 613 PF00017 0.393
LIG_SH2_STAT5 732 735 PF00017 0.460
LIG_SH2_STAT5 811 814 PF00017 0.245
LIG_SH3_1 240 246 PF00018 0.570
LIG_SH3_1 466 472 PF00018 0.347
LIG_SH3_2 599 604 PF14604 0.433
LIG_SH3_3 136 142 PF00018 0.605
LIG_SH3_3 193 199 PF00018 0.719
LIG_SH3_3 20 26 PF00018 0.655
LIG_SH3_3 240 246 PF00018 0.650
LIG_SH3_3 40 46 PF00018 0.397
LIG_SH3_3 466 472 PF00018 0.392
LIG_SH3_3 547 553 PF00018 0.285
LIG_SH3_3 596 602 PF00018 0.531
LIG_SH3_3 614 620 PF00018 0.370
LIG_SH3_3 756 762 PF00018 0.309
LIG_SUMO_SIM_anti_2 449 456 PF11976 0.307
LIG_SUMO_SIM_par_1 160 166 PF11976 0.449
LIG_SUMO_SIM_par_1 639 644 PF11976 0.330
LIG_TRAF2_1 495 498 PF00917 0.457
LIG_TYR_ITIM 37 42 PF00017 0.258
LIG_UBA3_1 947 956 PF00899 0.445
LIG_WW_3 467 471 PF00397 0.430
MOD_CDK_SPxxK_3 372 379 PF00069 0.580
MOD_CK1_1 125 131 PF00069 0.436
MOD_CK1_1 149 155 PF00069 0.518
MOD_CK1_1 24 30 PF00069 0.548
MOD_CK1_1 262 268 PF00069 0.321
MOD_CK1_1 286 292 PF00069 0.262
MOD_CK1_1 367 373 PF00069 0.556
MOD_CK1_1 383 389 PF00069 0.540
MOD_CK1_1 450 456 PF00069 0.426
MOD_CK1_1 474 480 PF00069 0.575
MOD_CK1_1 501 507 PF00069 0.704
MOD_CK1_1 517 523 PF00069 0.578
MOD_CK1_1 524 530 PF00069 0.588
MOD_CK1_1 544 550 PF00069 0.325
MOD_CK1_1 582 588 PF00069 0.562
MOD_CK1_1 686 692 PF00069 0.657
MOD_CK1_1 806 812 PF00069 0.251
MOD_CK1_1 846 852 PF00069 0.398
MOD_CK1_1 889 895 PF00069 0.405
MOD_CK1_1 923 929 PF00069 0.597
MOD_CK2_1 238 244 PF00069 0.727
MOD_CK2_1 257 263 PF00069 0.244
MOD_CK2_1 45 51 PF00069 0.399
MOD_CK2_1 641 647 PF00069 0.406
MOD_CK2_1 691 697 PF00069 0.697
MOD_CK2_1 754 760 PF00069 0.320
MOD_CK2_1 899 905 PF00069 0.463
MOD_CK2_1 91 97 PF00069 0.602
MOD_Cter_Amidation 933 936 PF01082 0.504
MOD_GlcNHglycan 100 103 PF01048 0.562
MOD_GlcNHglycan 109 113 PF01048 0.584
MOD_GlcNHglycan 118 121 PF01048 0.500
MOD_GlcNHglycan 124 127 PF01048 0.421
MOD_GlcNHglycan 154 157 PF01048 0.402
MOD_GlcNHglycan 206 209 PF01048 0.673
MOD_GlcNHglycan 210 213 PF01048 0.604
MOD_GlcNHglycan 231 234 PF01048 0.624
MOD_GlcNHglycan 285 288 PF01048 0.388
MOD_GlcNHglycan 382 385 PF01048 0.590
MOD_GlcNHglycan 388 391 PF01048 0.360
MOD_GlcNHglycan 415 419 PF01048 0.311
MOD_GlcNHglycan 47 50 PF01048 0.436
MOD_GlcNHglycan 473 476 PF01048 0.539
MOD_GlcNHglycan 567 570 PF01048 0.592
MOD_GlcNHglycan 587 591 PF01048 0.421
MOD_GlcNHglycan 694 697 PF01048 0.634
MOD_GlcNHglycan 727 730 PF01048 0.623
MOD_GlcNHglycan 805 808 PF01048 0.196
MOD_GlcNHglycan 837 840 PF01048 0.391
MOD_GlcNHglycan 896 899 PF01048 0.406
MOD_GlcNHglycan 922 925 PF01048 0.617
MOD_GSK3_1 121 128 PF00069 0.539
MOD_GSK3_1 145 152 PF00069 0.623
MOD_GSK3_1 173 180 PF00069 0.312
MOD_GSK3_1 200 207 PF00069 0.608
MOD_GSK3_1 24 31 PF00069 0.521
MOD_GSK3_1 282 289 PF00069 0.397
MOD_GSK3_1 367 374 PF00069 0.583
MOD_GSK3_1 414 421 PF00069 0.281
MOD_GSK3_1 446 453 PF00069 0.285
MOD_GSK3_1 501 508 PF00069 0.622
MOD_GSK3_1 517 524 PF00069 0.600
MOD_GSK3_1 528 535 PF00069 0.468
MOD_GSK3_1 582 589 PF00069 0.573
MOD_GSK3_1 666 673 PF00069 0.615
MOD_GSK3_1 682 689 PF00069 0.473
MOD_GSK3_1 72 79 PF00069 0.377
MOD_LATS_1 171 177 PF00433 0.307
MOD_LATS_1 433 439 PF00433 0.307
MOD_LATS_1 723 729 PF00433 0.526
MOD_LATS_1 815 821 PF00433 0.305
MOD_N-GLC_1 131 136 PF02516 0.491
MOD_N-GLC_2 167 169 PF02516 0.456
MOD_N-GLC_2 414 416 PF02516 0.333
MOD_N-GLC_2 591 593 PF02516 0.499
MOD_NEK2_1 175 180 PF00069 0.270
MOD_NEK2_1 200 205 PF00069 0.589
MOD_NEK2_1 3 8 PF00069 0.571
MOD_NEK2_1 371 376 PF00069 0.661
MOD_NEK2_1 403 408 PF00069 0.326
MOD_NEK2_1 446 451 PF00069 0.432
MOD_NEK2_1 539 544 PF00069 0.453
MOD_NEK2_1 565 570 PF00069 0.641
MOD_NEK2_1 64 69 PF00069 0.410
MOD_NEK2_1 754 759 PF00069 0.358
MOD_NEK2_1 791 796 PF00069 0.245
MOD_NEK2_1 803 808 PF00069 0.245
MOD_NEK2_1 829 834 PF00069 0.334
MOD_NEK2_1 843 848 PF00069 0.233
MOD_NEK2_2 69 74 PF00069 0.410
MOD_OFUCOSY 416 422 PF10250 0.348
MOD_PIKK_1 177 183 PF00454 0.351
MOD_PIKK_1 493 499 PF00454 0.591
MOD_PK_1 819 825 PF00069 0.307
MOD_PKA_1 229 235 PF00069 0.506
MOD_PKA_2 229 235 PF00069 0.604
MOD_PKA_2 236 242 PF00069 0.558
MOD_PKA_2 378 384 PF00069 0.578
MOD_PKA_2 386 392 PF00069 0.370
MOD_PKA_2 515 521 PF00069 0.491
MOD_PKA_2 585 591 PF00069 0.489
MOD_PKA_2 626 632 PF00069 0.584
MOD_PKA_2 657 663 PF00069 0.590
MOD_PKA_2 69 75 PF00069 0.418
MOD_PKA_2 818 824 PF00069 0.273
MOD_PKB_1 817 825 PF00069 0.279
MOD_Plk_1 108 114 PF00069 0.493
MOD_Plk_1 520 526 PF00069 0.503
MOD_Plk_4 447 453 PF00069 0.445
MOD_Plk_4 59 65 PF00069 0.285
MOD_Plk_4 754 760 PF00069 0.350
MOD_Plk_4 761 767 PF00069 0.260
MOD_Plk_4 796 802 PF00069 0.210
MOD_Plk_4 819 825 PF00069 0.326
MOD_Plk_4 943 949 PF00069 0.429
MOD_ProDKin_1 138 144 PF00069 0.529
MOD_ProDKin_1 201 207 PF00069 0.709
MOD_ProDKin_1 220 226 PF00069 0.531
MOD_ProDKin_1 329 335 PF00069 0.256
MOD_ProDKin_1 372 378 PF00069 0.590
MOD_ProDKin_1 525 531 PF00069 0.603
MOD_ProDKin_1 534 540 PF00069 0.490
MOD_ProDKin_1 613 619 PF00069 0.601
MOD_ProDKin_1 629 635 PF00069 0.344
MOD_ProDKin_1 641 647 PF00069 0.539
MOD_ProDKin_1 832 838 PF00069 0.209
TRG_DiLeu_BaLyEn_6 917 922 PF01217 0.659
TRG_ENDOCYTIC_2 39 42 PF00928 0.288
TRG_ER_diArg_1 192 195 PF00400 0.425
TRG_ER_diArg_1 240 243 PF00400 0.508
TRG_ER_diArg_1 561 564 PF00400 0.596
TRG_ER_diArg_1 935 937 PF00400 0.595
TRG_ER_diArg_1 948 950 PF00400 0.446
TRG_Pf-PMV_PEXEL_1 920 925 PF00026 0.671

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM78 Leptomonas seymouri 40% 100%
A0A3S7WVF1 Leishmania donovani 99% 100%
E9AS58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QDA8 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS