Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYC0_LEIIN

TriTrypDb:

LINF_190015600

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HYC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.590
CLV_NRD_NRD_1	167	169	PF00675	0.671
CLV_NRD_NRD_1	196	198	PF00675	0.734
CLV_NRD_NRD_1	218	220	PF00675	0.484
CLV_NRD_NRD_1	24	26	PF00675	0.559
CLV_NRD_NRD_1	54	56	PF00675	0.525
CLV_PCSK_KEX2_1	169	171	PF00082	0.659
CLV_PCSK_KEX2_1	195	197	PF00082	0.770
CLV_PCSK_KEX2_1	24	26	PF00082	0.559
CLV_PCSK_KEX2_1	54	56	PF00082	0.513
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.684
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.770
CLV_PCSK_SKI1_1	128	132	PF00082	0.484
CLV_PCSK_SKI1_1	277	281	PF00082	0.573
CLV_PCSK_SKI1_1	79	83	PF00082	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.607
DOC_MAPK_gen_1	227	236	PF00069	0.642
DOC_MAPK_gen_1	275	282	PF00069	0.600
DOC_MAPK_gen_1	54	61	PF00069	0.482
DOC_USP7_MATH_1	104	108	PF00917	0.731
DOC_USP7_MATH_1	122	126	PF00917	0.516
DOC_USP7_MATH_1	152	156	PF00917	0.765
DOC_USP7_MATH_1	163	167	PF00917	0.687
DOC_WW_Pin1_4	176	181	PF00397	0.672
DOC_WW_Pin1_4	97	102	PF00397	0.746
LIG_14-3-3_CanoR_1	11	16	PF00244	0.455
LIG_14-3-3_CanoR_1	156	162	PF00244	0.563
LIG_FHA_1	137	143	PF00498	0.633
LIG_FHA_1	205	211	PF00498	0.590
LIG_FHA_1	257	263	PF00498	0.617
LIG_FHA_1	76	82	PF00498	0.579
LIG_FHA_2	209	215	PF00498	0.573
LIG_Integrin_RGD_1	197	199	PF01839	0.620
LIG_LIR_Gen_1	53	62	PF02991	0.584
LIG_LIR_Nem_3	14	18	PF02991	0.470
LIG_LIR_Nem_3	19	23	PF02991	0.467
LIG_LIR_Nem_3	53	59	PF02991	0.589
LIG_PCNA_yPIPBox_3	269	280	PF02747	0.628
LIG_Pex14_2	126	130	PF04695	0.634
LIG_SH2_CRK	20	24	PF00017	0.506
LIG_SH2_GRB2like	239	242	PF00017	0.592
LIG_SH2_SRC	239	242	PF00017	0.592
LIG_SH2_STAP1	56	60	PF00017	0.481
LIG_SH2_STAP1	86	90	PF00017	0.596
LIG_SH3_3	103	109	PF00018	0.728
LIG_SH3_3	95	101	PF00018	0.759
LIG_SH3_4	108	115	PF00018	0.665
LIG_TYR_ITIM	18	23	PF00017	0.505
LIG_UBA3_1	279	286	PF00899	0.527
LIG_WRC_WIRS_1	123	128	PF05994	0.575
MOD_CK1_1	100	106	PF00069	0.681
MOD_CK1_1	135	141	PF00069	0.710
MOD_CK1_1	179	185	PF00069	0.708
MOD_CK1_1	64	70	PF00069	0.466
MOD_CK2_1	104	110	PF00069	0.743
MOD_CK2_1	208	214	PF00069	0.627
MOD_GlcNHglycan	186	189	PF01048	0.714
MOD_GlcNHglycan	201	205	PF01048	0.566
MOD_GlcNHglycan	211	214	PF01048	0.592
MOD_GlcNHglycan	63	66	PF01048	0.483
MOD_GlcNHglycan	68	71	PF01048	0.461
MOD_GSK3_1	100	107	PF00069	0.707
MOD_GSK3_1	113	120	PF00069	0.631
MOD_GSK3_1	132	139	PF00069	0.479
MOD_GSK3_1	174	181	PF00069	0.742
MOD_GSK3_1	200	207	PF00069	0.736
MOD_N-GLC_1	11	16	PF02516	0.526
MOD_N-GLC_1	184	189	PF02516	0.740
MOD_N-GLC_2	241	243	PF02516	0.579
MOD_NEK2_1	113	118	PF00069	0.651
MOD_NEK2_2	163	168	PF00069	0.607
MOD_PKA_2	75	81	PF00069	0.580
MOD_Plk_1	11	17	PF00069	0.561
MOD_Plk_1	132	138	PF00069	0.656
MOD_Plk_1	163	169	PF00069	0.609
MOD_Plk_4	122	128	PF00069	0.641
MOD_ProDKin_1	176	182	PF00069	0.669
MOD_ProDKin_1	97	103	PF00069	0.747
MOD_SUMO_for_1	130	133	PF00179	0.621
MOD_SUMO_for_1	142	145	PF00179	0.671
MOD_SUMO_for_1	263	266	PF00179	0.585
MOD_SUMO_for_1	29	32	PF00179	0.556
MOD_SUMO_rev_2	173	177	PF00179	0.785
TRG_ENDOCYTIC_2	20	23	PF00928	0.505
TRG_ENDOCYTIC_2	56	59	PF00928	0.485
TRG_ER_diArg_1	167	170	PF00400	0.704
TRG_ER_diArg_1	23	25	PF00400	0.558
TRG_ER_diArg_1	54	56	PF00400	0.509
TRG_NLS_MonoCore_2	282	287	PF00514	0.648
TRG_NLS_MonoExtC_3	127	132	PF00514	0.480
TRG_NLS_MonoExtC_3	167	172	PF00514	0.701
TRG_NLS_MonoExtC_3	282	288	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD46	Leptomonas seymouri	53%	100%
A0A3S7WVP3	Leishmania donovani	99%	100%
A0A422NC58	Trypanosoma rangeli	41%	100%
A4HA55	Leishmania braziliensis	76%	99%
D0A642	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AS54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QDB2	Leishmania major	91%	100%
V5BKZ5	Trypanosoma cruzi	42%	100%